1 vegfr 2 and neuropilin 1 expression by cytokines and growth factors in ra sfs and huvecs
Báo cáo y học: "B lymphocyte stimulator (BLyS) isoforms in systemic lupus erythematosus: disease activity correlates better with blood leukocyte BLyS mRNA levels than with plasma BLyS protein levels" ppsx
... Research & Therapy 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 Vol No Collins et al signaling through Bcmd/BR3 regulates peripheral B lymphocyte numbers Curr Biol 20 01, 11 :19 86 -19 89 Hsu BL, ... (19 .4–66.8) 35 .1 (20 .4–66.3) Sex (female/male; n) 27 /3 52/ 8 56/4 36 /1 Asian 11 5 Black 3 Hispanic 13 51 49 32 White 0 Number of patients - 17 50 31 Mean dosage (mg/day) - 5.5 10 .8 6.0 Dosage range ... 2. 5 10 2 30 1 30 Cyclophosphamide - Azathioprine - 27 15 Mycophenolate mofetil - 13 Methotrexate - 42 2 Sulfasalazine - 17 0 Hydroxychloroquine - 36 53 36 Leflunomide - Any TNF antagonist - 18 ...
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Báo cáo y học: "nfluence of atorvastatin on coronary calcifications and myocardial perfusion defects in systemic lupus erythematosus patients: a prospective, randomized, double-masked, placebo-controlled study" docx
... 0. 02- 0 .26 (0 .13 ± 0.05) - 16 (26 .7%) 11 (18 .3%) aCL IgG (RU/ml) 0.68 - 12 1.56 (14 .4 ± 20 .3) 20 (33.3%) aCL IgM (RU/ml) 1. 62- 52. 93 ( 12 .1 ± 10 .6) 26 (43.3%) antib2GPI IgG (RU/ml) 0 .16 -95.33 (3.8 ± 15 .3) ... 3.9 ± 5 .1 ns ALT (IU/l) AST (IU/l) 27 .1 ± 8.6 26 .1 ± 6 .2 39 .1 ± 51. 4* 40 .2 ± 56.6* ns ns CPK (IU/l) SLEDAI 53 .2 ± 37.5 71. 2 ± 57 .2 ns 0 - 12 (median 4) 0 - 12 (median 2) ns * in one patient increased ... read and approved the final version of the manuscript Competing interests The authors declare that they have no competing interests Page of 9 10 11 12 13 14 15 16 17 18 19 20 Received: 13 January...
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Báo cáo y học: "Association of elevated transcript levels of interferon-inducible chemokines with disease activity and organ damage in systemic lupus erythematosus patients" docx
... (-0. 32 to +14 .17 ) 30 5. 72 (-0.44 to +14 . 81) NS Anti-Ro 24 6.05 (1. 85 to 13 .96) 43 5.47 ( -1. 76 to +15 .69) NS Anti-Sm 13 11 .56 (3.89 to 23 . 82) 54 3.56 ( -1. 72 to + 12 .66) 0.0 21 1 Anti-RNP 23 10 .28 (3.08 ... Mucosal ulcer 4. 21 (1. 95 to 14 .33) 59 5.93 (-4.46 to +14 . 01) NS Haematological 19 7.39 ( -2. 77 to +13 . 91) 48 5.09 (0.59 to 14 . 81) NS Proteinuria 26 8. 511 (2. 01 to 23 .25 ) 41 3.39 ( -1. 56 to + 12 .56) NS ... (3.08 to 18 .97) 44 2. 95 ( -1. 72 to + 12 .56) 0.0 21 2 Anti-nucleosome 24 7.50 (1. 63 to 15 .69) 43 3.73 (-0.46 to +13 . 91) NS Predisone dose >30 mg/day 38 4.76 ( -1. 56 to + 12 .66) 29 7. 72 (2 . 12 to 19 .89)...
