apos apos specific apos apos vs apos apos non specific apos apos effects of stress on the cns
báo cáo hóa học: " Different gait tasks distinguish immediate vs. long-term effects of concussion on balance control" ppt
... separation of the CoM and CoP on day 28 Both of these indicate a conservative control of mediolateral balance based on a distance-velocity model of the CoM with respect to the base of support ... parameters may be used to test these hypotheses ther investigation of the complex issue of balance control following concussion A major limitation to our study is that control subjects did not perform ... imbedded in the longitudinal curves for subjects with concussion Another limitation is the inclusion of individuals with previous concussions within both groups This was unavoidable given the limited...
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Báo cáo y học: "Parvovirus B19 Genotype Specific Amino Acid Substitution in NS1 Reduces the Protein’s Cytotoxicity in Culture"
... orientation of the side chain and hence a change in the secondary structure of that region in the protein Since the I181M substitution did not obliterate B19 NS1 cytotoxicity, but only reduced it, the ... and therefore direct experimental verification of the role of amino acid variation on replication efficiency or viral fitness must await the availability of such tools However, based on the results ... previously reported to be the mechanism of B19 NS1-induced cytotoxicity (34, 35) Further confirmation for the reduction of apoptosis in the PathI transduced population of HepG2 cells was obtained...
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BANK-SPECIFIC, INDUSTRY-SPECIFIC AND MACROECONOMIC DETERMINANTS OF BANK PROFITABILITY pptx
... investigation of the effect of the macroeconomic environment, owing partly to the small time dimension of the panels used in the estimation Second, in most of the literature, the econometric methodology ... affect the performance of the banking sector The effect of the business 35 This is due to the considerable size reduction of the dominant bank of the sector, the establishment and development of other ... account of the effect of internal and industry -specific determinants on bank profitability, but the effect of the macroeconomic environment is not adequately dealt with The time dimension of the...
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báo cáo hóa học:" Identification of a public CDR3 motif and a biased utilization of T-cell receptor V beta and J beta chains in HLA-A2/Melan-A-specific T-cell clonotypes of melanoma patients" potx
... segments The juxtaposition of these segments [2], the lack of precision during V(D)J gene rearrangement and the removal and/or addition of nontemplate encoded nucleotides at V(D)J junctions [3], ... Moreover, the overall percentage of non- polar amino acids at these CDR3 positions in the clonotypes carrying 12-amino acidlong CDR3s, which were the most commonly represented among the Melan-A -specific ... of the T cells bearing the public motif However, whatever the function of these clonotypes is, the occurrence of this public CDR3 sequence may have implications for the tracking of tumor Ag-specific...
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Báo cáo hóa học: " The application of adjuvant autologous antravesical macrophage cell therapy vs. BCG in non-muscle invasive bladder cancer: a multicenter, randomized trial" pptx
... Maintenance consisted of cycles (at month and month 6) of weekly BEXIDEM or BCG instillations Dose reductions of BEXIDEM due to toxicity were not allowed Dose reductions of BCG to 2/3 or 1/3 of the recommended ... study was conducted in 43 centres in Spain, Hungary, France, Germany, Belgium and Luxembourg in accordance with the Declaration of Helsinki, the International Conference on Harmonisation guideline ... performed at 3, 6, and 12 months The primary safety endpoint was based on the incidence of AEs according to the Common Terminology Criteria for AEs (CTCAE) The relationship of an AE to study treatment...
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Báo cáo hóa học: "Validation of the nausea and vomiting of pregnancy specific health related quality of life questionnaire" pot
... made substantial contribution to acquisition of data, analysis and interpretation of data, and drafting of the article AB made substantial contribution to conception and design of the study, analysis ... on the endowment Pharmaceutical Chair of the Famille Louis-Boivin on 'Medications, Pregnancy and Lactation' at the Faculty of Pharmacy of the University of Montreal and CHU Ste-Justine Page of ... quality of life As of now, no pregnancy -specific questionnaire allows for the evaluation of QOL during the gestational period Because NVP is a prevalent condition in pregnancy, the NVPQOL questionnaire...
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báo cáo hóa học:" The influence of a weight-bearing platform on the mechanical behavior of two Ilizarov ring fixators: tensioned wires vs. half-pins" pdf
... construction, the transfixion of soft tissue by the tensioned wires or the transfixion of the hindfoot within the frame Efforts have been made to simplify both the application and configuration of the ... measure the interfragmentary motion at the site of the defect, the relative motion of the bone fragments to the rings and the relative motion between the rings There were three transducers at the ... to the anatomical conditions, and the tibiae were mounted eccentrically in the sagittal plane to mimic the soft tissues of the calf At the site of the osteotomy, the distance between the bone...
