evidence for cerebral metabolic impairments in alzheimer s disease
Tài liệu Báo cáo khoa học: Animal models of amyloid-b-related pathologies in Alzheimer’s disease docx
... pathogenesis Therapeutic studies in AD models Access to good animal models is crucial to success in developing disease- modifying therapeutics However, AD neuropathology is incomplete in the Ab-expressing ... cholinergic hypothesis, scopolamineinduced amnesia, excitotoxic lesions of the basal forebrain and aged primates have been used to assess cognitive deficits Current symptomatic drugs for AD were successfully ... by crossing PDGF–a-synuclein and APP-SweInd, which led to a 1.6-fold increase in a-synuclein inclusions in comparison with transgenic mice that expressed only wild-type human a-synuclein Similar...
- 21
- 559
- 0
Báo cáo khoa học: Levels of mTOR and its downstream targets 4E-BP1, eEF2, and eEF2 kinase in relationships with tau in Alzheimer’s disease brain doc
... either polyglutamine or polyalanine expansions in Huntington disease, Huntington related diseases, and various forms of a-synuclein associated with Parkinson disease and synucleinopathies [27] Taken ... Foundation, SADF (Insamlingsstiftelsen for ¨ Alzheimer- och Demensforskning), Socialstyrelsens Stiftelser, Stiftelsen for Alderssjukdomar, and Svenska ¨ ˚ Lakaresallskapet ¨ ¨ FEBS Journal 272 ... eEF2 in its N-terminus (Thr56) that subsequently blocks eEF2 binding to ribosomes, resulting in decreased rates of protein synthesis Dephosphorylation of eEF2 relieves its translational restriction...
- 10
- 376
- 0
báo cáo hóa học: " Using animal models to determine the significance of complement activation in Alzheimer''''s disease" pptx
... models of human disease generally have similar pathological findings to the human disorders, distinct differences remain These models may be appropriate for studying some aspects of a disease process, ... The PS/APP mouse carries both of these transgenes and has been extensively used as a model for studying processes relating to the formation of SPs Aβ deposition occurs more rapidly in these mice ... celecoxib in the treatment of progression of Alzheimer' s disease [abstract] Sixth International Stockholm/Springfield Symposium on Advances in Alzheimer Therapy 2000:180 Van Gool WA, Weinstein HC, Scheltens...
- 12
- 628
- 0
báo cáo hóa học: " Maximal COX-2 and ppRb expression in neurons occurs during early Braak stages prior to the maximal activation of astrocytes and microglia in Alzheimer''''s disease" pdf
... Demographic characteristics of the cases used in this study Shown are differences between groups of the cases used in this study [PMI post-mortem interval, SD standard deviation] Braak score for neurofibrillary ... 25 26 Pasinetti GM, Aisen PS: Cyclooxygenase-2 expression is increased in frontal cortex of Alzheimer' s disease brain Neuroscience 1998, 87:319-324 Combrinck M, Williams J, De Berardinis MA, Warden ... Braak stage instead of being defined as control or AD Other, previously described [17], discrepancies are most likely due to differences in pathological disease state and investigated brain area,...
- 5
- 449
- 0
báo cáo hóa học: " Peripheral reductive capacity is associated with cognitive performance and survival in Alzheimer''''s disease" potx
... out using LSS scores as proxy of status (p < 0.025, lowest vs highest LSS scores) As shown in Figure 2, high serum AOC levels predicted a longer survival of AD patients (CPHR, co-varying MMSE scores, ... Alzheimer' s disease [10] All participants underwent a physical examination, blood tests and neuroimaging assessments They also underwent cognitive assessments using the Cambridge Examination for Mental ... deficit, we used the MMSE scores as proxy of status (control vs AD) and of disease progression Subjects were divided into three mutually exclusive groups ranked by increasing MMSE scores [below 20...
- 6
- 371
- 0
báo cáo hóa học: " The microglial NADPH oxidase complex as a source of oxidative stress in Alzheimer''''s disease" ppt
... attenuates ROS production These findings suggest that these kinases are involved in upstream signaling cascades responsible for activating NADPH oxidase assembly in response to fAβ peptides [28,30] ... functional events in Alzheimer' s disease J Alzheimers Dis 2004, 6:171-175 Markesbery WR: Oxidative stress hypothesis in Alzheimer' s disease Free Radic Biol Med 1997, 23:134-147 Shimohama S, Tanino H, ... progressive pathophysiology associated with this disease The results summarized in this review suggest that ROS and iNOS released through NADPH-dependent mechanisms contribute to the extensive...
