3 common genetic variants in candidate genes modify the risk for supraventricular arrhythmias
Báo cáo y học: "Role of STAT4 polymorphisms in systemic lupus erythematosus in a Japanese population: a case-control association study of the STAT1-STAT4 region" pot
... located in the introns of STAT4 and in LD with each other In contrast, significant association was not detected for SNPs in the STAT1 region (P > 0.05) To confirm the association detected in the ... were performed To test the significance of each SNP conditional on the genotypes of other SNPs, logistic regression analysis was performed under the additive model for the minor allele Assuming a ... a role in the pathogenesis of SLE A possible role of SNPs in the STAT1-STAT4 region other than the haplotype tagged by rs7574865T has recently been excluded in Caucasians [10] However, in view...
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Báo cáo y học: "TLR7 single-nucleotide polymorphisms in the 3’ untranslated region and intron 2 independently contribute to systemic lupus erythematosus in Japanese women: a case-control association study" ppsx
... with the observations in the Chinese population [7], which demonstrated increased TLR7 transcripts in individuals carrying rs3853839G On the other hand, evidence for an association of the intronic ... for each other as expected on the basis of LD between the two (Table and Figure 1) In agreement with these findings, when only the patients and controls carrying the risk genotypes of the 3’ UTR ... Biosystems) under the following conditions: 50°C for minutes and 95°C for 10 minutes, and 50 cycles at 95°C for 15 seconds and at 60°C for minute, and then the cycle threshold (CT) value for each sample...
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Báo cáo y học: "Lack of association of a variable number of aspartic acid residues in the asporin gene with osteoarthritis susceptibility: case-control studies in Spanish Caucasians" potx
... confirmation in the same ethnic population Therefore, although it remains possible that ASPN could be a crucial modulator in OA by fine-tuning transforming growth factor beta in the repair of ... variation in the number of D residues in ASPN in hip OA, knee OA or hand OA susceptibility in Spanish Caucasians This result reinforces the overall lack of association reported in other studies in Caucasians ... not remain significant after accounting for the multiple comparisons performed The overall results therefore indicate that the ASPN microsatellite is not associated with OA susceptibility in European...
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Báo cáo y học: "Association of single-nucleotide polymorphisms in RHOB and TXNDC3 with knee osteoarthritis susceptibility: two case-control studies in East Asian populations and a meta-analysis" docx
... who were enrolled at the Center of Physical Examination All individuals included in the study were Han Chinese living in and around Nanjing None dropped out during the study In addition, a population ... P, Niu J, Felson DT: Lower prevalence of chondrocalcinosis in Chinese subjects in Beijing than in white subjects in the United States: the Beijing Osteoarthritis Study Arthritis Rheum 2006, 54:3508-3512 ... studies The minor allele frequencies of TXNDC3 in East Asian individuals were significantly different from those in UK control individuals The corresponding German frequency was 13%, which was within...
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Báo cáo y học: "Association of a single nucleotide polymorphism in growth differentiate factor 5 with congenital dysplasia of the hip: a case-control study" ppt
... compare the GDF5 genotype with the allele distributions in the case-control study The differences in the clinical information between the genotypes were tested using the Mann-Whitney test, the Kruskal-Wallis ... to the Medical School of Nanjing University, China The controls had no symptoms or histories of CDH All subjects included in the study were of Han Chinese origin living in and around Nanjing ... dropped out during the process of the study The study was approved by the ethical committee of the participating institutions, and informed consent was obtained from patients and controls The ages...
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Báo cáo y học: "Association between occupational exposure to mineral oil and rheumatoid arthritis: results from the Swedish EIRA case–control study" docx
... year in which this time point occurred was defined as the index year The same index year was used for the corresponding control Only data on exposures up to the index year have been analysed in the ... is the proportion of the incidence among persons exposed to two interacting factors that is attributable to the interaction per se (i.e reflecting their joint effect beyond the sum of their independent ... and smoking Further adjustment for occupational class only marginally changed the estimates and was not retained in the final analyses No mineral oil Mineral oil No SE No mineral oil Mineral oil...
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Báo cáo y học: "Association of functional variants of PTPN22 and tp53 in psoriatic arthritis: a case-control study" docx
... genotyped in the Toronto population for the R620W variant of PTPN22 For the PsA patients the G/G, G/A and A/A genotypes were 153, 43 and 7, respectively, whereas for the Toronto control individuals they ... Of the 238 PsA patients genotyped for the R620W variant of PTPN22 in the Newfoundland cohort, the C/C, C/T and T/T genotypes for cases were 191, 44 and 3, respectively For the 149 controls, the ... baseline risk for PsA of between 0.005 and 0.01 For each candidate gene, 100 simulated data sets were created, the trend test was performed, and we counted the number of simulations in which the...
