Bài viết nghiên cứu nhằm so sánh đặc điểm lâm sàng, cận lâm sàng của 3 nhóm bệnh nhân lao phổi tái phát có vi khuẩn nhậy cảm, đa kháng thuốc và kháng thuốc; xác định tính kháng thuốc của vi khuẩn lao và các yếu tố liên quan đến bệnh lao phổi tái phát có vi khuẩn kháng thuốc.
Jour Fran Viet Pul 2011; 02(03): 1-79 JOURNAL OF FRANCO-VIETNAMESE ASSOCIATION OF PULMONOLOGY 2011 JFVP All rights reserved www.afvp.info ORIGINAL ARTICLE Lâm sàng, cận lâm sàng tính kháng thuốc vi khuẩn lao bệnh nhân lao phổi tái phát ThS Nguyễn Thu Hà 1, GS.TS Trần Văn Sáng 1, PGS.TS Đinh Ngọc Sỹ 1,2 : Bộ môn Lao & Bệnh phổi - Đại học Y Hà Nội : Bệnh viện Phổi Trung Ương SUMMARY Introduction The proportion of mycobacterium tuberculosis strains with drug resistance in Viet Nam is higher than other neighboring countries and in other countries in the world Objectives: To compare clinical and paraclinical features of the three groups of patients with relapse of pulmonary tuberculosis classified as sensitive, multi-drug resistant and drug resistance To determine the phenotype of mycobacterium tuberculosis strains with drug resistance and associated factors for relapse of pulmonary tuberculosis Methods This is a descriptive and prospective study of 106 patients with relapsed pulmonary tuberculosis The definition of relapsed pulmonary tuberculosis is that of WHO The studied patients were divided into three groups based on degree of resistance of the incriminatory strain: sensitive group (33 patients), multi-drugs resistance (34 patients), drug resistance (39 patients.) Results and conclusion The proportion of patients treated with streptomycin (S) or isoniazid (H) and showing clinical evoked signs such as night sweats, weight loss, moist rales on auscultation, pulmonary nodular lesions with 2nd-degree on RT, the presence of acid-fast bacilli (AFB) on the sputum smear test was higher in groups II and III (p