animal models of sugar and fat bingeing relationship to food addiction and increased body weight
Báo cáo khoa học: Recent insights into cerebral cavernous malformations: animal models of CCM and the human phenotype pptx
... This minireview explores the contributions of animal models to bridge this gap and add to our growing understanding of CCM pathophysiology Conservation of CCM genes The genes responsible for CCM ... development of numerous experimental animal models, as discussed below Human phenotype Although humans are generally not considered in the category of animal models of disease, one can view the field of ... al of the relevant cell types in the formation of vascular malformations in CCM is needed to put these studies into a physiological context Ultimately, the goal of all research into CCM is to...
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Báo cáo y học: " Characterization of protein tyrosine phosphatase H1 knockout mice in animal models of local and systemic inflammation" docx
... recorded and mean values of left and right paws were used as reaction index for the individual animal A cut-off of 25 seconds was used to avoid tissue damage in case of absence of response Automated ... leading to increased Bcl10, to NFκB pathway activation and IL8 production [25,26] CARR injection in the hind paw of the mouse is one of the most commonly used models of inflammation and inflammatory ... the activation of TRAF6 (TNF Receptor Associated Factor 6) and in the immediate activation of NFκ B, MAPK and JNK pathways, leading to the early production of pro-inflammatory cytokines as TNFα,...
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Báo cáo khoa học: "Acute renal failure – definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group" doc
... these principles and other guidelines for the use of animal models in the study of ARF Despite their limitations, animal models remain fundamental to improving our understanding of human ARF [28-30] ... applied to design of animal model Additional issues that must be considered to optimize the model Proper randomization of animals Models should be chosen on the basis of their relevance to the ... [28-30] There are three basic types of animal models in use for study of ARF: ischemia; toxins and sepsis models; and several subtypes Each has its own advantages and disadvantages, which are summarized...
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Tài liệu Báo cáo khoa học: Animal models of amyloid-b-related pathologies in Alzheimer’s disease docx
... 1391 Animal models of Alzheimer’s disease O Philipson et al Transgenic animal models Models devoid of any disease-causing APP mutations Animal models expressing wild-type (wt) human APP are of ... with animal models of AD Concluding remarks and future perspectives Transgenic techniques have revolutionized our ability to develop animal models of AD, and also contributed significantly to the ... accumulation of CAA in leptomeningeal and cortical vessels with few diffuse plaques, severe loss of SMCs, weakening of vessel walls leading to hemorrhage and perivascular microgliosis and astrocytosis...
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Tài liệu Báo cáo Y học: Short peptides are not reliable models of thermodynamic and kinetic properties of the N-terminal metal binding site in serum albumin doc
... Wroclaw Stock solutions of NiCl2 and CuCl2 were standardized gravimetrically with dimethylglyoxime and complexometrically with EDTA, respectively Concentrations of stock solutions of HSA and BSA ... Tables and thus present only the novel data: protonation constants for DAHKam and VIHN, and stability constants (log a values) of Cu(II)-VIHN, Cu-DAHKam and Ni-DAHKam systems The parameters of CD and ... values) of Ni(II) and Cu(II) complexes of peptides at I = 0.1 M (KNO3) and 25 C Standard deviations on the last digits are given in parentheses EPR The X-band EPR spectra of Cu(II) complexes of VIHN...
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Báo cáo khoa học: "Corpus-Based Induction of Syntactic Structure: Models of Dependency and Constituency" pdf
... each side of a head is always the special symbol STOP Models like Paskin (2002) avoid modeling STOP by generating the graph skeleton G first, uniformly at random, then populating the words of s conditioned ... its right stop to so Figure 4(c) and figure 4(d) show the sealing operations, where STOP derivation steps are generated The left and right marks on node labels represent left and right STOPs that ... fraction of parses of s with a node labeled x extending from position i to position j The model can be re-estimated from these counts For example, to re-estimate an entry of PSTOP (STOP |h, left,...
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báo cáo hóa học:" Immunological considerations of modern animal models of malignant primary brain tumors" doc
... demonstrate increased resistance to radiation induced apoptosis [38,39], and p53 deficiency alters autoantibody levels in models of autoimmunity [40] as well as reduces mast cell susceptibility to IFN-γ ... investigators to alter the function of specific genes of interest and thus exploit defined genetic lesions to produce more biologically correct models of CNS cancers that result from activation and/ or ... expansion of activated lymphocytes, and the ability of leukocytes to respond to cytokines, rely on the proper functioning of the genes that have been modified in developing transgenic mouse models...
