apos body map apos analysis to visualize expression profiles for groups of genes across all tissues and diseases
Báo cáo y học: "Exon creation and establishment in human genes" doc
... for details) Figure 7a, b show the mean exonic and intronic densities of the two ESE sets considered (ESEcomb and SRall) for PS-Alu and pseudo-Alu The mean exonic densities of ESEcomb and SRall ... exonic and intronic information This measure is defined for each exon as the relative difference between exonic and intronic densities for a given set of regulators (see Materials and methods for ... distributed around zero for all SREs tested (ESEcomb, -0.029; SRall, -0.006; and ESScomb, -0.055) On the other hand, all real exons show positive values for ESEs and negative for ESSs In particular,...
- 17
- 188
- 0
ARBITRATION – A GOOD CHOICE FOR DISPUTES WITH ECONOMIC AND COMMERCIAL NATURE
... case of a panel of three arbitrators, normally, each party will appoint one arbitrator, and the party appointed arbitrators will appoint their president 32 All arbitrators shall be impartial and ... time and money in trying to resolve the dispute by all ways and still end up having to go to legal means10 which guarantee a decision to be reached and enforceable at law The guarantee of a decision ... determination of rights and obligations of the parties, and such decision must be final and binding A procedure that does not lead to a final and binding award is not arbitration7, and such award shall...
- 15
- 1,456
- 1
Báo cáo y học: " Is interleukin-1 a good target for therapeutic intervention in intervertebral disc degeneration: lessons from the osteoarthritic experience" pdf
... of IL-1ra (150 mg, the maximum tolerated dose) [8] We performed a multicenter, randomized, double-blind, placebo-controlled study to evaluate the clinical response, safety, and tolerability of ... osteophytes, and significant improvement in clinical indicators of pain and disease activity A first randomized controlled trial in patients with knee OA demonstrated a good safety profile for one ... therapeutically relevant In the context of LBP, the use of IL-1 blockers is very attractive, although many questions need to be addressed before starting to use such therapy: what is the best route of...
- 2
- 412
- 0
Why Copying LIS from a Developed Country Does Not Work for a Developing Country?
... and social implications The LIS suitable for developing countries must be capable of providing a sound base for economic and environmental planning This is ... ộđ ự ộ ộ ự ự ả ệ ố ấ ể From Pharaohs to Geoinformatics FIG Working Week 2005 and GSDI-8 Cairo, Egypt April 16-21, 2005 ộ TS – Applied SIM and SDI Trung Tran and Don Grant TS9.6 Why Copying LIS ... practice Accordingly developing countries may require a more complex approach to an LIS than the relatively simple use of the LIS in many developed countries SUMMARY (Vietnamese) FIG t ch c qu c...
- 2
- 422
- 0
Tài liệu THE ELEMENTS OF BACTERIOLOGICAL TECHNIQUE A LABORATORY GUIDE FOR MEDICAL, DENTAL, AND TECHNICAL STUDENTS pptx
... flame (for the sterilisation of platinum needles, etc.) Muffle furnace (for the sterilisation of filter candles, and for the destruction of morbid tissues) Hot air (for the sterilisation of all ... temperature of 175° to 180° C will effect the same result and offers the more convenient method of sterilisation This method is only applicable to glass and metallic substances, and the small bulk of ... neatly and roll the strip of wool lightly between the thumb and fingers of both hands to form a long cylinder Double this at the centre and introduce the now rounded end into the open mouth of the...
- 666
- 511
- 0
A NEW TOOL FOR SCALING IMPACT: HOW SOCIAL IMPACT BONDS CAN MOBILIZE PRIVATE CAPITAL TO ADVANCE SOCIAL GOOD doc
... Impact Bonds and pay -for- success contracts In January 2012, Massachusetts issued Requests for Response for performance-based financing to expand support for chronically homeless adults and youth ... instrument, and issuing the SIB They attract investment capital, for instance, by creating and facilitating access to tools that allow investors to analyze, measure, and price the risk of the investment ... major barrier to the growth of nonprofits lies in the nature of funding for the social sector Traditionally, nonprofit programs and social services have been supported by government and philanthropy...
- 36
- 262
- 0
Báo cáo khoa học: Synthesis and characterization of a new and radiolabeled high-affinity substrate for H+/peptide cotransporters pdf
... have been shown to be useful to study the expression and conformation of recombinant membrane transporters [19], labeled substrates and inhibitors with a broad range of affinity to the respective ... component of [14C]Gly-Sar uptake, of 8% in Caco-2 cells and of 4% in SKPT cells, measured in the presence of excess of Gly-Sar (30 mM and 20 mM, respectively), was subtracted from the total uptake to ... trans conformers of their substrates [22,23] Taking the cis ⁄ trans content of Bip-Pro (78% ⁄ 22%) into account, we obtained Ki trans values for Bip-Pro of 5.2 lm in Caco-2 cells and of 0.75 lm...
