... Okamoto Y, Minami S, Matsuhashi A, Kumazawa NH, Tanioka S, Shigemasa Y: Migration of canine neutrophils to chitin and chitosan J Vet Med Sci 1994, 56:1215-1216 Usami Y, Okamoto Y, Minami S, Matsuhashi ... PMNs Freshly isolated polymorPMNs phonuclear neutrophils (PMNs) were pre-stained with μg/ml calceinAM and seeded on a polycarbonate filter placed above a well containing (a) N-formyl-methionyl-leucyl-phenylalanine ... study was therefore to compare the response of PMNs to two chitosan preparations of a defined DDA, namely 80 M chitosan and 95% deacetylated (95 M) chitosan The 95 M chitosan was investigated because...
... measured We followed this basic approach (ex vivo stimulation of whole blood) to develop pharmacodynamic biomarker assays for a candidate therapeutic antibody, Ab-01 Ab-01, a human antibody generated ... assay system is well suited to examining the relationship between pharmacokinetics and pharmacodynamics (PK/PD), the intended clinical use of the assay system [13] A third critical contribution, ... de Lange EC, Della Pasqua OE, Ploeger BA, Voskuyl RA: Mechanism-based pharmacokinetic-pharmacodynamic (PK-PD) modeling in translational drug research Trends Pharmacol Sci 2008, 29:186-191 Kola...
... with septic syndrome due to VAP and those with septic syndrome caused by other types of infection, namely acute pyelonephritis, primary bacteremia, intraabdominal infection, communityacquired pneumonia ... observed Among patients who developed VAP only two had initially presented with other infections, namely peritonitis and cholecystitis, and among patients with other infections Page of (page number...
... circulatory conditions, we did not adapt dilution volumes of the different agents to possible hemodynamic potentials but in a fixed manner as compared to HH infusion alone Furthermore the study cannot ... and its stability over time, which indicates clot building potential at the time of analysis A dynamic time course of coagulation impairment and possible recovery from impairment cannot displayed ... have weakened the coagulation impairing effect of HH Despite this, to reflect comparable hemodynamic potential greater volumes of colloid infusions were admitted leading to a higher dilution...
... R.N., American Medical Association – Yank D Coble, Jr., M.D., American Nurses Association – To be named, American Osteopathic Association – Michael Clearfield, D.O., American Pharmaceutical Association ... typically makes up 60–70 percent of the total serum cholesterol It contains a single apolipoprotein, namely apo B-100 (apo B) LDL is the major atherogenic lipoprotein and has long been identified by ... trials∆: Montreal Heart Institute Study, INTACT ∆ See List of Studies appendix for listing of the full names of these clinical trials II–4 Results of clinical trials of LDL lowering find support from...
... high temperature (50 000 K) torsion dynamics run, two 15 ps cooling stages (the first one employing torsion dynamics, the second one employing cartesian dynamics) and gradient minimization Out ... sake of comparison with the hydrodynamics simulations The internuclear N-H distance of 0.102 nm and 15N chemical shift anisotropy of 160 p.p.m were used The hydrodynamic calculations were performed ... University of California, San Francisco, CA, USA) Relaxation analysis and hydrodynamic calculations The backbone amide dynamic parameters were derived in the spirit of the Lipari–Szabo model-free approach...
... according to producers' protocols Cells were then cultured in RPMI 1640 supplemented with 100 μg/ml Kanamycin, 10 mM Hepes, mM sodium pyruvate, mM Glutamax and non-essential amino acids (all from GIBCO ... βactin gene expression in each sample, by using the −ΔC t method [22] For all genes analysed, dynamic linear range of expression-detection was consistent at least up to Ct value of 35 which was...
... with similar temporal profiles following a single dose of LXR-623 We conclude that the pharmacodynamic effects of synthetic LXR agonist compounds can be measured in vivo by monitoring the expression ... [N-(2,2,2,trifluoro-ethyl)-N-[4-(2,2,2,-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-phenyl]-benzenesulfonamide] [8,22] and GW3965 [3-(3-(2-chloro-3-trifluoromethylbenzyl2,2 diphenylethylamino)propoxy)phenylacetic ... surrogate transcriptional markers of biological efficacy ABCA1 and ABCG1 were evaluated as pharmacodynamic markers of LXR-623 exposure in a single ascending dose study of LXR-623 in healthy human volunteers...
... compound pharmacodynamic biomarker To determine whether the drug-induced expression patterns observed were biologically meaningful, these data were then compared to a published pharmacodynamic biomarker ... profiling of whole blood In order to identify an optimal strategy for the identification of pharmacodynamic biomarkers in whole blood, we established two model systems to identify and apply the best ... SAHA dose-dependent manner By definition, these genes would be potential markers of SAHA pharmacodynamic effects in whole blood We expected that these gene sets would have significant overlap with...
... cell receptor-deltadeleting elements in human T cells J Immunol 1997, 158:1208-1216 10 Liu W, Putnam AL, Xu-Yu Z, Szot GL, Lee MR, Zhu S, Gottlieb PA, Kapranov P, Gingeras TR, Fazekas de St Groth...
... 2007, 108:68-77 Golding A, Rosen A, Petri M, Akhter E, Andrade F: Interferon-alpha regulates the dynamic balance between human activated regulatory and effector T cells: implications for antiviral...
... 2007, 108:68-77 Golding A, Rosen A, Petri M, Akhter E, Andrade F: Interferon-alpha regulates the dynamic balance between human activated regulatory and effector T cells: implications for antiviral...
... patients who have coronary heart disease Physiological signs of inadequate oxygenation such as hemodynamic instability or symptoms of myocardial ischemia occur Drainage of more than liter of blood...
... patients who have coronary heart disease Physiological signs of inadequate oxygenation such as hemodynamic instability or symptoms of myocardial ischemia occur Drainage of more than liter of blood...