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creactive protein structure affects function

Tài liệu Báo cáo khoa học: Interaction between very-KIND Ras guanine exchange factor and microtubule-associated protein 2, and its role in dendrite growth – structure and function of the second kinase noncatalytic C-lobe domain docx

Tài liệu Báo cáo khoa học: Interaction between very-KIND Ras guanine exchange factor and microtubule-associated protein 2, and its role in dendrite growth – structure and function of the second kinase noncatalytic C-lobe domain docx

Báo cáo khoa học

... (KIND) is a putative protein protein interaction module. Four KIND-containing proteins, Spir-2 (actin-nuclearfactor), PTPN13 (protein tyrosine phosphatase), FRMPD2 (scaffold protein) and very-KIND ... compilation ª 2011 FEBS 1655Introduction Protein protein interactions play important roles inthe molecular recognition and functional modulationbetween proteins in many signal transduction path-ways ... for 1 h, followed byrotation with protein A-sepharose or protein G-sepharose(GE Healthcare UK Ltd) at 4 °C. Proteins immunoprecipi-tated with the antibody protein A- or G-sepharose com-plexes...
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Báo cáo khoa học: Evolutionary changes to transthyretin: structure and function of a transthyretin-like ancestral protein doc

Báo cáo khoa học: Evolutionary changes to transthyretin: structure and function of a transthyretin-like ancestral protein doc

Báo cáo khoa học

... these proteins, all tetrameric, showed signifi-cant similarity to the published structures oftransthyretin. By way of example, a comparison of the structure of S. dublin TLP with the structures ... 3D structures of transthyretin from various organ-isms have been well characterized. The first transthyre-tin crystal structure to be solved (that of human) waspublished in 1978 [34]. The Protein ... site of TLPappears to have been sufficient for the acquisition ofnew functional properties of the protein whilst its over-all structure was unchanged. Furthermore, the distri-bution of TLPs in...
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Tài liệu Báo cáo khoa học: Structure and function of active chromatin and DNase I hypersensitive sites pdf

Tài liệu Báo cáo khoa học: Structure and function of active chromatin and DNase I hypersensitive sites pdf

Báo cáo khoa học

... in a constitutively active state byCXXC domain proteins that bind to non-methylatedCG sequences. These proteins include MLL1 and theCG-binding protein Cfp1 that itself recruits both Set1and ... 3822–3831.80 Melcher M, Schmid M, Aagaard L, Selenko P, LaibleG & Jenuwein T (2000) Structure- function analysis ofSUV39H1 reveals a dominant role in heterochromatinorganization, chromosome ... Perturbation of nucleosome structure by the erythroid transcription factorGATA-1. J Mol Biol 279, 529–544.244 Armstrong JA & Emerson BM (1996) NF-E2 disruptschromatin structure at human beta-globin...
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Tài liệu Body Size: The Structure and Function of Aquatic Ecosystems pptx

Tài liệu Body Size: The Structure and Function of Aquatic Ecosystems pptx

Điện - Điện tử

... circles 0.6:1 (redrawn from Koehl, 1995).BODY SIZE AND SUSPENSION FEEDING 21Body SizeThe Structure and Function of Aquatic EcosystemsEdited byALAN G. HILDREWSchool of Biological and Chemical ... Allen, A. P. & Brown, J. H.(2006). Food web structure and dynamics:reconciling alternative ecological currencies.In Ecological Networks: Linking Structure toDynamics in Food Webs, eds. M. ... in the rate of fluid passing over or through feeding structures. Tocounter this, many animals extend their bodies, or just their feeding structures,up through the velocity gradient where they...
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Tài liệu Báo cáo khoa học: Salt-induced formation of the A-state of ferricytochrome c – effect of the anion charge on protein structure docx

Tài liệu Báo cáo khoa học: Salt-induced formation of the A-state of ferricytochrome c – effect of the anion charge on protein structure docx

Báo cáo khoa học

... stabilizers of structured formsof proteins and are often employed in studies aimed atclarifying aspects of the folding process of proteins[34], including cytochrome c [18]. Concerning this last protein, ... mechanism(s) and the factors affecting protein stabilization, in this article we extend our knowledgeon anion protein interactions by determining the effecton the protein produced by anions carrying ... dena-tured (ÆÆÆÆ) protein are shown for comparison. Protein concentration:10 lM. Other experimental conditions were as described in thelegend to Fig. 1.F. Sinibaldi et al. Anion-modulated structure...
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Tài liệu Báo cáo khoa học: Structure and function of plant aspartic proteinases pptx

