... the lowdensitylipoprotein (LDL) receptor pathway A lattice model for LDL binding J Biol Chem 266, 19296– 19302 Hwang J & Menon KM (1983) Characterization of lowdensity and high densitylipoprotein ... plasma levels of lowdensity lipoproteincholesterol Am J Hum Genet 78, 410–422 Leren TP (2004) Mutations in the PCSK9 gene in Norwegian subjects with autosomal dominant hypercholesterolemia Clin ... lowdensitylipoprotein receptor mediated by the cytoplasmic domain J Biol Chem 262, 16127–16134 Anderson RG, Goldstein JL & Brown MS (1980) Fluorescence visualization of receptor-bound low density...
... the intima of the artery wall, arising from cholesterol and cholesteryl ester accumulation by macrophage cells present in the artery wall [3] Lowdensity lipoproteins (LDLs) are the likely source ... Binding site on macrophages that mediates uptake and degradation of acetylated lowdensity lipoprotein, producing massive cholesterol deposition Proc Natl Acad Sci USA 76, 333–337 Khaw KT, Wareham ... Knott HM, Brown BE, Davies MJ & Dean RT (2003) Glycation and glycoxidation of low- density lipoproteins by glucose and low molecular weight aldehydes: formation of modified and oxidised proteins Eur...
... Inhibition of oxidation of human low- densitylipoprotein by phenolic substances in red wine Lancet 341, 544–547 Miyagi Y, Miwa K & Inoue H (1997) Inhibition of lowdensity lipoprotein oxidation by flavonoids ... 57 of low- densitylipoprotein Am J Clin Nutr 53, 314S– 321S Jialal I & Grundy SM (1992) Effect of dietary supplementation with alpha-tocopherol on the oxidative modification of low- densitylipoprotein ... research fellowship References Goldstein JL & Brown MS (1977) The low- densitylipoprotein pathway and its relation to atherosclerosis Annu Rev Biochem 46, 897–930 Grundy SM (1986) Cholesterol...
... Steinberg D (1997) Lowdensitylipoprotein oxidation and its pathological significance J Biol Chem 272, 20963–20966 10 Keller JN, Hanni KB & Markesbery WR (1999) Oxidized low- densitylipoprotein induces ... acid-induced protein damage FEBS Lett 532, 80–84 49 Noguchi N & Niki E (1994) Apolipoprotein B protein oxidation in low- density lipoproteins Methods Enzymol 233, 490–494 FEBS Journal 273 (2006) 1275–1284 ... (1997) Comparison between copper-mediated and hypochlorite-mediated modifications of human lowdensity lipoproteins evaluated by protein carbonyl formation J Lipid Res 38, 992–1001 38 Draczynska-Lusiak...
... Assembly and secretion of very -low- densitylipoprotein Biochem J 268, 1–13 Rusinol, A., Verkade, H & Vance, J.E (1993) Assembly of rat hepatic very lowdensity lipoproteins in the endoplasmic ... densitylipoprotein particles displacing especially apolipoprotein A-I [28] Apolipoprotein B or lipids were not displaced from lowdensitylipoprotein (LDL) particles indicating that neither should ... U.J.F., Tsukamoto, K., Glick, J.M & Rader, D.J (2000) Hepatic apolipoprotein E expression promotes very lowdensity lipoprotein- apolipoprotein B production in vivo in mice J Lipid Res 41, 1673–1679...
... to the endocytosis receptors alpha2-macroglobulin receptor low- densitylipoprotein receptor-related protein and very -low- densitylipoprotein receptor involves basic residues in the inhibitor ... Specicity of serine proteinase serpin complex binding to very -low- densitylipoprotein receptor and alpha2macroglobulin receptor low- density- lipoprotein- receptor-related protein Eur J Biochem 248, ... Chappell DA, Strauss JF, 3rd & Strickland DK (1995) The very lowdensitylipoprotein receptor mediates the cellular catabolism of lipoprotein lipase and urokinase-plasminogen activator inhibitor...
... with lowdensitylipoprotein receptor-related protein in systemic autoimmune diseases J Immunol 2001, 166:1360-1369 Hussain MM: Structural, biochemical and signaling properties of the low- density ... one of the LDLR domains, which were thought to bind various ligands such as apolipoprotein Eβ very -low- density lipoproteins, lactoferrin, and aprotinin [17] (Fig 1) We divided the region with ... for the patients with and R175 Arthritis Research & Therapy Vol No Ooka et al Figure Map of low- density- lipoprotein- receptor-related protein (LRP2) Six gene fragments that, with overlaps, covered...
... dynamics in AD 13 1.4 ApoE receptors 14 1.4.1 Lowdensitylipoprotein receptor family 14 1.4.2 Lowdensity lipoprotein- related protein and 16 1.4.3 Dysregulated Wnt ... immunoprecipitation LCM control L-cell conditioned medium LDL lowdensitylipoprotein LOAD late-onset Alzheimer's disease LRP lowdensitylipoprotein receptor-related protein L-Wnt-3a cells L-cells ... manuscripts in preparation: Zhang L, Ong WQ, Ee PL Apolipoprotein E4 disrupts normal mitochondrial dynamics through binding to low- densitylipoprotein receptor-related protein 5/6 in SH-SY5Y cells...
