adrenergic regulation and heritable arrhythmias key roles of the slowly activating heart iks potassium
Báo cáo khoa học: Roles of the SH2 and SH3 domains in the regulation of neuronal Src kinase functions pptx
... auto-phosphorylation by modulating the kinase activity of the enzyme To determine the roles of the SH3 and ⁄ or SH2 domains in Src regulation of NMDAR phosphoryla- tion, the protein fragment corresponding ... independent of its kinase activity, and that dysfunction of the SH3 and ⁄ or SH2 domains does not affect this interaction The regulation of NMDARs by Src and other SFKs [7–12] has been found to be a key ... R175K mutations therefore inhibit interactions with ligands of the SH3 and SH2 domains, respectively, both intra- and intermolecularly, and thereby disrupt the overall functions of Src kinase [3,18–21]...
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Tài liệu Báo cáo khoa học: Verprolin function in endocytosis and actin organization Roles of the Las17p (yeast WASP)-binding domain and a novel C-terminal actin-binding domain doc
... expression level of the GFPtagged fusion proteins is indicative of that of the equivalent untagged proteins We examined whether the various charged-to-alanine substitutions affected the ability of full-length ... proteins, but we expect that the relative expression level of the tagged proteins is indicative of that of the equivalent untagged proteins To assess the function of these proteins in endocytosis ... expect that the relative expression level of the GFP-tagged proteins is indicative of that of the equivalent untagged proteins Lipid anchoring of C-Vrp1p bypasses the requirement for the LBD for...
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Tài liệu Báo cáo khoa học: Roles of the human Rad51 L1 and L2 loops in DNA binding doc
... in these eukaryotic and archaeal proteins (Fig 1A) Like the case of bacterial RecA, the L1 and L2 loops of the eukaryotic Rad51 proteins face A Roles of the HsRad51 L1 and L2 loops inside of their ... Roles of the HsRad51 L1 and L2 loops D231W (L1 loop) Table Changes in the fluorescence of tryptophan probes inserted in the L1 and L2 loop upon binding of nucleotides and DNA The fluorescence of ... Results Strategy of mutational analysis In order to study the functions of the L1 and L2 loops of HsRad51, we examined the effect of replacing the aromatic residues in the L1 and L2 loops with...
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Báo cáo khoa học: Respective roles of the catalytic domains and C-terminal tail peptides in the oligomerization and secretory trafficking of human acetylcholinesterase and butyrylcholinesterase potx
... major function of the t peptides is that they allow the assembly of tetramers of AChET [7] and of BChET [8] and their association with the structural proteins ColQ and PRiMA [9,10] These heteromeric ... three residues of peptide b (GNI) as a group; W8 and E9 together and separately; G13, N18, M22 and D23 together and separately; and N29 and D30 together, replacing these residues by the corresponding ... Oligomerization and secretion of AChE and BChE D Liang et al A B Fig Structures of AChE and BChE t peptides (A) Sequences of the C-terminal t peptides of human AChE and BChE These peptides (a and b) are...
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Báo cáo khoa học: Dual mitochondrial localization and different roles of the reversible reaction of mammalian ferrochelatase ppt
... additional regulation may exist in the expression of ferrochelatase, which plays a role in the iron-removal reaction of exogenous heme and the change in position of the heme-moiety of hemoproteins The ... membranes of mitochondria and the possible regulation of its reversible enzyme activity by phosphorylation Phosphorylation of the enzyme may relate to the activities and differential localization of ... phosphorylated in E coli, (Fig 4F, lower), the intensity of phosphoferrochelatase of S130A and S303A was decreased, and the band was not detected in the double mutant S130A and S303A, indicating that ferrochelatase...
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Family Life, Reproductive Health, and Population Education: Key Elements of a Health-Promoting School docx
... liberty, and security of the person; rights relating to the foundation of families and of family life; rights relating to the highest attainable standard of health and the benefits of scientific ... interventions The amount and nature of resources will affect the scope and amount of services that can be provided, the availability of trained staff, and the capacity to plan and evaluate efforts ... This document makes the assumption that in almost every school there are boys and girls who: • have inadequate understanding of the emotions and physiology of the human body and would benefit from...
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Báo cáo khoa học: FLIP and MAPK play crucial roles in the MLN51-mediated hyperproliferation of fibroblast-like synoviocytes in the pathogenesis of rheumatoid arthritis pdf
... left untreated The cells were harvested and assessed by western blot analysis for the expression of MLN5 1and FLIP proliferation of RA FLSs through the upregulation of MLN51 [7] In the present study, ... is upregulated in the FLSs of RA patients, and is enhanced days after GM-CSF treatment [7] In the present experiments, we assessed the dose and time kinetics of the effects of GM-CSF on MLN51 ... proliferation and blocking apoptosis in the pathogenesis of RA Results GM-CSF induces the proliferation of MH7A cells and the expression of MLN51 Our recent study has shown that GM-CSF is involved in the...
