4 connective tissue alterations in photoaging the role of matrix metalloproteinases and collagen synthesis
The role of matrix metalloproteinases (MMP) and their inhibitor in influenza a virus induced host lung injury
... host lung injury by minimising the destruction of pulmonary endothelium and epithelium, thus lessening leakage of proteinaceous viii material into the airways Influenza-induced host lung injury ... in the leakage of inflammatory exudates, edema fluid and plasma proteins into the lung interstitium and alveolar spaces and the collapse of the alveoli leads to impaired gaseous exchange in the ... (Unpublished data) In view of the fact that gelatinases MMP-2 and MMP-9 from inflammatory cells may aid the destruction of the integrity of basement membrane of the epithelium and endothelium, which...
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WORKING PAPER SERIES NO. 398 / OCTOBER 2004: MERGERS AND ACQUISITIONS AND BANK PERFORMANCE IN EUROPE THE ROLE OF STRATEGIC SIMILARITIES potx
... tend to follow two main kinds of empirical methods On the one hand there are a number of studies comparing pre- and post-merger performance On the other hand, another strand of the empirical literature ... effect of changes on the capital levels on performance hinges on the recent theory of the banking firm, which is based on the ‘specialness’ of banks in a setting in which there are asymmetries of information ... critical element in determining the success or failure of a deal Levine and Aaronovitch (1981) and Lubatkin (1983) were among the first to stress the importance of studying the strategic and organisational...
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Báo cáo khoa học: The role of helix 8 and of the cytosolic C-termini in the internalization and signal transduction of B1 and B2 bradykinin receptors potx
... binding was determined in the presence of lm unlabeled agonist and subtracted from the total binding to calculate the specific binding Internalization of [3H]BK and [3H]DAK To determine the internalization ... provide insight into the receptor specificity of the B2wt internalization motif The resulting data also hint at a receptor specific role of the putative helix in G protein activation and interaction ... expressed in percentage of total binding, decreasing the binding affinity of the FEBS Journal 272 (2005) 129–140 ª 2004 FEBS A Faussner et al Role of helix and C-termini in bradykinin receptors Fig Schematic...
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Báo cáo khoa học: The role of residues R97 and Y331 in modulating the pH optimum of an insect b-glycosidase of family 1 pdf
... explain the DpKa of E187 in the Y331F mutant, because in the R97K and R97M mutants the same increment in the pKa of E399 did not change signicantly the pKa of E187 This suggests that in the Y331F ... Taking into account the experimental errors, the pKa of E187 remained the same, but the pKa of E399 clearly increased Actually, the substitution of R97 by methionine or lysine resulted in the ... determinations using mM MUbglc as substrate The pH stability of the recombinant Sfbgly50 (n) was checked by incubating the enzyme in the same buers for an equal length of time and determining the...
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Báo cáo khoa học: Dissecting the role of protein–protein and protein–nucleic acid interactions in MS2 bacteriophage stability potx
... are unsure of the mechanism of DNA-induced stabilization of the protein, and whether it is related to the normal RNA-binding function of coat protein, as RNA binding had no effect The increased ... urea-induced and GdnHCl-induced changes in the secondary structure of the proteins, we analyzed the UV CD spectra of MS2 and VLPs in the absence and presence of 5.0 m and 9.0 m urea and 3.5 m and 5.0 ... the role of protein–protein and protein–RNA interactions in virus stability is not completely understood, and we have investigated these questions in this work We sought to determine the role of...
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báo cáo sinh học:" Task-shifting HIV counselling and testing services in Zambia: the role of lay counsellors" pot
... component of the training includes instruction as well as role- plays and case studies to ensure that trainees understand the concepts and methods of HIV counselling and testing In the four-week ... appeared during these interviews Almost all the lay counsellors we interviewed were interested in future training and continuing in what was considered a professional field, including obtaining advanced ... analysis All authors read and approved the final manuscript Acknowledgements A final point of interest is the challenge of maintaining the long-term sustainability of the lay counsellor programme,...
