every member of the steering committee participates in the meeting the project manager sends the status report to each member of the team prior to the meeting time so everyone can review it in advance
Báo cáo y học: "Serum protein profile in systemic-onset juvenile idiopathic arthritis differentiates response versus nonresponse to therapy" ppt
... arthritis Protein profiling by SELDI-TOF MS reveals patterns differentiating the responding from the nonresponding SJIA group The above data, using paired sera, demonstrate the ability of SELDI-TOF ... serum, their affinity with the copper matrix of the IMAC ProteinChip, and the relative desorption/ionization efficiencies of each protein In addition, the fact that the mass spectra generated in ... proteins SELDI-TOF MS analysis is capable of detecting small amounts of protein, hence the potential to detect proteins of relatively low abundance with affinity for the ProteinChip surface The...
- 10
- 368
- 0
Báo cáo khóa học: Surface nucleolin participates in both the binding and endocytosis of lactoferrin in target cells potx
... that the C-terminal tail of nucleolin should be implicated in the mechanism of binding of Lf to nucleolin In general, the crosslinking of a ligand leads to the clustering or capping of its surface ... the binding of HB-19 Similarly, the iron-binding hTf had no effect On the other hand, bLf inhibited the binding of HB-19 to cells In accordance with the involvement of both lobes of hLf in the ... order to investigate the domain in Lf implicated in its interaction with nucleolin, we investigated the capacity of various Lf constructs and derivatives to inhibit the binding of HB-19-fluo to CHO...
- 15
- 509
- 0
Báo cáo khoa học: The ‘pair of sugar tongs’ site on the non-catalytic domain C of barley a-amylase participates in substrate binding and activity potx
... carbohydrate binding However, mutating Ser378 in AMY1 to proline to mimic AMY2 did not elicit lack of binding as observed for the AMY2 structure [3] The func- tional analysis of the surface site furthermore ... site as well as to the active site cleft and the sugar tongs [21] The three rings dened at the Trp278Trp279 site corresponded to acarbose with the reducing-end glucose cleaved off and with the ... at the sugar tongs in the structure [3] In the present work, the sugar tongs site was demonstrated by site-directed mutagenesis of Tyr380 to be involved in enzymatic activity and conrmed to be...
- 13
- 385
- 0
Báo cáo y học: "Thioglycosides as inhibitors of hSGLT1 and hSGLT2: Potential therapeutic agents for the control of hyperglycemia in diabetes"
... hSGLT1, suggesting that differences in the aglycon binding site play an important role in the inhibitory effect of this substance In contrast, differences in the sugar binding site resulted in an preferen- ... small intestine and converted into its active form, a specific inhibitor of renal SGLT, resulting in inhibition of glucose reabsorption in the renal tubules [17, 19] This compound was the first ... metabolized in the intestine [27] Therefore, a chemical reaction to convert the substance in its active form, after intestinal absorption like in the case of O-glucosides, is not necessary In addition,...
- 9
- 650
- 0
(1) how learners approach learning, both in and out of classrooms, and (2) the kinds of strategies and cognitive processing they use in second language acquisition
... new words in a notebook Then I ask the teacher for the meaning and write down the meaning; sometimes look up the meaning of the new words at home using a dictionary, write the meaning in the notebook ... willing to have the interview recorded It was also made clear to the students that they did not have to state their names in the tape Along with recording the interview, the researcher also took ... “I find it hard to remember and the new words After some time, I usually forget the meaning and use of the words.” “If I see the words in the exercises many times, and the teacher explains the...
- 83
- 622
- 0
Tài liệu Báo cáo khoa học: Interleukin-1-inducible MCPIP protein has structural and functional properties of RNase and participates in degradation of IL-1b mRNA doc
... removed from the entire coding sequence of the MCPIP gene The coding sequence lacking the PIN domain was obtained in two steps First, the fragment of 423 bp situated in front of the PIN domain was ... experiment with fibroblasts is that MCPIP regulates the amount of IL-1b mRNA Involvement of PIN domain of MCPIP in the stability of IL-1b mRNA In order to find out whether the PIN domain in MCPIP ... endotoxin (LPS) One of the regulatory sequences involved in determining mRNA half life are the AREs, which can stimulate deadenylation of mRNA [20] and its degradation by the exosome in the 3¢...
