06 plaque platelets and plug the pathogenesis of acute coronary syndrome
Báo cáo y học: " Role of free radicals in the pathogenesis of acute chest syndrome in sickle cell disease" pot
... in these patients is probably multifactorial, because RBCs, WBCs, and the endothelium could each contribute to their aberrant metabolism We review the role of each of these cell types in the ... expression of molecules such as VCAM-1, ICAM-1, and endothelin-1 The adhesion molecules VCAM-1 and ICAM-1 facilitate interaction between sickle RBCs and WBCs and the endothelium, thereby promoting ... formation of oxidants within the vascular endothelium of the cremaster muscle Although endothelial production of oxidants is difficult to measure directly in human disease, these in vitro and in...
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Báo cáo y học: "α The role of HIF-1α in maintaining cartilage homeostasis and during the pathogenesis of osteoarthritis" pot
... Yudoh and colleagues [1] further analyzed the role of HIF-1 in chondrocytic energy generation, matrix synthesis and cell survival During hypoxic and normoxic conditions, functional inactivation of ... chondrocytes [11] Conclusion The results provided in the study by Yudoh and colleagues and previous reports by us and other groups strongly support the notion that HIF-1 is of pivotal importance in ... expression of hypoxia-inducible factor (HIF)-1a in articular chondrocytes: involvement of HIF1a in the pathogenesis of osteoarthritis Arthritis Res Ther 2005, 7:R904-R914 Silver IA: Measurement of pH and...
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Báo cáo y học: "Cartilage oligomeric matrix protein is involved in human limb development and in the pathogenesis of osteoarthriti" pptx
... stages of OA Materials and methods Sources of tissues Aborted human embryos were obtained according to the regulations of the Ethics Committee of the Medical Faculty of the University of Göttingen, ... to the OA grades (I – IV) proposed by Collins and McElligott [31] in the case of the 12 patients and classified as age-dependent healthy in the case of the control cartilage samples None of the ... B.Sc., for editing the manuscript and the Medical Faculty of the University of Göttingen for grants to NM Parts of the work were taken from the doctoral theses of TSC and MK References Hedbom E, Antonsson...
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Báo cáo y học: "Downstream molecular pathways of FLT3 in the pathogenesis of acute myeloid leukemia: biology and therapeutic implications" pps
... used to clone the gene encoding the mouse Flt3 ligand (FL) [13] The mouse FL cDNA was then used to clone the human FL gene [14] The mouse and human FL genes encode proteins of 231 and 235 amino ... improved by the development of effective chemotherapy in the 1970s and subsequently improved by the development of hematopoietic stem cell transplantation therapy in the 1980s However, the clinical ... through the phosphorylation of FOXO3a leading to suppression of its function, thereby promoting the survival and proliferation of AML cells [54] FLT3-ITD is also known to inhibit the expression and...
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Substance p regulates chemokine production in leukocytes implications in the pathogenesis of acute pancreatitis and associated lung injury
... that appear at the site of inflammation and have a central role in the clearance of infectious pathogens and the innate immunity Therefore, they have been implicated in mediating the acute- phase ... The aims of this study were to investigate the regulatory effect of SP-NK-1R on the expression of CC and CXC chemokines during experimental acute pancreatitis and the associated lung injury and ... performed to further confirm the attenuating effect of CP96,345 on the protein expression levels of MCP-1, MIP-1α, and MIP-2 in the pancreas and lungs and to localize these chemokines to their cellular...
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Báo cáo hóa học: " The incidence of acute encephalitis syndrome in Western industrialised and tropical countries" pdf
... patients with acute encephalitis syndrome (AES), and then classifying the patients according to the results of laboratory diagnostic tests AES is defined as the acute onset of fever and a change ... and 25 articles were finally chosen because they met the selection criteria and were representative of the spectrum of study type and disease incidence (Tables and 3) Studies were evaluated and ... of Taiwan [25,26] The study population was that of Taiwan itself and other offshore islands such as the Pescadores After patients were identified, blood and convalescent sera were obtained, and...
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Role of misfolded nuclear receptor co repressor (n cor) induced transcriptional de regulation in the pathogenesis of acute monocytic leukemia (AML m5
... input on some of the work done in this thesis and for taking the time to vet my thesis; A/Prof Chng Wee Joo and Prof Norio Asou for their kind assistance with the patient samples and A/Prof Motomi ... analysis of the molecular mechanism underlying the MCDL of N-CoR and its implication in the malignant growth and transformation of AML-M5 leukemic cells We also explored the potential of the MCDL of ... extracellular stimulus This results in the synthesis of PI-3,4,5-P3 and PI-3,4-P2 Binding of these phospholipids to the PH domain of Akt triggers the translocation of Akt to the plasma membrane where it...