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Báo cáo y học: "Association of the microsatellite in the 3'''' untranslated region of the CD154 gene with rheumatoid arthritis in females from a Spanish cohort: a case-control study" ppsx
... scattering of the data in the non-24CAs group was similar to that in the 24CAs group This indicated that the functional behavior of the samples included in the non24CAs group, in spite of the inclusion ... of a single individual to estimate the variation inherent in the assay, but it is likely that a significant amount of the scattering in the data is produced by interindividual variations in several ... J Immunol 2004, 173:976-985 32 Kosinski PA, Laughlin J, Singh K, Covey LR: A complex containing polypyrimidine tract-binding protein is involved in regulating the stability of CD40 ligand (CD154)...
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Báo cáo y học: "Association of MICA with rheumatoid arthritis independent of known HLA-DRB1 risk alleles in a family-based and a case control study" pps
... Local NKG2D expression is induced by tumor necrosis factor and interleukin-15 [12] These findings make MICA an interesting candidate gene for association studies in RA The highly polymorphic gene ... to specific genetic determinants [2] There is strong evidence [3-5] that additional genetic risk factors reside within a genomic region containing the strongest known genetic determinants of RA ... logistic regression analyses including all parents informative for MICA-250A and controlling for LD with HLA-DRB1 risk alleles (Table 2c) We did not find any indication that the observed protective...
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Báo cáo y học: "Association of the T allele of an intronic single nucleotide polymorphism in the colony stimulating factor 1 receptor with Crohn''''s disease: a case-control study" ppt
... tempting to hypothesize that the CSF1R protein plays a role in differentiation of intestinal epithelial cells as it does in macrophages The most intense cytoplasmic staining occurred in the terminal ... of the terminal ileum with cytoplasmic staining of the terminal web and lateral junctions of the epithelial cells (green arrow) B Staining of the superficial epithelium of the colon C Staining ... colitis in the presence of normal intestinal bacteria [8] The MDR1 protein may also play a role in host defense against intracellular bacteria by extruding them from the cell, explaining its...
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báo cáo khoa học: " The association of aggressive and chronic periodontitis with systemic manifestations and dental anomalies in a jordanian population: a case control study" pdf
... dens invaginatus into: • Type I: an enamel-lined invagination within the crown and not extending beyond the cementoenamel junction (CEJ) • Type II: the enamel invagination into the root, beyond the ... where there was uncertainty in the diagnosis of AP or CP were not included in this study The investigated dental anomalies included dens invaginatus, dens evaginatus, congenitally missing and ... present study including dens invaginatus, dens evaginatus, pegshaped lateral incisors and congenitally missing lateral incisors Interestingly, the dental anomalies investigated in this study...
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báo cáo khoa học:" Lack of association between celiac disease and dental enamel hypoplasia in a case-control study from an Italian central region" pdf
... diagnosis of CD [12]; in fact among the atypical aspects of CD (extra-intestinals), in the international literature has been reported some affections interesting the oral cavity, the most common are ... study performed among Italian individuals a risk factor for RAS, although no definitive statement is possible on their predictive role for CD more of these deficiencies are present, they should ... of the diagnostic process In conclusion, our data from central Italy confirming the higher prevalence of RAS or aphthous-like ulcers in patients with CD validate the hypothesis of their pathogenetic...
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Báo cáo y học: "Association between occupation and knee and hip replacement due to osteoarthritis: a case-control study" doc
... relatives to the cases, thus coming from the same genetic pool Furthermore, we explored the inheritance of different professions within the cohort Materials and methods The study was approved by the Ethics ... where the study was based This study is a part of a larger study on the effects of genes and environment on the risk for OA in the Icelandic population The cases in that study were drawn from the ... did this for all of our work class categories and calculated the odds ratio (OR) for inheriting the father's or the mother's work class Several work classes had a significant OR for inheritance,...
