development of novel antitumor agents

... distortion level, the radius of curvature of outlet size of distorted region tends to be increased whatever the inlet size of distorted region is 92 Chapter A Development of Novel Integral Method ξ ... 0.9 1.0 Fig 4.12 The predicted outlet size of distorted region vs α ( ) with higher inlet size of distorted region of 0.5 94 Chapter A Development of Novel Integral Method 0.22 ξ (0) = 0.1 0.20 ... size of distorted region vs α ( ) with smaller inlet size of distorted region of 0.1 To ease in comparing the results between different inlet sizes of distorted region, we define the level of distortion...

Ngày tải lên: 21/06/2014, 21:20

... the mechanisms of action and off-target effects of a drug can be gained An understanding of the molecular mechanisms that are triggered by a substance possibly may widen its field of indication ... of indication or promote the development of more specific compounds Another advantage of testing sorted cell populations is the ability to determine the contribution of a single cell type to the ... samples or tissues often are biased by variations in cellular composition, in vivo analysis of homogenous cell populations under stable conditions facilitates the detection of pathways that are...

Ngày tải lên: 09/08/2014, 08:22

Ngày tải lên: 14/11/2014, 08:07

... goal of this study is to develop novel microfabrication methods and microfluidic devices for BioMEMS applications The emphasis is on the development of new hot embossing techniques, the design of ... implementation of necessary microfluidic functions; integration of these functions with complete automation; and development of cost-effective manufacturing technology [Madou 2001] Microfluidics is ... contaminating the microfluidic channels 1.3 Outline Chapter contains a comprehensive literature review of microfabrication and and microfluidics Chapter contains experimental and simulation of the laser...

Ngày tải lên: 14/11/2014, 13:26

... FANGRUI Table of Contents Acknowledgements i Thesis Declaration iii Table of Contents iv Summary x xiii List of Tables List of Schemes xv List of Figures xx List of Abbreviations xxii List of Publications ... DEVELOPMENT OF NOVEL AMINO ACID-DERIVED MULTIFUNCTIONAL PHOSPHINES FOR ENANTIOSELECTIVE REACTIONS ZHONG FANGRUI (B.Sc., Zhejiang Univ.) A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY ... Meanwhile, significant progress has also been made in the development of chiral phosphines This thesis describes the development of novel amino acid-derived multifunctional phosphines for several...

Ngày tải lên: 09/09/2015, 10:06

... analysis of self-cleavage of Oligonucleotide in the presence of mM transition metal ions (Zn2+, Pb2+, Ni2+, Co2+ and Mn2+) 45 PAGE analysis of self-cleavage of Oligonucleotide in the presence of 20 ... absence of magnesium ions 50 3-13 Effect of potassium ion concentration on the self-cleavage reaction of Oligonucleotide 51 3-14 PAGE analysis of self-cleavage of Oligonucleotide in the presence of ... 1.2.2.3.3 Interaction of Small-Molecule with G-Quadruplex 1.3 i-Motif Structure of DNA 10 10 1.3.1 Discovery of i-Motif Form of DNA 11 1.3.2 Stoichiometries and Topologies of i-Motif DNA 11 ii...

Ngày tải lên: 11/09/2015, 16:04

... constant encouragement during my studies i Table of Contents Acknowledgements Table of Contents Summary List of Tables List of Figures List of Schemes List of Structures Abbreviations and Symbols i ... Polysaccharide-derived CSPs in HPLC 13 1.4.1 1.4.2 1.4.3 Early development of polysaccharide-derived CSPs Development of coated polysaccharide-derived CSPs Development of immobilized polysaccharide-derived CSPs ... addition of chloroform or dichloromethane generally improves the resolution of tested racemic analytes On the other hand, addition of tetrahydrofuran is only able to improve the resolution of a few...

Ngày tải lên: 14/09/2015, 08:40

... support and encouragement I TABLE OF CONTENTS ACKNOWLEDGEMENT I TABLE OF CONTENTS II SUMMARY V LIST OF FIGURES VIII LIST OF TABLES XII LIST OF SYMBOLS LIST OF NOMENCLATURE XIII XV CHAPTER INTRODUCTION ... resistance of permeation exists through out the cross-section of a symmetric membrane The development of asymmetric membranes has brought the application of membranes into a new era The advantages of ... solution free of microsolute, microsolute solution free of macrosolute Liquid Solution free of microions, concentrated solution of microions, fractionation of microions Liquid Solvent free of all solutes,...