- 10
- 490
- 0
Báo cáo khoa học: The Vps4 C-terminal helix is a critical determinant for assembly and ATPase activity and has elements conserved in other members of the meiotic clade of AAA ATPases pdf
... leading to release of the internal vesicles (exosomes), which are important for immune regulation and other biological functions [6] MVB sorting of signalling receptors such as growth factor receptors ... 1A) was to perform a sequence alignment of yeast Vps4p and human VPS4A and 4B (Fig 1B) to identify amino acids in the C-terminal helix that are highly conserved and predicted to be functionally ... in transport of endocytosed material, including alpha factor and 1430 both water- and membrane-soluble dyes, to the vacuole [41,42] To assess the importance of the C-terminal helix and b-domain...
- 23
- 490
- 0
Báo cáo khoa học: KCTD5, a putative substrate adaptor for cullin3 ubiquitin ligases docx
... included in the analysis Acknowledgements We are grateful to Dr Keiji Tanaka for the CUL4A and CULB cDNAs, to Dr Cristoff Geisen for the CUL1 and CUL3 plasmids, and to Dr Joan Conaway for the myc–Rbx1 ... antibody to HA, and ubiquitinated proteins that interact with KCTD5 were detected with antibody to myc WCLs were immunoblotted with the antibodies to HA and myc to assess the expression of the ... the case of KCTD3 and Q8TBC3, a human homolog of mouse seta-binding protein-1 [15], KCTD1 and KCTD15, and KCTD21 and KCTD6 Most of these sequences remain uncharacterized This analysis of KCTD...
- 11
- 402
- 0
Báo cáo khoa học: Adenylyl cyclase Rv0386 from Mycobacterium tuberculosis H37Rv uses a novel mode for substrate selection ppt
... Activities of Rv0386(1)175) and mutants Assays were conducted with 850 lM substrate and mM MnCl2 at pH 7.5 and 30 °C Standard errors of the mean are included (number of experiments in brackets) AC and ... and a 3¢ HindIII site and inserted into pQE30 Point mutations were introduced by PCR using the expression cassette as a template and standard molecular biology techniques The correctness of all ... 45 Mutational analysis of Rv0386(1)175) 35 25 18 14 Fig Purification of recombinant proteins SDS ⁄ PAGE analysis of purified wild-type and mutant Rv0386(1)175), 1–3 lg per lane, visualized by Coomassie...
- 8
- 401
- 0
Báo cáo khoa học: "Phrase Table Training For Precision and Recall: What Makes a Good Phrase and a Good Phrase Pair?" doc
... the sentence of the beginning word of the English(foreign) phrase and ie (je ) is the position of the ending word of the phrase We first train word alignment models and will use them to evaluate ... smoother and potentially it can alleviate the overestimation problem in HMM especially when training data size is small 3.2 Bilingual Information Metric Trying to find phrase translations for any ... phrase well to a foreign phrase, the posterior distribution of the English phrase generating all foreign phrases on the other side is significantly biased For instance, the posterior of one foreign...
- 8
- 472
- 0
Controlling Interest: Are Ceilings On Interest Rates a Good Idea? pptx
... lower overall costs of borrowing even for those able to obtain loans Additionally, non-interest charges make it more complicated for customers to comprehend the total cost of borrowing and more ... limitations, and other information pertinent to making an informed consumer choice Notes In an effort to enhance the ability of consumers to compare interest rate charges and, therefore, to discourage ... have become more aware of credit card terms and rates and more willing to search for the best deal, matching services to their needs And, importantly, a host of new competitors have entered the...
- 8
- 505
- 0
You Are a Brand!: In Person and Online, How Smart People Brand Themselves For Business Success
... I learned through fortune and misfortune to take control of my branding and to try to understand branding influences in the larger world Did I make mistakes? Of course, lots of them The only people ... we have to master branding ourselves in person and digitally if we want to succeed in challenging times All of these changes can add urgency to working on your personal brand and finally taking ... 10–14) Today, we all have to be entrepreneurs and branders, whether we work for a company or have our own business You have to master selfbranding not only to learn how to be selfdirected and have...