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Báo cáo khoa học: cGMP and glutathione-conjugate transport in human erythrocytes The roles of the multidrug resistance-associated proteins, MRP1, MRP4 and MRP5 pot
... Uptake of [3H]cGMP in the absence of ATP but in the presence of the nonhydrolysable ATP analogue, ATP-c-S, was less than 5% of the uptake in the presence of ATP The amount of [3H]cGMP taken up by these ... compared using an F-test on the ratio of the variance associated with the reduction in degrees of freedom to the variance of the fit with the smaller number of degrees of freedom [33], VR ¼ ðSSE2 ... to the protein concentration of the membrane vesicles, and all data were corrected for the amount of radiolabelled substrate bound to the filter in the absence of vesicle protein The substrate and...
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Discussion paper: Key concepts of the Alternative Investment Fund Managers Directive and types of AIFM pptx
... AIFMs that are significant in terms of their size or the size of the AIFs they manage, their internal organisation and the nature, the scope and the complexity of their activities to establish a ... determine types of AIFM, where relevant in the application of the AIFMD, and to ensure uniform conditions of application of the AIFMD Contents Definition of AIFM This section of the discussion ... determine types of AIFM, where relevant in the application of the AIFMD, and to ensure uniform conditions of application of the AIFMD The different types of AIFM will manage a variety of AIF legal...
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Báo cáo hóa học: " Fall prevention and vitamin D in the elderly: an overview of the key role of the non-bone effects" docx
... data in the study and takes responsibility for the integrity of the data and the accuracy of the data analyses Study concept and design: CA and OB Acquisition of data: CA and OB Analysis and interpretation ... [35] Selection of these strategies depends, apart from the nature of the disturbance, on the subject’s state of attention and previous experience [31,36] Maintenance of posture and balance during ... influences the occurrence and mechanism of the fall and its consequences due to its action on postural balance system - i.e., CNS and muscles - would then be feasible Evidence of the effectiveness of...
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Báo cáo y học: "Balance between survivin, a key member of the apoptosis inhibitor family, and its specific antibodies determines erosivity in rheumatoid arthritis" ppt
... expression and production of IL-6 deserves special attention in the view of recent success of the neutralization of IL-6 for alleviation of RA [35] These observations support the regulatory role of survivin ... joints, and metatarsophalangeal joints The presence of one erosion was sufficient to fulfil the requirement of an erosive disease We considered the presence of rheumatoid factor (RF) of any of the ... expressed the level of survivin and antibodies against survivin in the blood, in synovial fluid samples, as well as in cell lysates as the mean ± standard error of the mean The survivin levels in the...
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Báo cáo y học: "κ The roles of the classical and alternative nuclear factor-κB pathways: potential implications for autoimmunity and rheumatoid arthritis" ppsx
... role in the regulation of immune central and peripheral tolerance, and hence in autoimmune reactivity of the immune system Autoimmunity Autoimmunity is the result of a loss of tolerance (the ability ... producers of IL-17 We then discuss the biologic effects of Th17 and IL-17 in the context of RA, and the direct Page of 14 (page number not for citation purposes) Arthritis Research & Therapy Vol ... Involvement of the alternative pathway at the site of inflammation RA is a chronic inflammatory disease of the joints in which infiltration of immunocompetent cells and the proliferation of synovial...
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Báo cáo y học: "Understanding the roles of the transcription factors nuclear κ α factor-κB and hypoxia-inducible factor-1α in lung injury" pptx
... increased stability and binding in hypoxic conditions and is degraded rapidly in normoxia The accumulation of the α-subunits allows for αβ heterodimer formation and translocation into the nucleus during ... to selective upregulation of genes whose products are involved in hypoxia and inflammatory lung injury These include erythropoietin, vascular endothelial growth factor (VEGF) and glucose transporter ... as cystic fibrosis, and the use of pyrrolidine dithiocarbamate in transplantation to reduce neutrophil-associated oxidant lung injury Two new compounds, isohelenin and lisofylline, a phosphodiesterase...
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Zebrafish liver and pancreas development 1 roles of rbp4 in early liver formation 2 genetic ablation to deduce pancreas cell lineage
... in the core of the islet and account for 60-80% of the islet They mainly function to lower the blood sugar level through promoting the uptake of glucose in the target tissues (liver, muscle and ... (liver, muscle and the fat) and inhibiting the glucose production in the liver Conversely, the α-cells, accounting for 15-20% of the islet, are located at the periphery of the islet and they are responsible ... outgrowth of the branches, the tip progenitors leave the differentiated progeny in the trunk of the branches, where they eventually form endocrine, exocrine and duct cells In zebrafish, the exocrine and...