Tài liệu Báo cáo khoa học: Structure and function of plant aspartic proteinases pptx

Báo cáo khoa học

... program PROTEIN EXPLORERhttp://www.proteinexplorer.org.27Ó FEBS 2004 Plant aspartic proteinases (Eur. J. Biochem. 271) 2069REVIEW ARTICLE Structure and function of plant aspartic proteinasesIsaura ... barley-grain aspartic proteinase:a structural rationale for observed hydrolytic specificity. FEBSLett. 352, 131–136.37. O’Brien, J.S. & Kishimoto, Y. (1991) Saposin proteins: structure, function, and ... Tecnologia).References1. Davies, D.R. (1990) The structure and function of the asparticproteinases. Annu. Rev. Biophys. Biophys. Chem. 19, 189–215.2. Dunn, B.M. (2002) Structure and mechanism of the pepsin-likefamily...
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Tài liệu Báo cáo khoa học: a-Conotoxins as tools for the elucidation of structure and function of neuronal nicotinic acetylcholine receptor subtypes doc

Tài liệu Báo cáo khoa học: a-Conotoxins as tools for the elucidation of structure and function of neuronal nicotinic acetylcholine receptor subtypes doc

Báo cáo khoa học

... understanding of their structure- activity relationships,may start to provide a rational way to develop additionalpharmacological tools for the elucidation of nAChR structure and function. Ó FEBS ... pentameric quaternary structure of this protein (Fig. 1) and have provided valuableinformation about the channel architecture and dimensions.A deeper insight into the molecular structure, in particularthe ... (b2orb4) subunit to form functional channels [2,3,9]. However,pairwise combinations of the a6withtheb2orb4 subunitresulted in protein aggregation or very inefficient expressionof functional channels...
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Tài liệu Báo cáo khoa học: Cold survival in freeze-intolerant insects The structure and function of b-helical antifreeze proteins pdf

Tài liệu Báo cáo khoa học: Cold survival in freeze-intolerant insects The structure and function of b-helical antifreeze proteins pdf

Báo cáo khoa học

... insectsThe structure and function of b-helical antifreeze proteinsSteffen P. Graether and Brian D. SykesCIHR Group in Protein Structure and Function, Department of Biochemistry and Protein Engineering ... antifreeze protein; CfAFP, Choristoneura fumi-ferana antifreeze protein; DAFP, Dendroides canadensis antifreeze protein; DcAFP, Daucus carota antifreeze protein; INP, ice-nucleation protein; LpxA, ... describe the structure and dynamicsof each protein, and present a comparison of s bwAFP andTmAFPwitheachotherandwithproteinsthathaveasimilar fold. Structure of sbwAFP and TmAFPThe structure...
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Báo cáo khoa học: NMR solution structure and function of the C-terminal domain of eukaryotic class 1 polypeptide chain release factor pdf

Báo cáo khoa học: NMR solution structure and function of the C-terminal domain of eukaryotic class 1 polypeptide chain release factor pdf

Báo cáo khoa học

... solution structure of theC-domain. (A) Stereo view of the ensembleof the final 48 calculated structures.Twenty-four structures of the closed protein conformer are shown in red, and 24structures ... Mantsyzov et al. NMR structure and function of the eRF1 C-domainFEBS Journal 277 (2010) 2611–2627 ª 2010 The Authors Journal compilation ª 2010 FEBS 2623NMR solution structure and function of the ... in solution. The overall fold and the structure of the b-strandcore of the protein in solution are similar to those found in the crystal structure. The structure of the minidomain (residues...
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Báo cáo khoa học: Structure and function of KH domains docx

Báo cáo khoa học: Structure and function of KH domains docx

Báo cáo khoa học

... produces two protein protein interfaces. (B) One protein protein interface generated by two-fold NCS. (C) Other protein protein inter-faces also generated by two-fold NCS.R. Valverde et al. Structure ... the protein protein interaction.ABFig. 12. Schematic representation of protein protein surfaces offree and RNA-bound Nova-2 crystals. The schematic in (A) and (B)is based on the protein protein ... whichparts of the large proteins were involved in associa-ABFig. 13. Schematic representation of protein protein interfaces in the structure of PCBP. (A) was generated using Protein Data Bank coordi-nates...
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Báo cáo khoa học: Structure and function of N-acetylglucosamine kinase Identification of two active site cysteines pptx