... high -density lipoproteincholesterol (HDLC) levels in two separate cohorts of Asian adults HDLC refers to the cholesterol carried by small lipoprotein molecules, so called high density lipoproteins ... simulations, and apply it to a study searching for pathways and genes associated with high -density lipoproteincholesterol in two separate East Asian cohorts we describe a sparse regression method ... pathways used in our application study looking at pathways and genes associated with high -density lipoproteincholesterol levels in two Asian GWAS cohorts where l (lw0) and a(0ƒaƒ1) are parameters...
... sphere The major types of lipoproteins includes chylomicrons, very lowdensity lipoproteins (VLDL), lowdensity lipoproteins (LDL), lipoprotein Lp(a) and high density lipoproteins (HDL) Chylomicrons ... Chlamydia pneumoniae, and lowdensitylipoprotein Introduction The second model consists of human macrophage U937 cell line and lowdensity lipoprotein, after addition of lowdensitylipoprotein The model ... oxidation (Kuo C.C., et al 1993.) Following an elevation in plasma lowdensitylipoprotein (LDL) cholesterol levels will result in the penetration of lowdensitylipoprotein into the arterial wall...
... Northoff, H (1993) Prevention of endotoxin-induced monokine release by human low- and high -density lipoproteins and by apolipoprotein A-I Infect Immun 61, 5140–5146 Yu B., Hailman, E & Wright, S.D ... recombinant form) compensates the phosphate charges to an only very low degree, the zeta potential remains lower than )40 mV, which seems to be connected with the observation that albumin does not ... Distribution and kinetics of lipoproteinbound endotoxin Infect Immun 69, 2821–2828 Casas, A.T., Hubsch, A.P., Rogers, B.C & Doran, J.E (1995) Reconstituted high -density lipoprotein reduces LPS-stimulated...
... Metrology Index; HDL-C, high -density lipoprotein cholesterol; IMT, intima-media thickness; LDL-C, low- densitylipoprotein cholesterol; OR, odds ratio; oxLDL, oxidized low- density lipoprotein; piHDL, proinflammatory ... [5-7] The following lipids are rich in apoB: low- density lipoproteins (LDLs), very -low- density lipoproteins (VLDLs) (which are also rich in triglycerides), and intermediate -density lipoproteins ... esters Cholesterol esters are shuttled to apoB-rich low- density lipoproteins (LDLs) and very -low- density lipoproteins (VLDLs) by the actions of cholesterol ester transfer protein (CETP) Conversely,...
... References Fielding CJ: High Density Lipoproteins Weinheim: Wiley-VCH; 2007 Rothblat GH, Phillips MC: High -density lipoprotein heterogeneity and function in reverse cholesterol transport Curr Opin ... very bright for ND technology Abbreviations HDL: high density lipoprotein; rHDL: reconstituted HDL; RCT: reverse cholesterol transport; Apo: apolipoprotein; DMPC: dimyristoylphosphatidylcholine; ... Ray KK, Cannon CP: High -density lipoprotein and coronary heart disease: current and future therapies J Am Coll Cardiol 2010, 55:1283-1299 Dudley-Brown S: A shot of good cholesterol: synthetic...
... below 24.6 carriers of the rare C allele had a significantly higher BMI than T allele homocygotes (p=0.023) Whereas no effect was seen on total cholesterol and LDL, C allele carriers had a lower ... Student’s t-test analysis with genotype as the group variable and total cholesterol, triglycerides, vldl-, ldl-, hdl cholesterol and lipoprotein (a) as dependent variables Bonferoni’s correction for ... Clinical characteristics of patients above and below median BMI (24.6) Below median BMI n total n with chd n without chd Age (years) BMI (kg/m²) Cholesterol (mg/dl) LDL HDL VLDL Triglycerides (mg/dl)...
... the environment of ordered lipids [29] and accumulate in the low density, detergent-resistant membranes recovered after equilibrium density centrifugation of Triton X-100 lysates of mammalian ... vesicles with the target cell membrane [39] The low Mr C-terminal MSP-1 fragments, like the endogenous GPI-linked CD59, are selectively enriched in low density, detergent-resistant membranes of the ... However, following SDS/ PAGE separation of MSP-1 fragments, the labelled GPI anchors appear dissociated from the 19-kDa fragment carrying the C-terminal epitope (compare Figs and 3) The lower Mr...
... 3.7: The evolution of probability density functions with iteration number in density evolution See Example 3.5 z = f (x, y) the density of z can be found as follows: f (z)dz = f (x, y)dxdy ∆Dz ... very well with a much reduced complexity Introducing Low- Density Parity-Check Codes, Sarah Johnson ACoRN Spring School version 1.1 1.3 Low- density parity-check (LDPC) codes As their name suggests, ... Topic 1: Low- Density Parity-Check Codes 1.1 Introduction Low- density parity-check (LDPC) codes are forward error-correction codes,...