- 14
- 598
- 0
Tài liệu Báo cáo Y học: Proteolysis of bovine b-lactoglobulin during thermal treatment in subdenaturing conditions highlights some structural features of the temperature-modified protein and yields fragments with low immunoreactivity pptx
... allergenicity in these preparations could stem from the inability of the hydrolytic reaction to address all the sequential epitopes even in the denatured protein In fact, despite the apparent simplicity ... extensive, in spite of significant inactivation of the enzymes This indicates that the transient conformers originating in the course of thermal treatment had exposed novel access sites for either enzyme ... domain of the protein [32], that was hypothesized to be relevant also for the stabilization of associated forms of BLG in solution [20] In this context, it seems significant that chymotrypsin (specific...
- 11
- 526
- 0
Tài liệu Báo cáo khoa học: "The Structure of User-Adviser Dialogues: Is there Method in their Madness?" pdf
... use of the pronoun it in her dialogues to the use of it in Linde's dialogues The goal of this paper is to find evidence for the validity of the notion of discourse structure derived from the ... at the beginning of subdialogues than later in the subdialogues On the other hand, pronominal noun phrases play a role in indicating and realizing topic continuity in a dialogue Since new topics ... which appeared to be the execution of a plan to satisfy a goal of the user or the adviser on the basis of the task structure In addition to segmenting the dialogue into subdialogues, the relations...
- 7
- 399
- 0
Báo cáo khoa học: Human telomeric G-quadruplex: The current status of telomeric G-quadruplexes as therapeutic targets in human cancer pdf
... selective inhibition of cell growth, with normal human cell lines being relatively unaffected; (d) senescence; (e) inhibition of telomerase activity in cells; (f) competitive inhibition of hPOT1 binding ... which interacts with quadruplexes in the promoter region of the c-kit oncogene that is disregulated in gastrointestinal cancer cells (inhibiting c-kit expression), and telomeric quadruplexes The inhibition ... characteristic of the G-quadruplex ligand class as a whole, and the observations of on-target in vivo activity within clinically useful timescales are encouraging signs that significant single-agent clinical...
- 8
- 446
- 1
The Treatment of Uncertainty in EPA’s Analysis of Air Pollution Rules: A Status Report pot
... not offer any judgment on the relative plausibility of the various scenarios, leaving to the reader the task of integrating the information from the sensitivity analyses on the various sources of ... Discussion of Other Areas of Uncertainty EPA continues to provide a qualitative discussion of other factors that contribute to uncertainty in its health benefits analysis.19 In the final RIA for the ... evaluated by the RIA In addition, there are uncertainties associated with the use of air quality monitoring to develop these emissions reduction estimates and with the effectiveness of the identified...
- 24
- 427
- 0
Báo cáo khoa học: E2A participates in a fine control of pre-mature B-cell apoptosis mediated by B-cell receptor signaling via transcriptional regulation of survivin, IAP2 and caspase-8 genes pot
... enforced expression of an inhibitor of differentiation proteins that indirectly inhibit E2A function [12,13] In addition, ectopic expression of E47 or E12 induced apoptotic cell death in thymic lymphoma ... [inhibitor of caspase-activated DNase (CAD)] and inhibitor of apoptosis (IAP2), and activation of caspase activities [24] Based on these results, in this study, as a first step in elucidating the ... level of ICAD (to approximately 40%) by 24 h in E2A)/), i.e the rate of decrease in the amount of ICAD in the mutant was slower than that in DT40 Thus, in E2A)/), in the presence of PMA/ionomycin,...
- 11
- 349
- 0
Every Step of the Way potx
... did their best to deny our unity, using the policies of apartheid to divide South Africans and distort the growth of a common nationhood Even today, it might be said, some South African citizens ... acute in South Africa than they are in some other countries, but they are not peculiarly South African in any way And the extent to which a democratic South Africa is committed to the removal of the ... within the ‘national unity’ of the United States And so it has been on our own continent, too The achievement of a meaningful nationhood – the common recognition of fellow citizens – has been the...
- 18
- 253
- 0
A study on the translation of technical terms in the interface of common business website and their Vietnamese equivalent
... according to any pre-ordained methodology Robinson in her second survey of ESP in 1991 also accepted the primacy of needs analysis in defining ESP Her definition is based on two key definition criteria ... the interface of business websites Identifying the formation and meaning of English terms used in interface of business websites Giving some sugguestions in translating technical terms in ... according to which a translator seeks to translate the meaning of the original in such as way that the TL wording will trigger the same impact on the TC audience as the original wording did upon the...
