cell biology of prostate cancer and molecular targets

... administration of corticosteroids [44,45] Since then, the wealth of information that has emerged on SARS-CoV molecular and cellular biology, as updated in the preceding sections of this review, now offers ... Progress in cell biology of SARS-CoV: Signaling pathways Successful viral replication depends upon the ability of the virus to subvert cellular processes to their advantage and counteract cellular ... infected Vero E6 cells and expression of this protein alone was shown to induce apoptosis in cell culture [35,36] This raises the question of how apoptosis of SARS-CoV infected cells is balanced...

Ngày tải lên: 19/06/2014, 08:20

... administration of corticosteroids [44,45] Since then, the wealth of information that has emerged on SARS-CoV molecular and cellular biology, as updated in the preceding sections of this review, now offers ... Progress in cell biology of SARS-CoV: Signaling pathways Successful viral replication depends upon the ability of the virus to subvert cellular processes to their advantage and counteract cellular ... infected Vero E6 cells and expression of this protein alone was shown to induce apoptosis in cell culture [35,36] This raises the question of how apoptosis of SARS-CoV infected cells is balanced...

Ngày tải lên: 20/06/2014, 04:20

... microdomains and clusters at the cell surface of primary cells This was shown to favor the release of viral capsids into target cells rather than endocytosis of virions Similar to receptor-ligand interactions, ... deeper understanding of some of the first virushost interactions required for entry of this retrovirus The transmission of HIV-1 from dendritic cells to CD4+ T cells represents one of the crucial ... aspects of the cell biology and biochemistry of HIV-1 budding He first described some of the cellular apparatus that associates with Tsg101 In addition to the ESCRT-1 components Vps28 and Vps37,...

Ngày tải lên: 13/08/2014, 09:20

... Rossmann-fold topology and a substrate-binding domain Evolution has ‘modeled’ the structure of these AOD enzymes to fit different amine substrates and cellular landscapes LSD1 was the subject of a dali search ... [55] The volumes of the cavities are ˚ 601, 313, 637 and 1736 A3 for PAO, MAO N, MAO B and LSD1, respectively (B) Overview of the active site surrounding the flavin cofactor in each of the four structures ... peptide (residues 1–16 of the N-terminal tail) is in magenta (the two ends of the peptide, residues and 16, are labeled accordingly) The FAD cofactor is in yellow ball -and- stick representation...

Ngày tải lên: 16/03/2014, 02:20

... http://www.ro-journal.com/content/5/1/108 Page of 12 Figure Anti-neoplastic effects of ErPC3 and ionizing radiation on prostate cancer cells The prostate cancer cell lines PC3, DU145, and LNCaP, were irradiated ... efficacy of ionizing radiation and ErPC3 in prostate cancer cell lines In a first step, the anti-neoplastic effects of ErPC3 and ionizing radiation alone were analyzed in three different prostate cell ... (Deisenhofen, Germany) if not otherwise specified Cell lines and cell culture The prostate cancer cell lines LNCaP (p53 wild type, androgen-dependent, highly differentiated), PC3 (p53-/-, androgen-independent,...

Ngày tải lên: 09/08/2014, 09:20

... and CRC as described above Molecular alterations occurring at the key transition from hyperplasia to dysplasia include loss of expression of MLH1 in group CRC and loss of expression of MGMT and ... immunohistochemistry for MLH1] The glands to the left are normal and show nuclear expression of both MGMT and MLH1 The gland with features of serrated adenoma and the poorly differentiated adenocarcinoma ... families, about half of 117 which met the Amsterdam criteria, a high proportion of both polyps and CRC showed mutation of BRAF and ⁄ or methylation of the CIMP marker MINT31 Many of the polyps were...

Ngày tải lên: 22/03/2014, 17:20

... multiple cellular processes including endothelial cell proliferation, migration, reorganization of ECM and tube formation The advent of molecular studies allowed a new evaluation of the biology of ... of communication to other cell cell junctions and to cellsubstratum junctions Cadherin cluster forms a transmembrane core of adherens junctions at sites of the cell cell contacts During tumor ... Evolution of the Molecular Biology of Brain Tumors and the Therapeutic Implications nectin is almost absent but it is effective in the microenvironment of glioma cells, which coexpress large amounts of...

