antiemetic action of delta9 tetrahydrocannabinol and synthetic cannabinoids in chemotherapy induced nausea and vomiting
Combining global genome and transcriptome approaches to identify the candidate genes of small-effect quantitative trait loci in collagen-induced arthritis pptx
... animal models [15-22] Indeed, genes involved in arthritis show distinct expression patterns in certain tissues and pathological stages of the disease Genes involved in immunoinflammatory responses ... expressed in the blood cells in RA patients [18] Chemokines and adhesion molecules were upregulated in the joint at the initiation phase of arthritis in animal models [21,22], while genes involved in ... expression in LNs during CIA We present an extensive study of gene expression patterns in LNs of both genetically susceptible and resistant strains at four different phases of CIA In both strains,...
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Báo cáo khoa học: Role of Ca2+/calmodulin regulated signaling pathways in chemoattractant induced neutrophil effector functions Comparison with the role of phosphotidylinositol-3 kinase ppt
... calmodulin and PtdIns3K In guinea pig neutrophils, it has been demonstrated that inhibition of calmodulin results in inhibition of Rac and p21 activated kinases [50] Involvement of Rac in ROS ... role in the recycling of integrins, which are involved in cell adhesion and attachment [47] Additionally, it has been described that CaMKII counteracts the calcineurin induced affinity switch of ... Ca2+/calmodulin-dependent kinases (CaMKs) [21,22] CaMKs form a family of serine/threonine kinases activated by binding of Ca2+/calmodulin and includes, CaMKI, CaMKII, CaMKIV, CKLiK and CaMKK Until...
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Báo cáo y học: "Ultra-low microcurrent in the management of diabetes mellitus, hypertension and chronic wounds: Report of twelve cases and discussion of mechanism of action"
... elevation of both glucose and free fatty acid levels in the blood and an increase in oxidative stress (30,31) The high degree of oxidative stress might have an important role in decreasing insulin responsiveness ... pathogenesis of insulin resistance in humans using magnetic resonance spectroscopy Obesity (Silver Spring) 2006;14 (Suppl 1): 34S–40S 31 Boden G Role of fatty acids in the pathogenesis of insulin resistance ... role in the pathogenesis of both types of diabetes mellitus High levels of free radicals and the decline of antioxidant defense mechanisms lead to damage of cellular organelles and enzymes, increased...
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Tài liệu Báo cáo khoa học: Antifungal effects and mechanism of action of viscotoxin A3 docx
... death in human lymphocytes, and induce the generation of H2O2 in spores [9,15–18] In this work we have gained more information on the cellular targets and the mechanism of action of vis- cotoxins, ... cotoxins, by examining the interaction of VtA3 with fungal cells We describe a detailed investigation of the cellular and signalling characteristics of VtA3 -induced spore death in F solani, its ... preceded by an increase in the recording’s baseline, suggesting that toxin incorporation induced an increase in the membrane conductance Single-channel current vs voltage (I ⁄ V) plots of the activity...
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Tài liệu Báo cáo khoa học: Characterization and mode of action of an exopolygalacturonase from the hyperthermophilic bacterium Thermotoga maritima doc
... number printed in bold Catalytic residues are indicated by stars, and residues presumed to be involved in substratesubsite interaction are highlighted with arrows Insertions in PelB in comparison ... EPG2 are printed in italics comprises 10 complete turns PelB contains a few inserted b-strands (1a in Fig 2), and one large insert of 15 amino acids is present before the rst b-sheet of coil 3, ... described the amino acid residues in Aspergillus aculeatus polygalacturonase involved in hydrogen-bonding interactions between the substrate-binding-cleft residues and octaGalpA, and aligned the...
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Báo cáo khoa học: Assembly and molecular mode of action of the Helicobacter pylori Cag type IV secretion apparatus doc
... components are indicated in green, translocation factors in orange, and the effector protein CagA in red Overlapping boxes indicate probable protein–protein interactions Integrin heterodimers are indicated ... [36,42] On the other hand, CagY, CagA and CagI were also identified as Cag proteins binding to b1 integrins [36] In any case, interaction of secretion system components with b1 integrins is an important ... responsible for the induction of a pronounced pro -in ammatory response in vitro and in vivo, and the translocation and subsequent tyrosine phosphorylation of its effector protein CagA into various host...
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Addressing the Impact of Household Energy and Indoor Air Pollution on the Health of the Poor: Implications for Policy Action and Intervention Measures pot
... scarce and in areas of civil unrest and war (60) • Burns to children falling into fires (61, 62) • Accidental poisoning of children drinking kerosene (paraffin) stored in soft drink containers ... and those involved in production and marketing, in assessing local needs and developing solutions appropriate to those needs and circumstances In fact, many technologies have been developed and ... factor of 10, 20, and sometimes up to 50, exceeding even the high levels found outdoors in such cities as in coal-burning northern China (11) Typical 24-hour mean levels of PM10 in homes using biofuels...
