and six membered derivatives linked to pyrimidines or purines induce apoptosis of human metastatic breast cancer mcf 7 cells in vitro
Báo cáo y học: " Systems-level comparison of host responses induced by pandemic and seasonal influenza A H1N1 viruses in primary human type I-like alveolar epithelial cells in vitro" pdf
... Respiratory Research 2010, 11:1 47 http://respiratory-research.com/content/11/1/1 47 Page of InnateDB in order to identify transcription factors involved in the regulation of seasonal-, pandemic- and ... consisting of IL10R2 and IFNlR1 Upon binding of IFNs, corresponding receptor subunits dimerize to form the receptor complex and activate the JAK-STAT signalling pathway, which then results in downstream ... H1N1 influenza virus (but not pdmH1N1) encode zinc finger proteins, including ZNF 175 ZNF 175 contains 13 zinc fingers and a KRAB domain, for a motif known to be associated with Lee et al Respiratory...
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Báo cáo y học: "F-18 fluorodeoxyglucose positron emission tomography and/or computed tomography findings of an unusual breast lymphoma case and concurrent cervical cancer: a case report" docx
... Authors’ contributions NCN is the senior author and was involved in collecting patient information, reviewing the literature and doing the final proofreading of the manuscript CNH was involved in ... PET/CT, and can be of value for treatment planning FDG PET has been used in initial staging and monitoring of therapy in patients with cervical cancer [ 17] In a review article, the sensitivity and ... primary breast non-Hodgkin’s lymphoma Clin Nucl Med 2001, 26:299-301 Nihashi T, Hayasaka K, Itou T, Ito K, Kato R, Okae T, Ishigaki T: Findings of fluorine-18-FDG PET in extranodal origin lymphoma in...
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báo cáo khoa học: " Using transcriptomics to identify and validate novel biomarkers of human skeletal muscle cancer cachexia" pdf
... receptor tyrosine kinase Tie1 activates phosphatidylinositol 3-kinase and Akt to inhibit apoptosis Mol Cell Biol 2002, 22: 170 4- 171 3 Chan B, Sukhatme VP: Suppression of Tie-1 in endothelial cells in ... sepsis-induced degeneration or exercise training status Error bars represent SEM pathways of TIE1 are poorly understood, this receptor can interact with phosphoinositide 3-kinase and lead to phosphorylation ... including study of the UPP and autophagy systems, we sought to carry out both targeted and global molecular profiling in the skeletal muscle of cancer patients and relate our findings to clinical status...
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Applying macromolecular crowding to promote the expansion and adipogenic differentiation of human mesenchymal stem cells in vitro; an effect of matrix reciprocity
... interactions of integrins Cell Tissue Res (3):285-298 41 Mould AP, Askari JA, Aota SI, et al 19 97; Defining the topology of integrin alpha5beta1-fibronectin interactions using inhibitory anti-alpha5 and ... receptors for extracellular matrix: cooperative processing of extracellular information Curr Opin Cell Biol (5) :77 278 1 19 Farias E, Lu M, Li X, et al 2005;Integrin alpha8beta1-fibronectin interactions ... Hildebrand A, Romarís M, Rasmussen LM, et al 1994;Interaction of the small interstitial proteoglycans biglycan, decorin and fibromodulin with transforming growth factor beta Biochem J :5 275 34 24...
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Is complementary and alternative medicine (CAM) used to combat medical costs a study of consumers, medical professionals, and a CAM practitioner
... exclusion, or rarity, of CAM use within the industry is most likely a business decision by corporate elites in the industry to maintain control and profitability -decisions which profoundly influence ... becoming more willing to accept authorities on CAM as authorities on health and healing All of these factors would theoretically influence how individuals view CAM practitioners and CAM, in general ... roles or without performing for others In every interaction individuals give off impressions to others, and the ways in which people interact can have specific meanings In any interaction, humans...
