connecting the insult to the bcl 2 family
Báo cáo khoa học: The proapoptotic member of the Bcl-2 family Bcl-2 / E1B-19K-interacting protein 3 is a mediator of caspase-independent neuronal death in excitotoxicity pot
Ngày tải lên :
22/03/2014, 17:20
... neurons against glutamate-induced excitotoxicity BNIP3 is a BH3-only proapoptotic member of the Bcl- 2 family However, unlike in other members of the Bcl- 2 family, the BH3 domain of BNIP3 is not required ... distributed in the cytoplasm, owing to the lack of its transmembrane FEBS Journal 27 8 (20 11) 134–1 42 ª 20 10 The Authors Journal compilation ª 20 10 FEBS Z Zhang et al BNIP3 in excitotoxicity B A ... 0.0038, n = 4) To determine whether the BNIP3-mediated cell death pathway in excitotoxicity involved protein synthesis, we evaluated the effectiveness of the RNA synthesis inhibitor actinomycin...
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Báo cáo khoa học: " AT-101, a small molecule inhibitor of anti-apoptotic Bcl-2 family members, activates the SAPK/JNK pathway and enhances radiation-induced apoptosis" pdf
Ngày tải lên :
09/08/2014, 10:20
... known as Bcl2 homology (BH) domains The family consists of the anti-apoptotic Bcl- 2 group (such as Bcl- 2, Bcl- XL, Mcl-1), the pro-apoptotic Bax group (Bax, Bak and Bok) and the pro-apoptotic BH3 ... free to form the homomultimer and cause mitochondrial permeabilization Thus, the anti-apoptotic function of Bcl- XL /Bcl- 2 is largely attributed to their ability to interact with pro-apoptotic ... SAPK/JNK translocates to the mitochondria upon irradiation and other stress factors where it phosphorylates and inactivates anti-apoptotic Bcl- 2 family members, including Bcl- 2, Bcl- XL and Mcl-1 [49-51]...
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Báo cáo sinh học: "Electroporation increases antitumoral efficacy of the bcl-2 antisense G3139 and chemotherapy in a human melanoma xenograft" pot
Ngày tải lên :
18/06/2014, 22:20
... 1998, 4 :23 2 -23 4 Jansen B, Wacheck V, Heere-Ress E, Schlagbauer-Wadl H, Hoeller C, Lucas T, Hoermann M, Hollenstein U, Wolff K, Pehamberger H: Chemosensitisation 22 23 24 25 26 27 28 29 of malignant ... voltages (from 450 to 24 50 V) with sequential increases of 20 0 V and permits to regulate the number of pulses (from to 16) and the pulse duration (50 to 100 μs) The standard train is set to pulses of ... gene delivery Gene Ther 20 02, 9: 128 6- 129 0 38 Spugnini EP, Citro G, Porrello A: Rational design of new electrodes for electrochemotherapy J Exp Clin Cancer Res 20 05, 24 :24 5 -25 4 39 Livak KJ, Schmittgen...
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báo cáo hóa học:" Electroporation increases antitumoral efficacy of the bcl-2 antisense G3139 and chemotherapy in a human melanoma xenograft" ppt
Ngày tải lên :
20/06/2014, 04:20
... 1998, 4 :23 2 -23 4 Jansen B, Wacheck V, Heere-Ress E, Schlagbauer-Wadl H, Hoeller C, Lucas T, Hoermann M, Hollenstein U, Wolff K, Pehamberger H: Chemosensitisation 22 23 24 25 26 27 28 29 of malignant ... voltages (from 450 to 24 50 V) with sequential increases of 20 0 V and permits to regulate the number of pulses (from to 16) and the pulse duration (50 to 100 μs) The standard train is set to pulses of ... gene delivery Gene Ther 20 02, 9: 128 6- 129 0 38 Spugnini EP, Citro G, Porrello A: Rational design of new electrodes for electrochemotherapy J Exp Clin Cancer Res 20 05, 24 :24 5 -25 4 39 Livak KJ, Schmittgen...
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Báo cáo y học: "The AP-2 family of transcription factors." potx
Ngày tải lên :
14/08/2014, 16:20
... XP _22 523 8 XP _21 7356 NP_958 823 XP _23 6975 XP _23 3 526 G gallus NP_990 425 NP_99 022 6 - XP_ 426 224 - X tropicalis AAD5 328 9 - - - - X laevis AAA499 72 - - - - D rerio NP_789 829 NP_001019836 - - Other AP -2 ... AP -2 AP -2 AP -2 AP -2 AP -2 H sapiens 6p24 6p 12 20q13 .2 6p 12. 1 1p34.3 P troglodytes 6p 22. 3 6p 12 21 - - M musculus 13 A5-B1 A2-A4 H3-H4 A3 D2 .2 R norvegicus 17p 12 9q13 3q 42 9q13 5q36 G gallus ... Development 20 01, 128 : 123 1- 123 8 Genome Biology 20 05, 6 :24 6 http://genomebiology.com /20 05/6/13 /24 6 Genome Biology 20 05, 52 53 54 55 57 58 60 62 63 65 66 68 69 70 72 Genome Biology 20 05, 6 :24 6 information...
