1 hifs in bone modeling and remodeling
Báo cáo y học: "Elevated extracellular matrix production and degradation upon bone morphogenetic protein-2 (BMP-2) stimulation point toward a role for BMP-2 in cartilage repair and remodeling" pps
... imaging system There was a significant (30%) increase in safranin O staining intensity in the patella on day When the data of all time points were pooled, a significant increase in safranin O ... stained immunohistochemically for VDIPEN (Figure 1i–l) BMP-2 initially induced an increase in VDIPEN staining on day in patellar cartilage In tibial cartilage, elevated levels of VDIPEN staining ... VDIPEN staining (k) and NITEGE staining (q,p) Arrows point to intense staining around chondrocytes FastG, fast green; SafO, safranin O Co-incubation of several dilutions of BMP-2 protein with the...
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Case Study in Financial Modeling and Simulation of a Forestry Investment potx
... stock, planting, watering Maintenance:- weed control, fertilizing, pruning and thinning, fire and pest protection Inflows:wood; commercial thinning, final harvest non-wood; flora gathering, recreation, ... for Projects initial cash outlay inflows from sale of product Particular to Forestry long term maintenance timed on-going outlays:thinnings, maintenance, income- poles or timber? income – time ... Solving the Model 11 Solving the Model 12 Solving the Model Define and predict the long term benefits 13 Solving the Model Define and predict the long term benefits Asses the risks 14 Solving...
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báo cáo hóa học:" High correlation of the proteome patterns in bone marrow and peripheral blood blast cells in patients with acute myeloid leukemia" pot
... fixed in 50% ethanol, and 10% acetic acid for 12 hours Silver staining Proteins were visualized using the silver staining method employing a modification of the method of Heukeshoven according ... protein for phosphoserin motifs Regulated the interactions and subcellular localization of signalling molecules γ-Catenin Forms a complex with α- and β-Catenin to Cadherins, that are involved in ... formation and maintenance of the histo-architecture Plasmonogen activator inhibitor-2 (PAI-2) Involved in the regulation and inhibition of binding between urokinase-type plasminogen activator...
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Báo cáo y học: "Biology of recently discovered cytokines: Interleukin-17 – a unique inflammatory cytokine with roles in bone biology and arthrits" pdf
... thus helping to maintain homeostasis in bone remodeling Conversely, the bone resorbing activity of osteoclasts causes the release of various growth factors and bone cell mitogens that induce proliferation ... to be a bone destructive cytokine Interleukin-17 in other diseases IL-17 has been implicated in numerous other disease settings Intriguingly, IL-17 is highly homologous to an open reading frame ... HCM, Papapoulos SE, Löwik CWGM: Interleukin-17: a new bone acting cytokine in vitro J Bone Miner Res 1999, 14:1513-1521 55 Johnson RB, Wood N, Serio FG: Interleukin-11 and IL-17 and the pathogenesis...
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Báo cáo y học: "Bone morphogenetic proteins in destructive and remodeling arthritis" pdf
... [16] Bone morphogenetic proteins in ‘remodeling arthritis’ Our group has been investigating the role of BMPs in an animal model of remodeling arthritis [17,18] Spontaneous arthritis in aging male ... pleiotropic cytokines, growth factors and morphogens Increasing evidence supports a critical role for BMP signaling in joint remodeling, particularly in enthesophyte formation in SpA In addition, ... also inhibited osteophyte formation in collagenase-induced arthritis, a mouse model of joint instability leading to osteoarthritis [25] Papaininduced arthritis is a mouse model in which direct injection...
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Báo cáo y học: " A 1-year case-control study in patients with rheumatoid arthritis indicates prevention of loss of bone mineral density in both responders and nonresponders to infliximab" docx
... osteocalcin in this population contrast with the physiological association between osteocalcin and bone formation The findings suggest a defect in bone formation that may be explained, in part, ... markers of bone turnover and clinical parameters or bone mineral density values On looking for correlation between bone markers and clinical parameters in the whole population (control and infliximab ... of bone turnover All bone markers were measured using commercial assays, in accordance with instructions of the manufacturers Osteocalcin (normal values 15 to 46 ng/ml), C-terminal cross-linking...
