colon cancer current treatments and preclinical models for the discovery and development of new
LINH DAM NEW TOWN - SOLUTION FOR THE HIGH-DENSITY DEVELOPMENT OF NEW SETTLEMENTS IN THE SOUTH-WEST OF HANOI
... modern New Town, combined to the “natural” landscape and green space, and created a motivation for the development of the southern gateway of Hanoi capital Since 22 - 01 - 2009, the Minister of Construction ... to the northeast and east, water bodies to the north, and wetland to the south Spatially, the expansion of Hanoi stretches in the obvious directions, and the urbanization process follows the ... design” and “landscape design”, still deserve one of the new urban models of Hanoi and Vietnam, dealing with the high-density development in the south-west of Hanoi 3.4 Discussions With every new...
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LINH DAM NEW TOWN - SOLUTION FOR THE HIGH-DENSITY DEVELOPMENT OF NEW SETTLEMENTS IN THE SOUTH-WEST OF HANOI
... đình nhà chủ, 57,14% nhóm bán hàng rong 68,57% nhóm làm việc chợ lao động thuê trọ theo ngày (đêm), lại thuê nhà theo tháng Có khoảng 22,86% nữ lao động tự phải sống nơi có điều kiện sinh hoạt không ... lao động giúp việc “hài lòng” với công việc tại, tỷ lệ so với hai nhóm lao động tương đối cao, theo họ công việc không vất vả quê, thu nhập nhiều lao động gia đình chủ quan tâm 3.1.5 Định hướng ... họ tham gia vào đội ngũ lao động tự Họ phải làm công việc nặng nhọc với mức thu nhập thấp, kéo theo điều kiện sống mức tối thiểu, tạm bợ khu nhà trọ rẻ tiền với điều kiện sinh hoạt an ninh không...
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Risk of cancer from diagnostic X-rays: estimates for the UK and 14 other countries docx
... that the percentages of the cumulative risk attributable to radiation from diagnostic X-rays for the sum of the nine listed cancers and for all radiation-inducible cancers were the same Since there ... 3, 10, 12, and for males, and 1, 4, 11, 17, and for females ‡Number of cases in body of table rounded and not always, therefore, add up to the totals given Table 4: Estimated number of radiation-induced ... of cancer to age 75 years and number of cancer cases per year from diagnostic X-rays in the UK UK organ-specific radiation doses The relevant measure of dose for the risk of a specific type of...
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Báo cáo y học: "Chemotherapy in advanced bladder cancer: current status and future" pdf
... 27.6% and PR = 50%) [47] Therefore, the authors concluded the feasibility and the activity of this triple association This was the background of a phase III randomized trial developed by the EORTC ... 38% Page of 11 concerned 25 patients They showed a sustained ORR in 71% of the cases and 50% of complete responses (CR) Two randomized phase III trials demonstrated the superiority of the MVAC ... genes and activities of transcriptional factors involved in both cancer initiation and progression through alteration of either DNA or the structural components of chromatin Recently, the role of...
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Development and interpretation of machine learning models for drug discovery
... values, and the profiling of ligands against a panel of related targets Aside from the development of LBVS methods, understanding the resulting models is a key aspect in drug discovery Beneath the ... on the learning algorithm Individual decision trees and their ensemble in random forests for instance offer to assess the importance of each feature in terms of the number and order of splits they ... in the generated profile Thus, the regression value was maximal for the true profile of a training compound and minimal for the inverted true profile For prediction, a number of possible profiles...
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Tài liệu Báo cáo khoa học: Enzymes for the NADPH-dependent reduction of dihydroxyacetone and D-glyceraldehyde and L-glyceraldehyde in the mould Hypocrea jecorina doc
... interfering with the protein activity The tagged protein was purified and then used for further analysis In the reductive reaction, the Michaelis–Menten constant Km for DHA was mm, and the Km for NADPH ... in the genomic DNA For that reason, we amplified the open reading frame from cDNA For the second of the two potential glycerol dehydrogenases, we predicted no introns and therefore amplified the ... USA) three times for 30 s The mixture was then centrifuged in an Eppendorf microcentrifuge at full speed for 25 min, and the supernatant used for the analysis The protein content of the extract was...