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Báo cáo khoa học: Pituitary adenylate cyclase-activating polypeptide attenuates streptozotocin-induced apoptotic death of RIN-m5F cells through regulation of Bcl-2 family protein mRNA expression pdf
Ngày tải lên :
16/03/2014, 04:20
... apoptotic cascades, Bcl- 2 family members are major regulators of mitochondrial integrity and mitochondrion-initiated caspase activation [34] The Bcl- 2 protein family consists of pro-apoptotic ... (20 06) Hierarchical regulation of mitochondrion-dependent apoptosis by BCL- 2 subfamilies Nat Cell Biol 8, 1348–1358 35 Tsujimoto Y (20 03) Cell death regulation by the Bcl- 2 protein family in the ... 1471–1478 12 Onoue S, Ohshima K, Endo K, Yajima T & Kashimoto K (20 02) PACAP protects neuronal PC 12 cells from the cytotoxicity of human prion protein fragment 106- 126 FEBS Lett 522 , 65–70 5550...
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Báo cáo y học: "Coaggregation of Fc RI with Fc RIIB Inhibits Degranulation but Not Induction of Bcl-2 Family Members A1 and Bim in Mast Cells" ppsx
Ngày tải lên :
08/08/2014, 21:20
... Does Not Affect the Induction of A1 Apoptosis is regulated by members of the Bcl- 2 family A1, one of the antiapoptotic Bcl- 2 family members, is described as being important for the survival of ... Proapoptotic Bcl- 2 family member Bim is involved in the control of mast cell survival and is induced together with Bcl- XL upon IgE-receptor activation Cell Death Differ 20 05; 12: 136–44 29 Klippel ... mechanism by which SCF acts to prevent apoptosis in mast cells.19 Antiapoptotic members of the Bcl- 2 family are needed for cell survival One of the murine prosurvival Bcl- 2 family members is A1, which...
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Báo cáo khoa học: The autophagic response to nutrient deprivation in the hl-1 cardiac myocyte is modulated by Bcl-2 and sarco⁄endoplasmic reticulum calcium stores ppt
Ngày tải lên :
07/03/2014, 09:20
... Bcl- 2- ER versus vector (cumulative) Furthermore, in cells expressing Bcl- 2- ER, TG reduced autophagic activity to an even greater extent 40 * 30 20 10 -10 -20 Vector Bcl- 2- wt Bcl- 2- ER ** Fig Bcl- 2 ... GFP-LC3 Punctae B * 50 25 Vector Bcl- 2- wt Bcl- 2- ER Fig Bcl- 2 control of autophagic activity HL-1 cells were transfected with mCherry-LC3 and empty vector, GFP Bcl- 2- wt, or GFP– Bcl- 2- ER Experiments ... vector versus Bcl- 2- wt; **P < 0.001 for vector versus Bcl- 2- ER The small negative percent change seen with Bcl- 2- ER may be due to photobleaching steady-state autophagosome accumulation and autophagic...
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The Novell Guide to Network Volume 2 - Instructor Guide
Ngày tải lên :
26/10/2013, 23:15
... Binary 26 25 24 23 22 21 20 Decimal 128 64 32 16 10000001 0 0 0 129 11100000 1 0 0 22 4 00011110 0 1 1 30 Decimal 27 26 25 24 23 22 21 20 Binary 128 64 32 16 128 0 0 0 10000000 10 0 0 1 00001010 21 ... the following tables: Binary 27 ( 128 ) 26 (64) 25 ( 32) 24 (16) 23 (8) 22 (4) 21 (2) 20 (1) Decimal Equivalent 10000001 0 0 0 128 +1 = 129 Decimal 27 ( 128 ) 26 (64) 25 ( 32) 24 (16) 23 (8) 22 (4) 21 ... 7-11 The Novell Guide to Network + (Volume 2) 0 The result is the decimal equivalent of the byte Binary 27 26 25 24 23 22 21 20 Decimal 128 64 32 16 1 1 0 (1x 128 )+ (1x 32) + (1x8)+ (1x4)=1 72 0 0...