- 733
- 532
- 0
Báo cáo khoa học: Ki-1⁄57 interacts with PRMT1 and is a substrate for arginine methylation pptx
... wanted to map the regions of PRMT1 that are important for both its dimerization and its interaction with Ki-1 ⁄ 57 Therefore, we generated a series of truncations of PRMT1 and cloned them into the ... presence of freshly added Adox (20 lm) Lysis, fractionation of nucleus and cytoplasm, immunoprecipitation and SDS ⁄ PAGE were performed as above and autoradiography of the dried gel was performed ... constructs of Ki-1 ⁄ 57 were cotransformed and tested for interaction by assessing their ability to grow on the -Trp, -Leu, -His plates The presence of plasmids was confirmed by growth of all cotransformants...
- 16
- 367
- 0
Báo cáo khoa học: Kinetic mechanism for p38 MAP kinase a A partial rapid-equilibrium random-order ternary-complex mechanism for the phosphorylation of a protein substrate potx
... (JNKs) and the p38 MAP kinases, among others These enzymes are terminal components of three-tiered MAPK modules, each of which consists of a MAP kinase (MAPK), a MAPK kinase (MAPKK) and a MAPKK ... remain to be defined [1] Notably, the a and b isoforms are inhibited by the classic family of pyridinyl inhibitors related to SB 203580, whereas the c and d isoforms are not Thus, use of SB 203580, ... pharmacological tool employed to date, is transparent to two of the p38 MAPK isoforms Although a number of structural studies have been reported, showing for example, inactive p38 MAPKa with and without...
- 15
- 554
- 0
Báo cáo Y học: ik3-1/Cables is a substrate for cyclin-dependent kinase 3 (cdk 3) pdf
... were subject to digestion with trypsin and two-dimensional peptide mapping Spots A and B of peptide mapping for lane 4, and spots A0 and B0 of peptide mapping for lane 5, were subject to two-dimensional ... the anti-FLAG Ig WT and S-A indicate pMF–ik3-1 for expression of wild-type FLAG –p70ik3-1 (lanes and 2) and pMF–(S274A)ik3-1 for expression of FLAG –(S274A)p70ik3-1 (lanes and 4), respectively ... buffer, and then incubated in 15 mL of the kinase buffer containing mg of GST-pRb, mg of GST–ik3-1, mg of GST– ik3-1DN, or mg of GST–cdk2 as substrates in the presence of 25 mM ATP and 0.5 mCi of...
- 7
- 308
- 0
The Business Case for Fuel Cells: Why Top Companies are Purchasing Fuel Cells Today doc
... president and general manager of the material handling division of LiftOne, a division of Carolina Tractor and a material handling dealership, states that the cost of maintaining a fuel cell-powered forklift ... parallel to it, fuel cells can provide reliable power without disruption due to grid failure or blackouts This allows a store to continue its operations, and grocers to keep refrigerators and ... advantage of a fuel cell‘s unique benefits, especially for powering forklifts and providing combined heat and power to their stores and headquarters This report focuses on companies installing or...
- 99
- 317
- 0
Báo cáo khoa học: Identification of a preferred substrate peptide for transglutaminase 3 and detection of in situ activity in skin and hair follicles pdf
... regions of the hair follicle cells Discussion During differentiation of keratinocytes and hair formation, isopeptide cross-linking of several structural proteins is essential for the formation of ... will provide useful information for clarifying the process of cross-linking To date, with respect to the major members of the TGases family such as TGase 1, TGase and Factor XIII, we have investigated ... sequences displayed a unique tendency for each isozyme, Q-x-R ⁄ K-W-x-x-x-W-P to TGase 1, Q-x-P-WD-P to TGase and Q-x-x-W-x-W-P to Factor XIII (x and W are any amino acid and hydrophobic amino acid residues,...
- 11
- 645
- 0
Stakeholder Engagement: A Good Practice Handbook for Companies Doing Business in Emerging Markets pptx
... development impact of the mining sector and the contribution of foreign investors to the national and local economy In order to manage public expectations and create a forum to facilitate the ... power lines, and canals; sources of air, water, and land pollution) Identify the broad impact zones for each of these components (e.g., the area of land take, air and water pollution receptors, etc.) ... to engage with first, and why? ■ What is the optimal sequence of engagement? ✔ Refer to past stakeholder information and consultation Referring to historical stakeholder information related to...
- 201
- 533
- 0
Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các mục tiêu của chương trình xác định các nguyên tắc biên soạn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản khảo sát chương trình đào tạo gắn với các giáo trình cụ thể tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra đối với đối tượng giảng viên và đối tượng quản lí nội dung cụ thể cho từng kĩ năng ở từng cấp độ xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc mở máy động cơ rôto dây quấn đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến dòng điện stato i1 fi p2 động cơ điện không đồng bộ một pha sự cần thiết phải đầu tư xây dựng nhà máy thông tin liên lạc và các dịch vụ từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng 9 tr 25