changes in the immune system
Báo cáo sinh học: "Beyond toxicity: aryl hydrocarbon receptor-mediated functions in the immune system" docx
... promoting (though not in initiating) the differentiation of TH17 cells, and more importantly, in inducing them to secrete the cytokine interleukin (IL)-22 (a cytokine implicated in the defense of mucosal ... functional subsets, distinguished by the different cytokines they produce (indicated under each CD4 T cell type): the cytokines act on other immune cells, activating them in turn The four known subsets ... for their suppressive effect in this autoimmune model with a view to future application in treatment of the disease While the role of AhR in the induction of the cytokine IL-22 is now defined in...
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Báo cáo y học: "Gene regulation and signal transduction in the immune system" pptx
... catenin-like protein 1) as an AID-interacting protein Interestingly, he found that an AID mutant deficient in CTNNBL1 binding retains deamination activity but is impaired in class switching, ... division in cell-fate determination, and provided compelling evidence suggesting that the cell fate determinant Numb is critical in determining lineage commitment in the immune system Tannishtha Reya ... accessible chromatin, whereas Rag2 binding mirrored H3K4 trimethylation patterns, consistent with the results of Oettinger The role of the enzyme activation-induced cytidine deaminase (AID) in antibody...
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Báo cáo Y học: A new siglec family member, siglec-10, is expressed in cells of the immune system and has signaling properties similar to CD33 docx
... underlined, the transmembrane domain is in bold and amino acids in the ITIM motifs in the cytoplasmic domain are boxed The intron/exon boundaries as determined from accession no AC008750 are indicated ... affect binding of any of the adherent cell types Binding assays with siglec-expressing COS7 cells Results for COS7 binding experiments are shown in Fig 5C There was a significant increase in binding ... missing from the Y667F mutant indicating this to be the preferred tyrosine for interaction with SHP-1 SHP-2 binding, however, was only diminished by < 50% in the Y667F mutant, indicating that SHP-2...
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Báo cáo hóa học: " Changes in the criticality of Hopf bifurcations due to certain model reduction techniques in systems with multiple timescales" pdf
... perturbed systems and one can exploit the separation of time scales in the analysis of these (k + l)-dimensional models by splitting the system into the k-dimensional fast subsystem obtained in the singular ... that in some cases in which a Hopf bifurcation involves the fast variables, all the information needed to determine the criticality of the bifurcation is contained in the fast subsystem but in other ... bifurcation in the full system will persist in the singular limit as a Hopf bifurcation in the layer problem It might be tempting to proceed by determining the nature of the Hopf bifurcation in the layer...
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Báo cáo y học: "Regulating the immune system: the induction of regulatory T cells in the periphery Jane H Buckner1 and Steven F Ziegler2" pot
... transiently then die, whether they persist in the body as TR cells, or whether they return to their previous role as nonregulatory resting T cells remains unknown The balancing act required by the immune ... [56].Yet, in humans, it is impossible to prove whether the TR cells isolated from peripheral blood originate in the thymus, and are expanded in the periphery, or whether they have been generated in the ... (TGF-β) These cells can also be distinguished based on where they originate, in the thymus or in the periphery One prevailing model is that a class of regulatory T cells that originate in the thymus,...
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Báo cáo y học: "Changes in the mechanical properties of the respiratory system during the development of interstitial lung edema" ppt
... of the study, in writing the manuscript, in the design and development of the experimental set-up and the data processing algorithms, EZ contributed in the in the experimental activity performing ... Contributed in the design of the study and revised the manuscript, GM Contributed in the design of the study, in writing the manuscript and coordinated the study All authors read and approved the final ... and institute therapy long before the condition becomes lifethreatening Competing interests The authors declare that they have no competing interests Authors' contributions RLD Contributed in the...
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ROLE OF THE IMMUNE SYSTEM IN TUMOR PROGRESSION 1
... investigate the interactions between tumor cells and immune cells In Chapter 1, I investigate the tumor immune infiltrates in RETAAD mice I find that the immune infiltrates are all different in three ... of the cross-talk between cancer cells and the immune system must be analyzed in the context of the organ in which the tumor exists and the type of cells that the tumor recruits Melanoma In Singapore, ... Bcl-2 [21] These escaping tumor cells may also gain the ability to modulate the host immune system, increasing cancer-induced immunosuppression [19] For example, the secretion of indoleamine 2, dioxygenase...
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ROLE OF THE IMMUNE SYSTEM IN TUMOR PROGRESSION 2
... expression in the lungs of control vs PMNMDSC-depleted mice, k c is the fraction of proliferating cells in the lungs of control mice and k d is the fraction of proliferating cells in the lungs ... is the fraction of proliferating cells in the tumor of control mice and k d is the fraction of proliferating cells in the tumor of PMN-MDSC-depleted mice For tumors with ellipsoid shape, the ... time points, the population of melanoma cells in the lung can be described by the following equation (1): (1) 𝑁𝑁 = 𝑁𝑁0 𝑒𝑒 ( 𝜏𝜏 ) 𝑘𝑘𝑘𝑘 Where N is the number of melanoma cells at the end of the experiment,...
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Characteristics of Leachate from Citrus Groves and their Changes in the Collecting Reservoirs in Matsuyama, Japan
... collected at the middle parts of the grove from points Sampling points St.1 and St.2 are in the same stream, and sampling point St.3 is in the other stream The two streams flow together to be one ... the sampling point St.4 is situated in the joined stream, which is the only stream that flows into the reservoir The reservoir water was also sampled from point Po in the reservoir close to the ... streams flow together from 47 m above sea level The water in the stream is the leachate from the grove and it flows into a collecting reservoir at the foot of the hill The surface area of the reservoir...