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Báo cáo y học: "Association of the D repeat polymorphism in the ASPN gene with developmental dysplasia of the hip: a case-control study in Han Chinese" potx
... affiliated to the Medical School of Nanjing University All subjects studied in the study were Chinese Han living in and around Nanjing No subjects dropped out during the process of the study The study ... 0.002) (Table 2) The significance remained after applying the Bonferroni correction No significance was found in other alleles for comparisons of one allele vs all remaining alleles combined after ... WI, USA) according to the manufacturer’s instructions [33] DNA was genotyped for the ASPN microsatellite encoding the D repeat polymorphism after PCR amplification, the primers and thermal conditions...
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Báo cáo y học: "Attributable mortality of Acinetobacter baumannii infections in critically ill patients: a systematic review of matched cohort and case-control studies" doc
... significant increase in the length of stay in the ICU was reported for the cases with A baumannii infection [14,17,21], whereas in the remaining two studies no significant difference was found in the ... studies, as well as the outcomes of our interest in cases with A baumannii infection and controls, in Table As shown, the infection sites for the cases with A baumannii infection were the lower respiratory ... whereas in the other study the attributable mortality in the ICU was 30% It is noteworthy that two of these four studies did not match the patients for disease severity [16,17] Length of stay in the...
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THE VALUE OF RE USING PRIOR NESTED CASE CONTROL DATA IN NEW STUDIES WITH DIFFERENT OUTCOME
... We require the covariates in the prior study (those extracted from the registers and measured in the field) include the covariates of interest for the current study The information on the survival ... contribution of individual i given by the following: (5) with yi being the binary indicator taking the value one if individual i is a case in study B The weight ωi is calculated as the inverse of the probability ... provide more timely results using a cohort design, at first increasing the size of the cohort seems to be the way out But this will result in further cost in maintaining the cohort which may not be...
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Báo cáo y học: "Comparative study of control selection in a national population -based case-control study: Estimating risk of smoking on cancer deaths in Chinese men"
... reported their smoking habits in the early 1980s.17 Information obtained from the spouse on the husband’s smoking habits was highly consistent with information provided directly by the husband In this ... were formed within the study base with one group of cases and two different control groups The information on smoking history was obtained by interviews We interviewed informants (spouses or other ... about whether the dead person had smoked, although they were sometimes uncertain of the age when smoking began A validity study in Shanghai was conducted where the surviving spouse was the informant...
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Breast cancer risk in relation to occupations with exposure to carcinogens and endocrine disruptors: a Canadian case–control study pptx
... although there was limited power to distinguish them (Table 7) For Metric II, the point estimates for the second and third windows were close Exposures in farming and bars-gambling work exhibited the ... volunteered their time The funding bodies played no role of the design, collection, analysis, or interpretation of data, in the writing of the manuscript, or in the decision to submit the manuscript for ... assessments for investigating endocrine and other mechanistic aspects of breast carcinogenesis [69] Menopausal status Finding distinct patterns for pre- versus postmenopausal breast cancer, such as increased...
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Occupation and Breast Cancer: A Canadian Case–Control Study docx
... cancer risk. 10 Many substances shown to induce breast cancer in experimental mammals exist in high concentrations in occupational settings.11 In spite of the continuing increase in the incidence ... significance for any of the specific periods In the next step, the odds ratios for the independent variables (e.g., farming) indicate the effect of each variable, after adjusting for covariates, on the ... insults, either singular or in combination, may influence the initiation, promotion, and progression of carcinogenesis Both dose and timing of exposure may be important in terms of risk It has...
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Associated factors for treatment delay in pulmonary tuberculosis in HIV-infected individuals: a nested case-control study docx
... these tests The results of the univariate analysis of the factors associated to a delay in initiating treatment for TB in HIVinfected individuals are presented in Table The variables that indicated ... findings of this study regarding the presence of constitutional symptoms also explain the findings of these authors The present study considers that in order to reduce the delay in starting TB ... in the previous stage were introduced into the final multivariate model (including variables from all groups) and those with a P value ≤ 0.05 remained in the final model This study is part of the...
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Tìm thêm: xác định các mục tiêu của chương trình xác định các nguyên tắc biên soạn khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo gắn với các giáo trình cụ thể xác định thời lượng học về mặt lí thuyết và thực tế tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra đối với đối tượng giảng viên và đối tượng quản lí khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu nội dung cụ thể cho từng kĩ năng ở từng cấp độ xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ đặc tuyến mômen quay m fi p2 động cơ điện không đồng bộ một pha sự cần thiết phải đầu tư xây dựng nhà máy thông tin liên lạc và các dịch vụ phần 3 giới thiệu nguyên liệu chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008 chỉ tiêu chất lượng 9 tr 25