components of spatially organized signaling networks and microdomains
Báo cáo y học: " The anti-inflammatory effects of the tellurium redox modulating compound, AS101, are associated with regulation of NFB signaling pathway and nitric oxide induction in macrophages" doc
... design of the study, its coordination and drafted the manuscript BS conceived of the study, participated in the design and coordination of the study, and drafted the manuscript All authors read and ... regulation of cell survival genes and coordination of pro-inflammatory mediators such as iNOS and NO[2] Therefore, the modulation of iNOS expression by AS101 prompted us to examine the effect of AS101 ... from the Chief Scientist Office of the Ministry of Health, Israel This study was a part of the PhD thesis of Miri Brodsky Author details C.A.I.R Institute, The Safdiè AIDS and Immunology Research...
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Báo cáo y học: "The prokaryotic antecedents of the ubiquitin-signaling system and the early evolution of ubiquitin-like β-grasp domains" pps
... amino-terminal regions of a family of bacterial RNAses with the Mut7-C domain, the amino-terminal region of the family of tail assembly protein I of the lambdoid and T1-like bacteriophages, and the RnfH ... ubiquitinsignaling network sions involved in thiamine and MoCo/WCo biosynthesis and majority of other predicted operons (Table and Figure 4) The former set of operons is highly conserved and is ... superfamilies of the papain-like fold and pepsin-like, JAB, and Zincin-like metalloprotease superfamilies [10-16] Of these the most conserved are certain versions of the papainlike fold and the JAB...
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Tài liệu Introduction for the security : Networks and exchanges of data Computer security The risks ppt
... Networks and exchanges of data Computer security The risks Networks and exchanges of data For the exchange of the data, we've changed the technology The Intranets, the private networks ... clients and the partners Propose different services Profitability Networks and exchanges of data The connection between Internet and the company's network open a large way with a lot of persons ... lot of persons They can use this solution and they obtain a lot of services But Inside an Intranet we find a lot of data and information For the live of the company, they're critical If in the...
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Tài liệu Báo cáo khoa học: Compartmentalization and in vivo insulin-induced translocation of the insulin-signaling inhibitor Grb14 in rat liver pptx
... inhibitor of insulin signaling Consistent with this observation, overexpression of Grb14 in CHO-IR cells impairs Akt and ERK insulin signaling pathways and inhibits distal effects of insulin ... role for two of its binding domains, PIR and SH2 Oncogene 19, 2052– 2059 Daly RJ, Sanderson GM, Janes PW & Sutherland RL (1996) Cloning and characterization of GRB14, a novel member of the GRB7 ... with a high proportion of phosphorylated receptors having Grb14 bound to them Structural studies of the kinase domain of the IR in complex with the PIR–BPS of Grb14 and of the Grb14 SH2 domain...
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Tài liệu Báo cáo khoa học: Induction of uPA gene expression by the blockage of E-cadherin via Src- and Shc-dependent Erk signaling docx
... collagen gel, and showed that disruption of cell–cell adhesion induced Erk signaling downstream of E-cadherin This Erk activation was Src- and Shc-dependent and resulted in enhanced expression of the ... knockdown of all Shc isoforms strongly reduced Decma-induced Erk phosphorylation Moreover, expression of silent mutants of Shc isoforms showed that only p46Shc and p52Shc rescued the effect of the ... University of Basel, Switzerland) and details will be published elsewhere Plasmids and siRNAs Construction of expression vectors for HA-tagged fulllength mouse p46shc, p52shc, and p66shc and the...
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COMPONENTS OF REPRODUCTIVE ISOLATION BETWEEN THE MONKEYFLOWERS MIMULUS LEWISII AND M. CARDINALIS (PHRYMACEAE) potx
... applicable, and observed and expected occurrences of hybrids were compared using a chisquare test Greenhouse Measurements of Interspecific Seed Set and Hybrid Fitness We measured components of fitness ... pollen viability, and seed mass) on the progeny of the pure intra- and interspecific pollen treatments (see Pollen Competition above) The hybrid and parental offspring of 10 M lewisii and 10 M cardinalis ... difference of means Value computed as the mean of M lewisii and M cardinalis Measure of fertility equal to the mean of relative F hybrid pollen viability and seed mass Value based on rates of hybrid...