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Báo cáo hóa học: " The influence of colloidal parameters on the specific power absorption of PAA-coated magnetite nanoparticles" potx
... depending on the magnetic 4π R3 volume of the NP, VM = and Kan is the magnetic anisotropy energy constant of the magnetic core of the NP Therefore, the heat dissipation of a magnetic hyperthermia ... interaction will become relevant and contribute to the magnetic properties of the ferrofluid Since some controversies exists in theoretical studies about the influence of the dipolar interaction on the ... dispersions at different magnetite concentrations, ranging from 0.6 to 20 g L-1 Figure shows the evolution of the SAR with magnetite concentration The evolution of the SAR coefficient reveals that the...
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Báo cáo khoa học: " Effects of L-NAME, a non-specific nitric oxide synthase inhibitor, on AlCl3-induced toxicity in the rat forebrain cortex" doc
... positive effects of pre-treatment with NOS inhibitors on the development of neurotoxicity [33,38] In view of the above considerations, the present study was undertaken to examine if the nitrite ... reduction [24] Superoxide anion (∙O2 ) content was determined by the reduction of nitroblue-tetrazolium (Merck, Germany) in The effect of L-NAME on AlCl3 toxicity in the rat brain 17 the alkaline ... compared to both the controls and the AlCl3-treated animals After 30 d, L-NAME injection resulted in increased nitrite production in the Fig The effects of intrahippocampal drug injection on nitrite...
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Báo cáo y học: "Effect of allergen-specific immunotherapy with purified Alt a1 on AMP responsiveness, exhaled nitric oxide and exhaled breath condensate pH: a randomized double blind study" ppsx
... values At the time of writing, there has been only one published study[7] on the effect of SIT on airway responsiveness to AMP In a group of non- asthmatic subjects with allergic rhinitis monosensitized ... allergen[20] Therefore, immunotherapy with Alt a1 alone may well suffice to improve manifestations of sensitization to the entire allergen composition of A alternata The mechanism of action of SIT ... AMP responsiveness On the other hand, SIT appears to have no effect on airway responsiveness to methacholine This confirms the results of other controlled trials investigating the effect of SIT...
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Báo cáo khoa học: " Distinct effects of rectum delineation methods in 3D-confromal vs. IMRT treatment planning of prostate cancer" pdf
... distributions with the high dose region confined to the target volume and sparing of organs-at-risk [6,7] The correlation between the volume of the rectum within the high dose region and the risk for ... OARs The rectum was contoured in four different ways: 1) rectal wall based on manual delineation of the inner and outer contour of the rectal wall 2) rectal wall based on manual delineation of the ... 0.930); the slope of linear fit lines ranged between 1.01 (DWH vs DWH3) and 1.11 (DVH vs DSH) The influence of the rectal volume, the degree of rectal filling, on the relationship between the dose...
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Báo cáo y học: "Identification of intra-group, inter-individual, and gene-specific variances in mRNA expression profiles in the rheumatoid arthritis synovial membrane" pot
... in the design and coordination of the study, including supervision of the bioinformatic analyses RWK contributed to the design and coordination of the study and participated in the writing of the ... Alternatively, the less conservative Holm correction was applied for the correction of the data [24] The application of the Holm correction yielded results comparable to those obtained by Bonferroni correction ... individuals In contrast to conventional differential gene expression analyses, the determination of inter-individual gene expression variances, often affecting gene expression of members of the same...
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Báo cáo y học: " Allele-specific copy number analysis of tumor samples with aneuploidy and tumor heterogeneity" ppt
... and the time between occurrence of the aberration and tumor collection influence the proportion of tumor cells with each aberration [15] As a consequence of the tumor cell heterogeneity the average ... representative of the tumor cells of the tumor In the colon cancer material, DNA was extracted from sections of the tumor tissue, achieving a reasonable albeit not perfect representation of the tumor ... for the all-tumor-cell sample These were 35 large regions, representative of all types of copy number aberrations in the sample, and covered the majority of the genome We then observed whether the...