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Báo cáo khoa học: Cellular and molecular action of the mitogenic protein-deamidating toxin from Pasteurella multocida pptx
... protein serine ⁄ threonine protein kinase; MEK, MAPK serine ⁄ threonine protein kinase; MLCK, myosin light chain kinase (serine ⁄ threonine protein kinase); MLCPase, myosin light chain phosphatase; ... (activation) of the signaling pathway, and barred lines indicate the negative direction (inhibition) of the signaling pathway Full lines indicate interactions that are known to be direct, and broken lines ... hypertrophy reminiscent of that induced by norepinephrine activation of Gq-coupled receptors [97] Similar to norepinephrine, PMT suppresses the activation of Akt, a serine ⁄ threonine protein kinase that...
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Báo cáo khoa học: Enhancement of intracellular concentration and biological activity of PNA after conjugation with a cell-penetrating synthetic model peptide docx
... an increased intracellular availability of PNA In order to examine the ability of MAP to deliver PNA into intact cells, we investigated the cellular uptake of the conjugate of I with MAP in comparison ... internal standard e-fluoresceinyl lysine in order to eliminate irregularities of injection and buffer status Because the exact volume of the sample injected into the capillary remained unknown, the references ... the in uence of nociception on the beating rate of CM measured on day of culture without and with pretreatment with either 0.2 lM of I or II on day and after seeding The basal beating rate of...
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Báo cáo Y học: Isolation, enzymatic properties, and mode of action of an exo-1,3-b-glucanase from Trichoderma viride doc
... observed for the inverting exo-1,3-b-glucanase from T viride AZ36 Mode of action in the hydrolysis of laminarins The mode of action of the exo-1,3-b-glucanase was studied using laminarin from L digitata ... of laminarin (20 mg:mL21 in water) or with 20 mL of G3G3G3G (40 mM in water) The in uence of pH on stability of the enzyme was studied by incubating samples of the enzyme at 20 8C for 16 h in 100 ... per mg of laminarin Incubation was at 37 8C for 60 The reaction mixture was fractionated on a Sephadex G-25 (Fine) column equilibrated in water, separating oligosaccharides of degree of polymerization...
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Báo cáo khoa học: Mode of action of the microbial metabolite GE23077, a novel potent and selective inhibitor of bacterial RNA polymerase docx
... mechanism of action of RNAP inhibitors As a specific inhibitor of transcription initiation, GE23077 might exert its action by directly binding and inhibiting the RNAP r subunit, or by acting exclusively ... lipiarmycin [11] and rifampicin [16], or chain elongation, like streptolydigin [12] To obtain such information, the time course of RNAP inhibition was measured comparing the effect of adding GE23077 ... might inhibit RNA synthesis by preventing RNAP from binding to DNA Binding of RNAP to DNA is indeed one of the earliest steps of the transcription process and a possible molecular target of a...
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Báo cáo y học: "Diagnostic and prognostic value of antibodies against chimeric fibrin/filaggrin citrullinated synthetic peptides in rheumatoid arthritis" doc
... of citrullinated fibrinogen in a mouse model of arthritis [29] and the presence of immune complexes containing citrullinated fibrinogen in the sera and synovium of RA point to a direct role in ... majority of patients at baseline and during the follow-up In 56 patients, all four tests were available at baseline and at and years of follow-up CFFCP status remained stable in most patients during ... citrullinated fibrin, inducing TNF- secretion by macrophages [31] Together, these findings reinforce the role of citrullinated fibrinogen in RA pathogenesis and suggest that this protein could be...
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Báo cáo y học: "Glycogen synthase kinase 3, circadian rhythms, and bipolar disorder: a molecular link in the therapeutic action of lithium" docx
... bovine serum (GIBCO) and a mixture of penicillin-streptomycinglutamine (PSG from GIBCO) Puromycin-resistant MEF lines were grown, maintained, serum shocked, and serum starved in medium containing ... direct inhibition of GSK3 by lithium in vivo and in vitro, and (v) the role of Sgg/GSK3 in the modulation of period length in fruit fly and murine clocks, places GSK3 at the forefront of the ... expanded, and tested by Western blotting to determine the level of GSK3α knockdown, as well as any concomitant increase in cytosolic levels of β-Catenin protein GAPDH levels were used as a loading...