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Tài liệu BÁO CÁO " CURRENT STATUS AND ORIENTATION OF RESIDENTIAL AREAS IN QUANG XUONG DISTRICT, THANH HOA PROVINCE, VIETNAM " pot
... demands for land use of residential areas were also mentioned in the study The noticeable thing is that the future demands for land use of residential areas include land for housing; land for ... front and rear direction Based on the above development direction of residential areas and the land use standard in the Official Dispatch No 5763/ BTNMT ĐKTK, the future demands for land use of ... sustainability of social-economic development efforts The study would contribute to the practical and theoretical understanding of community performance in terms of planning for residential areas The study...
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Báo cáo khoa học: N-Glycosylation is important for the correct intracellular localization of HFE and its ability to decrease cell surface transferrin binding pptx
... 3222 in the presence or absence of tunicamycin Drug treatments resulted in the accumulation of forms of the mutant proteins that were of lower apparent molecular mass and of similar size to the unglycosylated ... triple mutant forms of HFE and incubated the cells in the presence and absence of tunicamycin Drug treatment resulted in the accumulation of an unglycosylated lower molecular mass form of the wild-type ... end of an a-helical region of the HFE a1 domain (V100 and W103A) as being of particular importance for TfR1 interactions [16,17,20] The effect of HFE binding to TfR1 is to lower the affinity of the...
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The importance of project management in small- and medium-sized enterprises (SMEs) for the development of new products through E-collaboration docx
... concept (either for the company or for the customer) It includes all activities from the development of an idea or a concept for a product, to the realization of the product during the production ... to h The participants were given an explanation regarding the purpose of the feedback, the purpose of the conceptual model, some background of the research that lead to the development of the ... al., 2005) and New product development New product development (NPD) is a business process for developing new products for a company, whether it is an upgrade of an existing product or a new concept...
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Báo cáo khoa học: Functional expression of olfactory receptors in yeast and development of a bioassay for odorant screening docx
... to yield the 40-kDa band The 51-kDa band thus represents the receptor monomer with the exclusive addition of mannose residues The presence of the immunoreactive bands in the lanes relative to ... considering the yeast I7 receptor discrimination between closely related ligands strongly suggests the authenticity of its ligand binding and the maintenance of the coding ability at the receptor ... under the control of the GAL10 promoter The induction of the yeast, by galactose containing media, results in overexpression of GAL4, in turn inducing an increase of the expression of the OR...
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Báo cáo khoa học: Discovery and characterization of a Coenzyme A disulfide reductase from Pyrococcus horikoshii Implications for the disulfide metabolism of anaerobic hyperthermophiles doc
... Both the mass of the tube and activity of the enzyme were monitored over time using standard NADH oxidase assay methods It was necessary to correct for the mass of the tube due to concentration of ... reduce the disulfides, and assayed as above Thiols were quantified by comparison of peak areas to standard curves of those standards Coenzyme A was measured as the sum of the areas of the CoA and ... determine directly from the spectrum the fate of the reduced pyridine nucleotide During the addition of the first equivalent of NADPH, there is a blue shift in the 380 nm peak and subsequent small...
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Báo cáo Y học: Structural basis for the inhibitory efficacy of efavirenz (DMP-266), MSC194 and PNU142721 towards the HIV-1 RT K103N mutant doc
... reduced by the stacking of Od1 in between the plane of the thiourea moiety and the Ca of G190 Hence, the undefined orientation of the N103 amide Od1 and Nd2 atoms may reflect the repulsive forces exerted ... by the K103N mutation The electron density for Cc of the K103N mutant structures is well defined but the quality of the map does not allow assessment of the orientation of the amide plane There ... we present the structural indications for the role of K103 and N103 in drug binding and the structural implications for the inhibitory efficacy of the inhibitors Efavirenz, PNU142721, and MSC194...
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Báo cáo khoa học: Structure of a trypanosomatid mitochondrial cytochrome c with heme attached via only one thioether bond and implications for the substrate recognition requirements of heme lyase potx
... blue) Also shown are the heme ligands (histidine and methionine in each case), the cysteines that form thioether bonds to the heme, and the methyl group of the alanine of the C fasciculata AXXCH ... methionine and histidine side chains that coordinate the heme iron, and the cysteine side chain that forms a thioether bond between heme and protein Also shown is the methyl group of the alanine of the ... identity and 72% similarity The structures are remarkably similar overall, and in the details of the heme attachment and heme position The rmsd between the structure of C fasciculata cytochrome c ˚ and...
