differentially expressed genes in the oxidative stress and antioxidant defense pathway from atox1 and atox1 mefs after arsenite and radiation treatment by pcrarray
Role of poly (ADP ribose) polymerase 1 and copper homeostasis factor, antioxidant protein 1 in the maintenance of genomic integrity
... pathway from ATOX1+ /+ and ATOX1- /- MEFs after arsenite and radiation treatment by PCRarray • Table 9: Differentially expressed genes in the oxidative stress and antioxidant defense pathway from ATOX1+ /+ ... PARP-1+/+ and PARP-1-/- MEFs following arsenite treatment • Table 3: Differentially expressed genes in the oxidative stress and antioxidant defense pathway from PARP-1+/+ and PARP-1-/- MEFs after arsenite ... ATOX1+ /+ and ATOX1- /- MEFs after arsenite and radiation treatment by PCRarray • Table 10: Bioinformatics search of Atox1 consensus sequences and response elements in the promoter of genes involved in...
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Tài liệu Báo cáo khoa học: Functional hierarchy of plasminogen kringles 1 and 4 in fibrinolysis and plasmin-induced cell detachment and apoptosis docx
... Lysine ⁄ fibrin binding sites of kringles modeled after the structure of kringle of prothrombin Proteins 3, 85–96 20 Thorsen S (1975) Differences in the binding to fibrin of native plasminogen and ... further explored by measuring the effect of the mAbs on the interaction of purified plasmin and Lys-Pg with fibrin and cells The binding of Lys-Pg was partially inhibited by both 34D3 and A10.2 mAbs ... (1988) The cellbinding domains of plasminogen and their function in plasma J Biol Chem 263, 11928–11934 24 Thewes T, Constantine K, Byeon IJ & Llinas M (1990) Ligand interactions with the kringle...
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Tài liệu Báo cáo Y học: Binding of gelsolin domain 2 to actin An actin interface distinct from that of gelsolin domain 1 and from ADF/cofilin pptx
... exist in the manner in which S1 and S2 bind actin and that they bind different, nonoverlapping sites [44] S1 binds G-actin primarily, S2 binds F-actin exclusively (in salts) and the ADF/cofilins bind ... gelsolin S2 sequences (and homologue S2 equivalents) within residues 197–226 (including the long helix of the domain) and within residues 161 – 172 (including the A strand and the AB loop in S2) in ... that S2 binds actin with a similar interface as S1 in addition to binding around the DNAse1 binding site in subdomain of actin The Puius model is attractive in that proposing two actinbinding sites...
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An Equilibrium Model of Rare-Event Premia and Its Implication for Option Smirks potx
... reference model by choosing a ¼ and b ¼ 0, and ventures into other models by choosing some other a and b Let P be the entire collection of such models defined by a and b We are now ready to define our ... market Therefore, the pricing kernel, which links the two distributions,plays an important role in resolving this puzzle and reconciling the information from the two markets Conversely, the empirical ... jump-timing aspect of the model Finally, by letting a ¼ and b ¼ 0, we reduce the set P to a singleton that contains only the reference model Effectively, this is the standard case of a risk-averse investor...
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Báo cáo Y học: Structural and serological relatedness of the O-antigens of Proteus penneri 1 and 4 from a novel Proteus serogroup O72 pptx
... Judging from the ratio of integral intensities of the signals for the O-acetyl and N-acetyl groups in the 1H NMR spectrum, the total content of the O-acetyl groups in the repeating unit is 0.75 In ... repeating unit lacking GlcII and, hence, having the structure In particular, the signal for C5 of GalNAcI in the minor series had the same chemical shift, d 75.7, as in the spectrum of the P penneri ... polysaccharide the GlcII residue is present in a nonstoichiometric amount As judged by the ratio of the integral intensities of the signals in the major and minor series, the average degree of glycosylation...
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Báo cáo khoa học: Inhibitors of protein phosphatase 1 and 2A decrease the level of tubulin carboxypeptidase activity associated with microtubules pptx
... were incubated in vitro, and carboxypeptidase activity was inferred from the increase of the reaction product, detyrosinated tubulin (Glu-tubulin), as a function of incubation time The slope of the ... confluence, and cytoskeletons were isolated and incubated in vitro for the stated durations At the end of the incubation period, Glu-tubulin was determined and expressed as in Fig s, control (incubation ... were incubated at 37 °C in 0.25 mL microtubule-stabilizing buffer containing taxol and protease inhibitors as above After various incubation times, the Glu-tubulin content was determined by immunoblotting...