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Báo cáo y học: "980 nm diode lasers in oral and facial practice: current state of the science and art"
... Following the suggestions of scientific literature on the advantages of the compactness, reliability, ease of use and affordability of the 980 nm Diode Lasers, we evaluated the efficacy and safety of ... are reduced [17,18] The lasers normally adopted offer the enormous advantage of being conveyed in a fibre, which serves as the working tip at the end of the handpiece The use of flexible, length-adjustable ... question the efficacy of the 980nm Laser for photosclerosis of lesions and areas with little melanin and hemoglobin pigmentation [7] Furthermore, to avoid exaggerated fluences and thermal damage to the...
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Báo cáo y học: "Incidence of Ocular Zoonoses referred to the Inflammatory and Autoimmune Ocular Diseases Service of the University of Parma - Italy"
... this case the patient had a panuveitis, which recovered only after a combination of medical treatment and surgery, with a final visual acuity of 40% in the affected eye [1] The only case of Lyme ... disease affected a 31 year-old farmer and his ocular manifestations are described in the specific section Figure 1: Geographical location of the province of Parma (Italy) References Mora P, Vecchi ... Parma (Italy) References Mora P, Vecchi M, Barbera L, Toscani M, Orsoni JG Use of systemic cyclosporin A in a case of severe Toxocara uveitis J Infect 2006; 52:159-161 http://www.medsci.org ...
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Radioactive waste in the Barents and Kara Seas - Russian implementation of the global dumping regime
... the homes and offices of several persons involved in the preparation of a report on the waste management of the Northern Fleet They later arrested one of them, a Russian citizen formerly with the ... incident of dumping of liquid radioactive waste in the Sea of Japan to irresponsibility on the part of the Navy and the nuclear industry, the Russian Minister of Environment informed the Consultative ... clout of Goskompriroda would strengthen those actors in the Soviet system who opposed the dumping practices of the Northern Fleet and encourage the formation of an effective coalition to counter the...
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Tài liệu Decision Analysis and Risk Management: Two Sides of the Same Coin pdf
... definition is then related to the four steps of the decision making process and finally to the three types of error (risk) that occur in each of the four steps The paper concludes with an example of how ... guesswork; they are “a stab in the dark.” So, to understand the quality of a decision we must understand the weaknesses in the inputs that have gone into the decision making process and in the approaches ... based on analysis of risk The thoroughness of the analysis determines the “quality” of the decisions High quality decisions are not the best decisions in hindsight They are the best decisions...
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Tài liệu Báo cáo khoa học: Toggle switches, pulses and oscillations are intrinsic properties of the Src activation/deactivation cycle doc
... by presenting the pulse of Src activity in the plane of the inactive and active fractions, si and s1 If the duration of the stimulus exceeds the critical value, the trajectory in the (si, s1) ... by number in the plane of the Csk and RPTP concentrations Within these two regions of monostability, there are parameter sets where the QSS dependence of the active Src fraction on the inactive ... transition from the Off state to On state (in the bistability domain) Regardless of the slope, the active Src fractions increase during the Off to On transition, whereas the value of the inactive...
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Tài liệu Báo cáo khóa học: Active-site residues and amino acid specificity of the bacterial 4¢-phosphopantothenoylcysteine synthetase CoaB pptx
... synthetase CoaB (Eur J Biochem 271) 169 Fig Analysis of the enzymatic activity of His-CoaB R206Q and A276V The synthesis of 4¢-phosphopantothenoyl-CMP (–cysteine, upper part of the figure) and of ... 4¢-phosphopantothenic acid, CTP and cysteine The synthesis of PPC occurs in two half reactions starting with the formation of 4¢-phosphopantothenoyl-CMP (activation of the carboxyl group of 4¢-phosphopantothenate) ... monomers with the monomer fold having features in common with a group of NAD-dependent enzymes on one hand and with the ribokinase fold on the other hand The structure of the human PPC synthetase complexed...
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Tìm thêm: khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản khảo sát chương trình đào tạo gắn với các giáo trình cụ thể xác định thời lượng học về mặt lí thuyết và thực tế điều tra đối với đối tượng giảng viên và đối tượng quản lí khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam nội dung cụ thể cho từng kĩ năng ở từng cấp độ xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 động cơ điện không đồng bộ một pha thông tin liên lạc và các dịch vụ phần 3 giới thiệu nguyên liệu từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng 9 tr 25