events reviewed by the joint commission resulting in death or permanent loss of function
Tài liệu Báo cáo khoa học: TEC family kinases in health and disease – loss-of-function of BTK and ITK and the gain-of-function fusions ITK–SYK and BTK–SYK pptx
... protein kinase B (PKB)] In AKT, a cysteine substitution of the corresponding R25 in the pleckstrin homology (PH) domain also results in loss of function [16,17], thereby demonstrating related functions ... mutations in the ITK 2004 SH2 domain may have additional effects when the protein remains stable, by acting as a dominant negative form, or by interfering with other functional parts of the molecule ... the linker B kinase region of SYK The PH domain of TFKs usually binds to phosphatidylinositol-3,4,5-trisphosphate, thereby bringing them in close proximity to other membrane-tethered signaling...
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Tài liệu The Joint Commission Sentinel Event Alert docx
... use information technology to monitor prescribing of opioids • Build red flags or alerts into e-prescribing systems for all opioids The red flags can be either for dosing limits or alerts, or for ... the use of opioids Effective processes Create and implement policies and procedures for the ongoing clinical monitoring of patients receiving opioid therapy by performing serial assessments of ... Monitoring should be individualized according to the patient’s response.19 The assessments are particularly important when the dose has been increased or another type of opioid is administered In...
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MALNUTRITION AND INFECTIOUS DISEASE MORBIDITY AMONG CHILDREN MISSED BY THE CHILDHOOD IMMUNIZATION PROGRAM IN INDONESIA pot
... collected on the history of any infant dying in the family before one month of age, any infant dying before 12 months of age, and any child deaths in the family before years of age The field teams ... stage of the interview The protocol for the NSS was approved by the Medical Ethical Committee of the Ministry of Health, Government of Indonesia The plan for secondary data analysis by Johns Hopkins ... declined in both sub-Saharan Africa and South Asia since 1995 (Bryce et al, 2003) In the present study, the main reasons cited by the mother, father, or guardian for not taking their child to the...
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Báo cáo Y học: The presence of a helix breaker in the hydrophobic core of signal sequences of secretory proteins prevents recognition by the signal-recognition particle in Escherichia coli doc
... (G-10L)prePhoE in the case of P48 crosslinked complexes and for WT prePhoE in the case of the TF crosslinked complexes These amounts were set to 100%, and the relative cross-linking efficiencies of the other ... SRP pathway The re-routing of (G-10L)prePhoE to the Sec translocon via the SRP instead of the SecB pathway could be explained by the increased hydrophobicity of the hydrophobic core of the mutant ... for panel (A) The precursor and mature forms of the PhoE proteins are indicated by p and m, respectively Of all the precursors tested, the mutant precursor with the strongest a-helix-promoting...
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Assembling and Supporting the Joint Strike Fighter in the UK potx
... and the Secretary of State for Defence of the United Kingdom of Great Britain and Northern Ireland Concerning the Cooperative Framework for Engineering and Manufacturing Development of the Joint ... (i.e., the forward and aft fuselage, the wings, and the tail) caused by moving FACO away from Fort Worth and to a UK site, thereby reducing work at Fort Worth and increasing the overhead rate there; ... Kingdom FACO and MR&U facility in the UK The baseline for the third sce nario incorporates the costs of an MR&U facility The incremental costs for this include only the cost effects of moving...
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Báo cáo khoa học: Modeling of ATP–ADP steady-state exchange rate mediated by the adenine nucleotide translocase in isolated mitochondria potx
... seen in Fig 3, the calculated values of the protonmotive force (PMF) in the presence of nigericin are higher than those in the absence of the ionophore The calibration of the safranine O uorescence ... showing the effect of the addition of cATR (in the concentrations indicated in the inset gure, in nM) on DWm, as indicated in the inset of (B) Data in (A) and (B) are shown as SEM from four independent ... protons into the matrix, bypassing F0 F1-ATPsynthase [6] The dotted line shows the result of the modeling after estimation of the unknown parameters The con- Modeling of ANT ditions of the described...
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Báo cáo khoa học: Functional transitions of F0F1-ATPase mediated by the inhibitory peptide IF1 in yeast coupled submitochondrial particles pdf
... on the pH of the medium containing no SMP or SMP treated with excess of oligomycin First-order kinetics of inhibition by IF1 [39] was fitted to the equation: Fig Time-course of ATP hydrolysis in ... states of ATPase (or GTPase): where E is the only active form of ATPase During ATP hydrolysis, IF1 can bind to the ATPase both in the absence and in the presence of D~Hþ Only in the presence l of ... determine the affinity of the latent state (E ¼ in the above scheme) of the ATPase for IF1:Kd is % lM This value is much higher than the Kd for the IF1–ATPase interaction in the absence of D~Hþ...
