... the enzyme responsible for the synthesis of palmitate, the precursor of FFAs The inhibition of signaling by trophic factors, removal of trophic factors or inhibition of fat synthesis result in ... HIF-1a is involved directly inthe accumulation of lipids triggered by QDs under the conditions of uncompromised cell survival inthe presence of serum On the basis ofthe results obtained in this ... signaling via the trk receptor in PC12 cells involves caveolin [51], and that caveolin associates with LDs [52] Therefore, NPs may induce the accumulation of lipids in PC12 cells by disturbing the...
... with the C-terminal domain deleted is consistent with this (Figs and 5) Hybrid proteins carrying the N-terminus of one protein and the Sm domain ofthe other localize according to the N-terminal ... for the latter, indicating that inthe absence of an N-terminal domain distinct localization is lacking Finally, the Lsm1p Sm domain by itself (LsmDN1DCp) accumulates in both the nucleus and the ... domains to its localizationThe N-terminus has the biggest effect on localization; the C-terminus plays a secondary role, determining the preferred localizationinthe absence ofthe N-terminus...
... early evening hours when the sun is setting The decline inthe energy value is due to a combination of increased part-loading of CCGTs, increased displacement ofthe small amount of incumbent ... screening curves without operational constraints were applied Though they not include uncertainty in wind generation inthe analysis, they find that the inclusion of operational constraints in investment ... binding inthe RT, thus limiting the options for maintaining a balance in RT The combined-cycle vintage (CCGT) modeled in this analysis, for instance, is assumed to not be able to start within...
... induced in HDC by histidine and histidine-analogs involve alterations inthe environment ofthe aromatic amino acid residues ofthe protein Fig Thermal denaturation ofthe free HDC holoenzyme and the ... Unfolding ofthe protein can be deduced from changesinthe spectra observed with increasing temperatures (Fig 9), as well as from thechanges observed inthe ellipticity at 222 nm (Fig 10) Nevertheless, ... resistance ofthe a-FMH-treated protein to thermal denaturation would indicate that the covalent binding ofthe adduct to the catalytic center could fix some secondary structure inthe enzyme, suggesting...
... Sonny.As the story nears completion, a single event brings the narrator out ofthe second phase and intohis third phase It is in this final pahse that the narrator obtains a true understanding of Sonny ... freedom.Finally, during the third phase, the narrator finally started caring about Sonny instead of try tocare for Sonny He no longer saw him as just something to be taken care of, he finally began ... brother He became sensitive to what offended Sonny and took caution to avoid them He was willing tobe interested in what Sonny interested in Finally, he was willing to sit and listen to Sonny instead...
... responses to changesin income The net effects ofchangesin nutrient availability caused by an increase in per capita income are listed inthe last column ofthe lower part of table According to the ... change inthe availability of 12 nutrients in response to a marginal increase inthe price of any one food group by 10-percent (holding the prices of other food groups constant) or to a 1-percent increase ... profiles, a change in beef price or consumer income will likely affect changesinthe foods purchased, thereby translating into the quantities of nutrients available in consumer diets Thus the...
... and inthe first half ofthe 1980s the health conditions of stands gradually worsened Inthe period after 1988 health improvement and decline ofthe stands alternated in individual years Inthe ... created inthe programme Microsoft Excel For further processing of data, various modules of Statistica 6.0 (StatSoft Inc.) were used The correlation was tested at the levels of significance of 0.05, ... average number of tips found in 83 20 main root sections (< mm in diameter) of 5 cm in length including their side branches The level of mycorrhizal infection was evaluated using two parameters:...
... compartmentalized expression ofthe isoflavonoid pathway leading to the synthesis of isoflavones inthe roots and cotyledons and an inducible isoflavonoid-phytoalexins synthesis inthe leaves of pathogen stressed ... transcripts of enzymes leading to the synthesis of flavonols, anthocyanidins and proanthocyanidins decreased in abundance inthe course ofthe resistance response, the increase in F3'H transcripts during ... downstream of F3H, thus giving preference to the isoflavone/phytoalexin branch ofthe pathway during the response to infection The critical nature of partitioning the naringenin substrate between F3H...
