areas of research that utilizes the sod2 mutant mouse 26
Expression dynamics of the hepatic mitochondrial proteome of the sod2+ mouse in response to troglitazone administration
... oncology However, the discussion here will be limited to the use of the HET mouse in drug toxicity assessment 25 Figure Areas of research that utilizes the Sod2 mutant mouse Both the heterozygous ... technical limitations, then the exogenous, synthetic mimetics of SOD2 enzyme can be used to overcome such problems The deleterious phenotypes of the Sod2 null mouse can be rescued and their life spans ... Physiologically relevant ROS/RNS 23 Figure Areas of research that utilizes the Sod2 mutant mouse 26 Figure Change in investment of successful new drug launch over time 28 Figure Increase...
- 226
- 1,830
- 0
Tài liệu Báo cáo khoa học: Role of Kupffer cells in pathogenesis of sepsis-induced drug metabolizing dysfunction pptx
... sepsis, triggering the production of proinflammatory cytokines and liver injury [13] Therefore, the present study aimed to elucidate the role of KCs in the regulation of CYP isoform activities and ... decreased the hepatic mRNA level of CD163 compared to that of sham group Twenty-four hours after cecal ligation and puncture (CLP), the hepatic mRNA level of CD163 was similar with that of the sham ... reduced the activity of selected isoforms of CYP by inducing phosphorylation of the isoforms [23] Activated KCs cause oxidative stress on the surrounding tissue, releasing large amounts of ROS...
- 11
- 769
- 0
Báo cáo khoa học: Change in structure of the N-terminal region of transthyretin produces change in affinity of transthyretin to T4 and T3 pdf
... testing the hypothesis that the N-terminal regions of TTR affect the affinities of TTR for thyroid hormones A previous study revealed that altering the structure of the N-terminal region influenced the ... region of crocTTR was deleted The affinity of T3 and T4 to both TTRs was studied and the results are a powerful demonstration of the relationship between the evolution of the primary structure of the ... the N-terminal region exert a greater influence on the affinity of T4 than on the affinity of T3 This could imply that the core of TTR has a major influence in determining the affinity of T3 and the...
- 11
- 457
- 0
báo cáo hóa học:" Using individual growth model to analyze the change in quality of life from adolescence to adulthood" potx
... asks SAS to use the "Between/Within" method for computing the denominator degrees of freedom for tests of the fixed effects NOTEST prevents the printing results of type tests of fixed effects ... respectively The significant intercept variance means that individuals varied in the level of physical health; the significant slope variance indicates that they varied in rate and direction of change ... [16], the slope parameter represents the average increase in the dependent variable for a unit increase in the predictor variable, while the intercept parameter represents the expected value of the...
- 7
- 352
- 0
báo cáo hóa học:" Physical activity and change in quality of life during menopause- an 8-year follow-up study" docx
... showed that the general model did not greatly improve the fit We also conducted a multinomial regression analysis because of this absence of assumptions and obtained the same results as in the ordinal ... increasing the presence of hypothalamic and peripheral ß-endorphin production Through these mechanisms, exercise may help to stabilize the thermoregulatory centre and diminish the risk of hot flushes ... because of their knowledge of the relationship between body fatness and chronic disease or whether it reflects a problem with body image is unknown In the study by Sammel et al [16] the major...
- 20
- 306
- 0
The genius in all of us new insights in david shenk
... stuck at the other end of the spectrum serve as an unwanted drag on modern society “Our ability to improve the academic accomplishment of students in the lower half of the distribution of intelligence ... ability” and is sourced all the way back to the parable of the talents in the book of Matthew The words “gifted” and “giftedness” date back to the seventeenth century The term “genius,” as it is ... implications for their newborn girl, it will a ect how they live, how they parent, and even how they vote Estimates of the actual number of genes vary Join other readers in online discussion of this chapter:...
- 239
- 919
- 0
Báo cáo y học: "Assessing the effect of HAART on change in quality of life among HIV-infected women." pdf
... one of the largest prospective cohort studies of HIV-infected and at-risk women in the U.S Acknowledging the challenges encountered in the analysis of observational data, we utilized methods that ... Most of these domains were stable or showed slight declines over subsequent followup, and there was no indication that HAART modified these trends These results suggest that continued use of HAART ... and without these variables in the models This phenomenon might be explained by the weak associations between these biological variables and QOL[1 ,26] Finally, with the inclusion of the time varying...