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báo cáo hóa học:" The role of FGF-2 and BMP-2 in regulation of gene induction, cell proliferation and mineralization" pptx
... BMP-2 maintained the mineralizing RNA profile of igf-1, alp, and bmp-2 and significantly increased expression of other genes associated with mineralization like col1a1, fn, ilgf-1, noggin and oc ... examined and photographed the cells on a Zeiss Axioskop using 20× Tritiated thymidine incorporation into DNA At the conclusion of the 24 hour incubation, the culture medium was removed and the ... We then visualized the mineralizing cells with 2% Alizarin Red After rinsing in distilled water and air drying the samples, we mounted the coverslips on microscope slides using Fluoromount and...
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báo cáo hóa học:" The role of FGF-2 and BMP-2 in regulation of gene induction, cell proliferation and mineralization" pdf
... BMP-2 maintained the mineralizing RNA profile of igf-1, alp, and bmp-2 and significantly increased expression of other genes associated with mineralization like col1a1, fn, ilgf-1, noggin and oc ... examined and photographed the cells on a Zeiss Axioskop using 20× Tritiated thymidine incorporation into DNA At the conclusion of the 24 hour incubation, the culture medium was removed and the ... We then visualized the mineralizing cells with 2% Alizarin Red After rinsing in distilled water and air drying the samples, we mounted the coverslips on microscope slides using Fluoromount and...
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Research for a Future in Space: The Role of Life and Physical Sciences ppt
... Engineering in providing services to the government, the public, and the scientific and engineering communities The Council is administered jointly by both Academies and the Institute of Medicine ... president of the National Academy of Engineering The Institute of Medicine was established in 1970 by the National Academy of Sciences to secure the services of eminent members of appropriate professions ... autonomous in its administration and in the selection of its members, sharing with the National Academy of Sciences the responsibility for advising the federal government The National Academy of Engineering...
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Báo cáo khoa học: "The role of Bcl-xL and nuclear factor-kB in the effect of taxol on the viability of dendritic cells" ppsx
... viability These findings provide a basic rationale for the use of taxol in DC immunotherapy and insights into the development of combinational DC therapies with other anticancer drugs that not harm the ... survival and maturation of DCs [11,17,20] To investigate further the mechanisms of taxol-induced changes, the viablity of TPCK, an inhibitor of the serine protease that inhibit NF-κB signaling pathway ... major cytokines involved in immune responses Importantly, taxol increased the expression of the anti-apoptotic protein Bcl-xL, and increased the mobilization of p65 subunit molecules into the DC...
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Báo cáo khoa học: " The role of marine salt and surfactants in the decline of Tyrrhenian coastal vegetation in Italy" ppt
... trees of P pinea, P tobira, Q ilex and A opalus growing When interpreting the results of the chemical analysis of rainwater and deposits it is necessary to bear in mind the interactions between the ... rinsing However part of the chlorides absorbed by the needle are released during rinsing In the rainwater samples there can be interferences with atmospheric dust and dry deposits of nonmarine ... those with the greatest impact the system because of the amount of salt and surfactants they transport, occur rather infrequently within the total number of samples examined Finally, the ratio...
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Báo cáo y học: "The role of synovial macrophages and macrophage-produced cytokines in driving aggrecanases, matrix metalloproteinases, and other destructive and inflammatory responses in osteoarthritis" pps
... cultures of MMP (TIMPs), and link metalloproteinases (MMPs), tisleukin (IL)-1 on the expression of matrix protein in (TNF)-α and/ or interleukin (IL)-1 on the expression of matrix metalloproteinases ... IL-1 and TNF, rather than a 'cytokine cascade' with either of these cytokines controlling the production of the other (Figure 4a) Both Enbrel and the neutralising anti-IL-1β antibody decreased the ... cytokines and/ or MMPs or indirectly due to cytokine-mediated inhibition of the production of growth factors [16] The majority of studies of the regulation of cytokines and destructive enzymes in...
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Báo cáo khoa hoc:"Muscle-related traits in cattle: The role of the myostatin gene in the South Devon breed" pps
... However, these two groups were very similar, supporting the view that the calf’s myostatin genotype is more in uential than that of its dam in determining the difficulty of calving The objective of ... comprising the log-likelihoods from analyses including and excluding the component from the model Other factors considered in the model were interactions of farm by genotype, farm by birth year and ... deletion is in the third exon of the gene and is a frameshift mutation resulting in the production of an inactive, truncated protein Other mutations associated with increased muscling have also...