Ngày tải lên: 14/09/2015, 08:49

... DEVELOPMENT OF NOVEL MICROEXTRACTION METHODS WITH APPLICATION TO ENVIRONMENTAL ANALYSIS BY XIANMIN JIANG A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY DEPARTMENT OF CHEMISTRY ... investigate the application of these techniques to trace environmental analysis These novel microextraction techniques include the use of a new type of fiber for SPME; a novel mode of LPME/HF, solvent ... (a) conditioning of solid phase; (b) eluting of the unwanted components; (c) clean-up; (d) eluting the analytes of intent; (e) evaporation of the organic solvent and concentration of the analytes...

Ngày tải lên: 15/09/2015, 17:09

... the incorporation of chemotherapeutical agents into LDL, the clinical development of the concept is still in its infancy One of the obstacles for the pharmaceutical application of LDL is its endogenous ... infusion of 5%, 10% and 15% emulsion of tributyrin at the dose of 1, and g/kg· · · · · · · · · · · · · · · · · · 109 7-1 Pharmacokinetic parameters of ATRA in rat plasma after intravenous injection of ... Therefore, the delivery of a 400 mg/kg dose of tributyrin to a 70 kg patient would involve a total dose of 28 g of INTRODUCTION tributyrin, which would require the ingestion of 56 capsules Clearly...

Ngày tải lên: 16/09/2015, 08:30

... 110 Effect of pH and CD concentration on EOF 111 Effect of pH on migration times 112 3 Effect of pH on enantioseparation of acid analytes …………….114 Effect of β-CDNH2 concentration ... ability of ALAMCDCl towards amino acids 77 iii Effect of ALAMCDCl on the electroosmotic flow 77 Effect of CD concentration on enantioseparation of Dns-amino acids 80 3 Effect of pH on ... especially those of pharmaceutical importance, has led to the rapid development of a variety of stereoselective separation technologies Capillary electrophoresis (CE) has become one of the most important...

Ngày tải lên: 16/09/2015, 08:30

... stated above, the key aim of this project focuses on the development of a novel family of positively charged single-isomer CDs and their application in the enantioseparation of acidic and neutral ... viscosity of running buffer is changing, which in turn, modifies the mobility of EOF To reduce this effect the apparent mobilities of enantiomers were normalized: μ norm app = μ app μ EOF μ 0EOF (5) ... Eq 1.4 μ eof = where μ eof is the electroosmotic mobility, ε is the dielectric constant of the soloution, and ζ is zeta potential μ eof depends, to a large extent, on the magnitude of the zeta...

Ngày tải lên: 16/09/2015, 08:30

... Synthetic Route 183 iii SUMMARY PART I: Development of Novel Methods for the Synthesis of Homoallylic Alcohols In the development of novel methods for the synthesis of homoallylic alcohols, two conceptual ... : DEVELOPMENT OF NOVEL METHODS FOR THE SYNTHESIS OF HOMOALLYLIC ALCOHOLS PART II : MULTIGRAM SYNTHESIS OF (−)-EPIBATIDINE KEN LEE CHI LIK B.Sc (Hons.), NUS A THESIS SUBMITTED FOR THE DEGREE OF ... (1R)-(-)-10-camphorsulfonic acid d density d doublet dd doublet of a doublet ddd doublet of a doublet of a doublet dddd doublet of a doublet of a doublet of a doublet de diastereoselectivity excess DIBAL-H...

Ngày tải lên: 16/09/2015, 17:11

... spectrum of CFE of E coli (P450pyr) 91 4.2.7 Optimization of biohydroxylation of N-benzyl pyrrolidine-2-one with E coli (P450pyr) 92 4.2.8 Kinetic constants of biohydroxylation of N-benzyl ... are of particular interest because of their short generation time and large diversity of metabolic pathways and enzymes In vivo screening of microorganisms is often used for the discovery of new ... spectra of CFEs of E coli (P450pyr): (") noninduced; ( -) induced with IPTG for h 98 Figure 4.4 Time course of the formation of (S)-N-benzyl-4-hydroxypyrrolidin-2-one in biohydroxylation of...