- 11
- 594
- 0
Báo cáo y học: " Change in level of productivity in the treatment of schizophrenia with olanzapine or other antipsychotics" ppsx
... component of the burden of illness and its economic cost [5,6] The financial cost of schizophrenia in the United States in 2002 was estimated to be $62.7 billion [6] In another study of the economic ... how often functional activities can be performed: 1, no useful functioning; 2, > 0% to ≤25% of the time; 3, > 25% to ≤50% of the time; 4, > 50% to ≤75% of the time; and 5, >75% to ≤100% of the ... how often functional activities can be performed: 1, no useful functioning; 2, > 0% to ≤25% of the time; 3, > 25% to ≤50% of the time; 4, >50% to ≤75% of the time; and 5, >75% to ≤100% of the...
- 9
- 370
- 0
Báo cáo y học: " Change in quality of life and their predictors in the long-term follow-up after group cognitive behavioral therapy for social anxiety disorder: a prospective cohort study" pptx
... statistically significant changes in the domains of the SF-36 or to detect potential baseline predictors of the SF-36 at the follow-ups Nevertheless, the changes of each of the SAD symptomatology scores ... explanation of the objectives and procedures of the present study The study protocol was approved by the Ethics Committee of the Nagoya City University Graduate School of Medical Sciences Treatment The ... deviations of the social functioning factor in the report was 0.40, which is similar to the value of the effect size in our study, so we should be cautious about concluding that CBT offers promising...
- 10
- 388
- 0
Báo cáo y học: " Development of a new ultra sensitive real-time PCR assay (ultra sensitive RTQ-PCR) for the quantification of HBV-DNA" pot
... DNA Analytical Sensitivity of the ultra sensitive RTQ-PCR The sensitivity together with the 95% and 50% HBVDNA detection limits of the assay were estimated by using the WHO st International Standard ... note that the specificity of the assay was 100% as shown previously [12] The differences between the newly developed method (ultra sensitive RTQ-PCR) and the previous one [12] were: 1) the utilization ... analysis was part of another study concerning the molecular typing of occult Hepatitis B in blood donors across Greece [15] The characteristics of these patients are shown in Table These samples...
- 6
- 536
- 1
Báo cáo y học: "The incidence of multidrug and full class resistance in HIV-1 infected patients is decreasing over time (2001–2006) in Portugal" potx
... better clinical management of the disease, the improved adherence, the extended experience of the clinician and the assistance of the virologist through the interpretation of the genotypic resistance ... available in a class the other hand, for 45% of the patients the on-therapy time could be underestimated since the date of therapy initiation was not certain To rule out these potential biases, ... data on other factors that might influence the incidence of resistance such as the exact number of days on therapy, persistence of resistance, adherence information and the higher impact of adherence...
- 8
- 292
- 1
Summary of doctoral dissertation epublic of korea vietnam strategic cooperative partnership and the way forward in the new context of global governance change in the 21st century
... model in the years to come Scope of the research The period covered by this study shall be limited to that extending from the end of the Cold War in 1991 to 2020 The dissertation analyzes the global ... should be based The objectives and tasks of the research The dissertation focuses on solving the following tasks: 1) Studying the importance of the changing process and characteristics of global governance ... PREFACE Background of the research Since the end of the Cold War in 1991, the global order and global governance have been changing rapidly The world is now in the process of an unprecedented...
- 27
- 506
- 0
Báo cáo y học: "Impact of drug classes and treatment availability on the rate of antiretroviral treatment change in the TREAT Asia HIV Observational Database (TAHOD" pdf
... U01-AI069907, and the Ministry of Foreign Affairs of the government of The Netherlands The National Centre in HIV Epidemiology and Clinical Research is funded by The Australian Government Department of Health ... different regions of the world to tailor adequate second line and salvage treatment strategies is thus warranted The aim of this study is to explore the rates and predictors of the change of combination ... cooperative network of clinicians throughout Asia and the Pacific that aims to expand the capacity for broader introduction of HIV/AIDS in the region TAHOD is the first collaborative study by the TREAT...