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Tài liệu Báo cáo khoa học: The crystal structure of human a-amino-b-carboxymuconatee-semialdehyde decarboxylase in complex with 1,3-dihydroxyacetonephosphate suggests a regulatory link between NAD synthesis and glycolysis ppt
... ACMSD in a ligand-bound form and can be used to provide insights into catalysis In particular, the residues involved in inhibitor binding can be suggested to be important players for recognition of ... progress of human HIV-1 infection in vitro [10], and to activate macrophages in proinflammatory processes [11] Most recently, abnormally high brain levels of PA have been reported in a murine model of ... mechanism is still incomplete In light of the reported ACMSD upregulation in the liver of streptozotocin-induced diabetic rats and the suppression of such elevation following insulin injection [21,22],...
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Tài liệu Báo cáo khoa học: Identification of different isoforms of eEF1A in the nuclear fraction of human T-lymphoblastic cancer cell line specifically binding to aptameric cytotoxic GT oligomers ppt
... Characterization of eEF1A in normal and cancer cells In order to compare the binding properties of the nuclear eEF1A in normal cells compared with those in cancer CCRF-CEM cells, human lymphocytes were ... exerted by cytotoxic GT oligomers and their selective binding to nuclear eEF1A In fact, in normal human lymphocytes no appreciable binding of GT oligomer to nuclear eEF1A was shown and, accordingly, ... (Eur J Biochem 270 ) normalizing the quantities of loaded proteins on a Coomassie-stained gel by referring to the P1 band (known to correspond to eEF1A) As reported in Fig 7A, in the CCRF-CEM...
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Báo cáo khoa học: Activator-binding domains of the SWI ⁄ SNF chromatin remodeling complex characterized in vitro are required for its recruitment to promoters in vivo pot
... approximately 50% in strains lacking either the Swi1 or the Snf5 activator-binding domains (Fig 3) In the strain lacking both activatorbinding domains, the level of SWI ⁄ SNF recruitment is reduced to background ... snf5) lacking both activator-binding domains (SWI1D329-655, SNF5D2-3 27) , strain YPP211 (white bars, DABDsnf5) lacking the Snf5 activator-binding domain (SNF5D2-3 27) and strain YPP2 47 (dark grey ... lacking the Snf5 activator-binding domain (SNF5D2-3 27) and strain YPP2 47 (dark grey bars, DABDswi1) lacking the Swi1 activator-binding domain (SWI1D329-655), relative to the wild-type tested in...
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Báo cáo khoa học: Bridging the gap between in silico and cell-based analysis of the nuclear factor-jB signaling pathway by in vitro studies of IKK2 ppt
... exposure of cells to a multitude of external stimuli, including the cytokines tumor necrosis factor (TNF-a) and interleukin-1a (IL-1a), thus initiating numerous and diverse intracellular signaling ... number of target genes encoding regulators of immune and inammatory responses and also genes involved in apoptosis and cell proliferation [36] In this paper, we report the results of cell-based, in ... of the untreated cells in terms of their frequency The effects of exposing the cells to the inhibitor were slight, amounting to a modest reduction in amplitude and a delay in the rst oscillatory...
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Báo cáo khoa học: Curcumin suppresses the dynamic instability of microtubules, activates the mitotic checkpoint and induces apoptosis in MCF-7 cells ppt
... apoptosis in MCF- 7 cells [10] Curcumin is found to induce apoptosis in several cell lines [1 ,7, 10] It stimulated Bax-mediated p53-dependent apoptosis in MCF- 7 cells [10] Curcumin promotes the action of ... curcumin has been found to bind to purified tubulin, to inhibit tubulin polymerization in vitro and to depolymerize microtubules in HeLa and MCF- 7 cells in culture [12] In addition, curcumin has ... Curcumin induced apoptosis in MCF- 7 cells MCF- 7 cells were incubated with 0.1% dimethylsulfoxide (control) and different concentrations (12–36 lM) of curcumin for 48 h and then stained with Annexin...
