... ubiquitous, oxidizing, and highly toxic air pollutant is generated photo-chemically from nitric oxides and hydrocarbons O3 isassociatedwith an immediate impairment of lung function and contributes ... data analysis and prepared the manuscript FRP supervised the animal experiments using SP-D deficient mice and advised on data analysis YC participated in most of the animal experiments and developed ... between and 12 weeks of age Animals received water and food ad libitum The protocols were approved by the Institutional Animal Care and Use Committee of the University of Pennsylvania and GlaxoSmithKline...
... surgery, (b) history of schizophrenia, (c) history of adrenal gland disease, (d) history of glucocorticoid therapy for more than consecutive days within year, (e) preoperative Page of 11 left ventricular ... Page of 11 use CAM-ICU Definition and examples of delirium features were explained and discussed For the purpose of training and standardization, eligible patients were randomly selected and each ... increased riskof postoperative delirium in this risk- adjusted analysis (odds ratio [OR] 3.091, 95% confidence interval [CI] 1.763 to 5.418; P < 0.001) Replacement of serum cortisol level with serum...
... Thus, this period of endotoxemia represents the first “hit” in a two “hit” model ofrisk Faist et al first used this “two hit” hypothesis to describe the increased riskof development of sepsis in ... conclusion of CPB isassociatedwith a significant riskof the development of postoperative infections Further research is necessary to assess whether a targeted strategy of rapid measurement of endotoxin ... of sternal wound infection or mediastinitis, three cases of cellulitis at the site of vein graft harvesting, and one case of pneumonia One patient developed both urosepsis and wound cellulitis...
... association with multiple falls, under single-task and overall This is consistent with our previous finding that time to FLM was the component most consistently associatedwith physiological and cognitive ... independent of other risk factors, but with no added benefit of measurement under dual-task conditions Time to the first lateral movement under single-task may be the best measures of this risk Conflicts of ... 95%CI 1.01, 2.73) Discussion In this population-based study of older community-dwelling people, slower overall GI time under single and dual-task was associatedwith increased riskof multiple falls...
... ratio of 2:1 to 6:1 [14] Unlike similar diseases of other joints, TMJ disorders occur primarily in women of reproductive age [14] Given the gender and age distribution of these disorders and the ... collagen and glycosaminoglycan (GAG) content in fibrocartilaginous disc explants Our findings are consistent with the hypothesis that relaxin-mediated induction of MMPs isassociatedwith the loss of ... hormone-treated disc hemisection were standardized to the values of the control hemisection within each animal and the fold changes were plotted as histograms The statistical significance of differences...
... contribution of statins to operative risk However the absence of statin treatment was associatedwith an increase in mortality in the subset of high risk patients with an estimated riskof mortality of ... is retrospective and nonrandomized This introduces the issue of selection bias and other confounding variables The statistical analysis minimizes this possibility, but it cannot eliminate this ... meeting DAD assisted in study design and statistical analysis KAS developed the database and performed statistical analysis DHB assisted in study design and manuscript preparation TDM assisted in manuscript...
... means (± standard deviations) in cases of normal distribution or as medians (interquartile ranges) in cases of nonnormal distribution BMI, body mass index; CRP, C-reactive protein; DAS28, disease ... 0.31 0.55 Combination of DMARDs, percentage 31 25 29 25 0.24 0.38 TNF-blocking agent, percentage 11 11 0.73 0.65 Prednisolone only, percentage 1.00 0.42 Cardiovascular risk factors Current smoker, ... hydroxychloroquine only, tumour necrosis factor-blocking agents, combination of disease-modifying antirheumatic drugs, pack-years, smoking, erosions, DAS28 (disease activity score using 28 joint...
... Lack of association between glucocorticoid use and presence of the metabolic syndrome in patients with rheumatoid arthritis: a cross-sectional study Arthritis Res Ther 2008, 10:R145 Page of (page ... associates with a reduced prevalence of the metabolic syndrome in rheumatoid arthritis patients over the age of 60: more than just an anti-inflammatory effect? A crosssectional study Arthritis Res ... to TET) and an Arthritis Research Campaign infrastructure support grant (grant number 17682, given to the Dudley Group of Hospitals NHS Foundation Trust, Department of Rheumatology) HJ is supported...
... analysis showed a logarithmic relation This is the first report suggesting that increased duration of mechanical ventilation isassociatedwithdecreased diaphragmatic force, measured with a ... Page of 10 Figure Regression analysis for TwPdi and total duration of mechanical ventilation; cumulative duration of BIPAP/ASB, PSV, and IPPV at the time of measurement; and cumulative dose of ... of data and critical appraisal of the manuscript GG-R assisted in performing the measurements, obtaining patient data, and had a major impact on the interpretation of data and critical appraisal...
... development of gastric cancer The Gab1 A/A decreased the riskof H pylori seropositivity, whereas the Gab1 G/A+A/A was associatedwith gastric atrophy risk In order to find out if the Gab1 polymorphism ... our all gastric cancer cases had evidence of H pylori infection because of the earlier presentation or diagnosis ofcancer In summary, the Gab1 A/A was associatedwith the low riskof H pylori infection ... study of the molecular mechanisms of action of this polymorphism Because these results were based on the low frequency of A/A, they might be inconsistent due to the random errors Studies of a...