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Applications of electrospinning and supercritical carbon dioxide foaming techniques in controlled release and bone regeneration 1
... containing bone morphogenetic protein (BMP-2) and/or nanoparticles of hydroxyapatite (nHAp) using electrospinning, and showed its ability in inducing in vitro bone formation from human bone marrow-derived ... science and bioinformatics (Donald and Mohammad, 2001) Chapter 1.1.1 Cells Tissue engineering utilizes living cells as engineering materials Examples include using living fibroblasts in skin replacement ... processed into porous fibrous scaffolds for tissue engineering applications using the electrospinning process Scaffolds generated by electrospinning contain nanoscale fibers with microscale-interconnected...
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Báo cáo y học: " Polysaccharides from the root of Angelica sinensis protect bone marrow and gastrointestinal tissues against the cytotoxicity of cyclophosphamide in mice
... by a 45-minute incubation in peroxidase-labeled streptavidin (from DAKO kit) Finally the sections were stained with diaminobenzidine-H2O2 solution at room temperature The number of stained cells ... therefore not surprising that CY administration resulted in a decrease in the proliferating cell number in both the gastric and duodenal tissues Indeed the decrease in cell proliferation in gastric tissue ... level and a 22% decrease in the c-Myc protein level in the corresponding NS group A 52% decrease in the expression level was noted in the ODC protein expression assay In contrast, EGF expression...
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Tài liệu Báo cáo khoa học: Lipopolysaccharide-evoked activation of p38 and JNK leads to an increase in ICAM-1 expression in Schwann cells of sciatic nerves ppt
... lymphocytes towards in ammatory sites [35,36] SCs have been implicated in human in ammatory demyelinating neuropathies such as ´ Guillain–Barre syndrome and chronic in ammatory demyelinating polyneuropathy ... of cytokine induced expression of intercellular adhesion molecule (ICAM-1) in an intestinal epithelial cell line, a process blocked by proteasome inhibitors Gut 42, 779–787 23 Lakshminarayanan ... the intensity of ICAM-1 staining was much greater and significantly co-localized with S100 (Fig 7D–F) Using 4346 specific inhibitors of MAPKs resulted in a weakened intensity of fluorescence in the...
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Báo cáo khoa học: Insulin like growth factor-1-induced phosphorylation and altered distribution of tuberous sclerosis complex (TSC)1⁄TSC2 in C2C12 myotubes pptx
... rapamycin (mTOR) plays a critical role in regulating the rate of protein synthesis and cell hypertrophy in skeletal muscle [3–6] mTOR is a serine ⁄ threonine kinase of the phosphatidylinositol kinase-related ... protein binding Having established the importance of the S939 site in TSC2 for the phosphorylation-dependent 14-3-3 interaction, we next aimed to determine whether this site had a role in the increased ... phosphoinositide 3-kinase (PI3K) and its downstream effector Akt, triggering multiple downstream signaling events, including mTOR activation [8] Studies in both Drosophila and mammalian cells have indicated...
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Báo cáo khoa học: a-1 Antitrypsin binds preprohepcidin intracellularly and prohepcidin in the serum pdf
... binding Table In vivo interactions of a-1 antitrypsin with preprohepcidin, prohepcidin and mature hepcidin Insert in pBT Insert in pTRG Growth on CTCK platesa Preprohepcidin Prohepcidin Hepcidin ... of hepcidin is with the iron exporter molecule ferroportin We were interested in whether we could identify new protein– protein interactions of preprohepcidin, prohepcidin and hepcidin in vivo ... After binding hepcidin, ferroportin is internalized, phosphorylated, ubiquitinated and degraded by hepatocytes and macrophages [18,19] The action of hepcidin is different in intestinal cells: instead...
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Báo cáo khoa học: Glutathione transferases kappa 1 and kappa 2 localize in peroxisomes and mitochondria, respectively, and are involved in lipid metabolism and respiration in Caenorhabditis elegans pot
... observed as strong punctate staining in intestinal cells and in the epidermis The number and intensity of fluorescent structures increased strongly in the intestine during larval development (Fig ... specifically involved in the b-oxidation of fatty acids, either through its catalytic activity, a certain transport function or interaction with other proteins Interestingly, its role in adiponectin regulation ... expressed in adipose tissue and interact with adiponectin Adiponectin is an adipokine specifically secreted from adipose tissue, which plays a key role in glucose and lipid metabolism in insulin-sensitive...