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báo cáo khoa học: "Feedback GAP: study protocol for a clusterrandomized trial of goal setting and action plans to increase the effectiveness of audit and feedback interventions in primary care" pdf
... maximum of For patients with diabetes, a maximum score of would indicate testing of urinary microalbumin and serum LDL within a year, measuring BP and glycosylated haemoglobin within six months, and ... having active prescriptions for a statin and an angiotensin-modifying agent For patients with IHD, a maximum score of would indicate testing fasting blood glucose within two years and LDL within ... review of the use of theory in the design of guideline dissemination and implementation strategies and interpretation of the results of rigorous evaluations Implement Sci 2010, 5:14 Dawson L, Zarin...
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Báo cáo y học: "Anti-inflammatory effects and possible mechanism of action of lupeol acetate isolated from Himatanthus drasticus (Mart.) Plumel." ppt
... model which induces paw edema and substantial leukocyte migration, mediated by histamine and serotonin in the initial phase of the inflammatory process, and by prostaglandin and bradykinin in later ... Anti-hyperalgesic and morphine-sparing actions of propentofylline following peripheral nerve injury in rats: mechanistic implications of spinal glia and proinflammatory cytokines Pain 2003, 104:655-664 ... K: The formalin test in mice: dissociation between inflammatory and non-inflammatory pain Pain 1987, 30:103-114 Winter CA, Risley EA, Nuss GW: Carrageenin -induced oedema in hind paw of the rat:...
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Báo cáo y học: " Peripheral blood and neuropsychological markers for the onset of action of antidepressant drugs in patients with Major Depressive Disorder" pps
... of 25% in healthy control is assumed Therefore, it is planned to assess 70 healthy controls Page of 10 high in the first rating and increased during the course of the training [64] The training ... panel of pro- and anti-inflammatory cytokines was measured in a case/control population of MDD showing elevation of a number of additional cytokines not previously implicated in MDD, as well as of ... conflicting findings The finding of an HPA dysfunction in depressed patients during acute phase has led to the development of neuro-endocrine challenge tests as putative biomarkers Another interesting...
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Báo cáo khoa học: "Anti-viral properties and mode of action of standardized Echinacea purpurea extract against highly pathogenic avian Influenza virus (H5N1, H7N7) and swine-origin H1N1 (S-OIV)" docx
... interesting option in the control and treatment of influenza virus infections Methods Standard Echinacea Preparation Echinaforce® (obtained from A Vogel Bioforce AG, Roggwil, Switzerland) is a standardized ... triplicate, and titrations in duplicate acid containing receptor If EF could inhibit this interaction by binding to the HA, then entry of virus might be prevented Receptor binding of functional HA can ... Echinaforce®; FFU: focus-forming unit; HA: hemagglutinin; HAU: hemagglutinating units; IV: influenza virus; PFU: plaque-forming unit; RNP: (viral) ribo-nucleoprotein; S-OIV: swine-origin influenza...
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Báo cáo khoa học: " Mechanisms of the action of povidone-iodine against human and avian influenza A viruses: its effects on hemagglutination and sialidase activities" doc
... concentrations Binding of influenza A viruses to sialoglycopolymers and guinea pig erythrocytes and inhibition by PVP-I In agreement with hemagglutinins from avian and human influenza viruses, ... determination of inhibition of HA binding, a 25-μl aliquot of fetuin or PVP-I serially diluted in PBS was preincubated with 25 μl of virus (4 HAU) in 96-well U-bottom plates at 4°C for h Hemagglutination ... PVP-I inhibits influenza A virus sialidase activity was investigated by determining kinetic parameters of human A/PR/8/34 (H1N1) sialidase on hydrolysis of MUNA in the absence and presence of an inhibitor...
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báo cáo khoa học: " Synthetic xylan-binding modules for mapping of pulp fibres and wood sections" ppt
... comparison to staining of mature (normal) birch and pine tissues (Figure 4E – H) In normal pine sections, X-2 binding was mainly detected in border pit regions (earlywood) and inner surface of cells ... approach and report on the application of a range of engineered xylan-binding CBMs for targeting xylan in wood (birch and pine) sections and on the surface of birch kraft pulp fibres The advantages of ... biotechnological processing Relative affinity (%) wt CBM4-2 X-2 X-6 X-13 binding mechanism of many xylan-binding CBMs involves sandwiching of the ligand, which then requires access to both faces of the carbohydrate...
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Tìm thêm: xác định các mục tiêu của chương trình khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn xác định thời lượng học về mặt lí thuyết và thực tế tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra đối với đối tượng giảng viên và đối tượng quản lí khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct mở máy động cơ lồng sóc mở máy động cơ rôto dây quấn hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 sự cần thiết phải đầu tư xây dựng nhà máy phần 3 giới thiệu nguyên liệu từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008 chỉ tiêu chất lượng 9 tr 25