... non-surviving patients and on the genotype relative risks the statistical power of the significant associations were 81%, 96% and 91%, respectively The relative risks of -173 and -794 alleles and genotypes ... characteristics of patients with severe sepsis and patients with abdominal surgery without signs of infection or inflammation (* unpaired t test, ** Fisher's exact test) Severe Sepsis (n = 169) ... Genotype and allele distribution of healthy controls, patients with abdominal surgery, and patients with severe sepsis were tested by chi square test Survivors and non-survivors of severe sepsis were...
... early identification and intervention of this condition Early diagnosis and intervention is warranted since there is considerable evidence that women with PCOS are at increased risk for infertility, ... II diabetes and cardiovascular disease [6,7] There is also growing evidence for increased riskof obstructive sleep apnea, depression, nonalcoholic fatty liver disease and certain cancers [8-11] ... cutoff of >10 cm3 was associatedwith 98.2% specificity, but only 45% sensitivity, in discriminating between normal and polycystic ovaries [35] Since 2003, both a lower threshold of cm3 [35] and...
... and distributions of B-lymphocyte subpopulations, and the comparison of patients positive and negative for RA -associated HLA DRB1 alleles Patients and methods Ninety-four patients with long-standing ... be associated not only with production of RF [22], but also production of a variety of other autoantibodies [2,6,23,24] The goal of the present study was therefore the analysis of frequencies and ... followed since the onset of their disease and who have been described previously were recruited [26] Detailed clinical and laboratory data, and serial radiographs of hands and feet were available...
... population of Caucasian RA patients, and that this polymorphism is also associatedwith levels of sTNFRs released in vitro by isolated T cells from RA patients The two receptors appear to promote distinct ... polymorphism and sTNFR serum levels The genotype and sTNFR level data for the T676G polymorphism in patients with early and established disease are shown in Table The T and G alleles had frequencies of ... genotypes and synovial fluid levels of sTNFRs This is probably not surprising because no correlation was found between synovial fluid and serum levels of sTNFRs, which is consistent with previous...
... reflection of increased degradation of collagen and enhanced turnover of proteoglycans rather than a lack of synthesis of cartilage collagen This lack of association between CPII and radiographic ... serum and urine [5-9] These biomarker assays may be of use in distinguishing RA patients with rapid progressive and slow progressive joint damage, and may help to identify the severity of joint disease ... Association of baseline levels of markers of bone and cartilage degradation with long-term progression of joint damage in patients with early rheumatoid arthritis: the COBRA study Arthritis Rheum...
... Discussion In our study, we discovered that CA12 expression was strongly associatedwith histologic grades of the cervical cancer As CA12 and histologic grade were significantly associatedwith ... Expression of CA12 in cervical cancer: correlation with clinicopathological characteristics The new combined category of CA12 expression and histological grade is significantly associatedwith survival ... expression isassociatedwith histological differentiation of cervical cancer CA12 expression was observed in 57.1% (16/28), 48.3% (56/116), and 25.0% (9/36) of WD, MD, and PD tumors respectively, with...
... number of actively involved or affected joints, and number of patients with uveitis or remission Consistent with the previous report by Barton and coworkers [25] on RA and MBL polymorphisms, we ... mobility-restricted) joints, disease remission status (current remission, active disease after previous remission, or continuously active disease) and presence of uveitis Furthermore, the number of cumulative ... oligoarthritis patients with active disease (as compared with patients with a current remission) differed statistically significantly (P < 0.01) including micro-organisms, cellular debris, and agalactosyl...
... The levels of cyanidin-3-galactoside differ in red and green stripes of ‘Honeycrisp’ and ‘Royal Gala’ HPLC traces at 520 nm of A) green and B) red stripes of ‘Honeycrisp’ and C) green and D) red ... accepting of a range of apple types [2] Peel pigments not only affect visual appeal, they also contribute to the fruit’s nutritional value Apples have been associatedwith lowered risks ofcancerand ... suggestions, to Dwayne Jensen of P&FR, Ruakura for assistance with LCMS of phenylpropanoids, and to Harpartap Mann and Richard Espley for assistance with RNA extraction and real-time protocols AT...
... development of IPF In humans, the gene encoding IL-8 is located on chromosome 4q12-q21 and consists of four exons and three introns [13] Polymorphisms of IL-8 are associated increased riskof developing ... effect of polymorphisms of the IL-8 gene on the riskof IPF We genotyped and compared the frequencies of three SNPs of the IL-8 genes in 237 subjects with IPF and 456 normal controls and evaluated ... MAFs and sample sizes and Page of assuming a relative riskof 1.5, using PGA (Power for Genetic Association Analyses) software [21] Results Clinical profiles of study subjects Clinical profiles of...
... airway isassociatedwith acute lung injury in the presence of hyperoxia [45] In contrast, adiponectin is inversely associatedwith biomarkers of inflammation andwith BMI [19,46], and low levels of ... Discussion This study evaluated the association of BMI and systemic levels of leptin and adiponectin with levels of exhaled NO and exhaled 8-isoprostanes in subjects with stable asthma and healthy ... Association of the ratio of serum leptin and serum adiponectin with the log of exhaled NO in subjects with asthma and conFigure trols Association of the ratio of serum leptin and serum adiponectin with...