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Báo cáo khoa học: Structural studies of the capsular polysaccharide and lipopolysaccharide O-antigen of Aeromonas salmonicida strain 80204-1 produced under in vitro and in vivo growth conditions docx
... and O-chain LPS are composed of linear trisaccharide repeating units containing 3 -linked 2-acetamido-2-deoxy-D-quinovose, 4 -linked 3-[(N-acetyl-L-alanyl) amido]-3-deoxy-D-quinovose and 3 -linked ... 4.43 71 .0 3.29 77 .4 3.35 80.5 4.12 72 .9 3.34 72 .6 3.56 73 .3 176 .0 4.32 49.3 3.65 55 .7 3.33 72 .5 4.42 50.8 5.31 100.3 4.66 99.5 4.20 50.9 4.03 53.8 3.93 68.2 3 .75 80.5 4.32 70 .6 3.42 77 .4 4.52 72 .6 ... determined following the hydrolysis of the carboxyl-reduced CPS Presence of L-alanine was confirmed by amino acid analysis For this, 0.6 mg of CPS was hydrolysed in 5 .7 M hydrochloric acid containing...
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báo cáo hóa học:" Rat model of metastatic breast cancer monitored by MRI at 3 tesla and bioluminescence imaging with histological correlation" ppt
... Vectastain® Elite ABC Kit was used to detect the human breast cancer cells Immunostaining kits were purchased from Vector laboratories (Vector Laboratories, Inc., Burlingame, CA) Sections were incubated ... were obtained and stained with hematoxylin and eosin of brain and other organs that had photon flux activity on pre-terminal BLI Histological sections were of the brain were obtained in approximately ... with protamine sulfate [12-21] in order to monitor the early implantation of tumor cells in the brain and to determine the sensitivity of T2* weighted tesla MRI to the labeled cells and the subsequent...
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báo cáo hóa học: " Does quality of life among breast cancer survivors one year after diagnosis differ depending on urban and non-urban residence? A comparative study" potx
... surveys, of which 272 7 contained QOL information Analyses reported in this paper include women for whom QOL data were available and who had no prior history of breast cancer, with 675 living in urban ... eight or more points in mean FACT-B+4 scores, five or more points in mean FACT-G scores, three or more points on the breast cancer concerns subscale and two or more points for all other Page of 10 ... generalizable to the wider population of breast cancer survivors Further, QOL of survivors were compared to peers without breast cancer, including matching for place of residence, allowing for more accurate...
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Báo cáo hóa học: " CdTe quantum dots with daunorubicin induce apoptosis of multidrug-resistant human hepatoma HepG2/ADM cells: in vitro and in vivo evaluation" pptx
... uptake of the DNR into HepG2/ADM cells Staining and flow cytometry analysis to detect apoptosis Using acridine orange/ethidium bromide (AO/EB) dye mixture staining for apoptotic cells, apoptotic ... DNR-mediated apoptosis in HepG2r/ADM cells, we investigated apoptosis- related protein expression in the cells (Figure 6C) DNR or Cdte QDs cannot induce apoptosis strongly in HepG2r/ADM cells due to multidrug ... cancer cells J Nanosci Nanotechnol 2008, 8:2301-23 07 Raffray M, Cohen GM: Apoptosis and necrosis in toxicology: a continuum or distinct modes of cell death? Pharmacol Ther 19 97, 75 :153- 177 Linder...
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Báo cáo hóa học: " Novel Strategy to Fabricate PLA/Au Nanocomposites as an Efficient Drug Carrier for Human Leukemia Cells in Vitro" pdf
... and incubated together for more than 12 h to form the PLA/Au nanocomposites The solution of daunorubicin (3.3 × 10 -4 mol/L) was mixed into the nanocomposites and stored in the dark at 4°C for ... at 37 C in a humidified atmosphere containing 5% CO2, while μg/mL doxorubicin was contained in the culture to maintain K562/AO2 cells drug resistance in its daily culture The inhibition of cell ... was incubated for 48 h in a 5% CO2 incubators at 37 C, and then 20 μL of mg/mL MTT was added to the wells and incubated for an additional h Subsequently, it was centrifuged at 1,000 rpm for 10 and...