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Báo cáo y học: "Myeloid dendritic cells display downregulation of C-type lectin receptors and aberrant lectin uptake in systemic lupus erythematosus" pdf
... of dying cells and autoreactivity Curr Top Microbiol Immunol 20 06, 305 :16 1 -17 6 43 Kaplan MJ: Apoptosis in systemic lupus erythematosus Clin Immunol 20 04, 11 2: 21 0 - 21 8 44 Marai I, Tincani A, Balestrieri ... Lett 20 06, 10 4:46- 52 Ross GD: Regulation of the adhesion versus cytotoxic functions of the Mac -1/ CR3/αM 2- integrin glycoprotein Crit Rev Immunol 20 00, 20 :19 7 -22 2 Bave U, Magnusson M, Eloranta ... (Oxford) 20 06, 45 :10 87 -10 95 28 Gill MA, Blanco P, Arce E, Pascual V, Banchereau J, Palucka AK: Blood dendritic cells and DC-poietins in systemic lupus erythematosus Hum Immunol 20 02, 63 :11 72 -11 80 29 ...
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Báo cáo y học: "Underexpression of mitochondrial-DNA encoded ATP synthesis-related genes and DNA repair genes in systemic lupus erythematosus" pot
... 59 303 8.83 × 10 -4 Inflammatory response 48 18 7 2. 68 × 10 -6 Cell growth and/ or maintenance 5 72 4,0 92 3.09 × 10 -3 28 27 12 3 12 2 2.99 × 10 -3 5.34 × 10 -3 Cell motility 62 3 42 3.78 × 10 -3 Regulation ... response 19 2 17 6 963 887 7.36 × 10 -11 7.69 × 10 -10 Immune response 15 9 7 92 2.45 × 10 -9 Response to stress 14 7 8 72 2.39 × 10 -4 Response to pest/pathogen/parasite 97 5 01 2. 09 × 10 -5 Response to wounding ... Competing interests The authors declare that they have no competing interests Received: January 2 011 Revised: 11 March 2 011 Accepted: 15 April 2 011 Published: 15 April 2 011 References Kotzin BL:...
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Báo cáo y học: "Reduced IgG anti-small nuclear ribonucleoprotein autoantibody production in systemic lupus erythematosus patients with positive IgM anti-cytomegalovirus antibodies" pdf
... http://arthritis-research.com/content /11 /1/ R27 10 11 12 13 14 15 16 17 18 19 20 21 Moreland LW Philadelphia: Lippincott Williams and Wilkins; 20 05 :14 97 -15 21 Denman AM: Systemic lupus erythematosus – is a viral aetiology ... (2, 870 to 12 ,10 0) 5, 413 ± 1, 713 (2, 900 to 8,700) 5,9 62 ± 2 ,13 5 (2, 870 to 12 ,10 0) Lymphocyte (/μl) 14 93 ± 688 (15 4 to 3,400) 14 50 ± 676 (15 4 to 2, 890) 15 15 ± 7 02 (26 9 to 3,400) 27 3.8 ± 63.9 (13 7 ... (0 .1 to 23 ) Age at diagnosis (years) 29 .2 ± 12 .1 (7 to 57) 24 .9 ± 10 .9* (7 to 57) 31. 5 ± 12 .3* ( 12 to 57) Mexican SLEDAI 2. 88 ± 2. 97 (0.0 to 12 ) 3.30 ± 3 .26 (0.0 to 10 ) 2. 67 ± 2. 83 (0.0 to 12 )...