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Báo cáo khoa học: "Cell death by the quinoxaline dioxide DCQ in human colon cancer cells is enhanced under hypoxia and is independent of p53 and p21" pdf
... investigate the cytotoxicity of DCQ in HCT116 human colorectal cancer cell lines that are either wildtype for p53 and p21, null for p53, or null for p21 to determine the role of these genes in ... This result is interesting in light of the literature showing that hypoxia selects for p53 mutant tumors [26] Furthermore, interfering with HIF-1a is important for effective antitumor therapy [37] ... [11] detects the frequency of SSBs and alkaline-labile lesions in DNA Images of a minimum of 50 cells per treatment were analyzed using the CometScore™software Percentage of DNA in the tail region,...
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Báo cáo y học: "Magnetically retainable microparticles for drug delivery to the joint: efficacy studies in an antigen-induced arthritis model in mice" doc
... present in the joint months after the injection and generated no inflammatory response or damage to the synovial lining Influence of magnetic field on microparticle retention Based on their good joint ... results obtained for the uptake of 99mTc Discussion using a scale ranging from to sections for the total joint inflammation Histological grading of the knee4 using a scale ranging from to (-) indicates ... accumulation of macrophages in the synovial space as well as in the periarticular zone Moreover, the Prussian blue staining was negative, revealing the absence of SPIONs in the particles The images of the...
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Báo cáo y học: "Traditions and plant use during pregnancy, childbirth and postpartum recovery by the Kry ethnic group in Lao PDr" potx
... normal chores, including the care of the older offspring A spatial taboo in the third postpartum phase prohibits the mother and infant from entering into the parental bedroom for a period of at ... or heated, for washing the neonate Medicinal plants are collected either by the husband in the vicinity of the hut, or supplied by relatives if collected from further away The mother is not allowed ... constructed for shelter [35] The practice of giving birth outside the village, and remaining there for a period of - days can be viewed as a viability test of mother and infant, and in the case of the...
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Báo cáo y học: "Health status in COPD cannot be measured by the St George’s Respiratory Questionnaire alone: an evaluation of the underlying concepts of this questionnaire" ppt
... evaluated the ten sub-domains of the main domains Symptoms, Functional Impairment, and Quality of Life See Table for definitions of the subdomains and corresponding instruments Statistical Analyses The ... manuscript for important intellectual content JM participated in the design of the study, the acquisition of the data, and in the critical revision of the manuscript for important intellectual ... measured by the sections of the SGRQ, and which aspects of health status are not covered by the SGRQ The sections of the SGRQ correlated significantly with most sub-domains of the NIAF, indicating...
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Báo cáo sinh học: " Ovine progressive pneumonia provirus levels are unaffected by the prion 171R allele in an Idaho sheep flock" pptx
... status in this study indicates that the presence of a specific PRNP genotype does not influence the presence or magnitude of OPPV infection in this flock The study demonstrated that the frequency of ... PBL using a commercial kit (Gentra, Minneapolis, Minnesota) PRNP Genotyping DNA amplification and sequencing of the ovine PRNP ORF was performed similarly to previous experiments using forward ... using commercial software (Vector NTI, Invitrogen; Carlsbad, CA or Lasergene Seqman Pro v7.1, DNAstar, Inc, Madison, WI) and codon variants reported by single letter code (e.g glutamine Q, arginine...
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Difficulties encountered by the 9th form students in learning English vocabulary at Chu Văn An Secondary School, Thanh Hóa = Những khó khăn trong việc học từ vự
... and interesting ways for vocabulary acquisition Moreover, students only think of vocabulary learning as knowing the primary meaning of new words, they ignore all other functions of the words ... vocabulary in spoken or written form The quality and thoughtfulness of the production influences the quality of storage of the word However, from the findings in the previous part, the students’ ... also the forms For example, learning words in a word list is different from learning the same words in a passage Remembering a word meaning is different from learning to use the same word in real...
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LV ENGLISH FINAL CONSONANT SOUNDS EXPERIENCED BY THE TENTH FORM STUDENTS IN QUANG NAM PROVINCE
... by Ministry of Education and Training All of them have acquired certain knowledge of English - The tenth-form students must be aware of the importance of pronunciation in listening and speaking, ... the tape and choose the words they heard for the separated sentences and use the linking signs for the conversation That was also the aim of the feedback in the practice of conversation 33 The ... the information from the students’ actual perception sounds in sentences by realizing the words and the linking sounds that they heard The identification of the mistakes was the recognition in...