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Báo cáo y học: " In vivo imaging approaches in animal models of rheumatoid arthritis" pot
... of tissue [8] In vivo studies on autoantibody involvement in human rheumatoid arthritis are thus possible An alternative mode of imaging is the use of single photon imaging of γ-emitting isotopes ... applied to studies on cell transfer in the murine autoimmune disease model experimental autoimmune encephalitis [2] and has been applied to examination of transcription factor nuclear factor-κB ... 111In or 99Tc Imaging of γ-emitting isotopes is referred to as single photon emission commuted tomography This approach as been used to follow isotope-labeled materials in joints of arthritis patients...
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Báo cáo y học: " Gene therapy in animal models of rheumatoid arthritis: are we ready for the patients" pdf
... therapeutic strategies of restoring the cytokine balance and genetic synovectomy in animal models of RA, as summarized in Figs and Restoring the cytokine balance 184 In animal models of arthritis it ... approaches to arthritis In cytokine targeting, the objective is to restore the (local) cytokine balance in arthritis in order to silence the inflammatory process and/ or to stop the destruction of cartilage ... adenovirally transduced to express FasL to eradicate antigen specific T-cells and TACI (transmembrane activator and calcium modulator and cyclophilin ligand interactor) to block antigen specific...
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Báo cáo y học: "Role of fibroblast growth factor 8 (FGF8) in animal models of osteoarthritis" doc
... injection of FGF8 causes degradation of the ECM of the articular cartilage and release of S-GAG into the synovial fluid In addition, the injection of FGF8 decreased the bone weight of the patella to ... splicing of loop III of FGFR1 to FGFR3 leads to distinct functional variants (IIIb and IIIc) that have different ligand-binding specificities and affinities FGF8 can bind to three receptors – FGFR2IIIc, ... the potential use of anti-FGF8 antibody in the treatment of articular tissue degradation and pain in OA An anti-FGF8 antibody is expected to attenuate the symptoms of rheumatoid arthritis We...
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Báo cáo y học: "Colony variability under the spotlight in animal models of arthritis" pps
... same inbred strain of mouse, the universally studied BALB/c, which is the most susceptible to PGIA The goal of the research was to compare the incidence and severity of PGIA and proteoglycan-induced ... proteoglycan-induced spondylitis and to determine expression patterns of a panel of relevant genes in a large number of distinct colonies of the susceptible mouse strain BALB/c Although induction of disease by ... epidemiology of rheumatoid arthritis Curr Opin Rheumatol 2006, 18:141-146 van der Helm-van Mil AH, Huizinga TW: Advances in the genetics of rheumatoid arthritis point to subclassification into distinct...
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Báo cáo y học: "Lessons from animal models of arthritis over the past decade" pot
... References Conclusion Models are tools that mimic aspects of human disease It is clear that animal models have contributed considerably to further our understanding of arthritic processes and concomitant ... role of autoantibodies in RA has shifted the interest of researchers to passive IC models such 10 11 12 13 14 The Scientific Basis of Rheumatology: A Decade of Progress This article is part of ... amounts of ICs are needed to stimulate inflammatory mediator release from phagocytes It is likely that IC models mimic part of the RA pathology There is growing interest in the use of passive IC models, ...
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Báo cáo sinh học: "Estimating variances and covariances for bivariate animal models using scaling and transformation" pot
... !2, and so a scaled vector of x can be found to satisfy [Al] function of x and Aj z Hence vectors S can be calculated to satisfy [11] Each vector can be i substituted into !11! in order to find ... elements in common, and the random effects u , i 2 l , l u e and e normally distributed The vectors Yl and y are of length n and n and matrices X X Z and Z are of size n t n x m and n x m Our 2 , x, ... models Model The first and simplest model is of the form with and var(e l ) l and var(e I and e and e are uncorrelated, and the ) e Q ’;1 fixed effects #i and (3 have no elements in common, and...
