biological basis of genetics
Tài liệu Báo cáo khoa học: Molecular basis of glyphosate resistance – different approaches through protein engineering doc
... molecular mode of action of glypho-sate and the molecular basis for glyphosate resistance.Structure and function of EPSPSEPSPS catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate ... 4% of thetotal soluble protein content of the cell [48].Fig. 3. Microbial mechanisms of glyphosatedegradation. (A) Two principal pathways of glyphosate degradation are known.Top: cleavage of ... however, was devoid of substrate or inhibitor,and consequently did not reveal the nature of theactive site or the mode of action of glyphosate. A dec-ade later, the crystal structure of EPSPS was...
- 14
- 794
- 0
Tài liệu Báo cáo khoa học: EGF receptor in relation to tumor development: molecular basis of responsiveness of cancer cells to EGFR-targeting tyrosine kinase inhibitors docx
... phos-phorylation state of their proteins, thereby changingthe amount and localization of Bcl-2 family members.However, each type of cancer has its own way of disrupting the balance of the networks of signalingcascades ... with stimulation of ERK1 ⁄ 2 andPak1 pathways, gefitinib might lead to inhibition of invasiveness of human cancer cells through the inhibi-tion of ERK1 ⁄ 2 and Pak1. The use of gefitinib in cellswith ... inhibi-tion of Akt- and ERK1 ⁄ 2-dependent pathways eventu-ally change the expression level of one or more of these Bcl-2 family members.BadBad is one of the ‘death-promoting’ members of theBcl-2...
- 11
- 611
- 0
Tài liệu Báo cáo khoa học: Basis of recognition between the NarJ chaperone and the N-terminus of the NarG subunit from Escherichia coli nitrate reductase pdf
... centre of geometry of the NarG(1–15) peptide. Onlythe best structures of each of the 10 best clusters are depicted(HADDOCK score). Surface residues of NarJT in brown form thebottom of the ... thecomplex by 10-fold, as judged by koff. The physiologicalchaperone cycle probably consists of the rapid binding of the N-terminus of the partner, regardless of whetherit is a twin-arginine signal ... completion of thematuration process of the partner. The nature of thesignal that may trigger dissociation of the complexremains unclear; however, we propose that a localperturbation of the hydrogen...
- 10
- 685
- 0
Tài liệu Báo cáo khoa học: Neuronal growth-inhibitory factor (metallothionein-3): evaluation of the biological function of growth-inhibitory factor in the injured and neurodegenerative brain pdf
... regulating synaptic levels of zinc, asthe GIF-deficient mice had a reduced content of Zn(II)within a number of brain regions [28].ROS scavenging ability of GIFThe coordination of redox-active metal ... secretion of the MT1 and MT2 isoformsby cultured astrocytes has also recently been reported.The secretion of MT1 and MT2 by astrocytes appearsto be regulated because the basal levels of proteinsecretion ... binding of Zn, leading to the for-mation of SDS-soluble monomeric zinc-bound Ab andsoluble copper-bound GIF [38]. Therefore, the metalswap led to simultaneous modification of the finalform of Ab(1–40)...
- 9
- 664
- 0
Tài liệu Báo cáo khoa học: Branched N-glycans regulate the biological functions of integrins and cadherins doc
... speculate that modifi-cation of particular sites, which are involved in regula-tion of the conformation of integrin, determine theextent of cell migration.The mutual regulation of GnT-III and E-cadherinTo ... of glycosyltransferase regulation to the function of the adhesion molecules integrin and E-cadherin. Biological significance of GnT-III, GnT-Vand Fut8GnT-IIIGnT-III catalyzes the addition of ... described above, modulation of adhesion moleculeglycosylation might significantly alter the biological function of adhesion molecules. Because of the impor-tant roles of glycosylation, functional...
- 10
- 477
- 0
Tài liệu Báo cáo khoa học: Design, structure and biological activity of b-turn peptides of CD2 protein for inhibition of T-cell adhesion ppt
... region of 500 MHz ROESY spectrum of cVY cyclic peptide in 90% H2O/10% D2O.Fig. S3. Amide region of 500 MHz ROESY spectrum of cEL cyclic peptide in 90% H2O/10% D2O.Fig. S4. Amide region of ... monomer of hCD58 wasunmerged from the complex of hCD2–hCD58) [30].2876 L. Jining et al. (Eur. J. Biochem. 271) Ó FEBS 2004 Design, structure and biological activity of b-turn peptides of CD2 ... region,supporting the conformational dependence of the peptideinhibition. Two different methods of inhibition of celladhesion were used to evaluate the biological activities of peptides. Both the assays indicated...
- 14
- 657
- 0
Tài liệu Báo cáo khoa học: The structure and biological characteristics of the Spirochaeta aurantia outer membrane glycolipid LGLB pdf
... Amide linkage between C-6 of residue E and an amino group of the aspartic acid wasidentified on t he basis of the HMBC correlation b etweenH-2 of aspartic acid and C-6 of the GalA E, thu s showingthat ... shifts of H-1, C-1 andC-5 signals. The position of C-6 signals of uronic acids wasfound from HMBC correlations to H-5 protons. Connec-tions between monosaccharides were identified on the basis of ... the loss of Q from I-D-N-Q (m/z 648.20) o r from theloss of F f rom F -I-D-N (m/z 732 .18). However, many o thercombinations of fragments are also possible, because of theexistence of branches...
- 11
- 632
- 0
Tài liệu Báo cáo khoa học: Physicochemical characterization and biological activity of a glycoglycerolipid from Mycoplasma fermentans ppt
... based on the property of lysates of amebocytes of the horseshoe crab Limulus polyphemus,toform a solid gel in the presence of minute amounts of endotoxins. The comparison of LPS and MfGl-II in ... determination of the supramole-cular aggregate structure confirms the existence of a mixedunilamellar/cubic structure for MfGl-II, similar to thatobserved for the lipid A moiety of LPS. The biological ... likelyin the light of the high negative charge density of theheadgroup of the latter, leading to different migration in theHPLC purification process. Additionally, the absence of alipoprotein...