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Báo cáo khoa học: "A paraneoplastic manifestation of metastatic breast cancer responding to endocrine therapy: a case report" ppsx
... caused by cancer but are not due directly to local infiltration or metastatic spread They are thought to be due to either inappropriate secretion of hormones or the production of anti-tumoral antibodies ... illustrating the need for physicians to maintain a high index of suspicion for paraneoplastic syndromes in women presenting with unusual neurological symptoms with no obvious cause In breast cancer patients ... patient responding to an aromatase inhibitor This suggests that endocrine therapy may be an appropriate treatment for the paraneoplastic manifestations of breast cancer in patients with hormone responsive...
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Báo cáo khoa học: "Effects of propranolol in combination with radiation on apoptosis and survival of gastric cancer cells in vitro" ppsx
... of Figure Apoptosis induction by isoproterenol or propranolol in combination with irradiation in BGC-823 and SGC -79 01 cells There was an increasing rate of apoptosis in gastric cancer cell lines ... Analysis of the data and plotting of the figures were performed with the aid of software (Origin Version 7. 5 and SPSS Version 13.0) Results Expression of b1- and b2-adrenergic receptors in SGC7901 and ... promoting apoptosis To determine whether the radiosensitizing effect of propranolol is mediated by apoptosis, the effect of propranolol on the induction of apoptosis was examined using flow cytometric...
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Báo cáo khoa học: " No supra-additive effects of goserelin and radiotherapy on clonogenic survival of prostate carcinoma cells in vitro" ppsx
... C: Gonadotropinreleasing hormone type II antagonists induce apoptotic cell death in human endometrial and ovarian cancer cells in vitro and in vivo Cancer Res 20 07, 67: 175 0- 175 6 Dobkin-Bekman M, ... Antiproliferative effects of luteinizing hormone-releasing hormone (LHRH) agonists on human androgen-independent prostate cancer cell line DU 145: evidence for an autocrineinhibitory LHRH loop Cancer Res 1994, ... Goserelin incubation and irradiation induced the expression of phosphorylated ERK1/2 in LNCaP cells In PC-3, only the combination of irradiation and goserelin increased the level of phosphorylated...
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Báo cáo y học: "Cyclooxygenase inhibition lowers prostaglandin E2 release from articular cartilage and reduces apoptosis but not proteoglycan degradation following an impact load in vitro" ppt
... stimulates incorporation of proline into collagenase digestible proteins in human articular chondrocytes: identification of an effector autocrine loop involving insulin-like growth factor I Mol ... following traumatic injury The inhibition by COX inhibitors of PGE2 release following trauma may provide an opportunity for early clinical intervention to reduce cell death from apoptosis Our in vitro ... from apoptosis induced by actinomycin-D [48] In addition, PGE2 is a chondrocyte growth inhibitor that requires NO for its production [49], and both PGE2 and NO are downstream mediators of IL-1...
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Báo cáo y học: "Two specific drugs, BMS-345541 and purvalanol A induce apoptosis of HTLV-1 infected cells through inhibition of the NF-kappaB and cell cycle pathways" ppsx
... better insights into how to inhibit HTLV-1 infected cells We sought to identify the targets of a range of NF-κB and CDK inhibitors in HTLV-1 infected and uninfected cells by culturing MT-2, MT-4, ... Induction Page 15 of 16 (page number not for citation purposes) AIDS Research and Therapy 2008, 5:12 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 of endonuclease-mediated apoptosis in tumor ... classes of inhibitors against one another In Table 1, they are ranked as high, moderate, and poor inhibitors and the reported activities of these molecules against variety of CDKs and IKKs are indicated...
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