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Báo cáo y học: "Neuropsychological patterns in systemic lupus erythematosus patients with depression" potx
... Controls 13 10 25 42. 5 ± 9.5a 14 .2 ± 2. 1a 42. 9 ± P value 10 .5a 43.5 ± 11 .5a 0.966 2. 3a 2. 0a 0 .17 3 14 .7 ± 15 .5 ± 9/4 8 /2 23 /2 0 .19 8 0 / 12 /1 0/9 /1 2/ 23/0 0.403 aData are presented as mean ± standard ... symptoms in systemic lupus erythematosus: an update Psychosom Med 19 93, 55: 21 9 -22 8 Available online http://arthritis-research.com/content/9/3/R48 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 Kozora ... ± 7.9 0. 327 Written comprehension 47.8 ± 11 .9 51. 2 ± 13 .6 49.4 ± 11 .4 0.793 43.6 ± 11 .5 52. 8 ± 9 .2 52. 6 ± 7.4 0. 017 1
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Báo cáo y học: "The VH gene repertoire of splenic B cells and somatic hypermutation in systemic lupus erythematosus" potx
... 2 -15 3 -22 6 -13 * 01 5-5* 01 5 -24 * 01 2- 2* 01 6 -13 * 01 6* 02 4* 02 6* 02 4* 02 3 1 1 4* 02 6* 02 5* 02 4* 02 4* 02 4* 02 3* 02 2 (1) 1 (1) 5(3) 1 11 3 (1) 3* 02 6*03 4* 02 4* 02 4* 02 1* 01 4* 02 13 (10 ) 3 (1) 1 3 (2) 2* 01 6*03 ... 5 -24 * 01 VH3-74* 01 VH4-4*03 VH4-30.4* 01 2- 2* 01 VH4-34* 01 VH4-59 1- 26 * 01 VH5- 51* 01 2- 2* 01 VH5- 51* 01 2- 2* 01 VH5- 51* 01 4-4* 01 5* 02 B C D VH3-07 VH3 -23 VH3-33 VH3- 72* 01 VH4-59* 02 VH5- 51* 01 VH5- 51* 01 2 -15 ... chain genes identified from spleen tissue JH gene A VH2-5* 02 VH3 -15 * 01 VH3 -23 * 01 VH3-30*03 VH3-43* 02 VH3-74* 02 VH5- 51 3 -10 * 01 2- 21 * 02 1- 26 * 01 3 -22 * 01 5* 02 4* 02 5* 02 4* 02 2 -15 * 01 3 -10 6* 02 4* 02 1- 26 *01...
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Báo cáo y học: "Interactions among type I and type II interferon, tumor necrosis factor, and -estradiol in the regulation of immune response-related gene expressions in systemic lupus erythematosus" potx
... number CD40 Hs 010 02 913 _m1 CD1C Hs0 023 3509_m1 CD14 Hs0 016 9 12 2_ g1 Chemokine (C-C motif) receptor (CCR7) Hs0 017 1054_m1 IL12B Hs0 023 3688_m1 IL-4 receptor (IL4R) Hs0 016 623 7_m1 Prostaglandin E synthase ... protein (IFITM1) Hs 016 525 22_ g1 Interferon-stimulated gene, 15 kDa (ISG15) Hs0 019 2 713 _m1 Interferon regulatory factor (IRF7) Hs0 024 21 9 0_g1 2' ,5'-oligoadenylate synthetase (OAS1) Hs0 024 2943_m1 2' ,5'-oligoadenylate ... Hs00388 714 _m1 Guanylate binding protein (GBP1) Hs0 026 6 717 _m1 Guanylate binding protein (GBP2) Hs0 026 9759_m1 IL 8RA Hs0 017 414 6_m1 C-type lectin domain family 4, member E (CLEC4E) Hs003 72 017 _m1 TNF-induced...
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Báo cáo y học: "Practical and theoretical barriers to the prevention of accelerated atherosclerosis in systemic lupus erythematosus" docx
... Rheumatology, Allergy and Immunology, Bulfinch 16 5, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 0 21 1 4, USA Tel: +1 617 726 28 70 or +1 617 7 32 50 81; fax: +1 617 726 28 72; e-mail: kcostenbader@partners.org ... and lupus: a work in progress Arthritis Rheum 20 01, 44 :2 21 5 -2 21 7 Giri S, Parke AL, Waters DD: Controlling cardiovascular risk factors in systemic lupus erythematosus J Musculoskel Med 19 98, 15 : ... Med 19 76, 60 :2 21 - 22 5 Manzi S, Meilahn EN, Rairie JE, Conte CG, Medsger TA Jr, Jansen-McWilliams L, D’Agostino RB, Kuller LH: Age-specific incidence rates of myocardial infarction and angina in...