- 10
- 537
- 0
IMPACT OF FOREIGN DIRECT INVESTMENT ON ECONOMIC STRUCTUAL CHANGE IN HO CHI MINH CITY
... economic center of the region and the country, has a dominant role over the capability of the country’s economic growth The city is the one that leads the attraction of FDI, has the advantage in ... to 2010 due to the impact of the economic crisis in the world) The achievement of economic growth of the city not only has important implications for the city itself, for the Southeastern region ... of the overall development of the sector and program of structural change of the economy Starting from the planning, the Ho Chi Minh city initiative priority projects in the sectors Do well the...
- 20
- 592
- 0
Báo cáo y học: " Implementation of a new emergency medical communication centre organization in Finland an evaluation, with performance indicators"
... implemented, the Health Care Services became responsible for the 15 new EMCC One of the first actions of the new organization was to make the same stipulations regarding the competence and education of the ... during the period 2002-2005 were available from the municipality-based databases The rest of the data could not be gathered since it was impossible to retrieve it from the old databases The estimated ... and of these, 54 026 (79.9%) were from the municipality-based centers, and 13 584 (20%) were from the new EMCC A comparison between the municipality-based centers and the new EMCC indicates that...
- 5
- 495
- 0
Negotiating agrarian change livelihood agriculations of the commercial craft peasantry in northern vietnam
... that a variety of relationships exist between the landowners and the landless, in the context of agricultural commercialization Despite this, they still concede the existence of the process of ... to maintain their modes of livelihood articulation, in the context of labor scarcity (3) Within the process of the re-organization of rural labor, the inward movement of migrants and the gender ... connected the local craft industry to multiple levels of the economy? How has the instability of the market shaped local forms of livelihood? The overall objective of the study is to identify the ways...
- 347
- 483
- 0
Empirical investigation of market value change in vietnam stock market
... better than that of the estimation model without industry dummy The results are the same in terms of the number of significant variables and the directions of relationship Of which, the results ... volatility on the nine independent variables shows that the explanatory power of the model is 0.30 which means that 30% of the variation in the dependent variable is explained by the used set of independent ... examine the roles of the number of trades, size of trades, and share volume in the volatility-volume relation in the Shanghai Stock Exchange and confirm that mainly the number of trades drives the...
- 100
- 599
- 0
Tài liệu Women Sufficiently Represented in New Drug Testing, but FDA Oversight Needs Improvement doc
... In the 1970s, FDA recommended the exclusion of women of childbearing potential from early clinical drug trials because of concerns for the health of the women and of their potential offspring The ... production and analysis of data on the effects of drugs in women In 1994, the Institute of Medicine (IOM) reported that the FDA guidance that discouraged the participation of women of childbearing potential ... reflected the prevalence of the disease in the total population but were not necessarily statistically sufficient to prove the safety or efficacy of the drug for either sex Despite the participation of...
- 40
- 496
- 0
Tài liệu Báo cáo khoa học: Treatment of neutral glycosphingolipid lysosomal storage diseases via inhibition of the ABC drug transporter, MDR1 Cyclosporin A can lower serum and liver globotriaosyl ceramide levels in the Fabry mouse model doc
... disease, the primary pathology is in the kidney [1], the major site of Gb3 synthesis in man [11], and in the heart, possibly due to the association of Gb3 synthesis with the microvasculature GSL synthesis ... considered that the increased renal Gb3 of the Fabry mouse might extend to the glomerulus to provide a model of the human disease In the cortex of wild-type kidney, subpopulations of renal tubules ... binding indicates that the Fabry mouse will not serve as a model of HUS in man The increased Gb3 expression in virtually all the renal tubules of the Fabry mouse shows that the lack of Gb3 detection...
- 12
- 432
- 0
Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các nguyên tắc biên soạn khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản khảo sát chương trình đào tạo gắn với các giáo trình cụ thể xác định thời lượng học về mặt lí thuyết và thực tế điều tra đối với đối tượng giảng viên và đối tượng quản lí khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 động cơ điện không đồng bộ một pha thông tin liên lạc và các dịch vụ phần 3 giới thiệu nguyên liệu chỉ tiêu chất lượng 9 tr 25