Ngày tải lên: 23/03/2014, 10:20

... involvement of avb3 integrin in TPD52 mediated migration of LNCaP cells towards vitronectin Similar to breast cancer cells, prostate cancer cells metastasize to the bone, which consists of extracellular ... overexpression of TPD52 and (B) cell proliferation after downregulation of TPD52 Viability of cells was measured in a colorimetric MTT assay by the detection of formazan formation The proliferation of control ... leading cancer death, next to lung and colorectal cancer In the present study, we demonstrate the physiological consequences of TPD52 expression in the androgen responsive prostate cancer cell line...

Ngày tải lên: 30/03/2014, 02:20

Ngày tải lên: 01/04/2014, 13:20

... therapy and only two previous cases has been reported in literature till date It’s probable that the association of granulosa cell tumor and the use of tamoxifen for breast cancer is just a random ... within granulosa cell tumor of the ovary: morphologic, immunohistologic, and molecular analyses of the two different tumor cell populations Hum Pathol 2002, 33(4):445-8 Early Breast Cancer Trialists’ ... were showed in the studies of tamoxifen oncogenicity an elevated of the incidence of granulosa cell tumors at 36% in two groups of female mice receiving or 50 mg/kg of tamoxifen [23] In their...

Ngày tải lên: 09/08/2014, 03:22

... Kutik S, Rainville C: Coexistence of pernicious anemia and prostate cancer: ‘an experiment of nature’ involving vitamin B12 modulation of prostate cancer growth and metabolism: a case report J ... MF: Multivitamin use and risk of prostate cancer in the National Institutes of Health-AARP Diet and Health Study J Natl Cancer Inst 2007, 99:754-764 Tisman and Garcia Journal of Medical Case Reports ... detection and staging of prostate cancer Clin Cancer Res 2005, 11:6582-6588 21 Hultdin J, Van Guelpen B, Bergh A, Hallmans G, Stattin P: Plasma folate, vitamin B12, and homocysteine and prostate cancer...

Ngày tải lên: 10/08/2014, 23:20

... (IA, B, and C) and µg (IIA, B, and C) or coincubated with µg (IIIA, B, and C) of RNA from LNCaP cells The electroporation conditions were 300 (IA and IIA), 400 (IB and IIB), or 500 V (IC and IIC) ... flow cytometry, and data from 10,000 events in mononuclear cell gates were collected and analyzed by Cell Quest Pro software Results are expressed as the percentage of positive cells Immune responses ... depend on a variety of cellular processes, including transport of the MHC complex to the antigen presenting cell surface and its recognition by T -cell receptors as non-self The core of these activities,...

Ngày tải lên: 14/08/2014, 19:22

... of hypoxia (1% O2, 24h) and over-expression of hChK on cell population doubling time of prostate cancer cells 83 xv Figure 28 Effect of over-expression of hChK on cell morphology of ... [14C]acetate and [18F]FDG in prostate cancer cells 31 Figure 12 Uptake of radiolabeled choline in PC-3 prostate cancer cells 41 Figure 13 Uptake of radiolabeled choline in LNCaP prostate cancer ... expression of ChK in prostate cancer cells 61 4.2 Over-expression of HIF1 decreases uptake and phosphorylation of choline in prostate cancer cells 62 4.3 HIF1 binding sites and...

Ngày tải lên: 24/08/2014, 10:38

... Expression of multiple cftr/Cftr isoforms in the gills of P annectens in freshwater…………………………………… 4.2.11 154 Cftr isoforms and polymorphism in lungs and gills of P annectens—a clue to the huge genome of ... variant or isoform…… 207 xii Lists of Figures Fig The cDNA nucleotide sequence and the translated amino acid sequence of the coding region of the predominant form (isoform 1) of cftr and Cftr, respectively, ... sequence of the predominant form (isoform 1) of Cftr from the lung of Protopterus annectens and those of other animal species obtained from Genbank Sequences are arranged in descending order of similarities...

