changes of blood brain barrier permeability following intracerebral hemorrhage and the therapeutic effect of minocycl
báo cáo hóa học: " Anandamide inhibits Theiler’s virus induced VCAM-1 in brain endothelial cells and reduces leukocyte transmigration in a model of blood brain barrier by activation of CB1 receptors" pdf
... Anandamide inhibits VCAM-1 induced by TMEV in brain endothelial cells by CB1 receptors The endothelial blood brain barrier protects the CNS from the changing environment in both physiologic and ... a key stage in the disease Therefore, here, we investigated the role of CB1 receptors and the effects of the inhibitor of AEA uptake, UCM-707, on VCAM-1 expression in wild type and CB1 knockout ... immunohistochemistry studies and participated in the interpretation of data and revising manuscript draft FC, FL and FD participated in the design of the study, interpretation of data and revision of manuscript...
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báo cáo hóa học: " Lipopolysaccharide-enhanced transcellular transport of HIV-1 across the blood-brain barrier is mediated by luminal microvessel IL-6 and GM-CSF" potx
... employed the luminal chamber as the loading chamber Effects of LPS, IL-6, and GM-CSF on the expression of tight junction proteins To examine the effects of LPS, IL-6, and GM-CSF on the expression of ... cytokines/chemokines and LPS, regulate the permeability of the BBB to HIV-1 BECs express LPS receptors, such as Toll-like receptor (TLR)-2, TLR-4, and CD14 [27] and are targets of LPS The barrier function of the ... entry into the brain because of blood- brain barrier (BBB) efflux transporters so that the brain serves as a reservoir for HIV-1 [2] and a source for viral escape [3] Therefore, HIV-1 in the brain...
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Báo cáo y học: "Effect of magnesium sulfate administration on blood–brain barrier in a rat model of intraperitoneal sepsis: a randomized controlled experimental study" ppt
... of the BBB and the role of a permeability defect in the formation of cerebral edema using other models of cerebral damage [18-20] In our previous experimental study we evaluated the effects of ... reaches the brain site it interacts with the endothelial cells forming the BBB and inhibits their activation [4,24,25] To our knowledge, the present data are the first to show the positive effects of ... not shown) One of the major pitfalls in the interpretation of the data was the difficulty of establishing a dose response for magnesium In our present study the dose and the timing of magnesium...
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Báo cáo y học: "Inhibition of complement C5a prevents breakdown of the blood-brain barrier and pituitary dysfunction in experimental sepsis" ppt
... physiological conditions, the BBB maintains the cerebral micro-environment by tightly regulating the passage of molecules into and out of the brain to protect the brain from microorganisms and neurotoxic ... regulation of the immune response [71,72] We found upregulation of C5aR in the pituitary based on mRNA and protein levels following CLP and reversal of these changes by administration of anti-C5a ... sepsis, the antibody-mediated blockade of anaphylatoxin C5a prevented breakdown of the blood- brain barrier, reducing cerebral and pituitary edema formation, as assessed by extravasation of albumin and...
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Application of biologically active micelles in drug delivery across the blood brain barrier
... of effective antibiotics from the bloodstream to the brain parenchyma or spinal cord (Pardridge, 1997; Rubin and Staddon, 1999), due to the existence of the blood brain barrier (BBB) or the blood ... although 12% of all drugs are active in the CNS, only 8% of them are active in the brain for the treatment of diseases or disorders (Lipinski, 2000) The BBB lies between the blood flow and the brain ... parenchyma The blood brain barrier (BBB) lies between the blood flow and the brain parenchyma The BBB prohibits most foreign molecules entering from the blood to brain, including CNS drugs The limited...
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Nanoparticles of biodegradable polymers for delivery of therapeutic agents and diagnostic sensitizers to cross the blood brain barrier (BBB) for chemotherapy and MRI of the brain
... History and Anatomy of the Blood Brain Barrier 1.1.2 Functions of the Blood Brain Barrier 1.1.3 Clinical Significance of the Blood Brain Barrier 1.2 METHODS TO OVERCOME THE BLOOD BRAIN BARRIER 1.3 NANOPARTICLES ... membranes of the brain capillary endothelial cell Fig The BBB as a selective sieve With these two functions of the blood brain barrier, the brain capillaries allow the passage of oxygen and other ... the presence of glutathione, likely via cotransport, is required [13] 1.1.2 Functions of the Blood Brain Barrier The main function of the blood brain barrier is to protect the brain The BBB serves...