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Tài liệu The Novell Guide to Network Volume 2 - Instructor Guide doc
Ngày tải lên :
21/12/2013, 06:19
... Binary 26 25 24 23 22 21 20 Decimal 128 64 32 16 10000001 0 0 0 129 11100000 1 0 0 22 4 00011110 0 1 1 30 Decimal 27 26 25 24 23 22 21 20 Binary 128 64 32 16 128 0 0 0 10000000 10 0 0 1 00001010 21 ... the following tables: Binary 27 ( 128 ) 26 (64) 25 ( 32) 24 (16) 23 (8) 22 (4) 21 (2) 20 (1) Decimal Equivalent 10000001 0 0 0 128 +1 = 129 Decimal 27 ( 128 ) 26 (64) 25 ( 32) 24 (16) 23 (8) 22 (4) 21 ... 7-11 The Novell Guide to Network + (Volume 2) 0 The result is the decimal equivalent of the byte Binary 27 26 25 24 23 22 21 20 Decimal 128 64 32 16 1 1 0 (1x 128 )+ (1x 32) + (1x8)+ (1x4)=1 72 0 0...
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Tài liệu The Insider’s Guide to PR: Chapter 2 DO YOU FIT THE BILL? ppt
Ngày tải lên :
23/12/2013, 00:15
... to sell in your story to that media s C: you decide to leave it till the next day s 10 The working day at the office is finally over and you decide to take one of your clients out to dinner to ... on the facts only s C: you blame your team mates for not doing enough preparation and leave it up to them to present s The presentation goes really well in the end, and the client asks you to ... task is to draft a press release for the new product launch A: you quickly draft the release and send it to all the mainstream media without speaking to the journalists first s B: you write the release...
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Tài liệu Therapist''''s Guide to Clinical Intervention The 1-2-3''''s of Treatment Planning pdf
Ngày tải lên :
15/02/2014, 02:20
... Stress 421 Successful Stepfamilies Honor 422 Communication Emotional Stress 421 Self-Care 421 422 Validation 422 Respect 422 Responsibility 422 423 Discipline 423 Parent-Centered Structure 423 Helping ... Stress 22 8 Stress Signals 22 9 Critical Problem Solving 22 9 Assertiveness Conflict Resolution 23 0 Time Management Self-Care 23 0 Tips for Stress Management 22 8 23 0 23 0 23 0 Contents IX Tips to Simplify ... Present Illness 21 3 Occupational History 21 4 Past Psychiatric History and Relevant Medical History 21 4 Family History 21 4 Developmental History 21 5 Social History (Distinguish Prior to Disability,...
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Báo cáo khoa học: Copper-containing nitrite reductase fromPseudomonas chlororaphis DSM 50135 Evidence for modulation of the rate of intramolecular electron transfer through nitrite binding to the type 2 copper center pot
Ngày tải lên :
07/03/2014, 15:20
... gy gx T1Cu T2Cu As-puried With NO2 2. 220 2. 0 52 2.036 5.8 2. 350 2. 34 2. 110 ND 2. 040 ND 10.7 12. 0 ể FEBS 20 04 Cu-containing nitrite reductase from Ps chlororaphis (Eur J Biochem 27 1) 23 67 Upon reduction ... 0.03; CoCl2, 0.6 and Na2B2O7, 0.1 The optical density, the concentrations of nitrate [17] and nitrite [18], the pO2 and the pH of the medium were monitored, and the composition of the gaseous ... ể FEBS 20 04 23 62 D Pinho et al (Eur J Biochem 27 1) from the electrode and donates them to the Nir, in the presence of nitrite Under these conditions, the shape of the voltammogram becomes...
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Báo cáo khoa học: Characterization of a cathepsin L-associated protein in Artemia and its relationship to the FAS-I family of cell adhesion proteins pot
Ngày tải lên :
07/03/2014, 16:20
... S (20 02) Cathepsin L is essential for embryogenesis 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 and development of Caenorhabditis elegans J.Biol Chem 27 7, 3477–3486 Kirschke, H (1998) Cathepsin ... positions 99 20 2 (DRAG) and 26 5 27 2 (GTTMQGKS) [35] Having recognized CLAP as a member of the fasciclin family of proteins, we were interested to know whether the protein – like many other fasciclins ... 111–115 Britton, C & Murray, L (20 02) A cathepsin L protease essential for Caenorhabditis elegans embryogenesis is functionally conserved in parasitic nematodes Mol Biochem Parasitol 122 , 21 –33 Warner,...