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Báo cáo y học: "Acute pressure overload of the right ventricle. Comparison of two models of right-left shunt. Pulmonary artery to left atrium and right atrium to left atrium: experimental study" doc
... the size of the opening made with standard balloon septostomy techniques is imprecise and variable from patient to patient The mortality rate is relatively high and sometimes related to severe ... baseline to 10 minute of the pCO2 of the left atrium variable (p = 0.016) and the percentage change from baseline to 20 minute of the pCO2 of the left atrium variable (p = 0.023) Least, the pO2 of ... pressure overload of the right ventricle Comparison of two models of right-left shunt Pulmonary artery to left atrium and right atrium to left atrium: experimental study Journal of Cardiothoracic...
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báo cáo khoa học: " Models of the human metabolic network: aiming to reconcile metabolomics and genomics" pps
... systems together, with hormone signaling, nutrient and O2 delivery, and metabolite and CO2 disposal, as relevant to all tissues On the other hand, there appear to be few signs that models of human ... subjected to the most detailed biochemical analysis and computer modeling of all known cell types, and has been a fruitful guide to the future of metabolic simulations and quantitative analysis of metabolic ... [22] And there is another subtlety: not all sites Page of in an end product of a metabolite may ever be labeled because of the particular subset of combinatorial shuf fling of carbon atoms at...
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Báo cáo y học: " First Siena International Conference on Animal Models of " pptx
... and userfriendly to the experimentalist Animal models that may be of great benefit to the study of the mechanisms involved in the development of COPD were described The importance of animal and ... months in some species) and the importance of the choice of animal and strain Of people who smoke 15–20% develop COPD, and the lesions produced in these models are similar to those observed in humans ... discussed a variety of other animal models and outlined the approaches necessary to develop drugs for the treatment of COPD Mechanistic models that mimic certain aspects of the disease are widely...
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Báo cáo khoa học: "Beneficial effects of erythropoietin in preclinical models of shock and organ failure" ppsx
... EPO, which have been reported in other models of disease [11] Thus, the beneficial effects of EPO in rodent models of endotoxaemia may vary with doses of EPO and LPS, as well as species (rat or ... Thiemermann Thus, Mitra and coworkers [10] concluded that the observed beneficial effects of EPO in murine endotoxaemia are secondary to both antioxidant and anti-inflammatory effects of EPO, which have ... period of days [12] The reported beneficial effects of EPO in preclinical models of shock, trauma and haemorrhage are exciting, but further studies are warranted to determine the effects of EPO...
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Báo cáo y học: "Animal models of copper-associated liver disease" doc
... hepatitis, and cirrhosis [1] Animal models of Wilson's disease The LEC rat [36] and the toxic milk mouse are the only known valid animal models of Wilson's disease [11,37] Animal models of Wilson's ... necrosis [54], mitosis of hepatocytes [36], and apoptosis [56] After this stage, surviving rats develop chronic hepatitis, cholangiofibrosis, preneoplastic foci and nodules, and hepatocellular carcinomas ... a week of the onset of jaundice [36] Histological changes of acute hepatitis in LEC rats occur prior to weeks of age, and the most drastic changes occur from 17 to 20 weeks of age [36] A recent...
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Báo cáo y học: "New animal models for evolution and development" pdf
... the posterior) end of the embryo to take advantage of, or to make possible, its long germ-band mode of development Michalis Averof (Institute of Molecular Biology and Biotechnology (IMBB), Crete, ... inactivation leads to severe perturbation of expression of the early segmentation genes engrailed and even-skipped Averof’s group, together with Reinhard Schröder’s group at the University of Tübingen ... population of ciliary photoreceptor cells that was present in the brains of ancient bilaterians It has been estimated that more than half of all known animal species are parasitic at some stage of their...
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Anti inflammatory effects of inhibitors of the tyrosine kinase signaling cascade in animal models of asthma
... activation of these pathways leads eventually to mast cell degranulation, synthesis and release of lipid mediators (e.g CysLTs and PAF), and the production and secretion of cytokines, chemokines and ... (Th2 cells), together with other inflammatory cells such as mast cells, B cells and eosinophils, and inflammatory cytokines and chemokines (Busse and Lemanske, 2001; Herrick and Bottomly, 2003) ... PLCγ2 leads to the release of intracellular Ca2+ and activation of PKC, which subsequently induce the activation of MAPKs, and transcription factors, including NFκB and nuclear factor of activated...
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