3role of androgens and ar in the pathogenesis and development of pca
Báo cáo khoa học: FLIP and MAPK play crucial roles in the MLN51-mediated hyperproliferation of fibroblast-like synoviocytes in the pathogenesis of rheumatoid arthritis pdf
... GM-CSF is involved in the proliferation of primary RA FLSs [7] In the present study, we investigated cell proliferation and MLN51 expression using an RA FLS cell line, MH7A, in the presence of GM-CSF ... summarized in Fig Discussion In ammatory cell in ltration and the expansion of an aggressive FLS population in the synovial membrane are the pathological hallmarks of RA [1,24] A number of growth ... localization, and regulation of the stress-activated protein kinases, extracellular signal-regulated kinase, c-JUN N-terminal kinase, and p38 mitogen-activated protein kinase, in synovial tissue and cells...
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RECENT ADVANCES IN THE PATHOGENESIS, PREVENTION AND MANAGEMENT OF TYPE 2 DIABETES AND ITS pptx
... entrapment of the median and ulnar nerves a thickening of the perineurium and epineurium were observed Furthermore, teased fibre analysis revealed thinning and retraction of the myelin as well as intercalated ... compression involving mechanisms such as inflammation, and stretching and tethering of the nerve during joint movements Schwann cells are believed to be one of the primary mediators of demyelination ... Fig Technique of the biopsy procedure (a) Landmark for the incision is one fingerbreadth proximal to the ulnar head The PIN and the anterior interosseous artery are seen on the interosseous membrane...
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Báo cáo y học: "Eotaxin and FGF enhance signaling through an Extracellular signal-related kinase (ERK)-dependent pathway in the pathogenesis of Eosinophilic Esophagitis" doc
... JK, JP, and LN and KN aiding in obtaining biopsy and blood samples NR and LH were involved in enrolling and consenting patients JH drafted the manuscript All authors read and approved the final ... (FGFR) are tyrosine kinase receptors that are specific for particular FGF subsets and can be found in a variety of tissues, including epithelial and mesenchymal tissue [20] bFGF increases the half-life ... the pathogenesis of EoE by enhancing activation of eosinophils through synergy with eotaxin via the ERK signaling pathway The data may be used in the possible diagnosis and prognosis of EoE In...
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Báo cáo y học: "γ The role of the complement and the FcγR system in the pathogenesis of arthritis" pdf
... resulted in a better understanding of the role of the complement system and FcγRs, although the relative contributions and the hierarchy of these two pathways in the manifestation of disease are still ... FcγRI/III and C 5aR [54] In support of this view it was shown that the C5a anaphylatoxin, acting through the C 5aR, is a major regulator of the transcription of activating and inhibitory FcγRs in IC-induced ... at the same time and, for B cells, on the very same cell Both FcRs and complement receptors are involved in the binding of ICs and phagocytosis; they deliver signals leading to the activation and...
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Báo cáo y học: "Dipeptidyl peptidase IV activity and/or structure homologs: Contributing factors in the pathogenesis of rheumatoid arthritis" doc
... structurally similar but enzymatically inactive (DPP6, DPP10) In some instances, the DPPIV activity is clearly intrinsic whereas in others the nature of the DPPIV activity remains debatable In these latter ... levels of SP in SF are high in RA [67], and downstream signaling leads to varying consequences depending upon the target cells Mononuclear phagocytes respond with increased prostaglandin E2 and ... chemokines and cytokines that attract new T cells and monocytes, thereby increasing the inflammatory response and exacerbating degeneration Some of the proposed interactions and mechanisms are outlined...
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Báo cáo y học: "Cartilage oligomeric matrix protein is involved in human limb development and in the pathogenesis of osteoarthriti" pptx
... taken (inset) The arrowhead in the inset indicates COMP staining (f) At gw 12, COMP staining is found in the outer regions of the diaphysis and is mainly pericellular (inset) Bars = 70 µm in (f), ... the main defect; note the stronger staining for COMP on fibers (arrows) Bars, 0.4 µm in (a) and (b) and 0.2 µm in (c) and inset joint cartilage tissues in the pericellular, territorial, and interterritorial ... patients in the late stages of OA, an increase in staining intensity was found in the pericellular space (Figure 4b) In healthy cartilage, COMP staining was also found in the territorial and interterritorial...