- 12
- 413
- 0
báo cáo hóa học: " Neuroinflammation in Alzheimer’s disease wanes with age" pdf
... is measured Assessments for different antibodies were performed in adjacent sections and blind to the pathological and clinical categorization Statistical analyses The Kruskall-Wallis test was ... Clinical status, demographic information, disease duration, neuropathological staging and APOE genotype of control and AD cases used in this study Case Diagnosis Sex Age (years) GDS Braak Brain ... years is 29% compared to 7% in older control cases For AD cases, the incidence of APOE4 in cases younger than 80 years is 57% compared to 29% in older AD cases Page of Discussion In this study,...
- 8
- 337
- 0
Báo cáo y học: " Sigma-1 receptor agonist fluvoxamine for delirium in patients with Alzheimer’s disease pot
... detailed study is necessary Delirium is regarded as syndrome that consists of several domains of symptoms, such as disturbance of consciousness, cognitions, and perceptions [17] At present, it is unclear ... is currently stable Discussion To our knowledge, this is the first report demonstrating that fluvoxamine monotherapy is effective for treating the delirium of patients with Alzheimer s disease ... together, it is likely that the difference for pharmacological actions (agonist or antagonist) of SSRIs at sigma-1 receptors may be involved in the mechanisms of different effects of these SSRIs [4-6]...
- 3
- 351
- 0
Tài liệu Báo cáo khoa học: A facile method for expression and purification of the Alzheimer’s disease-associated amyloid b-peptide pdf
... amino acid analysis and sequencing Amino acid analysis was performed at the Amino Acid Analysis Center, University of Uppsala, Sweden Sequence analysis was performed using an Applied Biosystems ... Discussion Because extensive evidence supports a crucial role for Ab in Alzheimer s disease pathogenesis, there is huge interest in understanding the structural and biological properties of this molecule ... pure as the synthetic peptides purified by reverse-phase HPLC, a finding corroborated by LC-MS analysis (Figs and S2 ) The fibril-forming properties of Ab peptides were assessed using a continuous ThT-binding...
- 16
- 691
- 0
Memory performance in healthy elderly without Alzheimer’s disease: effects of time and apolipoprotein-E pptx
... Information from the neurological, psychiatric and neuropsychological assessments were reviewed in a consensus conference comprised of neurologists, psychiatrists, and neuropsychologists Based ... background were included as covariates in subsequent analyses The GEE analyses yields beta values which represent associations between a factor score and variables included in the model A significant ... individuals without AD or QD, but other cognitive skills remained stable Increased age was associated with lower scores in all cognitive domains while increased education was associated with higher scores...
- 7
- 474
- 0
PET in the Evaluation of Alzheimer’s Disease and Related Disorders docx
... cognitive functioning Cognitive screening includes using validated screening instruments, such as the MMSE, and brief bedside assessments Cognitive screenings are usually sensitive to significant cognitive ... distinguish from Parkinson s disease, but the parkinsonism in DLB differs from Parkinson s disease by being more often symmetric, with less pronounced tremor (if any) Hallucinations are also ... toward scan interpretation that integrates the visual and quantifying information present in clinical PET scans Visual Assessment Systematic visual examination of a clinical brain PET scan involves...
- 231
- 535
- 0
Báo cáo khoa học: The modulation of metal bio-availability as a therapeutic strategy for the treatment of Alzheimer’s disease pptx
... These authors demonstrated that an increase in oxidative stress alters APP processing and generates an increase in Ab production If an oxidative stressinduced increase in Ab production promotes ... role for metal dyshomeostasis in all aspects is clear In the AD affected brain, metal dyshomeostasis is evident in the form of a substantial increase in the levels of extracellular metals and ... is increased in cerebrospinal fluid in Alzheimer s disease but not Parkinson s disease Alzheimer Dis Assoc Disord 8, 190–197 Hye A, Lynham S, Thambisetty M, Causevic M, Campbell J, Byers HL, Hooper...
- 9
- 634
- 0
Báo cáo khoa học: Therapeutic approaches for prion and Alzheimer’s diseases pot
... [14,105,106] Whether similar approaches can be used for prion disease remains to be determined Prion disease Interest in prion disease has greatly increased subsequent to the emergence of BSE in England ... (2–21 days depending on class and isoform) and the potential for inducing serum sickness with resultant complications such as renal failure or lymphomas Nevertheless, clinical trials for passive ... the cerebral vessel Ab in these autopsies suggests a potential role of CAA and an excessive Th-1 response in the genesis of the in ammatory sideeffects [57] This is an important issue because...
- 15
- 581
- 0
Báo cáo khóa học: FRET evidence for a conformational change in TFIIB upon TBP-DNA binding pptx
... using Microsoft s EXCEL SOLVER to perform least-squares curve fitting, with S (d2) of 0.001 The observed rate constant kobs was calculated from each set of data by nonlinear regression analysis ... Nevertheless, the decrease in the emission intensity ratio, observed for both AdML and AdE4, strongly suggests that TFIIB undergoes a change from a somewhat ÔclosedÕ conformational state in the apo form ... constraint, it is fairly safe to assume that a change in FRET with CYIIB monitors a conformational change in TFIIB Similar FRET-based conformational indicators have been successfully used for...
