america he worked with deaf mutes at boston university soon bell started experimenting with ways of transmitting speech over a long distance this led to the invention of telephone
... Scouts Association crossing the Atlantic Question 3: What are the Scouting groups that girls can join? The Girl Guides Association and the Camp Fire Boys and Girls Question 4: What are the three aims ... later an American businessman, William Boyce, got lost in London A boy helped him and explained that he was a scout This meeting ledtothe Scout Association crossing the Atlantic in 1910 Although ... tothe Scouts Association crossing the Atlantic in 1910? An American businessman, William Boyce got lost in London A boy helped him and explained that he was a scout This meeting ledtothe Scouts...
... the data ES created the figures and wrote the manuscript HJ and ME helped withthe statistical analysis RK and MAM oversaw the research, helped analyzed the data and edit the manuscript All authors ... independently associated with death, multivariate analyses were performed on variables that were associated with death in the exploratory bivariate analyses or ofa priori interest These variables included: ... are presented as mean with standard deviation in parentheses Data presented in graphs are mean with error bars indicating the standard error ofthe mean (SEM) The odds ratios for death are calculated...
... solution was added to each well, the cells were incubated for another hours, and the absorbance at 450 nm was measured by using a microplate reader (BioTek Instruments) The amount ofthe formazan dye, ... have recently come under increasing scrutiny Arsenic trioxide may be a promising candidate for the treatment of other malignancies The combination therapy of arsenic trioxide and other chemotherapeutic ... had an upward trend and reached a peak at 12 hours and the difference as compared with hour was statistically significant (P < 0.05) By time, the activated Bax also presented an upward trend and...
... contribute to maintaining the RCL in a state witha relatively facilitated passage through the gate region during latency transition, via an effect on the conformation of b strand 5A and ofthe buried ... anilide substrate for uPA The amount of active PAI-1, and thus the specific inhibitory activity, was calculated from the total amount of PAI-1 that had to be present to inhibit half ofthe uPA ... shutter region affect the rate of latency transition by affecting the rate of passage ofthe RCL through the gate region Based on the aminoacid sequence ofthe RCL and b strand 5A being directly...
... between thea and b chains, resulting in the monophasic autoxidation rate overthe basic pH range Tothe acidic autoxidation, essentially the same explanation is valid At acidic pH, the displacing ... include a movement ofthe iron atom into the heme plane witha simultaneous change in the orientation ofthe proximal (F8) histidine, a rotation ofthe a1 b1 dimer relative tothe other a2 b2 dimer about ... ´ against the acidic autoxidation must have been produced by the formation ofthe a1 b1 or a2 b2 contact To see more quantitatively the effect ofthe a1 b1 or a2 b2 contact on the autoxidation reaction,...
... 5′-ATCGTGGGCGGGCACGAGGCG (at the beginning of exon 2, corresponding to bases +82 to +101 ofthe cDNA); and PR-3 ‘antisense’, 5′-GCGGCCAGGGAACGAAAGTGCA (at the end of exon 4, corresponding to bases ... RW, Masi AT, McShane DJ, Mills JA, Stevens MB, Wallace SL, Zvaifler NJ: The American College of Rheumatology 1990 criteria for the classification of Wegener´s granulomatosis Arthritis Rheum 1990, ... 23 24 25 26 Van der Woude FJ, Van Es LA, Daha MR: The role ofthe cANCA antigen in the pathogenesis of Wegener’s granulomatosis A hypothesis based on both humoral and cellular mechanisms Neth...
... inside the inflamed parenchyma The responses were more pronounced when MSC treatment was initiated early in the course ofthe disease Reversal with IL-2 treatment indicates that anergy rather than ... scarring tissue damage is often present On the other hand, MSCs may also actively participate in initiating AD [3], they have the potential to favour spread of melanoma metastases [4] and, although mostly ... stimulate T cells MSCs also inhibit the IL-1 and CD40 ligand induced maturation of immature into mature DCs Aggarwal and Pittenger [28] also demonstrated that MSCs cause immature DCs to decrease...
... (saline) All animals were killed with carbon dioxide atthe end ofthe observation period and subjected to necropsy Statistical analysis Data are expressed as the mean ± standard error ofthe ... this article provide a strong rationale for the clinical investigation of F8-IL10 as a novel biopharmaceutical for the therapy of patients with rheumatoid arthritis who have failed at least two ... relevant findings were observed in the blood biochemical parameters atthe end of week and atthe end ofthe treatment period in any groups Pharmacokinetic data were obtained during the toxicology...
... 13.3% Page of population differences in anatomy ofthe brachial plexus This variant anatomy is important in explaining the outcome of attempted subscapular block in hemiplegic patients with painful ... emerge as separate branches from the posterior cord (PC) In this specimen, the PC further gave rise tothe medial cutaneous nerve ofthe arm (Mcna) and medial cutaneous nerve ofthe forearm (Mcnfa) ... wide range of variation suggests Table Population variance ofthe incidence of axillary origin ofthe subscapular nerves AUTHOR POPULATION LowerUppersubscapular subscapular from Axillary from Axillary...