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Báo cáo y học: "ISOLATION OF CHLAMYDIA PNEUMONIAE FROM SERUM SAMPLES OF THE PATIENTS WITH ACUTE CORONARY SYNDROME"
... from the serum samples of the patients with acute coronary syndrome Furthermore, using combination of bacteriological and PCR-based methods we show herein that patients with acute coronary syndrome ... informed about the purpose of the study and have given written consent regarding participation in the study Initial observation has been done on the group of 18 patients with acute coronary syndrome ... cells and/ or macrophages residing in the atherosclerotic plaques However regardless of the origin, we can claim that the presence of virulent chlamydial particles in serum is an apparent sign of...
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Management of Acute Coronary Syndromes - part 9 pdf
... concepts of the pathogenesis of the acute coronary syndromes Circulation 2001; 104:365–372 78 Dollar AL, Kragel AH, Fernicola DJ, Waclawiw MA, Roberts WC Composition of atherosclerotic plaques in coronary ... acute myocardial infarction (25) ANTI-ATHEROSCLEROTIC MECHANISMS OF CHOLESTEROL LOWERING The complexity of the pathogenesis of atherosclerosis makes it difficult to understand what parts of the ... reminded that the early stages 662 Fang and Plutzky of atherosclerosis move in an abluminal direction, thereby preserving the dimensions of the lumen despite the presence of significant atherosclerosis...
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Management of Acute Coronary Syndromes - part 10 docx
... (exclusive of drug cost) (p ϭ 0.018) If the cost of the drug were less than $1270, then the strategy would be effective and cost saving The Randomized Efficacy Study of Tirofiban for Outcomes and Restenosis ... HOSPITAL ACUTE CORONARY SYNDROME PATHWAYS An overview of our critical pathways for acute coronary syndromes is shown in Fig There are two pathways for the different types of syndromes: two for acute ... streptokinase The major difference in the cost of the therapies was the cost of the drugs: $2750 for tPA and $320 for streptokinase The primary analysis assumed no increase in costs for the tPA group...
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Báo cáo khoa học: FLIP and MAPK play crucial roles in the MLN51-mediated hyperproliferation of fibroblast-like synoviocytes in the pathogenesis of rheumatoid arthritis pdf
... proliferation and blocking apoptosis in the pathogenesis of RA Results GM-CSF induces the proliferation of MH7A cells and the expression of MLN51 Our recent study has shown that GM-CSF is involved in the ... is upregulated in the FLSs of RA patients, and is enhanced days after GM-CSF treatment [7] In the present experiments, we assessed the dose and time kinetics of the effects of GM-CSF on MLN51 ... left untreated The cells were harvested and assessed by western blot analysis for the expression of MLN5 1and FLIP proliferation of RA FLSs through the upregulation of MLN51 [7] In the present study,...
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Báo cáo y học: "Eotaxin and FGF enhance signaling through an Extracellular signal-related kinase (ERK)-dependent pathway in the pathogenesis of Eosinophilic Esophagitis" doc
... enhances activation of eosinophils in EoE specifically Page of The increased global expression of bFGF led to the investigation of the local expression bFGF of the esophageal biopsies of the subjects ... subsets and can be found in a variety of tissues, including epithelial and mesenchymal tissue [20] bFGF increases the half-life of cells and could possibly increase the overall lifetime of the eosinophil ... essential to the transcription of ERK [18] and ERK feeds into the eotaxin-3 pathway, potentially further activating the eosinophil and improving its sensitivity and migration towards eotaxin in the esophageal...
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Báo cáo y học: "γ The role of the complement and the FcγR system in the pathogenesis of arthritis" pdf
... high levels of C5a in SF [21] and correlation of the levels of C5a with the number of neutrophils present in the SF of patients with RA [22] More direct evidence for the role of the complement ... although the relative contributions and the hierarchy of these two pathways in the manifestation of disease are still unclear In FcγR−/− mice, in which the surface expression of FcγRI and FcγRIII ... most striking characteristics of the K/B × N model is the extremely high titer of specific autoantibodies throughout the life of the diseased mice Titers in the order of 10 mg/ml specific anti-GPI...
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Báo cáo y học: "Dipeptidyl peptidase IV activity and/or structure homologs: Contributing factors in the pathogenesis of rheumatoid arthritis" doc
... secretion of Simultaneous application of TNF-α and IFN-γ to endothelial cells causes an increase in NPY, upregulation of the Y5 receptor, and complete loss of the Y2 receptor, together with an ... maintained and exacerbated by the activity of DPPIV Nevertheless, in two mouse models of inflammatory arthritis, the severity of joint damage correlated directly with levels of SDF-1α where the efficacy ... measured This is complicated further by a lack of understanding of the breadth of substrate and inhibitor specificities for the DASH family This is illustrated well by the CD26-knockout mouse that...
