Nghiên cứu hình thái, chức năng, mô bệnh học và kết quả phẫu thuật điều trị tinh hoàn ẩn tt tiếng anh

MINISTRY OF MINISTRY OF DEFENCE EDUCATION AND TRAINING VIETNAM MILITARY MEDICAL UNIVERSITY ======= NGUYỄN MẠNH THẮNG THE STUDY ON MORPHOLOGY, FUNCTION, HISTOPATHOLOGY AND SURGERY RESULTS OF CRYPTORCHIDISM Speciality : Surgery Code : 9720104 ABSTRACT OF THE THESIS FOR MEDICAL DOCTOR HA NOI - 2019 THE THESIS WAS COMPLETED IN VIETNAM MILITARY MEDICAL UNIVERSITY Scientific Supervisors: Prof.PhD Trần Quán Anh Assisstant Prof.PhD Nguyễn Quang The first Reviewer: The second Reviewer: The third Reviewer: The Thesis approved by Council of scientist in Vietnam Military Medical University At On References theThesis in: Vietnam National Library Library of Vietnam Military Medical University LIST OF PUBLICATIONS This Thesis is based on the following papers: Nguyễn Mạnh Thắng (2018), “Comments on characteristics of testicle volume, hormones, spermiogram in adult male with cryptorchidism”, Vietnam Medicine, Vol 471, No 2 Nguyễn Mạnh Thắng, Trần Quán Anh, Nguyễn Quang (2018), “Testosterone and gonadotropins in adult male with cryptorchidism: Compare pre and post orchidopexy”, Journal of military pharmaco-medicine, page196-198 INTRODUCTION Cryptorchidism is a popular sequela in reproduction – urology system in male baby The proportion of cryptorchidism accounted for 24% in full-term full-term infant and 20-30% in preterm infant Cryptorchidism is a long-term risk factor that cause many complications such as infertility, testicle cancer, change of hormone… Some studies showed that cryptorchidism cause alters of testicle’s structure and function, and it is believed as a cause of infertility Nowaday, some scientists concerned that relationship between decreasing competence of sperm and unilateral cryptorchidism and alter of the other normal testicle in scrotum Cryptorchidism related closedly to testicle cancer and suffer from cancer higher than from to 40 times in normal testicle in scrotum in many studies Guideline of many Association of Urology also showed that early operation help to prevent complications, the latest age of operation was 18 months old However, in fact there were many patients that were operated late In Vietnam, the proportion of puberty surgery was 3040% So that there were many male adult with cryptorchidism Besides, removing cryptorchidism in adult is popular in Vietnam It maybe affect to psycholory, hormone, decrease competemce of reproduction So there is a question that orchiopexy in male adult bring to effectiveness? Our study assess outcome of orchiopexy in male adult Objectives of our study were: Studying few characteristics of morphology, function, histopathology in adult male with cryptorchidism Assessing results of orchiopexy in male adult with cryptorchidism CHAPTER 1: BACKGROUND 1.1 The embryology of the testis 1.1.1 The non-gender stage The gender has not been differentiated from third and sixth of pregnancy 1.1.2 The development of testis From the seventh week is the seminiferous tubules and interstitial cells development 1.1.3 The testicular movement during pregnancy The movement happens during eighth to fifteenth week (including the testis formation and movement) The inguinal stage lasts from twenty-fifth to thirty-fifth week (inguinal and scrotum) 1.1.4 The contribution factor of testicular movement Up to now, it was fulfilled knowledge of mechanism, however it is concerned about anatomical and hormonal causes 1.2 Causes of cryptorchidism Theoretically, the testicular mal-movement is caused by the failure of each stage in testicular movement 1.2.1 Age and weight: Infants weighted under the real age (