an important clue to tumor suppressors involved in tumor susceptibility
Báo cáo khoa học: Immunonanoparticles ) an effective tool to impair harmful proteolysis in invasive breast tumor cells docx
... PLGA polymeric nanoparticles, potent protease inhibitor cystatin and a specific anti-cytokeratin monoclonal IgG, which can be internalized into cells, contributes specific targeting to invasive breast ... cystatin for h prior the analysis Internalization of nanoparticles into MCF-10A neoT can be seen as a shift in fluorescence intensity (thick line) in comparison to MCF-10A neoT cells grown in the ... against these antigens and used in cell targeting are only as specific as the expression of the antigen itself The other approach to raising antibodies, specific to tumor cells is to apply tumor...
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Báo cáo khoa học: An E3 ubiquitin ligase, Synoviolin, is involved in the degradation of immature nicastrin, and regulates the production of amyloid b-protein doc
... Synoviolin were found to include polyglutamine-expanded huntingtin [18], the tumor suppressor Synoviolin is involved in the degradation of nicastrin gene p53 [19] and Parkin-associated endothelin ... results were obtained from three independent experiments m integrin b1, mature integrin b1; im integrin b1, immature integrin b1 Right panel: the band intensities were quantified, and the percentage ... specificity to the ubiquitin system by directly interacting with the substrate proteins and helping to transfer ubiquitin to them Therefore, to determine whether NCT is the substrate of Synoviolin, we...
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Astrology, Psychology, and The Four Elements An Energy Approach to Astrology & Its Use in the Counseling Arts_1 pptx
... a minimum of meaning And it is meaning that man needs; and an understanding of man's need for meaning is necessary to any psychology of health and whole' ness Meaning is provided from within, ... my thanks also to Jim Feil, Dr Pierre Pannetier, and Dr Randolph Stone for helping me to gain some degree of insight into the workings of the four elements, and also to the many friends and students ... becoming in any way more shadowy or insubstantial than heretofore, or through mind becoming resolved into a function of the working of matter, but through substantial matter resolving itselfinto...
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Astrology, Psychology, and The Four Elements An Energy Approach to Astrology & Its Use in the Counseling Arts_2 pdf
... tinue to operate within and through an individual person during the course ofhis entire life Ifanything in astrology can be said to be "fated" or predetermined, it is this initial attunement to ... these planets in Aries In analyzing the balance or imbalance of the elements in an individual's chart, therefore, one should not be too hasty in making generalizations One chart factor can alter ... since they were meeting many obstaclesin their attempt to comprehend this important segment of the astrological language It seems to me that the main problem in coming to grips with the meaning...
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Using formative evaluation in an implementation project to increase vaccination rates in high-risk veterans: QUERI Series docx
... center and their willingness to answer questions [9] More than one informant was interviewed for the CCR for influenza and standing orders interventions [Standing orders (for this project): a protocol ... intervention When informants answered questions and provided information during interviews, the interviewer followed up in order to clarify responses and to determine additional information to be gathered ... used in this project to address the processes of implementing and enhancing adoption of multi-targeted interventions selected to increase vaccination rates for respiratory illnesses in veterans...
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báo cáo khoa học: "A microarray approach to identify genes involved in seed-pericarp cross-talk and development in peach" ppt
... signal efficiently transported to and within the mesocarp An Aux/IAA-encoding gene (ctg358) showed an opposite transcription profile in the two organs, being abundant in ES and LM It has been demonstrated ... negligible during late development ABA is known to play an antagonistic role with respect to auxin, GAs and CKs, as observed during fruit development in avocado [40] and tomato [41,42] According to the ... [17] It is interesting to note that in cv Springcrest, the down-regulation of ctg1026 at S3 and S4 occurs at a slower rate than in Fantasia and slr, thus confirming the uncoupling of seed and mesocarp...
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báo cáo khoa học: " Using formative evaluation in an implementation project to increase vaccination rates in high-risk veterans: QUERI Series" pps
... center and their willingness to answer questions [9] More than one informant was interviewed for the CCR for influenza and standing orders interventions [Standing orders (for this project): a protocol ... intervention When informants answered questions and provided information during interviews, the interviewer followed up in order to clarify responses and to determine additional information to be gathered ... used in this project to address the processes of implementing and enhancing adoption of multi-targeted interventions selected to increase vaccination rates for respiratory illnesses in veterans...