Báo cáo khoa học: Structure and function of N-acetylglucosamine kinase Identification of two active site cysteines pptx

Báo cáo khoa học

... andsecondary structures (I, II, and III). a-helices are indicated in bold, b-sheets are underlined. Mutated cysteine residues of GlcNAc kinase are labeledwith a star.Ó FEBS 2002 Structure and function ... S., Guinea, B., Sanchez, L., Roca, R., Valencia, A. & Bernad, A. (2002) FunctionalÓ FEBS 2002 Structure and function of GlcNAc kinase (Eur. J. Biochem. 269) 4217 ... GlcNAc kinase cDNAs wereexpressed in E. coli BL21 cells. The proteins were fused toa His-tag, which allowed purification of the proteins byNi-nitrilotriacetic acid chromatography and detection...
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Day one nucleic acid structure and function

Day one nucleic acid structure and function

Sinh học

... supercoiling.relaxed supercoiledProteins often bind to specific sequences of DNA.Example: Restriction enzyme EcoRI binds to the DNA sequence5’-GAATTC-3’3’-CTTAAG-5’ Protein – DNA interactionGenomesSource ... introns.Ribonucleotides have a 2’-OHDeoxyribonucleotides have a 2’-HChemical Structure of DNA vs RNADNA molecules are packaged in the cell as structures called chromosomes.Bacteria have a single chromosome. ... (genome)RNA is synthesized in the nucleus and exported to the cytoplasmNucleusCytoplasmDNARNA (mRNA)ProteinsreplicationtranscriptiontranslationIn eukaryotes,genes contain exons (coding regions)and...
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Cell Structure and Function Functi

Cell Structure and Function Functi

Sinh học

... NucleusNucleus Structure StructureNuclear envelopeNuclear envelope•Two Phospholipid bilayers with protein Two Phospholipid bilayers with protein lined poreslined poresEach pore is a ring of 8 proteins ... ReticulumEndoplasmic Reticulum Function RER Function RER•Proteins are modified as they move through Proteins are modified as they move through the RERthe RER•Once modified, the proteins are packaged ... fiber of DNA with proteins attachedproteins attachedChromatin – all of the cell’s DNA and the Chromatin – all of the cell’s DNA and the associated proteinsassociated proteins Why Are...
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CELLS Structure and Function Structure and Function

CELLS Structure and Function Structure and Function

Sinh học

... detoxification3.3.Transport of proteins from RERTransport of proteins from RERRERRERSERSERFunctions of EukaryoticFunctions of Eukaryotic Cell Features Cell Features Structure Structure Function( s) Function( s)Cilia ... distributes proteins and lipids from ERdistributes proteins and lipids from ERFunctions of Functions of Eukaryotic Cell Eukaryotic Cell FeaturesFeatures Structure Structure Function FunctionMitochondrionMitochondrionCaptures ... CELLSCELLS Structure and Function Structure and Function Cell = smallest unit of lifeCell = smallest unit of lifeFunctions of Eukaryotic Cell FeaturesFunctions of Eukaryotic Cell Features Structure...
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Báo cáo khoa học: MicroRNA-373, a new regulator of protein phosphatase 6, functions as an oncogene in hepatocellular carcinoma pdf

Báo cáo khoa học: MicroRNA-373, a new regulator of protein phosphatase 6, functions as an oncogene in hepatocellular carcinoma pdf

Báo cáo khoa học

... MicroRNA-373, a new regulator of protein phosphatase 6,functions as an oncogene in hepatocellular carcinomaNannan Wu*, Xuyuan Liu*, Xuemei ... of small noncoding RNAs that function as key reg-ulators of gene expression at the post-transcriptional level. Recently, micr-oRNA-373 (miR-373) has been found to function as an oncogene intesticular ... the protein phosphatase 6 catalytic sub-unit (PPP6C ), a negative cell cycle regulator, was identified as a directtarget gene of miR-373 by use of a fluorescent reporter assay. The mRNAand protein...
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