exogenous administration of cytokines into the central nervous system analysis of alterations in cell morphology and molecular expression
báo cáo hóa học: " Temporal expression and cellular origin of CC chemokine receptors CCR1, CCR2 and CCR5 in the central nervous system: insight into mechanisms of MOG-induced EAE" pptx
... around inflammatory foci in the spinal cord of rats with EAE, thus identifying potential determinants for trafficking of these cells to the CNS These findings are discussed in relation to therapeutic ... areas of the spinal cord displaying focal inflammation and demyelination (Fig 2E) Quantification of CCR1, CCR2 and CCR5 mRNAexpressing cells in relation to the stage of demyelinating activity The ... immunization) of EAE show extensive inflammation involving the white and grey matter (D), with marked demyelination in the inflammatory areas (F) The majority of the infiltrating inflammatory cells are...
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Báo cáo sinh học: "The long term effects of chemotherapy on the central nervous system" docx
... with certain brain tumors, especially for the very young Because of the rapid myelinization that occurs in infants, the finding by Noble and colleagues [1] of the adverse effects of chemotherapy ... 40% of the children in that study had IQs less than 85, a striking difference from the average As the dose and frequency of administration of methotrexate had been gradually increased over the ... radiation The response of investigators has been to reduce the dose and/ or volume of radiation and, in some cases, to eliminate radiation entirely, adding combination chemotherapy to the treatment...
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Báo cáo sinh học: "Systemic 5-fluorouracil treatment causes a syndrome of delayed myelin destruction in the central nervous system" doc
... treatment, there was a 2.5-fold increase in apoptosis in the subventricular zone (SVZ) and a 4-fold increase in the dentate gyrus of the hippocampus (DG) The increased cell death persisted in the SVZ and ... demyelinated axons, including partial or complete loss of myelin sheaths and increases in inter-laminar splitting of the myelin sheaths Analysis of transverse sections (Figure 9) provided further ... decreased levels of MBP in the CC and in the white-matter tracts of the striatum of treated animals (Figure 10) In agreement with the majority of the cell bodies in the mature CC belonging to oligodendrocytes...
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Báo cáo khoa học: "Immunohistochemical study of constitutive neuronal and inducible nitric oxide synthase in the central nervous system of goat with natural listeriosis" potx
... nNOS and iNOS in neurons increased when bacterial encephalitis occurred This is the first study of NOS expression in the goat brain with listeriosis The involvement of iNOS in bovine and caprine ... brainstem and the staining pattern was similar to those of control brains with nonneurological diseases In the microabscesses, iNOS was recognized in inflammatory cells (mainly macrophages) in the ... hematoxylin Magnification A and B, ×66 C and D, ×132 Immunohistochmical study of nitric oxide synthase in the central nervous system of goat Enhanced expression of nNOS and iNOS in L monocytogenes-infected...
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báo cáo khoa học: "Isolated angiitis of the central nervous system with tumor-like lesion, mimicking brain malignant glioma: a case report and review of the literature" pdf
... described the MRI features GL provided the pathological diagnosis TJ was the surgeon and gave the final approval of the version to be published Competing interests The authors declare that they have ... angiitis of the central nervous system: initial and follow-up MR features Neuroradiology 2009, 51:651-659 12 Ay H, Sahin G, Saatci I, Söylemezoğlu F, Saribaş O: Primary Angiitis of the Central Nervous ... central nervous system: serial MRI of brain and spinal cord Neuroradiology 2001, 43:599-607 14 Moore PM: Diagnosis and management of isolated angiitis of the central nervous system Neurology...
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báo cáo khoa học: "In vivo observation of gold nanoparticles in the central nervous system of Blaberus discoidalis" potx
... identify the organs affected by the nAuNPs The XPS was used to verify the presence of nAuNPs embedded in the brain tissue The confocal microscope and TEM were used to gain insights into the interaction ... vibration in the building Although proteins not break into ions, introducing charged particles into the nervous system causes an imbalance in the signal transmission that links to the insect’s locomotion ... eliminated by using only young males in this study The effects of temperature, humidity, and wind were diminished by maintaining them in a controlled environment However, the fluctuations in Rocha...