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Báo cáo khoa học: Systematic quantification of complex metabolic flux networks using stable isotopes and mass spectrometry pptx
... name of an amino acid in the legend refers to the weight of the depicted fragment ion of the TBDMS-derivative of the amino acid of 18 GC-MS runs and its standard deviation reflects the variance of ... concentration of valine was at the limits of the detection method (HPLC) The high standard deviations assigned to CER, OUR and the net consumption rate of ammonia (i.e 10%, 10% and 15% of the rate ... °C and centrifuged again for at 5040 g and 2–4 °C (in a rotor precooled to )20 °C) The pellet was then dried under a flow of nitrogen; of note, the pellet was kept in ice and the duration of drying...
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Báo cáo khoa học: Antibody-based proteomics Analysis of signaling networks using reverse protein arrays pdf
... modulation of regulatory networks [5,6] A direct benefit of such an approach would be the early recognition of ‘off target’ and side effects of drug candidates [7], as well as the identification of putative ... expression levels of selected signaling network components in mouse organs and brain areas (B) Relative expression levels of selected signaling network components from the heart and pancreas derived ... of the targeted kinase Because of the inherent potential promiscuity of kinase inhibitors, a more extensive characterization of compound activities across a wide range of signaling pathways and...
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Báo cáo khoa học: Interaction of the E2 and E3 components of the pyruvate dehydrogenase multienzyme complex of Bacillus stearothermophilus ppt
... Number Fig NMR spectroscopy of the interaction of PSBD and E3int Plots of the (A) 15N and (B) 1HN chemical shift changes between the [15N,1H]-HSQC spectra of free PSBD and the PSBD–E3int dimer (10 ... representing the PSBD of the dihydrosuccinyltransferase chain of the 2-oxoglutarate dehydrogenase complex of E coli [12] and of the dihydroacetyltransferase chain of the PDH complex of B stearothermophilus ... arrangement of structural motifs and loops, with the exception of loop L2 where differences exist Previously it was noted that upon superposition of the NMR structure and crystal structure, the tip of...
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Security and Privacy Vulnerabilities of In-Car Wireless Networks: A Tire Pressure Monitoring System Case Study ppt
... majority of message fields and their meanings for both TPS-A and TPSB These included temperature, pressure, and sensor ID, as illustrated in Figure We also identified the use of a CRC checksum and determined ... packet with a sensor ID of “DEADBEEF” and a tire pressure of PSI This testing also allowed us to understand the meaning of remaining status flags in the protocol gies, TPMS and ANPR systems exhibit ... match one of the known IDs of its tires, but appears to accept all other packets For example, we transmitted forged packets with the ID of the left front tire and a pressure of PSI and found...
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Báo cáo khoa học: Structure, signaling mechanism and regulation of the natriuretic peptide receptor guanylate cyclase pptx
... (a) Arg14 of ANP hydrogen bonds with Glu119 of ECD monomer A (Glu119A) and Asp62 of ECD monomer B (Asp62B) Arg95A and Asp62B are 1820 also hydrogen bonded, contributing to the stability of the complex; ... determination of the native structures in the absence of crystal contacts and in solution conditions closer to those of the native environment The three-dimensional reconstructions of the apo-ECD dimer and ... encoded by exons and 16, respectively ANP receptor ECD – biochemical and biophysical properties We expressed the ECD of rat NPRA in mammalian cells (COS cells and CHO cells), and purified it by...
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Báo cáo khoa học: Signaling pathways and preimplantation development of mammalian embryos potx
... preimplantation development of the mammalian embryo Red, Wnt signaling pathway; blue, Notch signaling pathway; green, BMP signaling pathway; yellow, PtdIns3K signaling pathway; gray, JAK-STAT signaling pathway ... kinase)-1, -2, -5, and MAPK ⁄ ERK1 are detected in unfertilized eggs and blastocysts Transcripts and the protein localization of p38-regulated and -activated kinase, p38 MAPK, MK2 and hsp25 have ... Transcripts of Wnt3a, -6, -7b, -9a and -10b have been detected in blastocysts, and Wnt1 and -4, Sfrp1 and Dkk1 are highly expressed at this stage [37] Receptors (Fz2, frizzled-2 and Fz4, frizzled-4),...
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components of cell and gene therapy
... brain and results in rigidity and tremor of the limbs Alzheimer’s isolates the hippocampus and regions of the cerebral cortex due to death of acetylcholine-rich neurons, causes dementia, and prevents ... cytotoxic and immunological effects The exclusion of these genes, however, often reduces the efficiency and length of transgene expression Control of the gene product will be a critical aspect of successful ... inheritance of early-onset Parkinsons’ has been established, and a susceptible gene associated with this group has been located on the long arm (q) of chromosome at band 21 224 COMPONENTS OF CELL AND...