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Báo cáo y học: "Activation of transforming growth factor-β1 and early atherosclerosis in systemic lupus erythematosus" pptx
... apoptotic cells in the total PBMC population at 24 hours, as measured by annexinV staining (median [interquartile range]: 3 .25 % [2. 25–5 .15 %] versus 2. 20% [1. 7–3.35%], P = 0. 0 12 ; Figure 1a) The TGFβAI ... an individual The TGF- 1 activation indices were similar between patients and control individuals (median [interquartile range] AI: 1. 63 [1. 31 1. 88] in SLE patients versus 1. 50 [1. 26 1. 73] in ... dissolution with plasmin Nature Medicine 19 95, 1: 9 32- 937 20 Lawrence DA: Latent-TGF-beta: an overview Mol Cell Biochem 20 01, 21 9 :16 3 -17 0 21 Emlen W, Niebur J, Kadera R: Accelerated in vitro apoptosis...
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Báo cáo y học: "Autoantibodies against the replication protein A complex in systemic lupus erythematosus and other autoimmune diseases" pps
... Therapy 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 Vol No Yamasaki et al human and murine autoimmune sera to U1 small nuclear ribonucleoprotein C protein J Clin Invest 19 96, 97 :2 619 -26 26 ... serially diluted 1: 5, starting from 1: 500 dilutions All sera were clearly positive on ELISA and their titers were 1: 12, 500 in one case, 1: 62, 500 in six, and 1: 3 12 ,500 in two, indicating that the ... screened by ELISA with the recombinant RPA 32 protein Antibodies against RPA 32 were found in 10 .9% (87 of 8 01) in breast cancer patients and in 10 .3% (4 of 39) in intraductal in situ carcinoma patients,...
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Báo cáo y học: "Toll-like receptors and innate immune responses in systemic lupus" docx
... controlled by Toll-like receptor signaling J Clin Invest 20 06, 11 6 :24 56 -24 63 65 Colonna M: Toll-like receptors and IFN-alpha: partners in autoimmunity J Clin Invest 20 06, 11 6 :2 319 -23 22 66 McClain MT, ... citation purposes) 20 21 22 23 24 25 26 27 28 29 30 31 immunostimulatory activity of vertebrate DNA J Immunol 20 03, 17 0:3 614 -3 620 Gursel I, Gursel M, Yamada H, Ishii KJ, Takeshita F, Klinman DM: Repetitive ... chromatin protein HMGB1 by necrotic cells triggers inflammation Nature 20 02, 418 :19 1 -19 5 53 DeMarco RA, Fink MP, Lotze MT: Monocytes promote natural killer cell interferon gamma production in response...
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Báo cáo y học: "Altered lipoprotein metabolism in chronic inflammatory states: proinflammatory high-density lipoprotein and accelerated atherosclerosis in systemic lupus erythematosus and rheumatoid arthritis" ppsx
... ILLUMINATE Investigators: Effects of torcetapib in patients at high risk for coronary events N Eng J Med 20 07, 357: 21 0 9 21 2 2 10 Lusis AJ: Atherosclerosis Nature (London) 20 00, 407 :23 3 -2 41 11 Van ... Biol 20 04, 24 :4 21 - 428 17 van Tol A: Phospholipid transfer protein Curr Opin Lipidol 20 02, 13 :13 5 -13 9 18 Le Goff W, Guerin M, Chapman JM: Pharmacological modulation of cholesteryl ester transfer ... subpopulations in predicting recurrent cardiovascular events in the Veterans Affairs HDL Intervention Trial Arterioscler Thromb Vasc Biol 20 05, 25 : 21 8 5- 21 9 1 15 Oram JF: The cholesterol mobilizing transporter...