... Contributed inthe design ofthe study and revised the manuscript, GM Contributed inthe design ofthe study, in writing the manuscript and coordinated the study All authors read and approved the final ... Contributed inthe design ofthe study, in writing the manuscript, inthe design and development ofthe experimental set-up and the data processing algorithms, EZ contributed intheinthe experimental ... confirming that after four hours of infusion only mild interstitial edema was induced The average spectra of Zrs obtained from the control and the treated groups measured at the beginning and at the...
... Detecting the thickness of individual layers non-invasively is of interest as it may allow the practice of examining individual layers as opposed to total thickness, to be adopted as part of routine ... obtained from all pigs inthe study A typical image is shown in Figure The image shows that despite the excellent imaging capabilities ofthe machine used, differentiation between the edge ofthe ... tool was first calibrated using calibration marks present inthe image and then used to measure the total thickness from the inner surface ofthe skin to the underlying muscle (total adipose thickness)...
... gene inthe context ofthe low T3 syndrome A first mechanism for increasing the local concentration of T3 inthe hypothalamus is increased local conversion of T4 to T3 More than 80% of T3 inthe ... content inthe hypothalamus EF participated inthe design ofthe study and assisted with thein situ hybridizations TJV assisted with the cloning of all the rabbit genes GVdB conceived ofthe study, ... eluted with a linear gradient of acetonitrile (28 to 42% in 15 minutes) in 0.02 M ammonium acetate (pH 4.0) at a flow of 1.2 ml/min The radio-activity inthe eluate was measured on-line using a Radiomatic...
... opens up the possibility that Wnt signaling is involved in claudin-1 expression and localization 99 Indeed, a study shows that increasing β-catenin increases the expression of claudin-1 in colorectal ... expression of claudin-1 inthe cytoplasm, with some nuclear expression of claudin-1 B) Treatment of these cells with PKA inhibitor results in nuclear translocation of claudin-1 in as little as 15 minutes, ... CLDN1 under the control of a nuclear localization signal (CLDN1-NLS), there is increased expression of claudin-1 inthe nucleus, but there are still large amounts of claudin-1 inthe cytoplasm...
... through the cultivation and the ratio ofthe increased amount of SS to the increased amount of Chl.a was higher than that ofthe algae Increased amount of SS were higher inthe cases of high ... collected at the middle parts ofthe grove from points Sampling points St.1 and St.2 are inthe same stream, and sampling point St.3 is inthe other stream The two streams flow together to be one ... periphery ofthe Seto Inland Sea The location ofthe research area and the distribution ofthe citrus groves in Matsuyama region are shown in Fig Matsuyama is situated in Shikoku Island inthe southwestern...
... suppression of respiration during hypoxia Inthe absence of differential regulation of a specific nuclear gene coding for the subunits of CytOX, changesinthe microenvironment ofthe cell may induce ... the effects of hypoxia on the steady state levels of nuclear genome encoded CytOX IV and Vb mRNAs There was no change inthe levels of these mRNAs in macrophages at h of hypoxia, the time point ... assayed in membrane fragments (SMP) by the method of Smith [20], wherein the rate of oxidation of ferrocytochrome c was measured by following the decrease in absorbency of its a band at 550 nm The...
... have unfolded a series of events beginning with the TNFa-mediated prevention ofthe effect of insulin on Foxa2 localization and leading to the abrogation of insulin inhibition of gluconeogenesis ... pretreatment on insulin action on thelocalizationof Foxa2 and Foxo1 within the cell Incubation with 50 nm insulin resulted in relative nuclear exclusion of Foxa2, with significant localizationinthe cytosol ... in Foxa2 occupancy ofthe PEPCK promoter This decrease was significantly (P < 0.01) attenuated in cells preincubated inthe presence of TNFa prior to insulin incubation In cells incubated in the...
... building intheInternational Style, while to others it still holds onto characteristics of Streamline Moderne In can be considered to be intheInternational Style primarily because of its lack of ... the top, there were other avenues oftheInternational Style that were becoming very popular, and one of these was the furniture A principle ofthe Bauhaus was to cater to the development of contemporary ... massive 'grandfather chair' and is made possible by using steel and leather The best use ofthe specific character of material and form of each element is used in order to obtain both minimal weight...