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Tài liệu Báo cáo khoa học: Adaptive changes in the expression of nuclear and mitochondrial encoded subunits of cytochrome c oxidase and the catalytic activity during hypoxia pptx
... during hypoxia In the absence of differential regulation of a specific nuclear gene coding for the subunits of CytOX, changes in the microenvironment of the cell may induce alterations in the ... significant increase in TN However, both the CytOX activity and heme content were reduced by about 50% in macrophages exposed to hypoxia, thus indicating a major change in the CytOX content in these ... H and L The L isolog is ubiquitously expressed in all the tissues whereas the H isolog is detected in the heart and skeletal muscle tissues [3] The Northern blot in Fig 1E shows that in both...
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Báo cáo khoa học: Nanoparticles can induce changes in the intracellular metabolism of lipids without compromising cellular viability docx
... signaling via the trk receptor in PC12 cells involves caveolin [51], and that caveolin associates with LDs [52] Therefore, NPs may induce the accumulation of lipids in PC12 cells by disturbing the ... stopper into each flask with a syringe, and the flasks were then shaken gently for 24 h at room temperature The filters were then removed and placed into scintillation vials containing scintillation ... HIF-1a is involved directly in the accumulation of lipids triggered by QDs under the conditions of uncompromised cell survival in the presence of serum On the basis of the results obtained in this...
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Changes in the Economic Value of Variable Generation at High Penetration Levels: A Pilot Case Study of California pot
... binding in the RT, thus limiting the options for maintaining a balance in RT The combined-cycle vintage (CCGT) modeled in this analysis, for instance, is assumed to not be able to start within ... screening curves without operational constraints were applied Though they not include uncertainty in wind generation in the analysis, they find that the inclusion of operational constraints in investment ... periods rather than always part-loading the resource The tradeoff is the increase in start-up costs to bring the generation offline and then back online at a later point 45 The heat rate curves and the...
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Báo cáo khoa học: Local changes in the catalytic site of mammalian histidine decarboxylase can affect its global conformation and stability pptx
... protect the enzyme against thermal denaturation The increased resistance of the a-FMH-treated protein to thermal denaturation would indicate that the covalent binding of the adduct to the catalytic ... structure in the enzyme, suggesting several interaction points for the adduct within the catalytic center in addition to those established by the internal aldimine alone From the shape of the a-FMH-treated ... induced in HDC by histidine and histidine-analogs involve alterations in the environment of the aromatic amino acid residues of the protein Fig Thermal denaturation of the free HDC holoenzyme and the...
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Paradoxical roles of the immune system during cancer development docx
... are continually fine-tuned as tissue microenvironments are altered Therefore, the immune system is integrally involved in maintaining tissue homeostasis as well as being implicated in the pathogenesis ... characterized by chronic infiltration of innate immune cells in the stromal tissue25,26 (FIG 2) Interestingly, the profile of infiltrating inflammatory cells in skin is distinct from that in cervix — pre-malignant ... However, in these studies deletion of the inhibitor of NFκB kinase (IKKβ) — a key intermediary of NFκB — in intestinal epithelial cells did not decrease intestinal inflammation, as measured by inflammatory...
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Báo cáo khoa học: Large conformational changes in the Escherichia coli tryptophan synthase b2 subunit upon pyridoxal 5¢-phosphate binding pot
... [40], indicating the importance of His86 in PLP binding The conformational changes in His86 upon PLP binding may correlate directly with interactions between the N and C domains, leading to the ... while the green squares in the fourth line indicate the hinge region in Ecb The hinge regions, including hinges (residues 48–56), (82–87) and (206–207), were defined using DYNDOM software The asterisks ... triggered by the local conformational changes induced by PLP binding to the active site PLP binding to the apo-Ecb induced the following major conformational changes (a) PLP bound to the N terminus of...
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Environmental Injustice and Human Rights Abuse: The States, MNCs, and Repression of Minority Groups in the World System pptx
... are: the murder of Wilson Pinheiro and Francisco “Chico” Mendes in the Amazon rain forest, the massacre of Father Nery Lito Satur and several others in the Philippines, and the public hanging ... been the rule rather than exception The “core” is generally described as a region of a world system (including the most powerful advanced industrialized nations) that dominates the system and the ... involved the skillful, strategic pursuit of political dominance by the numerical majority following the independence in the 1960s As explained by Naanen (1995, 49), the political power gained by the...
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Báo cáo khoa học: Thermal behaviour of cubic phases rich in 1-monooleoyl-rac-glycerol in the ternary system docx
... another way, with increasing temperature the bilayer gets thinner, with the minimal and the parallel surfaces of the polar/nonpolar interface approaching each other, again resulting in an increased ... results in a decrease in the size of the unit cell This is interpreted to be an effect of an increase in the curvature of the lipid bilayer affected by the increased mobility of the hydrocarbon chains ... present in the MO bilayer, the shorter tail will only affect the part of the MO molecule from the head group to the double bond, leaving the rest of the MO hydrocarbon chain free, while introducing...
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the changes in the narratots view of sonny
... Sonny.As the story nears completion, a single event brings the narrator out of the second phase and intohis third phase It is in this final pahse that the narrator obtains a true understanding of ... brother He became sensitive to what offended Sonny and took caution to avoid them He was willing tobe interested in what Sonny interested in Finally, he was willing to sit and listen to Sonny instead ... freedom.Finally, during the third phase, the narrator finally started caring about Sonny instead of try tocare for Sonny He no longer saw him as just something to be taken care of, he finally began...
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