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The role of hydrogen sulfide in the central nervous system implications in the treatment of alzheimers disease
... enhancing the activity of gamma-glutamylcysteine synthetase and up-regulating cystine transport The upregulation in gammaglutamylcysteine synthetase activity facilitates the redistribution of GSH into ... like tau is involved in microtubule assembly It serves as a binding for the tubulin Mutations in α-synuclein lead to loss of this binding ability, resulting in tubulin and α-synuclein aggregation ... stimulation of A2A receptors by HENECA resulted into the increase in intracellular cAMP levels Similar to the first part of the studies, NaHS inhibited the cAMP production in astrocytes These data...
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Genetic engineering and surface modification of baculovirus derived vectors for improved gene delivery to the central nervous system
... within the cell is reverse transcribed into double-stranded DNA which can then integrate randomly into the host cell genome The use of retrovirus vectors for gene delivery to the nervous system ... 1997;Walther and Stein, 2000) The specificity and stability of transgene expression from AAV vectors seems to be dependent of the brain area and the presence of receptors for AAV uptake on target cells ... PARTICLES 15 2.1 Introduction 2.1.1 Baculovirus and the Insect Cell Expression System Baculovirus can efficiently infect and replicate in host insect cells Figure 2.1 shows the structure and replication...
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Development of hybrid promoters and viral vectors for improved gene delivery to the central nervous system
... functional cells in the nervous system, carrying out the fundamental tasks of receiving, conducting and transmitting signals Therapeutic protection of these cells is one of the main goals of gene therapy ... one of the key issues of gene therapy The expression level and specificity of the therapeutic gene is primarily determined by the activity of the promoter at the transcriptional level, and the ... plasmid, and inserted into pFB1 between Avr II and Sal I The CMV E/PDGF promoter was then inserted into the sites of Kpn I and Hind III to drive the luciferase reporter gene Fig 2.2 shows the expression...
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INVESTIGATION OF MEMBRANE PROPERTIES IN THE CENTRAL NERVOUS SYSTEM OF DROSOPHILA MELANOGASTER STUDIED BY FLUORESCENCE CORRELATION SPECTROSCOPY
... catalyzes the hydrolysis of ceramide to sphingosine Ceramide is the simplest form of sphingolipid and was shown to promote clustering of nanoscale domains in supported lipid bilayers [46] and in cells ... as the major constituent instead of sphingomyelin (PE-cer has phosphoethanolamine as the head group, instead of the phosphocholine head group in SM) [32] Despite having shorter fatty acyl chains ... also given Chapter introduces the concepts and theory of FCS as well as the experimental setup of this instrument The calibration of the FCS system is also discussed The last part of this chapter...
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The study of the mediation of ohanin, a king cobra (ophiophagus hannah) toxin through the central nervous system
... completes the SPRY domain (Pung et al., 2006) 14 Binding Studies of Ohanin and Pro-ohanin The lack of natural abundance of ohanin (~1 mg/g of crude venom) and absence of pro-ohanin in the venom ... components in the brain, as this might be useful to the understanding of the control of locomotion and pain responses The identification of the receptor(s), and the identification of the specific ... Asia and into Pakistan and India The skin is either olive-green, tan, or black and it has faint, pale yellow cross bands down the length of the body The underbelly is cream or pale yellow, and the...
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Báo cáo khoa học: Planarian peptidylglycine-hydroxylating monooxygenase, a neuropeptide processing enzyme, colocalizes with cytochrome b561 along the central nervous system pptx
... the time of the emergence of the Plathelminthes in the evolutionary history The eye of the planarian is one of the most ancestral and primitive types of visual systems in animals and is 950 A ... White and yellow arrowheads point the same cell in (D), (E), and (F), respectively The expression signal for the PHM gene was observable in the cell body of neurons in the peripheral region of the ... stalks of the photoreceptor cells The structure appeared similar to that in the neuropil of the brain [57] In the stalk region of the photoreceptor cells, neuropeptides may be synthesized and work...
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Section III - Drugs Acting on the Central Nervous System docx
... levels of nervous integration The major monoamine-containing neurons of the brain (see below) are found here Together, these regions represent the points of central integration for coordination of ... within and between the regions of the brain Cellular Organization of the Brain Present understanding of the cellular organization of the CNS can be viewed simplistically according to three main ... Treatment of Central Nervous System Degenerative Disorders) Norepinephrine There are relatively large amounts of norepinephrine within the hypothalamus and in certain zones of the limbic system, ...