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Báo cáo y học: "MLN51 and GM-CSF involvement in the proliferation of fibroblast-like synoviocytes in the pathogenesis of rheumatoid arthritis" pps
... coordination and the writing of this manuscript, and also for interpretation and discussion of the data JJ, YEC and YJ performed most of the studies and were responsible for the execution of most of the ... factors in the SFs are involved in the proliferation of RA FLSs, and whether the factors have a role in the expression of MLN51 We determined the growth kinetics of FLSs at different passages and SFtreated ... by radiography of the hand, and all satisfied the diagnostic criteria of the American College of Rheumatology (formerly the American Rheumatism Association) for the classification of RA [16] RA...
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Báo cáo y học: " Induction of multiple matrix metalloproteinases in human dermal and synovial fibroblasts by Staphylococcus aureus: implications in the pathogenesis of septic arthritis and other soft tissue infections" pdf
... the normal expression and function of MMPs There are reports of other staphylococcal virulence factors associated with the pathogenesis and severity of SA [43-45] Whether these virulence factors ... to augment the risk of infection in patients with RA The reasons for the predominance of S aureus in SA and the mechanisms of pathogenecity are not yet fully understood The synovium of patients ... down the possible candidates to molecular-weight groups of the range of >30 to 50 based on our experiments using Centricon filtration of the culture supernatants Because the molecular weight of the...
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Báo cáo y học: "Glomerular matrix metalloproteinases and their regulators in the pathogenesis of lupus nephritis" pdf
... expression and protein levels of the MMPs are often found to be accompanied by increases in the levels of one or more of the TIMPs It is therefore not obvious what can be the net result of these opposing ... by TIMPs in the regulation of MMP activity has led to the hypothesis that shifts in the balance between these two families of proteins could distort the kinetics of membrane turnover and cause ... complex deposition and compromising the physical integrity of the membrane Central to the pathogenesis of lupus is continuous activation and proliferation of B-lymphocytes and T-lymphocytes with...
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Báo cáo y học: "Regulation of catabolic gene expression in normal and degenerate human intervertebral disc cells: implications for the pathogenesis of intervertebral disc degeneration" ppt
... degenerate NP cells as well as the effect of IL-1β and TNF-α on cytokine gene expression and the expression of the associated receptors and endogenous antagonists There Page of 10 (page number not for ... carried out the remainder of the experimental work AJF helped to secure funding and contributed to the preparation of the final manuscript JAH conceived and designed the study, secured funding and co-wrote ... centrifugation and the RNA was extracted using TRIzol™ and PureLink columns in accordance with the instructions of the manufacturer (Invitrogen Corporation) To prevent any DNA contamination of the RNA, the...
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Báo cáo y học: "Chemokine receptor expression and functional effects of chemokines on B cells: implication in the pathogenesis of rheumatoid arthritis" ppt
... CCL20, a ligand for CCR6, CCL19 and CCL21, ligands for CCR7, and CXCL12, a ligand for CXCR4 First, we analyzed the effects the chemokines on migration of peripheral blood B cells Each of the four ... peripheral B cells of both normals and subjects with RA, and CXCL12 enhanced the expression of ICOSL on both normal and RA B cells In contrast, the effect of CCL20, CCL19 and CCL21 was not significant ... migration of both CD27- and CD27+ B cells (Figure 3a) However, the migration induced by CCL21 was most prominent Comparison of the migratory effects of the chemokines on peripheral blood CD27- and...
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Báo cáo y học: " Central role of nitric oxide in the pathogenesis of rheumatoid arthritis and systemic lupus erythematosus" potx
... stress and TCRζ expression in RA T cells the possible role of NO Reduced GSH levels may contribute to the hyporesponsiveness of T cells from synovial fluid of RA patients [59,60] The expression of the ... [13] A central event in the antigen-specific interaction of T cells with antigen-presenting cells is the formation of the immunological synapse, in which the TCR complex and the adhesion receptor ... Overexpression of eNOS was associated with increased phosphorylation of the CD3ζ chain, ZAP-70, and extracellular signal-regulated kinases, and increased IFN-γ synthesis, but reduced production of IL-2 These...
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- dna methylation affects important developmental processes in both plants and animals the process of methylation of cytosines at c5 is catalysed by dna methyltransferases mtases
- have been studied as potential key molecules in the pathogenesis of the precancerous intestinal metaplasia of the human stomach however
- this book provides information on the clinical relevance of blood groups and on the importance of blood group antibodies in transfusion medicine in particular
- face expression recognition and analysis the state of the art
- syntax and semantics the grammar of causative constructions
- identify and discuss the roles of mass communication in national development
- listen and fill the blanks of paragraphs
- define inflation and discuss the effects of inflation on international business
- list and discuss the importance of communication in human society
- transglutaminase and the pathogenesis of coeliac disease
- oxidative stress and the pathogenesis of parkinsons disease
- the role of oxidative stress in the pathogenesis of polycystic ovary syndrome
- adp ribose polymerase activation in the pathogenesis of shock and inflammation
- adp ribose polymerase activation in the pathogenesis of diabetes mellitus and diabetic vascular dysfunction
- emerging concepts for the pathogenesis of chronic disabling inflammatory diseases neuroendocrine immune interactions and evolutionary biology
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