Ngày tải lên: 09/09/2015, 17:55

... RT-PCR and cloning for gs partial fragments…………… 4.1.2 RACE PCR and cloning of RACE products……………… 4.1.3 Analyses of gs and the deduced Gs isoforms…………… 4.1.4 The phylogenetic analysis of Gs isoforms………………… ... of gs1, gs2 and gs3 in M albus……………… 4.2.3 Phylogeny and conservation of Gs isoforms in M albus… 4.2.4 The Gs isoforms, Gs1, Gs2 and Gs3 are cytosolic enzymes 4.2.5 Differential expressions of ... sequence and the corresponding deduced amino acid sequence of the complete CDS of glutamine synthetase (A) isoform (gs1) from the intestine, (B) isoform (gs2) and (C) isoform (gs3) from the liver of...

Ngày tải lên: 13/10/2015, 15:54

... Biomarkers of Early Cancer and Cancer Risk Hepatocellular Carcinoma/Primary Liver Cancer Primary hepatocellular carcinoma (HCC) is fifth in cancer incidence worldwide and the third leading cause of cancer ... gastrointestinal and other associated cancers, lung and upper aerodigestive cancers and prostate and urologic cancers, each have biomarkers in prevalidation and validation phases in which the accuracy of experimental ... types of esophageal cancer are squamous cell carcinoma (cancer that begins in flat cells lining the esophagus) and adenocarcinoma (cancer that begins in cells that make and release mucus and other...

Ngày tải lên: 14/02/2014, 21:20

... Division of Cancer 14   Article | JNCI Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA (JHL, RGZ, SW); Formerly of Division of Cancer Epidemiology and Genetics, National Cancer ... in study and data management; and Rebecca Stanevich and Daniel Yereb formerly of the National Institute for Occupational Safety and Health and Mustafa Dosemeci, formerly of the National Cancer ... National Institutes of Health, National Cancer Institute, Division of Cancer 740 Epidemiology and Genetics and the National Institute for Occupational Safety and Health, Division of Respiratory Disease...

Ngày tải lên: 22/03/2014, 17:20

... T lymphocytes (cellular immunity), macrophages (phagocytic and one of several types of antigen-presenting cells), and mast cells Immunity and T and B cells There are two types of immunity: • ... proximal and distal tubule cells of the kidney and striated duct cells of the salivary glands Those cells are involved in extensive ion transport CONNECTIVE TISSUE Connective tissue consists of cells ... (tract and associated glands), endocrine, urinary, and male and female reproductive systems, as well as the eye and the ear The topics in tissue and organ histology and cell biology include light and...

Ngày tải lên: 22/03/2014, 21:20

... serum PSA and a lower likelihood of standard treatment In addition, substantially decreased growth of LNCaP prostate cancer cells was seen when such cells were incubated in the presence of serum ... polyphenols, lignans and other substances, are protective of normal cells The significant correlation between degree of changes in diet and lifestyle and degree of change in PSA and LNCaP cell growth ... care and promote an attitude of optimism and hope Paul H Lange Department of Urology University of Washington Seattle, Washington REPLY BY AUTHORS Changes in diet and lifestyle are of profound...

Ngày tải lên: 29/03/2014, 01:20

... of detecting prostate cancer, and it can signal the presence of cancer in individuals who display no symptoms of prostate abnormalities This test measures the level of a glycoprotein called prostate- speciÞc ... field of molecular and physical gastronomy since 1989 Kurti, emeritus professor of physics at the University of Oxford and a former vice president of the Royal Society, was born in 1908 and educated ... Dilemmas of Prostate Cancer Do the risks of aggressive treatment for early prostate cancer outweigh the benefits? This question is one of several unresolved issues faced by those who treat, and those...

Ngày tải lên: 12/05/2014, 14:54