- 9
- 665
- 1
Tài liệu Báo cáo khoa học: Moult cycle-related changes in biological activity of moult-inhibiting hormone (MIH) and crustacean hyperglycaemic hormone (CHH) in the crab, Carcinus maenas From target to transcript ppt
... products of the YO, ecdysoneand 25-deoxyecysone. Inhibition of 3-dehydroecdysonesynthesis was not measured, but this is a minor secretoryproduct of Carcinus YO [11]. Loss of sensitivity of YO ... inhibition of MIHtranscription by ecdysteroids during the time of maximaltitre (D2) is not likely. However, on the basis that premoulteyestalk neural tissues express high levels of ecdysteroidreceptor ... quantities of CHH were quitevariable at different stages, ratios of CHH/MIH werecalculated for pairs of sinus glands. This analysis showedthat the only consistent trend was that of moderate,statistically...
- 9
- 587
- 0
Tài liệu The Basis of Early Christian Theism ppt
... not of certainty, but of mere opinion.And this estimate of the function of philosophy with respect to theological truth, which the Fathers workedout on the basis of the concrete example of the ... the truth, but each only from one point of view, and on the basis of only onemethod of approach. The conclusions of each were the result of a process of more or less completeabstraction, and ... scholar of the Church University Board of Regents from July, 1895, to thepresent time.End of the Project Gutenberg EBook of The Basis of Early Christian Theism, by Lawrence Thomas Cole*** END OF...
- 32
- 339
- 0
Molecular Basis of Pulmonary Disease Insights from Rare Lung Disorders pdf
... theoccurrence of an outcome of interest. This might be a study of time until disease pro-gression or overall survival. In these types of study designs, it is the person-years of follow-up that ... PanosWhen you hear hoofbeats behind you, don’t expect to see a zebra.Theodore E. Woodward, MD, University of Maryland, Circa 1950 (1)Abstract The National Institutes of Health Of ce of Rare Diseases ... there are many different types of study designs; some of which require onlya fraction of the number of subjects required to the randomized controlled trial, whichis often considered the gold standard.Alternate...
- 443
- 248
- 0
GENOMIC DISORDERS The Genomic Basis of Disease doc
... typical integrationis then finished off by the formation of a second-strand nick and integration of the end of thecDNA (Fig. 2A). However, significant portions of the events appear to complete ... genomicrearrangements.Most of the Alu–Alu recombination events are between nearby elements, generally spanningdistances of less than 50 kb and often only a few kb in length. There are also a number of cases of chromosomal ... required further explanation of the need for theirsamples. I often thought of the irony of the situation. At these reunion parties, Dr. Garcia wouldoversee the administration of the electrical shocks...
- 446
- 291
- 0
Báo cáo khoa học: Biological role of bacterial inclusion bodies: a model for amyloid aggregation potx
... dis-covery of the reversibility of IB formation [6], the gen-eral acceptance of IBs being formed by functionalproteins [7] and the recognition of the amyloid-likearchitecture of IB proteins ... [21,70] or the control of polypeptide solubility in biological environments bythe thermodynamic [71] and kinetic stability of pro-teins [72]. In addition, the possibility of labellingaggregation-prone ... reduction of protein yieldeventually observed during co-production of this chap-erone and others [10], as a side effect of this strategy[29] addressed to improve the solubility of recombinantproteins....
- 9
- 432
- 0
Báo cáo khoa học: Protein–protein interactions and selection: generation of molecule-binding proteins on the basis of tertiary structural information potx
... different species [23–25]. The success of the series of studies shows that the stable framework structure of Fv enables the transfer of function by means of CDRreplacement.Barbas et al. first ... theCDR loop of the single variable heavy chain of aheavy-chain camel antibody (VHH) (Fig. 1B) by com-paring topologies between VHH and NCS (Fig. 2A);grafting of the CDR 3 loop of antilysozyme ... sequence of charyb-dotoxin with one of toxin a to express a new bindingfunction. Comparison of the X-ray crystal structuresbetween charybdotoxin and toxin a showed the struc-tural resemblance of...
- 9
- 505
- 0
Báo cáo khoa học: Role of different moieties from the lipooligosaccharide molecule in biological activities of the Moraxella catarrhalis outer membrane pot
... andconsisted of a linker (Glc-Kdo2)-lipid A structure. Thephenotype of this mutant was examined to investigatethe roles of different moieties of the LOS molecule in biological activities of the ... sites.The sites of primers used are indicated as small arrows (25, 26,and 40 of Table 1).ABFig. 3. LOS patterns of SDS ⁄ PAGE followed by silver staining (A)or western blotting (B) of M. catarrhalis ... ionswith m ⁄ z of 917.4 and 877.4 (unmarked) are mono-sodiated and anhydro forms of 895.4 ion, respectively.The ion with m ⁄ z of 797.4 was from the anhydro frag-ment ion of de-O-acylated...
- 10
- 406
- 0
Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các mục tiêu của chương trình khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản khảo sát chương trình đào tạo gắn với các giáo trình cụ thể xác định thời lượng học về mặt lí thuyết và thực tế tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu nội dung cụ thể cho từng kĩ năng ở từng cấp độ xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct mở máy động cơ lồng sóc mở máy động cơ rôto dây quấn hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 động cơ điện không đồng bộ một pha thông tin liên lạc và các dịch vụ từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008 chỉ tiêu chất lượng 9 tr 25