expression and action of cytokines in the brain mechanisms and pathophysiological implications
Tài liệu Báo cáo khoa học: Dmrt1 genes at the crossroads: a widespread and central class of sexual development factors in fish pdf
... studied in the context of gonadal induction and maintenance, illuminating its important function But what about the other dmrt genes? Table summarizes the expression pattern of these genes in fish ... zinc ion each, and binds to the minor groove of the DNA [6] Dmrts were originally described to play important roles during sex determination in flies and worms by regulating several aspects of ... dmrt1 expression is generally detected at higher levels in testes than ovaries The deep interest in Dmrt1 in the field of sex determination in fish came with the discovery of a dmrt1 homologue on the...
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Tài liệu Báo cáo khoa học: Roles of the human Rad51 L1 and L2 loops in DNA binding doc
... to examine whether these loops are actually involved in DNA binding Because aromatic residues are involved in the ssDNA binding by bacterial single stranded DNA-binding protein (SSB) and human ... monomer of poly(dT), showing that the changes were mainly due to the binding of the first DNA, while the binding of the second DNA had less in uence (Fig 5A) To ensure that the estimation of the protein:poly(dT) ... that of HsRad51 in the absence of DNA (Figs 2D,E) These results suggest that the Tyr232 residue is within neither the subunit–subunit interface nor the ATP-binding site In contrast to the salt-induced...
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Báo cáo khoa học: In vitro analysis of the relationship between endonuclease and maturase activities in the bi-functional doc
... increase the stability of the protein and slowed the reaction rate (data not shown) The inclusion of 5–10% glycerol increased stability two- to fivefold, depending on the preparation of protein, ... statement and suggests that the RNA binding site is still available and its binding affinity is not altered by the presence of DNA in the DNA binding site Interestingly, when nM RNA and 10 nM ... Each time the splicing reaction was minimally affected by prebinding the DNA to protein As the concentration of protein used, nM, yields a rate of splicing which is about 25% that of the maximal...
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báo cáo hóa học: " Tumor necrosis factor-mediated inhibition of interleukin-18 in the brain: a clinical and experimental study in head-injured patients and in a murine model of closed head injury." pot
... concomitant beneficial and adverse effects of pro-inflammatory mediators, depending on the kinetic of their expression and posttraumatic regulation in the injured brain [3,12,13] However, the TNF-dependent ... regulation of IL-18 in the murine brain: (1) The first part of the experimental study was designed to investigate a potential role of TNF-dependent regulation of intracranial IL-18 expression in a standardized ... corresponds to the time-point of maximal extent of intracerebral inflammation in the model of CHI used in this study [17] For assessment of intracerebral IL-18 levels, the murine brains were immediately...
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Báo cáo hóa học: " Research Article Analysis of the Tradeoff between Delay and Source Rate in Multiuser Wireless Systems" docx
... the computation of the variance of the blocks (the evaluation of the mean of the blocks is straightforward), which comes down to the computation of the expectation E[cu [n]cu [n + m]] The joint ... constraint Moreover, the in uence of the scheduling algorithm and the channel conditions (SNR, target BER) are captured in the mean and the variance mu and σu Thus, the evaluation of the user rates comes ... to obtaining the mean and the variance of the channel process seen by user u: (20) The delay constraint formed by the pair (Dt , ε) can be different for each user Nevertheless, we maintain the 3.2...
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Báo cáo khoa học: "Evaluation of the nuclear DNA content and GC percent in four varieties of Fagus sylvatica L" potx
... determined for the common beech and the tortuosa variety, after propidium iodide and mithramycin stainings Results are listed in table II In F sylvatica, the GC content was 40.0 ± 0.2 %; in the tortuosa ... 3.5 %), indicatthat DNA content in the tortuosa variety is the same as in the common beech Furthermore, in replicated analyses of common beech with or without tortuosa, the coefficients of variation ... at the low end of the range of known 2C genome sizes, as for instance Musa acuminata (1.2 pg), Vitis vinifera (1.0 pg) or Phaseolus augustii (1.1pg) [4, 11] The GC content was then determined...
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Báo cáo lâm nghiệp: " A flow cytometric evaluation of the nuclear DNA content and GC percent in genomes of European oak species" pptx
... ploidy level of Quercus plants on the basis of genome size relative to a standard plant of known ploidy MATERIALS AND METHODS The plant material was leaves of in vitro cloned plantlets of Q petraea ... calculation is based on only the first subpopulation of nuclei, the 2C peak, avoiding the higher levels Yet another source of variation can be the in vitro procedure However, the propagation procedure ... Willd and Q robur L Petunia hybrida cv Px Pc (2C 2.85 pg; 41 % GC) was selected as an internal standard The Q petraea and Q robur clones originated from donor trees in northeastern France (Lorraine)...
