... dihydrotestosterone inthe gland The periurethral portion ofthe gland increases in size during puberty and after the age of 55 due to the growth of nonmalignant cells inthe transition zone ofthe prostate ... (SRD5A2) gene have also been implicated inthe variations in incidence The incidence of autopsy-detected cancers is similar around the world, while the incidence of clinical disease varies Thus, environmental ... survival in prospective randomized trials The paradox of management is that although the disease remains the second leading cause of cancer deaths in men, only man in with prostate cancer will die of...
... based on the tempo ofthe illness as it unfolds inthe individual, relative to the riskto-benefit ratio ofthe therapy being considered No Cancer Diagnosis Prevention Several agents are under investigation ... control, in which the tempo ofthe illness is altered and symptoms controlled until the patient dies of other causes These can be equivalent therapeutically from a patient standpoint if the patient ... proviso that the risks and benefits ofthe performance of these tests are not defined The National Comprehensive Cancer Network advises testing at age 40, tailoring additional testing to the age-specific...
... Each core ofthe biopsy is examined for the presence of cancer, and the amount of cancer is quantified based on the length ofthe tumor within the core and the percentage ofthe core involved ... changed the clinical spectrum ofthe disease Now, 95–99% of newly diagnosed cancers are clinically localized, 40% are not palpable, and of these, 70% are pathologically organ-confined The downside of ... ongoing Until the results of these studies are available, men are advised to make an informed decision about whether to undergo testing A diagnostic algorithm based on the DRE and PSA findings...
... to the extent ofthe disease within the gland, the presence or absence of capsular invasion, involvement of seminal vesicles, and extension of disease to lymph nodes Because ofthe inadequacy of ... staging, the staging system was modified to include the results of imaging studies Unfortunately, no single test has proven to indicate accurately the stage or the presence of organ-confined ... histologic grade) often determines biologic behavior The presence or absence of perineural invasion and extracapsular spread are also recorded Prostate Cancer Staging The TNM staging system includes categories...
... undetectable inthe blood within weeks, based on the PSA half-life inthe blood of days If PSA remains detectable, the patient is considered to have persistent disease After radiation therapy, in contrast, ... to assess The more advanced the disease, the lower the probability of local control and the higher the probability of systemic relapse More important is that within the categories of T1, T2, ... rates range from 25 to 89% Part ofthe variability relates to how the complication is defined and whether the patient or physician is reporting the event The time ofthe assessment is also important...
... further shaping ofthe dose, allowing the delivery of still higher doses to the prostate and a further reduction in normal tissue exposure These advances have enabled the safe administration of doses ... with intensity-modulated radiation therapy (IMRT) to maximize the dose to the prostate and to minimize the exposure ofthe surrounding normal structures The addition of IMRT has permitted further ... disruption ofthe vascular supply and not the nerve fibers Neoadjuvant hormone therapy has also been studied in combination with radiation therapy The aim is to decrease the size ofthe prostate...
... waiting, or deferred therapy, is a policy of monitoring the illness at fixed intervals with DREs, PSA measurements, and repeat biopsies ofthe prostate as indicated, but with no therapeutic intervention(s) ... disease on scan For these patients the central issue is whether the rise in PSA results from persistent disease inthe primary site, systemic disease, or both In theory, disease inthe primary site ... estimated that 10–15% of patients had "insignificant" cancers Given the multifocality ofthe disease, a concern is the limited ability to predict pathologic findings on the basis of a needle biopsy,...
... potency The initial rise in testosterone may result in a clinical flare ofthe disease These agents are therefore contraindicated in men with significant obstructive symptoms, cancer-related pain, ... disease at the same time intervals was 23, 32, and 53%, vs 47, 69, and 79% if the doubling time was short (
... first 2–4 weeks of treatment to protect against the flare Intermittent Hormone Therapy Another way to reduce the side effects of androgen depletion is to administer hormones on an intermittent basis ... differentiation pathway In this way, the surviving cells that are allowed to proliferate inthe presence of androgen will retain sensitivity to subsequent androgen depletion Applied inthe clinic, androgen ... normal in 60–70% of patients, and measurable disease regression occurs in 50%; improvements in bone scan occur in 25% of cases, but the majority remains stable Duration of survival is inversely...
... act by relaxing the smooth muscle ofthe bladder neck and increasing peak urinary flow rates No data show that these agents influence the progression ofthe disease Surgical approaches include TURP, ... Always the time after you finished urinating? Over the 5 how often past month, have you had to urinate again less than h after you finished urinating? Over the past month, how often have you found ... regardless ofthe size ofthe gland, while those with an inability to urinate, gross hematuria, recurrent infection, or bladder stones may require surgery In patients with symptoms, uroflowmetry...
... in 66.7% of cases, and in 33.3% they were localized outside the gland inthe vicinity ofthe hilus and ofthe distal portion ofthe excretory duct Following submandibulectomy or slitting ofthe ... a dominance of non-epithelial tumors inthe first years of life In still another study [40] the non-epithelial tumors were the most frequent benign neoplasms inthe parotid region (50%) in newborns ... group of patients, since they presented at our clinic for operative therapy in well-defined cases Concrements were located intraglandularly or found in Page ofthe proximal portion ofthe Wharton’s...