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the blood – brain barrier
... M E., and Brown, W J (1977) The large apparent work capability of the blood- brain barrier: A study of mitochondrial content of capillary endothelial cells in brain and other tissues of the rat ... through the diaphragm and the costal cartilages left of the sternum up to the level of the clavicle A transverse cut is made in the diaphragm The heart is then grasped using the index and thumb of the ... (2001) Molecular and cellular permeability control at the blood- brain barrier Brain Res Rev 36, 258–264 106 Rubin, L L., and Staddon, J M (1999) The cell biology of the blood- brain barrier Annu Rev...
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báo cáo hóa học: " Neuro-Inflammation, Blood-Brain Barrier, Seizures and Autism" pot
... W A and Erickson, M A.: The blood- brain barrier and immune function and dysfunction Neurobiol.Dis 2010, 37:26-32 44 Quan, N.: Immune-to -brain signaling: how important are the blood- brain barrierindependent ... (IL-6, mtDNA, TNF and VEGF), some of which increase the expression of vascular endothelial cell adhesion molecules (VCAMs) and permit exit of circulating lymphocytes in the brain Focal brain inflammation ... activation and seizures, through secretion of pro-inflammatory mediators and regulation of the BBB permeability Mast cell function inhibitors, especially those blocking the effect of NT, such...
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Hình thái và chức năng của hàng rào máu não (blood brain barrier)
... dụ: nhồi máu não, xuất huyết não chấn thương sọ não ), có chứng tượng mở hàng rào máu não (Brain- Blood Barrier opening) bù trừ có tính chọn lọc phá hủy mặt cấu trúc giải phẫu cách đơn (Lee et ... trúc phức tạp tinh vi, chúng nối vùng đỉnh khe liên tế bào biểu mô với hàng rào nội mô (endothelial barrier) Chúng có chức “dây kéo” (zipper) nhằm liên kết màng tế bào vùng đỉnh (apical membrane) ... nhu mô não, ví dụ trình bệnh xơ cứng rãi rác viêm não (Andersson et al, 1992) Các tế bào đơn nhân vào hệ thần kinh trung ương thường kèm theo gia tăng luồng protein huyết vào dịch não tủy Ngoài...
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EVOLUTION OF THE MOLECULAR BIOLOGY OF BRAIN TUMORS AND THE THERAPEUTIC IMPLICATIONS pdf
... mortality of the patient Moreover, the presence of the blood- brain barrier (BBB) limits the passage of a wide variety of anticancer agents The high incidence of recur‐ rence and poor prognosis of malignant ... cytotoxic chemotherapies The existence of blood- brain and blood- tumor barriers impede drug delivery to the tumor and adjacent brain infiltrated with tumor In addition the low therapeutic index between ... invasiveness in matrigel-assay and coculture experiments Furthermore, downregulation of cathepsin-L in 11 12 Evolution of the Molecular Biology of Brain Tumors and the Therapeutic Implications human...
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Báo cáo hóa học: " Large-scale fabrication of ordered arrays of microcontainers and the restraint effect on growth of CuO nanowires" ppt
... show the formation process of array of microboats of Cu on glass substrate The wall thickness of microboats is dependent on the thickness of the deposited film, while the height is dependent on the ... http://www.nanoscalereslett.com/content/6/1/86 Page of design of the study and discussion of growth mechanism of CuO nanowires NX participated in the design of the study, and critically revised the manuscript for important ... nanowires grew only in the inner surface of the microboats and microbowls Their diameters are 30-80 nm and length 0.5-4 μm The microstructure of the individual CuO nanowires was further examined using...
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báo cáo khoa học: " In vitro analysis of the cytotoxicity and the antimicrobial effect of four endodontic sealers" ppt
... bacteria there will be a decrease of the pH in the periapical tissues, and thus there are special demands for the sealing agents [31] The major task in reducing the bacterial load, concentrated in the ... region of the root canal, is achieved by the mechanical effects of instrumentation and the use of antimicrobial solutions for irrigation Different studies have shown the essential role of chemo-mechanical ... of E faecalis Therefore, the present in vitro study aimed at comparing the biocompatibility and the possible antibacterial Page of effect on E faecalis and P micra of the four different root filling...
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báo cáo hóa học:" Effective transvascular delivery of nanoparticles across the blood-brain tumor barrier into malignant glioma cells" docx
... therapeutics [21], these pores are narrow enough to prevent the effective transvascular passage of most nanoparticles [22-25] If the upper limit of the therapeutically relevant pore size of the ... charge on the dendrimer surface and disruption of the blood- brain barrier Conclusion In this study, we identified the precise physiologic upper limit of blood- brain tumor barrier pore size, and demonstrated ... Institute (NCI), and the Radiology and Imaging Sciences Program (CC) We thank Guofeng Zhang of the Laboratory of Bioengineering and Physical Science (NIBIB) and Yide Mi of the Radiology and Imaging...