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Báo cáo y học: "Gender-specific effects of HIV protease inhibitors on body mass in mice" ppt
... http://www.aidsrestherapy.com/content/4/1/8 Ovariectomy reverses the effects of ritonavir in female mice To determine if hormonal factors from the ovary contribute to the gender -specific effects of ritonavir on ... ritonavir as described above Briefly, a small incision was made through the abdominal skin and muscle layer of the animal around the area of the kidneys to expose the ovary The distal portion of ... Removing the female sex hormones prevents the effects of ritonavir on Animals All animals were housed in the AAALAC certified animal facilities at the University of Kentucky Animals were maintained on...
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Báo cáo y học: "Effects of recombinant human growth hormone on HIV-1-specific T-cell responses, thymic output and proviral DNA in patients on HAART: 48-week follow-up" ppt
... T-cell responses, in chronic HIV-1 infection [1] Here we assessed the effects of rhGH therapy on the immune system of chronically HIV-1-infected individuals, in the con- text of long-term successful ... infection and clonal deletion [15] Therefore the adverse effects of HIV-1 should be taken into account when immunotherapy is used to induce such responses Nevertheless, induction of HIV-1 -specific T-cell ... stable population of cells, at baseline a complete lack of both CD4+ and CD8+ HIV- 1specific T-cell responses was noted in 11 of 12 individuals To address the specificity of the responses generated...
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Báo cáo y học: "Relative effectiveness and adverse effects of cervical manipulation, mobilisation and the activator instrument in patients with sub-acute non-specific neck pain: results from a stopped " ppt
... front of the clinicians Secondly, by not having a placebo control group the results obtained may be explained by non -specific effects due to the attention given to the participants in each of the ... higher proportion of these adverse effects as compared to manipulation, and mobilisation had a higher proportion of adverse effects as compared to manipulation The reason why the Activator instrument ... neck pain and, therefore, there is a lack of evidence to determine if the treatment of subacute neck pain could reduce the occurrence of chronic neck pain The category of subacute non -specific neck...
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Báo cáo y học: "S-100B and neuron-specific enolase as predictors of neurological outcome in patients after cardiac arrest and return of spontaneous circulation: a systematic review" ppt
... indication of what is happening in the brain of the CA patient, which might be useful for optimization of therapeutic intervention in future cases of CA However, there are few investigations on the ... indication of what is going on in the brain of the patient, which might be useful for optimization of therapeutic intervention in future cases Conclusions The present study shows that the measurements ... criterion regained consciousness They further concluded, based on the results of ROC analysis, that a cut-off value of 80 ng/mL for peak NSE concentration predicted 'persistent coma' at a specificity...
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Báo cáo y học: " Individual mRNA expression profiles reveal the effects of specific microRNAs Amit Arora and David AC Simpson" pot
... miRNA detection Our analysis of a limited number of gene expression profiles has demonstrated the major impact of miRNAs upon mRNA expression The programs are amenable to provision of an online service ... whether there was significant difference between the medians of the ranked gene expression values of the two sets, the nonparametric one-sided Wilcoxon rank sum test was employed To test the ... to the seed region and cross-species conservation reduce the falsepositive rate [3-5] The resulting higher specificity of this algorithm maximizes the ability to detect effects on expression of...
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Báo cáo sinh học: "Tissue specific promoters improve specificity of AAV9 mediated transgene expression following intra-vascular gene delivery in neonatal mice" pptx
... to identify which one of a group of promoters confers the greatest degree of cardiac specific expression and concurrently, which provides a broad biodistribution of expression across both cardiac ... revealed the strongest β-galactosidase expression levels were from the Desmin promoter The CMV promoter showed the next highest expression levels followed by the other promoters Analysis of nonheart, ... for the tissue of interest Several groups have demonstrated the unique ability of the AAV9 capsid to yield extraordinarily high levels of transgene expression in the heart [8-11] Each of these...
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chi et al - 2010 - the effects of auditors’ pre-client and client-specific experience on earnings quality and perceptions of earnings quality in taiwan
... assumption underlying the mandatory audit partner rotation policy is that the lack of client -specific experience of the incoming audit partner can be alleviated by his prior non- client -specific ... in the U.S setting provide no evidence of a deterioration of earnings quality with longer audit firm tenure However, a limitation of these studies is that they cannot take into account the contemporaneous ... discretionary accruals, and the coefficient on FT is insignificant In addition, the sum of the coefficients on PT and FT is insignificant when the dependent variable is negative discretionary accruals...
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