... Myelodysplasia, and Related BoneMarrowFailure Syndromes (Part 1) Harrison's Internal Medicine > Chapter 102. Aplastic Anemia, Myelodysplasia, and Related BoneMarrowFailure Syndromes Aplastic ... leukemia (AML) Some acute lymphoid leukemia Some lymphomas of bonemarrow Pancytopenia with Cellular BoneMarrow Primary bonemarrow diseases Myelodysplasia Paroxysmal nocturnal Secondary ... leukopenias). Hematopoietic failure syndromes are classified by dominant morphologic features of the bonemarrow (Table 102-1). While practical distinction among these syndromes usually is clear,...
... Aplastic Anemia, Myelodysplasia, and Related BoneMarrowFailure Syndromes (Part 2) Aplastic Anemia Definition Aplastic anemia is pancytopenia with bonemarrow hypocellularity. Acquired aplastic ... bonemarrow hypocellularity. Acquired aplastic anemia is distinguished from iatrogenic marrow aplasia, marrow hypocellularity after intensive cytotoxic chemotherapy for cancer. Aplastic anemia ... typical physical anomalies and the development of pancytopenia early in life, can also present as marrowfailure in normal-appearing adults. Acquired aplastic anemia is often stereotypical in its...
... Chapter 102. Aplastic Anemia, Myelodysplasia, and Related BoneMarrowFailure Syndromes (Part 3) Radiation Marrow aplasia is a major acute sequela of radiation. Radiation damages ... a notorious cause of bonemarrow failure. Vast quantities of epidemiologic, clinical, and laboratory data link benzene to aplastic anemia, acute leukemia, and blood and marrow abnormalities. ... environment. The association between marrowfailure and other chemicals is much less well substantiated. Drugs (Table 102-3) Many chemotherapeutic drugs have marrow suppression as a major toxicity;...
... products cooperate in a repair complex to maintain telomere length. In Shwachman-Diamond syndrome, marrow failure is seen with pancreatic insufficiency and malabsorption; most patients have compound ... thrombotic episodes occur in patients with large PNH clones (>50%). Functional studies of bonemarrow from PNH patients, even those with mainly hemolytic manifestations, show evidence of ... for the aplastic anemia/PNH syndrome is selection of the deficient clones because they are favored for proliferation in the peculiar environment of immune-mediated marrow destruction. Constitutional...
... Related BoneMarrowFailure Syndromes (Part 5) Pathophysiology Bone marrowfailure results from severe damage to the hematopoietic cell compartment. In aplastic anemia, replacement of the bone ... responsible for benzene-induced tissue injury. Excessive generation of toxic intermediates or failure to detoxify the intermediates may be genetically determined and apparent only on specific ... severe damage to the hematopoietic cell compartment. In aplastic anemia, replacement of the bonemarrow by fat is apparent in the morphology of the biopsy specimen (Fig. 102-1) and MRI of the...
... http://www.medsci.org 75 searchers have transplanted the bonemarrow stem cells into the necrotic femoral heads, and results show bone marrow stem cells can remove vascular lesions and promote ... GFP labeled MSCs were noted in the lungs, liver, bone marrow and normal and necrotic femoral heads of rabbits, and the number of MSCs in bone marrow was higher than that in the, femoral head, ... with autologous bonemarrow grafting. Indian J Orthop. 2009 Jan;43(1):40-45 35. Sun Y, Feng Y, Zhang C. The effect of bonemarrow mononu-clear cells on vascularization and bone regeneration in...
... All rights reserved Research paper Polysaccharides from the root of Angelica sinensis protect bonemarrow and gastrointestinal tissues against the cytotoxicity of cyclophosphamide in mice Marco ... hemopoietic stem cells. It is not known whether AP has an effect on CY-induced cytotoxicity on bone marrow and gastrointestinal tract. In this study, we assessed the protective actions of AP on ... cancer therapeutic regimen. In the present study, we investigated whether AP could protect the bonemarrow and the gastrointestinal tissues from the cytotoxicity of CY in mice. We also profiled...
... graft-versus-host disease after bone marrow transplantation. Thorax 39:887, 1984 IO. Graham J, Muller NL, Miller RR, Shepherd JD: Intrathoracic complications following allogeneic bonemarrow transplantation. ... following pediat- ric bonemarrow transplantation. Society for Pediatric Radiology, Colorado Springs, CO April 29, 1994 15. Thomas ED, Storb R, Clift RA: Bonemarrow transplantation. ... air-flow obstruction in marrow transplant recipients. Am Rev Respir Dis 129541,1984 4. Holland HK, Wingard JR, Beschorner WE, Sara1 R, Santo GW: Bronchiolitis obliterans in bonemarrow transplantation...
... bonemarrow (Table 2). On/off-phenomena ofthe identified spots were observed in four cases: Spot No.19 (annexin 6) was found in patient A in the sample ofperipheral blood but not in bone marrow, ... bonemarrow aspirates using a proteomicapproach with 2D-electrophoresis in newly diagnosedpatients with AML.Materials and methodsSample preparation and solubilizationBlast samples from bone ... the two-dimensional patterns of patient A. Different expression of spot 19 (annexin 6) in the bonemarrow sample in comparison to peripheral blood.#02-05p #02-02bAnnexin 67676777712912967...