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Báo cáo Y học: Loss-of-function variants of the human melanocortin-1 receptor gene in melanoma cells define structural determinants of receptor function doc
... demonstrated for the Leu93Arg mutant Therefore, the lack of specific binding of melanocortins to the Leu93Arg receptor most likely reflects an actual impairment of the receptor binding properties ... particularly in all members of the melanocortin receptors subfamily We next tried to correlate the MC1R genotype of several of the HMC lines with their degree of responsiveness to agonists, by studying their ... protein In many GPCRs, the third intracellular loop and the cytoplasmic C-terminal extension are the main regions involved in coupling to the G proteins [2] It is clear that in the case of the...
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Báo cáo lâm nghiệp: "Contribution of different solutes to the cell osmotic pressure in tap and lateral roots of maritime pine seedlings: effects of a potassium deficiency and of an all-macronutrient deficienc" pptx
... placed either in insulin-type syringes (for the inorganic ion analysis) or in 1.5 mL microtubes (for the soluble sugar and amino acid analysis), immediately frozen in liquid nitrogen and stored at ... varied with the stimulus and with the type of roots For instance, growth of LR of cotton seedlings was more inhibited by salinity than was primary root growth [19] TR growth of Phaseolus remained almost ... a coefficient corresponding to the dilution of cell sap by apoplasmic sap or by water remaining on the surface of the roots The dilution coefficients were 1.15, 1.28 and 1.75 for TRA, TRPA and...
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Báo cáo khoa học: "The script concordance test in radiation oncology: validation study of a new tool to assess clinical reasoning" potx
... are made in the clinical reasoning process Scoring reflects the degree of concordance of these judgments to those of a panel of reference A series of studies, held in domains such as intra-operative ... series of case-based tasks As it is inferred that high scores correspond to optimal use of information in the context of these specific tasks, the test therefore provides an indication of clinical ... aiming for a residency in radiation oncology Senior residents had scores that were close to those of the panel, thus indicating readiness for autonomous practice in the tested domains On the other...
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Báo cáo y học: " Loss of function mutation in toll-like receptor-4 does not offer protection against obesity and insulin resistance induced by a diet high in trans fat in miceg" pdf
... the TLR4 Further, we hypothesize that a loss of function mutation in TLR4 may protect against high TF diet-induced inflammation and insulin resistance in mice Therefore, the objective of this current ... exacerbated in the presence of loss of function mutation in TLR4 Furthermore, our results indicate that TLR4 independent pathways may be involved in TF-diet-induced obesity, hyperglycemia, hyperinsulinemia, ... first study that investigated the effects of diet high in TF on obesity and circulating glucose, insulin, leptin, and inflammatory markers in mice with loss of function mutation in TLR4 It has...
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Báo cáo y học: "Loss of function mutation in toll-like receptor-4 does not offer protection against obesity and insulin resistance induced by a diet high in trans fat in mice" docx
... the TLR4 Further, we hypothesize that a loss of function mutation in TLR4 may protect against high TF diet-induced inflammation and insulin resistance in mice Therefore, the objective of this current ... exacerbated in the presence of loss of function mutation in TLR4 Furthermore, our results indicate that TLR4 independent pathways may be involved in TF-diet-induced obesity, hyperglycemia, hyperinsulinemia, ... first study that investigated the effects of diet high in TF on obesity and circulating glucose, insulin, leptin, and inflammatory markers in mice with loss of function mutation in TLR4 It has...
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Báo cáo y học: "The terrorist bomb explosions in Madrid, Spain – an analysis of the logistics, injuries sustained and clinical management of casualties treated at the closest hospital" potx
... very often suffer the worst forms of both blunt and penetrating trauma The three major causes of injuries in such incidents include the blast effect or shock wave, flash burns from the heat of the ... provide the information required for analysis of injuries and mortality patterns The ‘critical mortality rate’ – the death rate among the critically injured survivors – more accurately reflects the ... One of the most consistent injury patterns noted among survivors of terrorist bombings is the overwhelming predominance of relatively minor, noncritical injuries that are not life-threatening...
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Tìm thêm: xác định các mục tiêu của chương trình khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản khảo sát chương trình đào tạo gắn với các giáo trình cụ thể xác định thời lượng học về mặt lí thuyết và thực tế tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra đối với đối tượng giảng viên và đối tượng quản lí khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu nội dung cụ thể cho từng kĩ năng ở từng cấp độ xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc hệ số công suất cosp fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến dòng điện stato i1 fi p2 động cơ điện không đồng bộ một pha sự cần thiết phải đầu tư xây dựng nhà máy từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008 chỉ tiêu chất lượng 9 tr 25