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Báo cáo y học: "Critical role of the major histocompatibility complex and IL-10 in matrilin-1-induced relapsing polychondritis in mice" doc
... distress in the acute phase, which in two mice had high scores However, the symptoms in these strains did not proceed in relapses as they did in the QD and B10.Q mice, and therefore resulted in a ... pathogenesis of both diseases [16,18,19] and T cells are required in order to induce disease [10,20] No data have been reported on the role of cytokines in RP, either in patients or in the corresponding ... MIRP On the other hand, the murine MIRP and CIA models are both dependent on B cells for the induction of clinical symptoms [16,17] In addition, the complement system plays a major role in the pathogenesis...
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Báo cáo y học: " T4 genes in the marine ecosystem: studies of the T4-like cyanophages and their role in marine ecology" doc
... they are homologues of host genes The most obvious of these is the collection of genes that are involved in altering or maintaining photosynthetic function of the host The most well studied and ... enzyme in the synthesis of the polyamines spermidine and spermine With polyamines implicated in the stabilising the psbA mRNA in the cyanobacterium Synechocystis [64], altering structure of PSII ... product of trx is thioredoxin, an important regulatory protein that is essential in the co-ordination of the light-dark reactions of photosynthesis by the activation of a number of enzymes, one of the...
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Báo cáo khoa học: "The influence of the PRKAG3 mutation on glycogen, enzyme activities and fibre types in different skeletal muscles of exercise trained pigs" pot
... semitendinosus in the carriers and the non-carriers of the PRKAG3 mutation are presented in Table The CS activity was higher (P < 0.05) in the carriers of the PRKAG3 mutation than in the non-carriers ... 0.05) in m biceps femoris and m longissimus dorsi in the carriers than in the noncarriers Discussion The main new finding of this study is, that after exercise training the PRKAG3 mutation influences ... PRKAG3 mutation in m longissimus dorsi and in m semitendinosus than in the noncarriers In all muscles the activity of HK was higher (P < 0.05) in the carriers and the activity of phosphorylase...
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Báo cáo y học: " The role of the humoral immune response in the molecular evolution of the envelope C2, V3 and C3 regions in chronically HIV-2 infected patients" pdf
... concentrated in the C2 region The four N-glycosylation sites in C2 and the site in the beginning of V3 were highly conserved in all patients throughout infection which is strongly indicative of convergent ... important role in the folding of the glycoproteins, in infection and in evasion from the host immune response (reviewed in [69]) We found that, as for HIV-1 [51,58], the majority of potential N-glycosylation ... References Competing interests The authors declare that they have no competing interests Authors' contributions NT designed and coordinated the study PB performed most of the cloning and sequencing experiments...
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Báo cáo y học: "Inhibition of complement C5a prevents breakdown of the blood-brain barrier and pituitary dysfunction in experimental sepsis" ppt
... cells, relaying into the brain inflammatory response and jeopardising the functional integrity of the BBB [55-57] In the present study, we found that, during experimental sepsis, the antibody-mediated ... decreases the intracellular production of proinflammatory cytokines and chemokines by inhibiting nuclear factor-κB activation and reduces cellular expression of VCAM1, ICAM-1 and E-selectin [76] During ... Production of the cytokines interleukin and by murine brain microvessel endothelium and smooth muscle pericytes J Neuroimmunol 1993, 47:23-34 53 Reyes TM, Fabry Z, Coe CL: Brain endothelial cell...
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Báo cáo y học: "Endothelial Circulating soluble urokinase plasminogen activator receptor is stably elevated during the first week of treatment in the intensive care unit and predicts mortality in critically ill patients" potx
... for inflammation and bacterial infection in clinical routine, CRP and PCT reached AUC statistics of 0.524/0.531 and 0.545/0.550 In comparison with these biomarkers of organ dysfunction and inflammation, ... analyses, including markers of inflammation/infection (CRP, PCT), hepatic (albumin, international normalized ratio (INR)) and renal (creatinine) function at admission, suPAR remained an independent ... proliferation and have been found to promote tissue invasion in malignant diseases by converting plasminogen into plasmin, resulting in degradation of extracellular matrix [1-4] Migration of inflammatory...