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design and performance of 3g wireless networks and wireless lans
... University of Waikato, New Zealand Stefan J Boddie, University of Waikato, New Zealand Ian H Witten, University of Waikato, New Zealand Section IV: Use and Impact Chapter XI Digital Libraries and Society: ... Participation summary of ICADL conferences ICADL 1998 # of Papers 23 # of Papers from Asia 18 # of Countries # of Countries from Asia # of Institutions 17+ # of Institutions from 12+ Asia # of Academic ... computer networks and various forms of information technologies around the world, a partial fulfillment of Bush’s 1945 dream “memex” of a personal microfiche-based system to tackle the problem of information...
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performance analysis of communications networks and systems
... biological networks, social networks and utility infrastructures for water, gas, electricity and transport (cars, goods, trains) Since these networks consists of a huge number of nodes and links ... identity holds for any random sum of (possibly dependent) random variables provided the number of those random variables is independent of the In the case of i.i.d random variables, we apply ... probability = ? 10 Random variables probability of the event of interest was dened as Pr [ ] = is the number of favorable outcomes (samples points of ) If the where number of outcomes of an experiment...
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báo cáo hóa học: " Measuring the ICF components of impairment, activity limitation and participation restriction: an item analysis using classical test theory and item response theory" potx
... conception and design of the study, the analysis and the drafting and revision of the manuscript MJ participated in the conception and design of the study and the drafting and revision of the manuscript ... has been the standard method of item analysis and has been a valuable tool over many years [20] However, CTT depends on the nature and size of the sample and the nature and number of items as well ... Measurement of patient outcome in arthritis Arthritis and Rheumatism 1980, 23:137-145 Lequesne MG, Mery C, Samson M, Gerard P: Indexes of severity of Osteoarthritis of the hip and knee Scandinavian...
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Báo cáo hóa học: " Improvement for detection of microcalcifications through clustering algorithms and artificial neural networks" ppt
... the detection and/ or classification of MCs, but the interpretation of MCs continues to be a Figure Block diagram of the proposed method Page of 11 difficult task mainly because of their fuzzy ... relative importance of membership and typicality values in the computation of the prototypes, respectively The parameters m and h represent the absolute weight of the membership value and typicality ... k-means and PFCM, Table shows the number of patterns assigned to classes MCs and NT, respectively, for our set of ten ROI images (16) (q) where se is the size of the SE, xse is the gray-level of the...
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Báo cáo hóa học: " Impact of the environment and the topology on the performance of hierarchical body area networks" ppt
... probability of transmission of a relay node as a function of a single terminal probability of transmission and for N Î {2, 4, 8} neighbor nodes and P leaf→relay = In Figure 10, the probability of transmission ... regardless of the value of r; and (ii) has the shape of a decreasing exponential function of z (for a given value of s) The ζ function can be approximated with a linear combination of negative ... transmission of a relay node is shown as a function of the probability of transmission of a single node, considering various values for the number N1 of nodes in a first-level cluster (i.e., leaves of...
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báo cáo hóa học: " Synchronization of nonidentical chaotic neural networks with leakage delay and mixed timevarying delays" pptx
... networks Obviously, when the considered drive and response neural networks are distinct and with time delay, it becomes more complex and challenging On the study for synchronization problem of ... investigate the effect of the leakage delay on the synchronization of two nonidentical chaotic neural networks with discrete and distributed time-varying delays as well as leakage delay and to propose ... trajectory of z1(t) and z2(t) of neural network (3) 30 20 z2 10 10 20 30 25 20 15 10 z1 10 15 20 25 Figure Phase trajectory of neural network (3) without the controller u(t) 30 t 40 50 60 Song and Cao...
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Báo cáo hóa học: " Research Article Probabilistic Coexistence and Throughput of Cognitive Dual-Polarized Networks" doc
... presence of wideband fading channel, the use of polarimetric diversity significantly increases the overall performance of the whole system and is thus of interest in the context of cognitive radio networks ... function of the probability of transmission Figure 13: Impact of the channel fading on the system-level performance The parameter value ν = and ν > correspond to narrowband scenarios and wideband ... The distance of the transmission is d0 = 15 m and the interferers are located at d = 25 m of the receiver Accessible region (Narrowband) (Wideband) ν=0 (Narrowband) 0.2 ν>0 (Wideband) 0.8 0.6...
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