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Báo cáo y học: "MLN51 and GM-CSF involvement in the proliferation of fibroblast-like synoviocytes in the pathogenesis of rheumatoid arthritis" pps
... next investigated whether SFs have an effect on the growth rate of RA FLSs, what kinds of factors in the SFs are involved in the proliferation of RA FLSs, and whether the factors have a role in the ... together with GM-CSF in the SF may be involved in RA pathogenesis in vivo To address the effects of GM-CSF in SF on the growth of RA FLSs, we cultured the RA FLSs in culture media containing ... in line with their gene expression patterns by microarray-based molecular studies [27] The histology of RA affected joints indicates chronic inflammation with hyperplasia in the synovial lining...
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Báo cáo y học: " Induction of multiple matrix metalloproteinases in human dermal and synovial fibroblasts by Staphylococcus aureus: implications in the pathogenesis of septic arthritis and other soft tissue infections" pdf
... of RA The risk is highest in severe, longstanding, seropositive disease The clinical presentation of joint infection is frequently atypical, and in 25% of cases, the infection is polyarticular ... or the severity of joint pathology Intra-articular injection of PGN into murine joints triggered arthritis in a dose-dependent manner [17] A single injection of this compound caused massive infiltration ... proteases/toxins cannot be completely ruled out, continued degradation of extracellular matrix component and the joint architecture even after clearing the infection and debris from the joint cavity indicates...
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Báo cáo y học: "Glomerular matrix metalloproteinases and their regulators in the pathogenesis of lupus nephritis" pdf
... MMPs and TIMPs are secreted by activated infiltrating cells and by cells intrinsic to the inflamed site, facilitating penetration into the tissue and structural remodeling as part of the healing ... overlapping morphological and clinical presentations of various kinds of inflammatory diseases of the glomerulus, the results of studies of the involvement of MMP activity in other renal pathologies ... parameters in such a strategy remain ill defined, including the target MMP(s), timing and duration of intervention, specificity, dosage and delivery system A more rigorous understanding of the...
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Báo cáo y học: "Chemokine receptor expression and functional effects of chemokines on B cells: implication in the pathogenesis of rheumatoid arthritis" ppt
... thank Fumiko Inoue and Aya Sato for the excellent technical support This work was supported in part by grants -in- aid from the Ministry of Health, Labor and Welfare, and the Ministry of Education, ... the four chemokines induced migration of both CD27- and CD27+ B cells (Figure 3a) However, the migration induced by CCL21 was most prominent Comparison of the migratory effects of the chemokines ... [1,2], B cells are considered to play important roles in the pathogenesis of RA In this regard, the synovial tissue of RA patients shows abundant accumulation of inflammatory cells, including T cells,...
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Báo cáo y học: "Downstream molecular pathways of FLT3 in the pathogenesis of acute myeloid leukemia: biology and therapeutic implications" pps
... [69-82] The compounds currently in development are heterocyclic compounds containing components that structurally mimic the purine ring of adenosine and become inserted into the ATP-binding site of ... end-joining fidelity Further analyses from the same research group using FLT3-ITD-expressing cell lines and bone marrow mononuclear cells from FLT3-ITD knock -in mice demonstrated that the end-joining ... effects of ATO and MEK inhibition, as well as ATO and FLT3 inhibition, on FLT3-ITD cells [101] The combination of ATO and AG1296, an FLT3 inhibitor, profoundly inhibited the growth and induced...
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Báo cáo y học: "α The role of anti-α-actinin antibodies in the pathogenesis and monitoring of lupus nephritis" pot
... by the assay used in this particular study would show a better correlation with anti-α-actinin antibodies Although intensive efforts are being invested into developing a more targeted lupus therapy ... these results in a larger number of patients are surely indicated Competing interests The authors declare that they have no competing interests Acknowledgments The authors acknowledge the important ... contributions of Yves Renaudineau (Brest, France) to several of the studies cited in this editorial Studies in the laboratory of CP are funded by the National Institute of Arthritis and Musculoskeletal...
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Báo cáo y học: " Central role of nitric oxide in the pathogenesis of rheumatoid arthritis and systemic lupus erythematosus" potx
... for increased endogenous NO synthesis, suggesting that overproduction of NO may be important in the pathogenesis of RA The in amed joint in RA is the predominant source of NO [45,46] Several investigators ... the TCR ζ chain in SLE T cells [64], which may explain the enhanced T-cell-activation-induced Ca2+ fluxing The potential role of NO in the regulation of FcR gamma expression clearly needs further ... 101:1696-1701 Krishnan S, Warke VG, Nambiar MP, Tsokos GC, Farber DL: The FcR gamma subunit and Syk kinase replace the CD3 zeta-chain and ZAP-70 kinase in the TCR signaling complex of human effector CD4...