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Báo cáo khoa học: Alternative initiation of transcription of the humanpresenilin 1gene in SH-SY5Y and SK-N-SH cells The role of Ets factors in the regulation ofpresenilin 1 pptx
... footprinting with SK-N-SH cells (25) as well as site C which corresponds to an unknown binding protein Arrowheads indicate the position of DNase I hypersensitive sites observed in footprinting ... contained control antibody buffer An arrow marks the position of supershifted complexes (B) The binding of in vitro translated ERM is eliminated by mutations in Ets motifs The binding of in vitro ... target sites in different genes In addition promoter sequences flanking the Ets motif determine activity through protein–protein interactions between Ets factors and factors binding at adjacent...
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Báo cáo khoa học: Glycogen synthase kinase 3b and b-catenin pathway is involved in toll-like receptor 4-mediated NADPH oxidase 1 expression in macrophages ppt
... GSK3b-b-catenin is involved in Nox1 expression A β-catenin β-actin 15 30 45 60 LPS (min) B β-catenin β-actin 10 50 100 500 LPS (ng·mL–1) C β-catenin (short) β-catenin (long) β-tubulin 15 30 45 60 ... essential role in inflammation and immune cells [25] In particular, many groups have shown that GSK3b-b-catenin is involved in Nox1 expression GSK3b, through TLR signaling, is necessary in inflammation ... oxidases in the gastrointestinal tract: a potential role of Nox1 in innate immune response and carcinogenesis Antioxid Redox Signal 8, 1573–1582 Ushio-Fukai M (2006) Redox signaling in angiogenesis:...
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Báo cáo khoa học: Liver receptor homolog-1 localization in the nuclear body is regulated by sumoylation and cAMP signaling in rat granulosa cells docx
... and Sox9 Mol Endocrinol 18, 2451–2462 39 Kim YH, Choi CY & Kim Y (1999) Covalent modification of the homeodomain-interacting protein kinase (HIPK2) by the ubiquitin-like protein SUMO-1 Proc Natl ... Billig H (2004) Inhibition of small ubiquitin-related modifier-1 expression by luteinizing hormone receptor stimulation is linked to induction of progesterone receptor during ovulation in mouse granulosa ... by inserting the corresponding fragments into pcDNA-Tag3A (Stratagene, La Jolla, CA, USA) cleaved with EcoRI and HindIII The BsrGI-BamHI fragment from pEGFP-LRH1-K213 ⁄ 289R was inserted into...
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Báo cáo khoa học: "Integrating history-length interpolation and classes in language modeling" pdf
... (i) occur after in the in the validation set, (ii) did not occur after in the in the training set, and (iii) occurred at least 10 times in the training set Because their training set unigram ... 8:1:1 into training, validation and test sets The training set contains • Unique-event bigram clustering The cluster corpus is the set of all sequences of two bigrams ∈ B2 that occur in the training ... the unigram input vocabulary B1 is set to the b most frequent unigrams in the training set and the bigram input vocabulary B2 is set to the b most frequent bigrams in the training set In this section,...
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Báo cáo khoa học: A steady-state competition model describes the modulating effects of thrombomodulin on thrombin inhibition by plasminogen activator inhibitor-1 in the absence and presence of vitronectin ppt
... upon binding PAI-1, VN is able to bind the chondroitin sulphate moiety of rl-TM independent of TM-bound thrombin Kinetic modeling using TM as a competitive inhibitor correctly predicts the inhibitory ... reaction between thrombin and PAI-1 These findings leave a role for TM open in altering the initial binding step between thrombin and PAI-1 or in changing the ability of thrombin to catalyze subsequent ... of dissociation of thrombin from TM, explaining the observed biphasic inhibition profiles These findings are in marked contrast to the binding of all other thrombin-binding components, and comprise...
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Báo cáo khoa học: Salt-inducible kinase-1 represses cAMP response element-binding protein activity both in the nucleus and in the cytoplasm pdf
... domain are shown The protein kinase A (PKA)dependent phosphorylation sites, Ser577 in SIK1 and Ser587 in SIK2, are indicated in bold The basic residues in domain 3B are indicated by underlines ... terminus was retained in the nucleus, but was also found to inhibit cell growth [51] FKBP12rapamycin-associated protein (FRAP; also called mTOR or RAF), another shuttling kinase, is involved in ... Calmodulin kinase II attenuation of gene transcription by preventing cAMP response 17 18 19 20 21 22 23 24 25 26 27 28 29 element-binding protein (CREB) dimerization and binding of the CREB-binding...
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