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Báo cáo y học: "Changes of uterine blood flow after vaginal radical trachelectomy (VRT) in patients with early-stage uterine invasive cervical cancer"
... changes of the blood supply to the uterus in two patients who experienced pregnancy and delivery Effects of these changes on the pregnancy courses are also discussed Patients and methods In the ... pregnancy The effects of blood supply on the fetal growth and the placental changes were also studied RT removes the cervix of the uterus, parametrium, and upper vagina through a vaginal approach and ... the lack of mechanical support of the residual cervix due to the dissection of the uterine cervix might be a cause of pPROM, and the following occurrence of preterm premature delivery Furthermore,...
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Báo cáo Y học: Changes in ultrastructure and the occurrence of permeability transition in mitochondria during rat liver regeneration ppt
... swelling medium and the absorbance of the mitochondrial suspension as a function of time was monitored either in the absence or in the presence of CsA (1 lM), the specific inhibitor of the mitochondrial ... inhibited by the addition to the mitochondrial suspension of CsA (Fig 5A), the specific inhibitor of the permeability transition pore of mitochondria [26] This change in permeability of the inner ... (2.2 ± 0.1 and 0.8 ± 0.05% of the total mitochondrial activity of GDH and AAT, respectively) (Fig 3B, columns a and c) As shown in Fig 4, the total activities of the matrix enzymes GDH and AAT were...
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báo cáo hóa học:" Physiologic upper limit of pore size in the blood-tumor barrier of malignant solid tumors" ppt
... characterize the differences in the permeability of the BTB of a malignant brain tumor to that of the BTB of a peripheral solid tumor, and to define the upper limit of pore size within the BTB of the ... compared the permeability of the BTB of RG-2 gliomas grown within the brain, the orthotopic site, to that of the BTB of RG-2 gliomas grown outside the brain in the temporalis skeletal muscle, the ... ectopic site, the permeability of the BTB of the breast cancer tumor growing in the brain is lower than the BTB of the original tumor in breast tissue, the orthotopic site[5] The brain tissue...
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Báo cáo y học: "Changes of medium-latency SEP-components following peripheral nerve lesion" pps
... become unmasked and supraliminal and account for the expansion of the cortical projection area of the intact nerve as observed in the monkey [6] (Figure 4) In the human the influence of collateral ... declare that they have no competing interests Authors' contributions RS participated in the design of the study, the selection and examination of the patients, drafted the manuscript and the pictures/tables ... surgery with skin transplantation in the area of the arms and hands, alcohol or drug abuse, and status post chemotherapy were excluded The SEPs of the hand nerves supplying areas adjacent to peripherally...
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Following are some pictures of StudyLink International and the staff.
... etc Therefore, they usually call to the office and demand to talk with their counselors or C.O (case officers) The company’s call center has fifteen extensions A receptionist has to remember these ... remember all of the counselors’ and C.Os’ names through their extensions within several hours of the first day I had made a lot of mistakes in transferring the calls, and I dealt with the call center ... TA081 ABSTRACT There are thousands of graduates from hundreds of universities and colleges every year Therefore, the amount of students who are ready to apply for a job is so much The raised question...
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Status and changes of mangrove forest in Mekong Delta: Case study in Tra Vinh, Vietnam
... mainly in the northeastern of Duyen Hai Hence, the changes of distribution of mangrove forests in the northeastern part of Duyen Hai in 1965, 1995 and 2001 could represent the varying status of mangrove ... of low density, 3343 of moderate density and 1301 of high density of mangrove forest; (C) 2001 of all region with with 8666 of low density, 2347 of moderate density and 1784 of high density of ... stratification of mangrove, non-mangrove and other land-use areas 2.3.6 GIS database The contour of the dykes separating the area between marine and freshwater were digitized from the topographical maps and...
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Seasonal Changes of Shallow Aquatic Ecosystems in a Bird Sanctuary Pond
... Asplanchna and Mesocyclops were observed A high density of zooplankton was observed at the end of April and May, and the dominant genera were Keratella and Difflugia, respectively One of the submerged ... Total weight of each species and its ratio to the sum of TWW for 10 dominant species Average weights of each species were the average of minimum and maximum weight data (Wild Bird Society of Japan, ... observed first in May and covered the pond’s surface between July and August The biomass showed a peak in August Effects of Waterfowl on Water Quality and Successive Seasonal Changes of Shallow Aquatic...
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