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Báo cáo y học: " Th2 cytokines and asthma Interleukin-4: its role in the pathogenesis of asthma, and targeting it for asthma treatment with interleukin-4 receptor antagonists" pot
... chain or the IL-13 receptor α chain Binding of IL-4 results in the tyrosine phosphorylation of signal transduction molecules including motifs similar to those involved in insulin signaling, the ... apoptotic and are eliminated Several cytokines, including IL-2, IL-4, IL-7, and IL-15, are effective in preventing the death of activated T cells Of these, IL-4 and IL-15 are the most effective [11] Inhibition ... surface The expression of IL-4 in the asthmatic lung and the secondary lack of Fas expression might explain the persistence of inflammatory cellular infiltrates in allergic asthma Apoptosis of TH2...
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Báo cáo y học: "Bench-to-bedside review: Functional relationships between coagulation and the innate immune response and their respective roles in the pathogenesis of sepsis" ppsx
... tethered to the amino-terminus of its extracellular domain Thrombin cleaves the amino-terminus of the PAR, allowing the internal ligand to autoactivate the receptor There are four known PARs in ... proteases, thereby accelerating the inactivation of these proteases [71,72] The conformational change in antithrombin induced by heparin is only part of the heparin mechanism, however For heparin to ... arginine residues from the carboxyl terminus of peptides and proteins In the case of fibrin, removal of carboxyl-terminal lysine residues renders the fibrin less sensitive to lysis by decreasing...
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Báo cáo y học: " HIV-1 Accessory Protein Vpr: Relevance in the pathogenesis of HIV and potential for therapeutic interventio" ppsx
... replication in non-dividing cells beyond the nuclear entry point The necessity of Vpr’s karyophilic properties for the infection of actively dividing cells suggests that the targeting of the PIC to the ... Later, Kamata and others found that Vpr aH1 and aH3 both bind importin-a, that the IBB domain of importin-a primarily determines this interaction, and that the C-terminal domain of importin-a, 393-462, ... material and virion proteins, which include gag proteins that comprise the matrix and nucleocapsid, the latter containing significant quantities of Vpr 2) Vpr promotes the binding of the PIC (including...
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CHARACTERISATION OF GLUTAMYL TRANSPEPTIDASE AND ELUCIDATING ITS ROLES IN THE PATHOGENESIS OF HELICOBACTER PYLORI
... Cloning of ggt gene (full length and individual large and small subunits) from H pylori and expressing the recombinant proteins in E coli Raising and characterizing specific polyclonal and ... ability to maintain long-term colonization in the gastric mucosa of the mice compared to the wild type strain, indicating the importance of catalase in the chronic persistence of H pylori (Harris et ... the National University of Singapore, particularly in the award of the NUS Research Scholarship that provided the necessary financial support for this research i Table of Contents CONTENTS PAGE...
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Substance p regulates chemokine production in leukocytes implications in the pathogenesis of acute pancreatitis and associated lung injury
... macrophages) in the pancreas are the main sources of chemokine production in caerulein-induced acute pancreatitis in mice and the alveolar macrophages, epithelial and endothelial cells are major chemokine-producing ... preliminary in vivo findings; 22 3) to elucidate the signaling mechanisms of SP-induced cellular inflammatory responses using the cellular models; and also 4) to examine effects of other neuropeptide(s) ... later part of the study for SP-induced cellular responses 1.5.3 PKC isoforms The PKC family proteins are phospholipid-dependent serine/threonine kinases comprising 12 isoforms The PKC isoforms are...
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philips sarah d. women's social activism in the new ukraine. development and the politics of differentiation. bloomington, 2008
... shared my interests in social justice struggles and learning about the lives of women in different parts of the world Their commitment to social change and their insights into the effects of ... welfare system; women have been compelled to engage in the care and defense of marginalized groups whose concerns and demands are increasingly delegitimized in the neoliberal moment Barbara Einhorn ... the state The role of the family in life-preparation and rearing of children is increasing This reorientation changes the function of the family and affects the demographic situation in the country”...
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báo cáo hóa học:" Role of the VEGF-Flt-1-FAK pathway in the pathogenesis of osteoclastic bone destruction of giant cell tumors of bone" pptx
... expression and the clinical stage of GCTs at presentation To determine the status of pY-Flt-1 and pY-FAK in GCT samples, the staining intensity of each specimen was scored as follows: (weak staining; ... profiles of VEGF and the VEGF receptors in GCT specimens TRAP Page of staining demonstrated the presence of bone-resorbing OCs (data not shown) To determine the immunolocalization of VEGF and the ... through paracrine and autocrine mechanisms, the Page of Figure Expression of pY-Flt-1 and pY-FAK in GCTs The sections were prepared as described in Fig and stained with antipY-Flt-1 (a) and anti-pY-FAK...
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