- 72
- 743
- 1
Report to the Congress on Practices of the Consumer Credit Industry in Soliciting and Extending Credit and their Effects on Consumer Debt and Insolvency pot
... requires the Board to examine whether the practices of the credit card industry with respect to soliciting and extending credit may contribute to rising consumer debt burdens and insolvency There ... Credit Industry customers or extend credit to them indiscriminately or without assessing their ability to repay debt Currently, the principal means of solicitation is direct mail, the bulk of ... household insolvencies The first three of the four requests by the Congress in section 1229(b) require a study of the extent to which, in soliciting customers and extending credit to them, the consumer...
- 30
- 543
- 0
Every Step of the Way doc
... did their best to deny our unity, using the policies of apartheid to divide South Africans and distort the growth of a common nationhood Even today, it might be said, some South African citizens ... acute in South Africa than they are in some other countries, but they are not peculiarly South African in any way And the extent to which a democratic South Africa is committed to the removal of the ... within the ‘national unity’ of the United States And so it has been on our own continent, too The achievement of a meaningful nationhood – the common recognition of fellow citizens – has been the...
- 18
- 243
- 0
Báo cáo khoa học: Adenine and adenosine salvage pathways in erythrocytes and the role of S-adenosylhomocysteine hydrolase A theoretical study using elementary flux modes Stefan Schuster and Dimitar Kenanov ppt
... 4) Some of them involve the modes starting from adenine obtained in the first simulation and include methyltransferase and SAHH2 in addition Some others involve the modes starting from adenosine ... Since adenine is a substrate of ADPRT, the elevation of ATP in the absence of adenosine kinase shows that adenine must be released in the process before being incorporated into ATP Indeed, studies ... III.12 remain intact It is interesting that the other ATP-producing modes (which drop out) involve ADA although it is an adenosine-degrading enzyme Interestingly, the modes of adenine salvage...
- 13
- 476
- 0
báo cáo hóa học:" Perioperative safety of two-team simultaneous bilateral total knee arthroplasty in the obese patient" docx
... planning needs Anticoagulation consisted of either warfarin, enoxaparin, or combination enoxaparin and warfarin therapy Most patients were discharged to home or to a rehabilitation facility on the ... for pain control in the majority of patients Dressings were changed on postoperative day and each day thereafter On postoperative day 1, physical therapy was initiated, as was an assessment of discharge ... anesthesia staff using clinical judgement as well as analysis of blood in the suction canisters, surgical towels, and the remainder of the surgical field; a final estimated blood loss was then...
- 6
- 365
- 0
báo cáo hóa học:" Trends in the clinical characteristics of HIVinfected patients initiating antiretroviral therapy in Kenya, Uganda and Tanzania between 2002 and 2009" pdf
... Clinic in Mbarara, which is located in the rural southwest part of the country Contributing sites in Tanzania include the Tumbi Regional Hospital in Kibaha, the Ocean Road Cancer Institute in ... cells/mm3 in China [22] Given the increasing consensus of the high D4T toxicity, crystallized in the WHO 2010 recommendations [14], monitoring declines in D4T use is an important objective of contemporary ... Services based in Nyanza Province and Nyanza Provincial Hospital In Uganda, affiliated sites include the Infectious Diseases Institute and Mulago Hospital, the Nsambya Hospital in Kampala and the Immune...
- 10
- 392
- 0
Báo cáo hóa học: " EXISTENCE OF ZEROS FOR OPERATORS TAKING THEIR VALUES IN THE DUAL OF A BANACH SPACE" potx
... E with E∗ , we apply Theorem taking X = Br , with the relativization of the weak topology of E, and taking τ as the weak topology of E Due to the kind of continuity we are assuming for A, the ... lower semicontinuous at x0 Hence, it remains proved that F is lower semicontinuous in X with respect to the strong topology and so, a fortiori, with respect to τ Since F is also with nonempty ... reflexive) Since f (·, y) is continuous for all y ∈ B1 , we then realize that the restriction of f to X0 × B1 satisfies the hypotheses of Theorem 3, B1 being considered with the relativization of the...
- 8
- 315
- 0
Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các nguyên tắc biên soạn khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn xác định thời lượng học về mặt lí thuyết và thực tế tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra đối với đối tượng giảng viên và đối tượng quản lí khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu nội dung cụ thể cho từng kĩ năng ở từng cấp độ xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct mở máy động cơ lồng sóc mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 sự cần thiết phải đầu tư xây dựng nhà máy từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng 9 tr 25