- 9
- 305
- 0
Báo cáo khoa học: RCAN1-1L is overexpressed in neurons of Alzheimer’s disease patients pot
... control tissues (a representative western blot is shown in Fig 3A) As human brain tissue is difficult to obtain, we focused on the most interesting regions for further studies These regions included ... complements data from rat tissues showing that calcineurin is also expressed in neurons [14,15] RCAN1 gene expression is significant in several tissues, particularly human brain, spinal cord, kidney, liver, ... shown to bind to and inhibit the serine–threonine protein phosphatase calcineurin [5] The brain is an especially interesting organ in which to examine RCAN1 expression, because calcineurin is...
- 10
- 302
- 0
Alterations of matrix metalloproteinases in the healthy elderly with increased risk of prodromal Alzheimer’s disease pot
... and a specificity of 87% in a large MCI study population [15] Statistics Statistical analysis was performed using the PASW software (former SPSS software, version 17.0.1 for Windows, SPSS Inc., ... assessment also included the Alzheimer s Disease Assessment Scale (ADAS-cog 85 points), clock test, cube copying test and A Quick Test of cognitive speed (AQT) These results were taken into consideration ... laboratory assistant Marit Emilsson for assistance in the TIMP-1 analysis This study was supported by unconditional grants by the Swedish Research Council; Stiftelsen för Gamla Tjänarinnor; Skåne county...
- 8
- 443
- 0
Báo cáo khoa học: LRRK2 in Parkinson’s disease: in vivo models and approaches for understanding pathogenic roles pdf
... mechanisms of many disease processes and will continue to impact our understanding of disease pathogenesis This minireview will examine the previous studies of genes for ROCO or LRRK2 homologs in slime ... known as frequent ‘contaminants’ in the process of searching binding proteins, the in vivo evidence for the relationship between ROCO proteins and cytoskeletons in D discoideum suggests a need ... enhanced sensitivity to endoplasmic reticulum stress induced by tunicamycin, a specific inhibitor for N-linked glycosylation Interestingly, this enhanced sensitivity is suppressed in mutant worms with...
- 10
- 527
- 0
Báo cáo khoa học: Amyloid-b protofibril levels correlate with spatial learning in Arctic Alzheimer’s disease transgenic mice docx
... contrast, in transgenic mice, functional deficits and loss of synapses are, at least in some models, observed in young transgenic animals devoid of plaque deposits, suggesting that soluble Ab species ... Discussion In the present study, Ab protofibril levels in young and aged animals were assessed in three different AD mouse models Ab protofibrils were present in both the brain and CSF of tg-ArcSwe ... conclusions drawn from such future studies in aged tg-ArcSwe mice would obviously not be straightforward because Ab burden and insoluble Ab are also increased The present study only suggests that...
- 12
- 299
- 0
Báo cáo khoa học: Amyloid–cholinesterase interactions Implications for Alzheimer’s disease pot
... plaques where it co-localizes with the Ab peptide [48] Butyrylcholinesterase is also present in neurofibrillary tangles In Alzheimer s disease the expression of butyrylcholinesterase increases substantially ... substantially in Alzheimer s disease patient s brain [47] Butyrylcholinesterase shares many structural and physicochemical properties with acetylcholinesterase [49] Therefore, butyrylcholinesterase was evaluated ... indolamines selectively inhibit cholinesterases in the histopathologic structures of Alzheimer s disease Ann NY Acad Sci 695, 65–68 Nakamura S, Kawashima S, Nakano S, Tsuji T & Araki W (1990) Subcellular...
- 8
- 254
- 0
Báo cáo khoa học: Implication of calpain in neuronal apoptosis A possible regulation of Alzheimer’s disease doc
... between calpains and caspases The striking similarity between the substrates for caspases and calpains raises the possibility that both protease families contribute to structural dysregulation ... cathepsins, which are implicated in neuronal cell death He suggested a possible cascade of events involving three protease systems: calpain-induced cathepsin release, cathepsin-mediated caspase ... apoptosis in astrocytes In this model of astrocyte apoptosis, translocation of the NF-kB p65 subunit to the nucleus is observed These findings indicate that, in this case, NF-jB acts as a death-promoting...
- 7
- 341
- 0
Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các mục tiêu của chương trình xác định các nguyên tắc biên soạn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản khảo sát chương trình đào tạo gắn với các giáo trình cụ thể xác định thời lượng học về mặt lí thuyết và thực tế tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến dòng điện stato i1 fi p2 động cơ điện không đồng bộ một pha sự cần thiết phải đầu tư xây dựng nhà máy thông tin liên lạc và các dịch vụ chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008 chỉ tiêu chất lượng 9 tr 25