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Báo cáo y học: "Regulatory T cells in systemic lupus erythematosus: past, present and future" pot
... Immunology 19 69, 17 :665-675 Krakauer RS, Strober W, Rippeon DL, Waldmann TA: Prevention Available online http://arthritis-research.com/content /10 /6 /22 7 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 of autoimmunity ... Trends Immunol 20 08, 29 : 429 -435 Fontenot JD, Rasmussen JP, Gavin MA, Rudensky AY: A function for interleukin in Foxp3-expressing regulatory T cells Nat Immunol 20 05, 6 :11 42 -11 51 β Marie JC, Letterio ... Clin Immunol 20 07, 12 3 :18 -29 Horwitz DA, Zheng SG, Wang J, Gray JD: Critical role of IL -2 β and TGF-β in generation, function and stabilization of Foxp3(+)CD4(+) Treg Eur J Immunol 20 08, 38: 9 12 - 915 ...
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Báo cáo y học: " Interactions among type I and type II interferon, tumor necrosis factor, and -estradiol in the regulation of immune response-related gene expressions in systemic lupus erythematosus" pptx
... number CD40 Hs 010 02 913 _m1 CD1C Hs0 023 3509_m1 CD14 Hs0 016 9 12 2_ g1 Chemokine (C-C motif) receptor (CCR7) Hs0 017 1054_m1 IL12B Hs0 023 3688_m1 IL-4 receptor (IL4R) Hs0 016 623 7_m1 Prostaglandin E synthase ... protein (IFITM1) Hs 016 525 22_ g1 Interferon-stimulated gene, 15 kDa (ISG15) Hs0 019 2 713 _m1 Interferon regulatory factor (IRF7) Hs0 024 21 9 0_g1 2' ,5'-oligoadenylate synthetase (OAS1) Hs0 024 2943_m1 2' ,5'-oligoadenylate ... Hs00388 714 _m1 Guanylate binding protein (GBP1) Hs0 026 6 717 _m1 Guanylate binding protein (GBP2) Hs0 026 9759_m1 IL 8RA Hs0 017 414 6_m1 C-type lectin domain family 4, member E (CLEC4E) Hs003 72 017 _m1 TNF-induced...
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Báo cáo y học: " Dysregulated balance of Th17 and Th1 cells in systemic lupus erythematosus" doc
... levels of Th17-driving cytokines and IL -10 in patients with SLE and healthy controls Plasma levels of Th17-polarizing cytokinesg(IL-1b, IL-6, IL- 21 , TGF-b, and IL -23 ) and IL -10 were measured in patients ... TGF-b, IL-1b, IL-6, IL- 21 , and IL -23 are involved in developing and/ or expanding Th17 cells, whereas IFN-g and IL-4, signature cytokines required for Th1 and Th2 differentiation, suppress Th17 cell ... they have no competing interests 20 Received: 26 October 20 09 Revised: 15 January 2 010 Accepted: 24 March 2 010 Published: 24 March 2 010 21 References Vratsanos G, Kang I, Craft J: Systemic lupus...
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Báo cáo y học: " Variability over time and correlates of cholesterol and blood pressure in systemic lupus erythematosus: a longitudinal cohort study" pptx
... Hg) 15 3 ( 12 .1) 725 (58.0) 15 (1. 2) 520 ( 41. 3) 12 DBP (mm Hg) 11 4 (9 .1) 804 (64.0) (0.6) 449 (35.6) BP (mm Hg) 19 0 (15 .1) 654 ( 51. 9) 21 (1. 7) 585 (46.4) 14 aElevated TC is defined as > 5 .2 mmol/L ... 0.00 01 Antimalarialsb -1. 32 -1. 96, -0.69 < 0.00 01 Immunosuppressivesc -1. 81 -2. 48, -1. 13 < 0.00 01 Antihypertensivesd 6.85 6 .17 , 7.53 < 0.00 01 Diabetese 2. 43 1. 16, 3.70 0.00 02 Smokingf 1. 12 0 .20 , 2. 04 ... (mmol/L) 5 .2 ± 1. 7 1. 1, 16 .1 4.9 SBP at start of study (mm Hg) 12 3 ± 19 .2 80, 22 0 12 0 DBP at start of study (mm Hg) 77 .2 ± 12 .0 55, 18 0 80 SD, standard deviation; Min, Max, minimum and maximum...
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