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Báo cáo y học: "Evaluating the efficacy of sequential biologic therapies for rheumatoid arthritis patients with an inadequate response to tumor necrosis factor-a inhibitor" ppsx
... response to treatment and number of failed TNF-a inhibitors is likely to play an increasingly important role in defining treatment strategies for RA patients who have had an inadequate response to ... Intravenous infusion every weeks Anakinra (Kineret, 2001) Recombinant IL-1 receptor antagonist that inhibits the binding of IL-1 to its receptor, thereby allowing regulation of IL-1 activity Subcutaneous ... Ichinose K, Kamachi M, Yamasaki S, Nakamura H, Origuchi T, Ida H, Eguchi K: Switching to the anti-interleukin-6 receptor antibody tocilizumab in rheumatoid arthritis patients refractory to antitumor...
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Báo cáo y học: "Evaluating the efficacy of sequential biologic therapies for rheumatoid arthritis patients with an inadequate response to tumor necrosis factor-a inhibitor" pps
... the potential to induce anti-dsDNA antibodies were found, namely, drugs and fever indicating an unknown infection Combining Anti-dsDNA-NcX test results and medical history with consequent exclusion ... (dsDNA) and the anti-dsDNA nucleosome ELISA (Nuc) and their combined intersections are shown (B) The same analysis as in Figure 2A is shown, including different detection techniques using Anti-dsDNANcX ... regard to any feature was always found for increased values of autoantibody assays The number of patients with a positive finding (ACR and SLEDAI 2000) or an abnormal finding (local laboratory)...
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Báo cáo y học: " Transcriptional profiling of inductive mesenchyme to identify molecules involved in prostate development and disease" ppsx
... growth factor (FGF), Notch, and transforming growth factor-β are also active The inductive mesenchyme involved in organ induction goes on to form signaling centers that are involved in growth and differentiation ... compartment is involved in the induction and organogenesis of various organs, including lung, limb, kidney, pancreas, prostate, and mammary gland In general, the process of organ induction begins with ... amplified and cloned into the pCR4-TOPO vector (Invitrogen) Sense and anti-sense probes were transcribed and labeled with digoxigenin using T7 and T3 RNA polymerase Dissected tissues were fixed in 4%...
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Báo cáo y học: "A novel scheme to assess factors involved in the reproducibility of DNA-microarray data" pdf
... electron transport Salvage of nucleosides and nucleotides Cell envelope, murein sacculus and peptidoglycan Transport and binding protein; amino acids, peptides and amines Glutamate family; Proline biosynthesis ... transcriptase enzyme for the Cy3 label and (ii) prolonged exposure to air and light of the dyes increasing the chance of oxidation and / or bleaching The main contributing factors identified in ... decreased with 16.1 % to 14.9 %, with the variance in the VG interaction remaining virtually unchanged By combining S2 and S3, the Gene × Array interactions occurring specifically on S2 and S3 are pooled...
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Báo cáo y học: "An innovative method to evaluate the suture compliance in sealing the surgical wound lip"
... no stain left after minutes, and that it takes minutes for the stain to move from one phase to another, i.e strong stain, then weaker stain Moreover, there is currently no commercial stain which, ... Corporation; Tokyo, Japan), an image analysis processor (Matrox; Montreal, QC, Canada), and a personal computer (Pentium 2, 166-MHZ processor; Intel; Santa Clara, CA) Clinical study Linear skin suture ... area of the stain at different time intervals (T0 = minute, T2 = minutes, T4 = minutes, T6 = minutes, and T8 = minutes) There was significant difference in the permeability of the stain through the...
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A methodology for validation of integrated systems models with an application to coastal-zone management in south-west sulawesi
... joining or combining something with something else The integrated approach is a way of perceiving and solving problems by integrating information, scientific disciplines, tools, interests and ... These phases include the following activities: defining public concern, determining multiple issues, defining measurable indicators, and interpreting information on measured indicators to derive ... as the change in an output y induced by a relative change in an input xi (e.g an increment of 10 kg BOD/day of the total BOD load to the coastal sea is induced by a 33 % decrease in the total water...
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USING BRAND AS AN EFFECTIVE WEAPON TO COMPETE IN THE MARKET: A CASE STUDY OF NHAT LINH COMPANY
... and maintain a strong brand To understand more how a company builds and manages its brand to get the full benefit from that, a study into the case of LiOA brand at Nhat Linh Co Ltd., an auto voltage ... fundamental change Step 5: Planning and evaluating performance Planning and tracking activities are designed to provide the following: • A clear plan for timing and objectives (in consumer terms) ... being reflected in brand position statement: augmenting an image, reinforcing an image or diffusing an image (4) Demonstrate an advantage 12 Finally, brand position should demonstrate an advantage...