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Developer''''s Guide to Building XML-based Web Services with the Java 2 Platform, Enterprise Edition (J2EE) pptx
Ngày tải lên :
14/03/2014, 23:20
... to the servlet The servlet then marshals this return value into an XML document The servlet returns XML to the client on a response Developer's Guide to Building XML-based Web Services with the ... layer to translate the incoming XML data into a format suitable for processing by our business service, and then translating the results of the business service into an XML format to return to the ... required to build web services today; you can still use the more general XML APIs to interact with the protocols directly JAXR is a convenience API which provides a Java API to perform the various...
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Connecting Developmental Constructions to the Internet: Identity Presentation and Sexual Exploration in Online Teen Chat Rooms pot
Ngày tải lên :
23/03/2014, 03:20
... 33 326 Chat 450 55 16 Chat Chat Chat Chat Chat Chat Chat Chat Chat 10 467 785 522 498 581 722 5 72 519 440 5556 59 49 69 66 44 41 64 52 68 567 19 18 15 12 18 17 17 134 26 13 24 22 17 22 22 30 ... (44%) 6 32 (55%) 8% 11% 7% 2% 4% 3% 5% 3% 5% 6% 6% 8% 5% 3% 5% 27 3 (47%) 326 (56%) 25 4 (44%) 65 (11%) 1 52 (26 %) 134 (24 %) 198 (35%) 118 (21 %) 125 (22 %) 165 (29 %) 407 (35%) 524 (46%) 3 72 ( 32% ) 190 ... Chat 5 92 44 22 18 Chat Chat Chat Chat Chat Chat Chat Chat Chat 10 683 763 813 654 1008 694 509 28 7 699 67 02 55 58 55 69 63 77 63 46 53 583 23 27 22 34 30 35 33 20 27 27 3 32 31 34 40 28 42 37 31...
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Professional iOS Network Programming: Connecting the Enterprise to the iPhone and iPad doc
Ngày tải lên :
23/03/2014, 06:20
... Responding to Remote Notifications Understanding Notification Best Practices Summary 22 4 22 9 23 4 23 6 24 0 24 3 24 4 PART IV: NETWORKING APP TO APP CHAPTER 11: INTER-APP COMMUNICATION URL Schemes 24 7 24 8 ... DEVICE -TO- DEVICE COMMUNICATION WITH GAME KIT 26 7 Game Kit Basics Peer -to- Peer Networking 26 8 27 1 Connecting to a Session Sending Data to Peers 27 2 27 4 Client-Server Communication Summary 27 9 28 0 ... a Custom URL Scheme Sensing the Presence of Other Apps Advanced Communication Shared Keychains 24 8 25 1 25 2 25 7 Enterprise SSO Detecting Previous Installations Summary 25 7 26 4 26 6 CHAPTER 12: DEVICE -TO- DEVICE...
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Báo cáo khoa học: Targeted disruption of one of the importin a family members leads to female functional incompetence in delivery docx
Ngày tải lên :
28/03/2014, 23:20
... of the cell cycle regulators cyclin D2 and p27Kip1 Mol Endocrinol 12, 924 –940 29 Leo C & Chen JD (20 00) The SRC family of nuclear receptor coactivators Gene 24 5, 1–11 30 Matzuk MM & Lamb DJ (20 02) ... regulation by ER and its cofactors On the other hand, the protein levels in the uterus FEBS Journal 27 8 (20 11) 1561–15 72 ª 20 11 The Authors Journal compilation ª 20 11 FEBS 1565 Reproductive organ ... whether these mice FEBS Journal 27 8 (20 11) 1561–15 72 ª 20 11 The Authors Journal compilation ª 20 11 FEBS Reproductive organ abnormalities in impa5 ) ⁄ ) mice T Moriyama et al A Fig Immunohistochemistry...
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Báo cáo khoa học: Bcl-2 and Bcl-xL play important roles in the crosstalk between autophagy and apoptosis pdf
Ngày tải lên :
28/03/2014, 23:20
... can bind to the BH3 receptor domain of Bcl- 2 or Bcl- xl, to disrupt the interaction between Bcl- 2 or Bcl- xl and Beclin In addition, Bcl- 2 ⁄ Bcl- xL phosphorylation results in Bcl- 2 ⁄ Bcl- xL dissociation ... by Bcl- xL J Biol Chem 27 4, 22 25 22 33 Green DR & Reed JC (1998) Mitochondria and apoptosis Science 28 1, 1309–13 12 Gross A, McDonnell JM & Korsmeyer SJ (1999) BCL- 2 family members and the mitochondria ... dissociation of these two 404 Table Bcl- 2 family members Bcl- 2 family member Prosurvival family members that contain four BH domains Bcl- 2 Bcl- xL Bcl- W Mcl-1 Bcl- B A1 Proapoptotic family members...
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