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Báo cáo sinh học: "How chemotherapy damages the central nervous system Christina A Meyers" ppsx
... hippocampus and the corpus callosum), primarily in progenitor cells and oligodendrocytes To determine whether these findings resulted in functional impairment, they investigated the auditory brainstem ... response in the mice at various times following treatment Loss of myelin is known to increase the latency between specific peaks in the auditory brainstem response, reflecting slowing of the impulse ... progenitor cells and nondividing oligodendrocytes than to many cancer cell lines in vitro They also found that the agents caused increased cell death and decreased cell division in the subventricular...
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Chemical drug assisted gene transfer a sensible approach to improve transgene expression in the central nervous system
... used in each injection The rate of injection was μl/min and the needle was allowed to remain in situ for mins before being slowly retracted at the end of each injection The intrathecal lumbar injection ... condensation of DNA into compact particles, uptake into the cells, release from the endosomal compartment into the cytoplasm, and uptake of the DNA into the nucleus This multi-step process indicates ... remain at large in terms of choosing appropriate MW PEIs and biodegradable linkages as well as designing the degree of cross-linking, the particle size and the surface charge of the resulting...
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The central nervous system
... organ of the system Whereas the brain develops out of expansions of the neural tube into primary and then secondary vesicles, the spinal cord maintains the tube structure and is only specialized into ... 5/20 The Central Nervous System of information processing take place in the basal nuclei All input to the basal nuclei is from the cortex into the striatum ([link]) The direct pathway is the projection ... which the pituitary gland is attached 9/20 The Central Nervous System Brain Stem The midbrain and hindbrain (composed of the pons and the medulla) are collectively referred to as the brain stem...
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Cancer of the Brain and Other Central Nervous System doc
... Cancer of the Brain & Other Central Nervous System: Number of Cases and Exclusions, 12 SEER Areas, 1988-2001 Brain Other CNS Number Selected/ Remaining Number Excluded Number Selected/ Remaining ... Cancer Institute NOS, Not Otherwise Specified 210 SEER Survival Monograph Chapter 25 Cancer of the Brain and Nervous System Table 25.7: Cancer of the Other Central Nervous System: Distributions and ... Tumors of the spine were the most common site with other CNS cancers, although malignant meningiomas of the brain had worse survival than those with malignant tumors in the spine Brain and other...
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Báo cáo y học: "The impact of therapy for childhood acute lymphoblastic leukaemia on intelligence quotients; results of the risk-stratified randomized central nervous system treatment trial MRC UKALL XI" ppsx
... boys Again, changes in therapy protocols such as lack of co -administration of high-dose methotrexate and avoidance of radiotherapy in young patients may explain the lack of difference in IQ in our ... below The finding of similar outcomes in males and females is reassuring Initial reports of inferior outcomes in girls came from relatively small studies using combinations of methotrexate and ... higher in the case of the latter Analysis of the IQ scores in our control group suggests the presence of a practice effect Out of 132 controls tested at the year time point, 37 were taking their...
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báo cáo khoa học: "Extensive central nervous system involvement in Merkel cell carcinoma: a case report and review of the literature" docx
... conceived the idea of the study All authors participated in data collection KAK wrote the manuscript All authors read and contributed to the editing of the manuscript and gave their approval of the final ... of MCC brain metastases will depend, as in many other types of brain metastases, on the number of metastases, systemic spread of the disease and the accessibility to surgery We believe that the ... but not in the surrounding edema Although the morphologic findings of the supratentorial mass on conventional MRI were consistent with meningioma, the occurrence of the extensive edema and the MR...
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Báo cáo y học: "Ischemia as a possible effect of increased intraabdominal pressure on central nervous system cytokines, lactate and perfusion pressures" ppsx
... Taking into consideration the current knowledge concerning the impact of IAH on the CNS we conducted an experimental study in animals in order to investigate whether increased ICP and intraspinal ... Citerio G, Malbrain M: The influence of intra-abdominal hypertension on the central nervous system: current insights and clinical recommendations, is it all in the head? Acta Clinica Belgica 2007, ... baseline IAP was increased at the beginning (9.9 mmHg) and at the end of the experiment (11.4 mmHg) An explanation of this is provided by the mechanism of action of fentanyl, administered for maintenance...
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