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báo cáo hóa học:" Gene and microRNA analysis of neutrophils from patients with polycythemia vera and essential thrombocytosis: down-regulation of micro RNA-1 and -133a" pot
... indicated by the bar and is expressed as -1 times the log of the p value The line represents the ratio of the number of genes in a given pathway that meet the cutoff criteria divided by the total ... Only the 30 pathways with the most significant changes are shown The p value for each pathway is indicated by the bar and is expressed as -1 times the log of the p value The line represents the ... sights into the molecular changes in ET and PV PV and ET neutrophils were characterized by the down-regulation of miR-1 and miR-133a and changes in the expression of many genes involved in inflammation...
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Báo cáo toán học: "Graphs Associated with Codes of Covering Radius 1 and Minimum Distance 2" ppsx
... which share the same colours, otherwise a double edge would be required as in the paths from vertices a and b in figure These four individual properties combine to the following result Theorem 10 ... be a graph obtained by removing a vertex and its incident edges from G From Lemma we know that G will also satisfy P1-P5 By the inductive hypothesis G has an OQW-associated code Using Lemma we ... corresponds to equivalence in codes: permutation of the rows, the columns and the symbols in L corresponds to permuting the symbols in each of the positions in C; permutation on the set {row, column,...
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Báo cáo khoa học: "Consequences of an excess Al and a deficiency in Ca and Mg for stomatal functioning and net carbon assimilation of beech leaves" ppt
... information about Ca2+ and Al3+ concentrations in the apoplast or in the cytosol 2.4 Statistical treatment The effects of nutrition treatments were investigated by analysing the variance on the ... deficient in calcium Combined stresses (+Al–CaMg plants) did not result in a further reduction in Ca and Mg leaf amounts On the other hand, potassium concentration was significantly increased by Al stress ... ABA and CO2 mole fraction in the air We also checked K concentrations in the guard cells of closed and open stomata Photosynthesis was estimated by determining chlorophyll concentrations in the...
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Báo cáo y học: "Thymic function and T cell parameters in a natural human experimental model of seasonal infectious diseases and nutritional burden" potx
... of both the mothers and their fetuses during pregnancy, and of their babies after birth, to deprivation and infectious burden may have a synergistic effect on the maturing immune system and long ... of standards containing telomeric DNA of known concentration were prepared by doubling dilution Sample DNA and standard were then placed in 0.2 μl tubes and heated at 95°C for minutes, and then ... usage by season of birth, in the CD8+ T cell subset The relative usage within the hungry/high infection or harvest/low infection season for each of the 24 TCRVb types is determined by expressing the...
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báo cáo khoa học: " FCR (Fludarabine, Cyclophosphamide, Rituximab) regimen followed by 90yttrium ibritumomab tiuxetan consolidation for the treatment of relapsed grades 1 and 2 follicular lymphoma: a report of 9 cases" pot
... than the prior treatment, eventually leading to refractory disease, and the question remains regarding whether the survival of patients with FL is improving with new treatment regimens In the ... utilized in the majority of patients during FCR treatment, and in all of them after 90 Y-RIT Despite the high incidence of grade or neutropenia there were no patients requiring hospitalization for infection ... for the treatment in this setting of patients, specially at age of 60-75 and earlier in first relapse; further studies will help to clarify the best strategy for incorporating RIT into the treatment...
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Báo cáo y học: "An exploration of how clinician attitudes and beliefs influence the implementation of lifestyle risk factor management in primary healthcare: a grounded theory study" pot
... to intervene The constructs identified in the model are largely in line with the main theoretical domains suggested by dominant psychological theories of motivation and action [7176], including ... screening and or intervention practices from baseline to post-intervention 1Low defined as scores in the clinician risk factor survey in the lowest quartile for those participating in an interview ... by providing insight into the process by which clinician beliefs and attitudes shape the implementation of risk factor management in routine PHC practice Given the many competing demands facing...
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Báo cáo y học: " Molecular characterization of genome segments 1 and 3 encoding two capsid proteins of Antheraea mylitta cytoplasmic polyhedrosis virus" pps
... (Qiagen) and eluted from the Ni-NTA column by buffer containing 250 mM imidazole [24,25] The amount of the purified protein was determined by the method of Bradford [40] using BSA as standard and the ... directly interacting with viral RNA indicating the role of capsid in RNA packaging, replication and transcription [17] Therefore, understanding the assembly of capsid not only provides insight into in ... addition to S1 and S3 encoded protein other virion proteins encoded by other genome segments may also helps in maintaining the stability and integrity of capsid Characterization of all the AmCPV genome...