... compounds lead to excitotoxicity and calciummediated cell death Taken together, some data support the hypothesis that IDO pathway modulation plays a role in the pathophysiology of cytokine-induced depression ... methotrexate after three years Since the episode of angina, the patient was started on a daily regimen of low-dose aspirin at 75 mg and simvastatin at 40 mg He continued to take various non-steroidal ... modulate inflammatory pain Descending spinal serotonergic pathways from the medulla have long been implicated in the physiology of pain modulation Zhao et al [14] showed that knockout mice that lacked...
... participated in the design ofthe study and discussion of data analysis SS conceived ofthe study, participated in its design and coordination, and helped draft the manuscript All authors read ... AGGTCTTAT GGTGCTGTCAC-3', Anti sense: 5'- TGT Page of 12 GTAATTCTGCTCCTTCC -3'; β-actin, Sense: 5'-TG GAATCCTGTGGCATCCATGAAAC -3', Antisense: 5'TAAAACGCAGCTCAGTAACAGTCCG-3'; IFNγ, Sense: 5'-AGCGGCTGACTGAACTCAGATTGTAG ... for natural killer cell inhibitory receptors? Proc Natl Acad Sci USA 1997, 94:5249 49 Kaneko F, Takahashi Y, Muramatsu R, Adachi K, Miura Y, Nakane A, Minagawa T: Natural killer cell numbers and...
... targets into measurable indicators, and teams had to deliver monitoring data toa central database In this study, these monitoring data were used to model the actual success ofthe teams An agreement ... were capable and willing to deliver enough monitoring data to calculate a before and after measurement (actual outcome) (n = 103) Indicator data were available of 94% ofthe operating theatre ... agreement was made withthe organisation funding the programme (as well as the independent evaluation, of which the current study is a part) that the data collection burden for participating hospital...
... calcification and non-specific acute and chronic inflammation A detailed histopathology report ofthe appendix along withthe attached mesoappendix showed a 1.5 cm perforation in the lumen ofthe appendix ... appendicular mass which was most likely a previously perforated appendix along the lateral abdominal wall The lateral abdominal wall peritoneum was excised withthe appendix to prevent any spillage of ... collected the data, helped in its interpretation and drafted the manuscript RA helped in identification and interpretation of pathology along with drafting the manuscript MRK conceived the study, helped...
... statistical analyses DVJ, FS, and PWB carried out the molecular genetic studies and immunoassays All authors participated in the design ofthe study and helped to draft the manuscript All authors read ... estimates remained significant after the Benjamini and Hochberg's adjustment (Table 2) The higher dN/dS ratios observed for blacks suggest that the rate of virus evolution is greater in this ... breakpoints with GARD [15], and then estimating the dN/dS ratios independently for each fragment Mean dN/dS ratios across races and treatments were compared using ANOVA, linear models (lm) and pairwise...
... not replicate to detectable levels The escape variant AS44, withthe intermediate length hairpin, replicated only marginally All other AS variants replicated efficiently (results are summarized ... 1B), although these variants reached maximal CAp24 values at least log lower than that of wild-type HIV1 This phenotypic difference can be explained by the Nefminus genotype of these viral strains ... Additional File Graphic quantification ofthe relative viral abundance in SupT1 and PBMC The density ofthe PCR products from Figures and were calculated withthe ImageJ software Click here for file...
... work and have read and approved the final manuscript In particular VG participated in the design ofthe study, data acquisition, analysis and drafting ofthe manuscript KS, KV and LK participated ... The position ofthe probe was selected atthe midway between the anterior superior iliac spine and the midpoint ofthe patella and was placed ventral tothe transverse plane and perpendicular ... in data acquisition, analysis and drafting ofthe manuscript PP, AK and AC revised critically the manuscript CR helped with data analysis, revised critically the manuscript and gave approval for...
... what the big important problems are? Mink: Exactly And what new tools or methods are needed to solve them So here’s a simple idea: At every big meeting ofthe American Chemical Society and the ... introduction to some important area of biology and end witha list of some ofthe major outstanding problems in that area and what sort of things would help get them solved That way, people from other ... each other Clifford: Now I’m the one who’s not understanding Mink: What I mean is that Greg is always complaining that chemists can’t understand one another because the physical chemists speak...
... Respira) We are grateful tothe patients and their relatives for agreeing to participate in this trial We would like to thank Dr Masuet and Dr Ramon (USAR) for their help withthe statistical analysis ... Comparative evolution of C-reactive protein ratio overthe days of treatment and between the two study groups The CPR ratio was calculated by dividing every day value by the CPR value at Day Mean ... all of them belonging tothe placebo group The duration of MV was 13 days (IQR to 26 days) for the placebo group and days for the only case in the MPDN group The differences not reach statistical...
... signaling, it has been proposed that the stimulatory mechanism is based on the ability of glypicans to facilitate and/or stabilize the interaction of Wnts with their signaling receptors, the Frizzled ... the carboxy-terminal end ofthe CRD domain, and generates two subunits that remain attached to each other by one or more disulfide bonds [7] Whether the convertase-induced cleavage of glypicans ... structural feature shared by all glypicans is the insertion sites for the heparan sulfate (HS) chains, which are located close tothe carboxyl terminus This places the HS chains close tothe cell...