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Báo cáo khoa học: "Abstracts of Papers for the 1963 Annual Meeting of the Association for Machine Translation and Computational Linguistics" pptx
... the National Science Foundation, in part by the U.S Army Signal Corps, the Air Force Office of Scientific Research, and the Office of Naval Research, and in part by the National Bureau of Standards ... first and compared among the four languages: 1) the category of gender, 2) the category of animateness, 3) the category of case and number The product of this comparative analysis is a set of formation ... parts of speech of * This work was supported in part by the National Science Foundation, and in part by the U.S Army Signal Corps, the Air Force Office of Scientific Research, and the Office of...
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POLLUTION PREVENTION TECHNOLOGIES FOR THE BLEACHED KRAFT SEGMENT OF THE U.S. PULP AND PAPER INDUSTRY potx
... adopt them Since the discovery of dioxins in pulp mill effluent, however, the U.S and international research and development effort has been impressive, and the rate of adoption of many of these ... (1) the current state of the art, (2) the economics of adoption, and (3) the level of adoption, of selected pollution prevention technologies in the U.S pulp and paper industry The focus of this ... limitations These limitations are currently under development 2.3.4 Chloroform Until recently, the pulp and paper industry has been the major industrial source of chloroform emissions in the United...
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ILLINOIS BOARD OF ADMISSIONS TO THE BAR FINANCIAL AUDIT AND COMPLIANCE EXAMINATION For the Two Years Ended September 30, 2005 Performed as Special Assistant Auditors for the Auditor General, State of Illinois_part1 docx
... Board of Admissions to the Bar is responsible for establishing and maintaining effective internal control over compliance with the requirements of laws and regulations In planning and performing ... Deputy Director of Administration Ms Lillian Walton Members of the Board President Mr David W Andich Secretary/Treasurer Mr Donald H Funk Member of the Board Mr Neil K Quinn Member of the Board Mr ... Board Mr Richard J Prendergast Member of the Board Mr Theodore L Kuzniar Member of the Board Mr John J Rekowski Member of the Board Mr Lawrence N Hill Board offices are located at: 625 South College...
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ILLINOIS BOARD OF ADMISSIONS TO THE BAR FINANCIAL AUDIT AND COMPLIANCE EXAMINATION For the Two Years Ended September 30, 2005 Performed as Special Assistant Auditors for the Auditor General, State of Illinois_part2 potx
... BOARD OF ADMISSIONS TO THE BAR FINDINGS AND RECOMMENDATIONS For the Two Years Ended September 30, 2005 Current Findings There were no current findings noted during our compliance testing for the ... BOARD OF ADMISSIONS TO THE BAR SCHEDULE OF FINDINGS For the Two Years Ended September 30, 2005 Prior Audit Findings Not Repeated There were no findings noted during the compliance testing for the ... Liabilities and Net Assets $ This is trial version www.adultpdf.com The accompanying notes are an integral part of this financial statement 14 Illinois Board of Admissions to the Bar Statement of Activities...
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ILLINOIS BOARD OF ADMISSIONS TO THE BAR FINANCIAL AUDIT AND COMPLIANCE EXAMINATION For the Two Years Ended September 30, 2005 Performed as Special Assistant Auditors for the Auditor General, State of Illinois_part3 docx
... in the State of Illinois The operations and related expenses of the Committee are administered by the Board Organizational Structure The Board consists of seven members of the Illinois Bar (the ... over the shorter of their useful lives or the term of the related leases by use of the straight line method The estimated useful lives of property and equipment are as follows: Buildings and Improvements ... This includes the processing of examination applications; the collection of examination and law student registration fees; and the administration and grading of the exams Additionally the Board has...
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ILLINOIS BOARD OF ADMISSIONS TO THE BAR FINANCIAL AUDIT AND COMPLIANCE EXAMINATION For the Two Years Ended September 30, 2005 Performed as Special Assistant Auditors for the Auditor General, State of Illinois_part4 pot
... applications, the collection of exam fees, the administration of the examination and the supervision of exam grading Additionally, the Board has the responsibility of processing applications for foreign ... fiscal year 2005 the Board hosted a two day seminar for all members of the Board and the five character and fitness committees to promote and insure uniformity in the character and fitness process ... licenses and collecting the related license fees The Illinois Supreme Court also established the Committee on Character and Fitness (the Committee), the expenses of which are paid from receipts of the...
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