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Hydrophytes may play an important role in sewage disinfection in constructed wetlands
... mg·L-1, respectively In conclusion, P hydropiper may play an important role in sewage disinfection in CWs, but its living inhibiting pathogenic micro-organisms in the ecosystem need to be further studied ... Guatemalan plants extracts as virucides against HIV-1 infection, J of Phytomedicine., 15: 520~524 Zhou Y X and Zhang Z S (1989) Toxic Methods of Aquatics Beijing, Agricultural Publishing Company ... showed significant antibacterial and antifungal activities Shen J G et al (2007) studied the anti-tobacco mosaic virus (TMV) about Ailanthus altissma and Brucea javanica, and indicated that their...
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An Integrated Approach to Teaching Literature in the EFL Classroom
... response to literature itself which is important Interpretation of texts by learners can bring about personal responses from readers by touching on significant and engaging themes An integrated ... Interpretation and Personal Response The focus of this final step is on increasing understanding, enhancing enjoyment of the text and enabling learners to come to their own personal interpretation ... are used to interpret literary discourse are essentially the same for interpreting any type of discourse Approaches to Teaching Literature Having decided that integrating literature into the EFL...
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An integration of the four english skills in teaching reading texts to beginner learners at asemlink international language centre
... Integrating the four skills in teaching means to combine the four skills in the teaching activities Using the integrated appoach to language teaching will bring the natural interaction in the language ... defined it as a preferred way of thinking, processing, and understanding information (p.31) It refers to a person's characteristic style of acquiring and using information in learning and solving ... effectiveness Instructors of both reading and writing have in many cases already begun to offer integrated instruction that allows students to view writing and reading in the same rhetorial context.”...
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Tài liệu Báo cáo khoa học: Epidermal growth factor receptor in relation to tumor development: EGFR gene and cancer ppt
... ligand-binding domain; a transmembrane domain; an intracellular tyrosine kinase domain; and a C-terminal regulatory domain [2] The extracellular domain is subdivided further into four domains ... homology in the C-terminal regulatory domain are relatively low, being 33, 24 and 28%, respectively regulin and epigen); (b) those that bind to EGFR and ERBB4 (including betacellulin, heparin-binding ... (2006) Kinetic analysis of epidermal growth factor receptor somatic mutant proteins shows increased sensitivity to the epidermal growth factor receptor tyrosine kinase inhibitor, erlotinib Cancer...
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Tài liệu Báo cáo khoa học: Epidermal growth factor receptor in relation to tumor development: EGFR-targeted anticancer therapy doc
... cell membrane The binding of ligand to EGFR induces receptor dimerization and consequent conformational changes that result in activation of the intrinsic tyrosine kinase, receptor autophosphorylation ... (EGFR-TKIs), gefitinib and erlotinib, compete with ATP for binding to the tyrosine kinase pocket of the receptor, thereby inhibiting receptor tyrosine kinase activity and EGFR signaling pathways (Fig ... USA, in patients with adenocarcinoma than in those with other histological subtypes of cancer, and in individuals who have never smoked than in those with a history of smoking [10] These clinical...
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Tài liệu Báo cáo khoa học: EGF receptor in relation to tumor development: molecular basis of responsiveness of cancer cells to EGFR-targeting tyrosine kinase inhibitors docx
... gefitinib and erlotinib ineffective inhibitors of EGFR kinase activity, blocks gefitinb-induced up-regulation of Bim and apoptosis [38] These experiments point to an important role for the induction ... that MKP-1 plays an important role in resistance against many types of stresses, including anticancer drugs, in various cell lines MKP-1 may be a rational target to enhance anticancer drug activity ... malignant phenotype In keratinocyte and cutaneous squamous cancer cells, gefitinib blocks EGF-induced cytoskeleton remodeling and in vitro invasiveness, as well as cell growth [60] Gefitinib also...
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Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các mục tiêu của chương trình khảo sát chương trình đào tạo gắn với các giáo trình cụ thể xác định thời lượng học về mặt lí thuyết và thực tế tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra đối với đối tượng giảng viên và đối tượng quản lí khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến dòng điện stato i1 fi p2 động cơ điện không đồng bộ một pha thông tin liên lạc và các dịch vụ từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008 chỉ tiêu chất lượng 9 tr 25