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In this paper, we investigate the relationship between migration and species distribution in multizone environment. We present a discrete model for migration of three competing species over three zones. We prove that the migration tactics of species leads
... F (the so-called structure function [5]) and vector (X1 , Xn , W1 , Wp ) where n is the number of components of the models (and leaves of the DFT) and p is the number of PAND gates in the ... cases, the simulation is performed on processors and the initial paths are in black while the correction step is in dotted red lines of the simulation For instance in the left part of Fig 1, the ... of the events occurring in the subtrees Now, we change the initial step of the simulation When we draw the random number, we check if un < S In that case we trigger the event in the subtree and...
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The u s presidency and executive power in the works of thomas pynchon, philip roth and cormac mccarthy
... discussed the presence of the Cold War in the Border Trilogy and The Road, and the influences of both the Reagan and Clinton administrations on McCarthy’s fiction Other critics have interrogated the ... Gravity’s Rainbow and Vineland (1990), and McCarthy’s No Country For Old Men (2005) These were also the years of the Cold War, furthering and deepening the general sense of paranoia and impending destruction, ... from the 1960s to the 1980s is marked in Vineland, unmistakeably, by the rise of first Nixon, and then Reagan The immense power of the executive branch to affect the lives, inner and outer, of individual...
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Sumary: The difference of the culture between Vietnam and US (lesson in the university)
... fruit as the thanks of yours - Acquaintances When acquaintances meet together in the street, they often smile together if they are at the same age If they are different about the age, the younger ... to the burial ground After three days of mourning, the family visits the tomb again, or worship the opening the grave After 49 days, the family stops bringing rice for the dead to the altar And ... finally, after 100 days, the family celebrates, or the end of the tears After one year is the ceremony of the first anniversary of the relative's death and after two years is the ceremony of the...
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Construing the world: conceptual metaphors and event-construal in news stories potx
... the defiant character of Tony Blair at the very beginning of the story and provides an apt introduction of the battle construal by introducing the readers to the theme of aggression/opposition: ... focus on the metaphorical style of literary texts) as well as with Lakoff (1992), while differing from these studies in broadening the focus to an examination of the interaction of linguistic ... quit on the eve of making history by becoming the Labour Prime Minister who has served the longest single period And he crushed the Chancellor's hopes of moving into No10 by saying: "There is...
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Báo cáo khoa học: The calpain 1–a-actinin interaction Resting complex between the calcium-dependant protease and its target in cytoskeleton doc
... to interact with Calp1 This indicates the presence of a calpain binding site in the C-terminal domain of smooth muscle a-actinin Involvement of the C-terminal domain of ask in Calp1 binding In ... binding site is included in the C-terminal domain of the ask molecule, and this binding is independent of the susceptibility of the a-actinin isoform to calpain proteolysis Identification of the ... to the origin of interactions [9,10,12,27] with the targets, the stability of complexes in the resting stage [3,48] and the activation state [7,33] of the binding calpain The topology of the interface...
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Báo cáo khoa học: "INTEGRATING TEACHING THE ENGLISH TENSE: NAIVE AND FORMAL GRAMMARS IN AN INTELLIGENT TUTOR FOR FOREIGN LANGUAGE TEACHING" pdf
... stands for the speaking time, i.e., the interval during which the sentence is being uttered Since the number of the potential temporal relations holding between the time intervals contained in ... that of maintaining the wealth of ideas and intuitions existing in the naive account of tenses while developing at the same time a computationally tractable model of the tense selection process In ... with the action to finish the thesis and the reference time is constituted by the time interval indicated with by the end of next month In some clauses the reference time may be absent and, in...
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Connecting Developmental Constructions to the Internet: Identity Presentation and Sexual Exploration in Online Teen Chat Rooms pot
... they are creating and, more to the point, co-creating their Internet environment through processes of social interaction The theoretical question then becomes, what are they creating and what role ... blind to the nicknames when coding their utterances, and were blind to the utterances when coding the nicknames Only the transcripts from the monitored service were coded for the presence of the ... containing age and gender information in the two Services We see that the majority of participants (55%) made declarations of identity Indeed, 12% of all utterances in the chat rooms contained...
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Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các mục tiêu của chương trình khảo sát chương trình đào tạo gắn với các giáo trình cụ thể xác định thời lượng học về mặt lí thuyết và thực tế điều tra đối với đối tượng giảng viên và đối tượng quản lí khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam nội dung cụ thể cho từng kĩ năng ở từng cấp độ phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 động cơ điện không đồng bộ một pha thông tin liên lạc và các dịch vụ phần 3 giới thiệu nguyên liệu từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008 chỉ tiêu chất lượng 9 tr 25