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Báo cáo y học: "Transcriptional regulation of matrix metalloproteinase-1 and collagen 1A2 explains the anti-fibrotic effect exerted by proteasome inhibition in human dermal fibroblasts" docx
... present in the cytosol and in the nuclei and triggers degradation of multi-ubiquitinated proteins [19] It maintains cell homeostasis by promoting clearance of damaged or improperly folded proteins and ... that PI results in a specific increase in binding of cJun to the most proximal AP-1 site of the MMP-1 promoter We next investigated whether binding of c-Jun to the MMP-1 promoter in the presence ... of the MMP-1 or COL1A2 genes (Figure 6a, b) In conclusion, the effect of PI dominates the influence of TGF-β in controlling the binding of both SP1 to COL1A2 and c-Jun to MMP-1 Discussion The...
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Báo cáo y học: "Heliox improves pulmonary mechanics in a pediatric porcine model of induced severe bronchospasm and independent lung mechanical ventilation" pdf
... Orsini et al extremely small when calibrating the PFT machine (Fleisch pneumotach) using known standards within the physiologic ranges encountered in this study, patient factors can introduce intra- ... assistance and support in completing this project References Barach A: The use of helium in the treatment of asthma and obstructive lesions in the larynx and trachea Ann Int Med 1935, 9:739–765 ... increase flow through constricted airways and improve pulmonary mechanics in the lung receiving heliox compared to the lung receiving nitrox Methods and materials This study was approved by the...
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Báo cáo y học: " A mechanistic model of infection: why duration and intensity of contacts should be included in models of disease spread" ppt
... duration and contact intensity are interrelated, thereby allowing an interpretation of how the consideration of the contact intensity might alter the findings presented in Figures 1ad and Figure shows ... are in most cases their loved ones, thereby indicating the higher likelihood of more intimate interactions than with casual acquaintances As a result, the conclusions from the analysis of the ... exposure and the risk of infection, we extrapolate the actual exposure from information about the duration and intensity of a contact between an infector and a susceptible individual The proposed...
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Báo cáo y học: "A continuum mathematical model of endothelial layer maintenance and senescence" ppsx
... of the aging of the organism to the aging of the EC wall The aim of the present paper is to develop a continuum mathematical model of the EC layer, incorporating maintenance and damaging factors ... then simulated by solving Eqs (2)–(8), using the initial cell density and hole profiles given by Eq (11) and Eq (10), respectively Let θ (t) be the fraction of holes remaining (in excess of the ... R (5) The second term on the right-hand side accounts for the death of all viable cells, and the last term is the rate of clearing dead cells from the endothelial wall The first term on the right-hand...
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The roles of histone deacetylases 1 and 2 in hepatocellular carcinoma
... healing of radiation- induced wounds and decrease skin fibrosis (Chung et al., 2004) Therefore, HDAC inhibitors greatly increase the therapeutic gain in cancer radiotherapy by enhancing the inhibition ... 2001) Interesting, ROS production can also transcriptionally induce and activate Bim, linking it to the involvement of the BH3only protein (Sade and Sarin, 2004) 21 1.11.1.2 Extrinsic pathway Other ... affecting the binding of transcription factors and methyl-binding proteins The hypermethylation at the promoter results in the silencing of numerous tumor-suppressor genes as well as other cancer-associated...
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Báo cáo y học: "Patients'''' recollections of experiences in the intensive care unit may affect their quality of life" doc
... for stress in our patients This can be explained by the traditionally strong family ties in the Portuguese culture Pain came in fourth place in the ranking of stressors This finding, together ... returned by mail and in the other five they were returned directly by hand when patients came to the follow-up consultation Informed consent was obtained from all patients at the time of the follow-up ... late in their ICU stay and some of them only after their discharge to the ward However, during their ICU stay they continue to have an emotional life, in a mixture of dreams, delusions and emotional...
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Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các mục tiêu của chương trình xác định các nguyên tắc biên soạn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra đối với đối tượng giảng viên và đối tượng quản lí khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam nội dung cụ thể cho từng kĩ năng ở từng cấp độ xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 động cơ điện không đồng bộ một pha thông tin liên lạc và các dịch vụ từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008