Ngày tải lên: 30/09/2015, 06:27

... weight ratio of CuO in spinel to SBA-15 viii List of Figures List of Figures Fig 3.1 Small angle XRD patterns of SBA-15,CuO/SBA-15 and Cu/SBA15 34 Fig 3.2 Large angle XRD patterns of CuO,CuO/SBA-15 ... the daily life of everyone As a major source of air pollution, vehicle exhaust is the problem of most concern of government and society Table 1.1 shows the exhaust composition of diesel engine ... to simulate the operation of diesel engines 1.3 Research objectives The purpose of this research is to explore the behavior of catalytic oxidation of NPACs and design novel catalysts for deNPAC...

Ngày tải lên: 04/10/2015, 15:57

... University of Agriculture and Forestry Degree Program Bachelor of environmental Science and Management Student name Vu Thi Hoai Student ID DTN1053110084 Thesis Tiltle Supervisor(s) Development of Novel ... Graphene Oxide Composite for the Removal of Heavy Metals from Aqueous Solution Prof Dr Nguyen The Dang, Thai Nguyen University of Agriculture and Forestry, Vietnam Prof Ruey-an Doong, National Tsing ... parents for their support & endless love VU THI HOAI TABLE OF CONTENTS LIST OF FIGURES LIST OF TABLES LIST OF ABBREVIATIONS PART I INTRODUCTION ...

Ngày tải lên: 12/10/2016, 10:22

... immobilize on the control well Increase rate of recovery for control ¼ titer of SQAG immobilized well ⁄ titer of control well Table SPR analysis of the binding of SQAGs to the immobilized peptide, MCAK184 ... A molecular target of SQAGs A S Aoki et al A B Fig Inhibition of the microtuble depolymerization activity of MCAK184 by SQAG in vitro In all assays, 120 nM of MCAK, 1500 nM of paclitaxel stabilized ... Occurrence of animal sulfolipid in the gametes of sea urchins Jpn J Exp Med 35, 315–318 Isono Y & Nagai Y (1966) Biochemistry of glycolipids of sea urchin gametes I Separation and characterization of...

Ngày tải lên: 19/02/2014, 17:20

... HF-LPME of chemical agents 91 4.3.2 Method validation for HF-LPME of chemical agents 96 4.3.3 Comparison of HF-LPME of chemical agents with SPME 97 4.3.4 Optimization of parameters for HF-LPME of ... deterioration in performance in any proficiency test Since 1996 to 2007, a total of twenty two official OPCW proficiency tests have been conducted As of the 23rd Official OPCW Proficiency Test, there are ... presence of nerve agents in various types of water such as tap, reverse osmosis, and deionized water [215] In a study of MIP-SPE for the determination of degradation products of nerve agents (Figure...

Ngày tải lên: 14/09/2015, 14:08

... ratios, thus allowing for the development of large sensor arrays highly useful in the area of biochips One of the major obstacles to overcome during the design of a continuous sensing system ... in changes of the pH can be combined with a pH-FET transducer, resulting in what is called CHEMFET of BIOFET In all of these devices, the surface potential developed at the surface of the semiconductor ... concentrations [111] This phenomenon has been utilized for the development of a series of gas sensors, and only in a few instances in the development of solution chemical sensors It has been found for example...

Ngày tải lên: 20/03/2014, 13:05

... fusion proteins of the K1, K2, K5, K13, K26, K51, K57 and K60 sequences exhibited significant levels of incorporation of Dansyl-Cd compared to the other sequences examined All of the highly FEBS ... proteins of each peptide were incubated with [3H]-putrescine in the presence of each TGase Most of the peptide sequences exhibited high reactivity with TGase 1, consistent with the results of the ... mutant analysis of the K5 peptide sequence To determine the role of each amino acid of K5 in TGase 1-mediated catalysis, we generated alanine substitution mutants for every residue of the 12-amino-acid...

Ngày tải lên: 23/03/2014, 06:20