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báo cáo khoa học: " Exploring the role of organizational policies and procedures in promoting research utilization in registered nurses" potx
... identify factors influencing the use of RBPs among staff nurses in the Canadian province of Newfoundland and Labrador with the specific aim of understanding the role of P&Ps in promoting research ... placed nurses in this study in the persuasion stage of adoption, overall In other words, they were aware of and believed in the value of the practices but were not using them to make clinical decisions ... understanding of the factors that influence nurses' use of RBPs, and the role that P&Ps may play in promoting research utilization in nurses Our findings suggest nurses use P&Ps to guide their...
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Báo cáo y học: "The role of mast cells and fibre type in ischaemia reperfusion injury of murine skeletal muscles" pot
... other studies are difficult to compare because of the wide variety of IR models in use In particular, there is a great deal of variation in the period of ischaemia, the muscle temperature during ... irrespective of the other abnormalities in these mice The role of mast cells has not been considered when investigating the susceptibility of different muscle fibre types Figure and EDL3(black ... and drafted the original manuscript WAM participated in the design of the study AM participated in design of the study and performed morphological analyses All authors provided intellectual input,...
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Báo cáo y học: "A systematic review of the role of vitamin insufficiencies and supplementation in COPD" docx
... COPD [106] Vitamin A and B Vitamin A (retinol and carotens) plays an important role in several functions of the human body including vision, bone and skin health, and further has an innate antioxidant ... protective role of vitamins against COPD but did not measure vitamins in serum or with a FFQ Therefore conclusions about the special role of any vitamin in COPD could not be obtained Vitamin D and COPD ... assessment of vitamins has the disadvantage that they represent the more recent intake, and for some vitamins such as vitamin C, the levels in peripheral blood are not representative of intake and not...
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Báo cáo y học: " The role of cyclin D2 and p21/waf1 in human T-cell leukemia virus type 1 infected cells" potx
... cyclin binding motifs, one at the N- and the other at the C- terminus [20] p21/waf1 (mut) is mutated at the N-terminus and is therefore still able to bind to cyclins through the C-terminus, making ... terminus and the other at the C terminus [20] p21/waf1 interacts with both cyclins and cdks, in contrast to the INK family CDKI members, which only bind to cdks [20] Interestingly, p21/cyclin ... represents the nucleolus, whereas the lighter blue staining represents the nucleoplasm As expected, the intensity of staining for cyclin D2 and p21/ waf1 was increased in HTLV-1 infected T-cells When the...
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ELUCIDATING THE ROLE OF REDOX EFFECTS AND THE KU80 C-TERMINAL REGION IN THE REGULATION OF THE HUMAN DNA REPAIR PROTEIN KU
... due to the lack of the linker region tethering together two molecules that are simply within range of the linker arm and possibly not involved in a genuine interaction (41) 10 Materials and Methods ... has the potential to influence the DNA binding activity of Ku (51) To further understand the role of the C-terminus of Ku80, we created two mutants The first mutant contains a truncated form of ... Preliminary work was performed to determine the elution volume of Ku70/80C and Ku80CTR independent of the other protein Individual proteins were pre-incubated in running buffer and applied to the...
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THE REGULATORY ROLE OF MATRIX METALLOPROTEINASES IN T CELL ACTIVATION
... is of interest to point out that in the gelatinases, collagen binding is conferred by the fibronectin type II-repeats and the Ser/Thr/Pro-rich collagen type V domain, whereas in collagenases, collagen ... pro15 form These enzymes are in an inactive state due to the thiol (SH-) group of the cysteine residue within the pro-domain interacting with the Zn2+ ion in the catalytic domain Disruption of this ... binding gelatin, laminin and collagens type I and IV MMP-9 also contains an additional Ser/Thr/Pro-rich collagen type V domain situated in the hinge region which is ~75 amino acid residues in...
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Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các mục tiêu của chương trình khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản xác định thời lượng học về mặt lí thuyết và thực tế khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu nội dung cụ thể cho từng kĩ năng ở từng cấp độ xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 động cơ điện không đồng bộ một pha sự cần thiết phải đầu tư xây dựng nhà máy thông tin liên lạc và các dịch vụ từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng 9 tr 25