... Applying intervention solution Intentionally choosing total 104 deck officers among 600 crews under the study who had not taken part in training course of maritime medicine to join the training ... conducted the intervention applying one inthe main proposed measures namely "strengthening maritime medicine training programs for companies’ deck officers under the provisions ofthe STCW Convention/2010 ... practice (intensive training for weeks at the Center for Marine Medicine Training subordinate Vietnam National Institute of Maritime Medicine) The students were evaluated in terms of knowledge...
... Newspaper : VN Express Date : December 1, 2012 Page/Link : http://vnexpress.net/gl/suc-khoe/2012/12/nhung-nan-nhan-vo-toi-cua-hiv/ The innocent victims of HIV Những nạn nhân vô tội HIV Nhận viên thuốc ... khám biết mắc bệnh”, bà Sáu kể Theo tư vấn bác sĩ, Trâm điều trị ngoại trú cách mang thuốc nhà uống tái khám theo lịch Việc chữa trị kéo dài chưa đến năm cô học sinh lớp phải bỏ học để nhập viện ... thiết Sinh viên TP Cần Thơ tuyên truyền thông điệp "Xét nghiệm HIV để bảo vệ người thân" mittinh hưởng ứng Ngày Thế giới phòng chống HIV/AIDS Ảnh: Phượng Hoàng “Người lớn có khả điều trị theo nhu...
... observations of intersex in fish have been increasing in regularity inthe Shenandoah River and Potomac River basins in Virginia (Blazer and others, 2007) The fish kills and observations of intersex ... rate-limiting barriers allowing the use ofthe same models to determine ambient water concentrations Previous data indicate that many chemicals of interest remain inthe linear phase of sampling for ... triolein represented 20 percent ofthe mass ofthe SPMDs conforming to a “standard SPMD” as defined by Huckins and others (2006) Two ofthe four SPMDs in each deployment canister and two of the...
... peering ahead into the dusky sea of pines Fresher and fresher came the wind from the sea, in puffs, in mild, sweet breezes, in steady, freshening currents, blowing the feathery crowns ofthe pines, ... note ofthe male bird, the fainter responses ofthe female, the thin plaints ofthe chicks, huddling under her breast; I heard 17 their flipper-like, embryotic wings beating sleepily as the birds ... again it darted into the surf, and, when I leaned out into the chilling drizzle, I saw nothing save the flat ebb crawling on the coast—I heard nothing save the purring of bubbles on seething...
... lesser of 10% ofthe value ofthe gift and $75, then the value ofthe advantage is considered to be zero For example, if the price to attend the benefit dinner is $200 and the value ofthe dinner ... for the value of an item before taxes HSFM requests that organizations donating a gift -in- kind provide an invoice stating the value (not cost) ofthe item as ofthe date ofthe donation A gift -in- kind ... to these goods and services received in exchange for a gift as the Advantage Inthe above example the advantage is the value ofthe dinner, i.e $40 In situations where the cost or portion of the...
... begins inthe gut ofthe sandfly, but the organism completes its life cycle inthe host following the fly bite The sandfly inoculates the host with the organisms inthe promastigote stage Once the ... weapon There are major forms of infection with the organism: cutaneous, inhalation, and gastrointestinal.93 The details of these forms of anthrax will not be discussed with the exception of gastrointestinal ... with inflammatory cells including neutrophils and eosinophils The presence of allergic mucin in a sinonasal specimen should alert pathologists to the possibility of AFS B, The fungi inthe allergic...
... that the development ofthe Negro and White proceeds on different lines While with the latter the volume ofthe brain grows with the expansion ofthe brain-pan, inthe former the growth ofthe ... always innate, a gift of Nature, and expressed inthe magnitude and weight ofthe brain and the development oftheCHAPTER THREE 34 convolutions, either inthe whole or inthe single parts In it, ... one only the path of Selection, ofthe preservation of favoured individuals and of favoured races The deadly enemy ofthe whole process of uplifting, ofthe Drang nach oben, ofthe course of history...
... [31,33] The similarity ofthe C-terminal domain of MABO to other proteins ofthe sarcosine dehydrogenase and oxidase family may indicate that this is the site of attachment of tetrahydrofolate to the ... mutagenesis ofthe MABO gene The amino acid substitutions inthe MABO protein were made with the aid ofthe Quick Change site-directed mutagenesis kit (Stratagene), according to the instructions ofthe ... protein with covalently attached flavin, synthesized only in bacteria grown inthe presence of nicotine The DNA carrying the sarcosine dehydrogenase-like ORF63, corresponding to a protein of 813...
... with the amino group ofthe main chain at Glu268 The oxygen ofthe main chain at Asp266 was bound to amino groups of main chain of Tyr269 and Ala270 by hydrogen bonds The interactions should maintain ... temperature indicates the stability ofthe structure ofthe protein The difference ofthe increments between the inactive temperature and the Tm should indicate that the mutations improved the stability ... surrounding residues ofthe depression, and the side chain ofthe mutated residue might restrain the mobility ofthe N-terminal region on the surface by interaction with the main chain of Lys26 by van...