Introduction of Nanotechnology in Pharmaceticals and Cosmetics

Introduction of Nanotechnology in Personal-care Products Le Thi Hong Nhan, PhD Department of Organic Chemical Engineering HCMUT, 2013 Content  Introduction  Mechanism  Classification  Preparation  Nano researches in HCMUT  Conclusion Drug submission •Preventing diseases Biologically active ingredients Drug substances Active agents Nutritional substances •Treating & healing diseases •Improving health •Protecting body General trend Functional products Pharmaceutical product in cosmetic base Pharmaceutical product Cosmetic product with active ingredient Cosmetic product Drug submission Non-invasive peroral (through the  mouth)  External (skin)  Transmucosal (nasal, buccal/sublingual, genital, ocular and          rectal)  Breathing tracks      Tablet Capsule Injection Ointment Eye drop Ear drop Inhalation Nose spray Dispersion Solution Lotion Powder Gels Novel drugs distribution systems Active agents Poor aqueous solubility Derivatives -> increasing aqueous solubility Decreasing size -> increasing aqueous solubility Nano technology Nanotechnology     Dramatic increases in solubility, in concentration saturation, and in dissolution velocity Particles below 1000 nm in size will not settle out, providing a long shelf-life Easier to pass through cell membranes in organisms and get interacted rapidly For drug (soft materials with melting points below 300oC), the reasonable goal is to aim at Sedimentation Sedimentation rate by Stoke law Brownian Forces => Isotropic movement Brownian movement rate by Einstein’s theory x 2k BTt  d The movement of solid particles with different sizes in water at 25oC Particle size (nm) Sedimentation rate (nm/s) Brownian movement rate (nm/s) 0.00043 54,250 10 0.043 17,155 100 4.30 5,425 1,000 430 1,716 10,000 43,005 543 Nanotechnology- Sedimentation stability  Nano particles => high stability of sedimentation  Micro particles => settling out easily => not use for injection products 10 Homogenization High Speed Homogenizers (rotor-stator) 35 Homogenization High pressure homogenization 36 Homogenization High pressure homogenization 37 Homogenization Piston-gap homogenization 38 Homogenization Piston-gap homogenization 39 Homogenization ULTRASOUND 40 Homogenization Factors Affecting Droplet Size:    Homogenizer – Machine Parameters (Pressure, Rotation Speed, Time) – Energy Density Component Phases – Interfacial Tension – Viscosity Emulsifier – Adsorption Kinetics – Interfacial Tension Reduction – Stabilization of Droplets Against Aggregation 41 Characterization & evaluation Size Nano systems Characteristic Abbreviations: DSC, differential scanning calorimetry; FFF, field fractionation; NMR, nuclear magnetic resonance; SEM, scanning electron microscopy; TEM, transmission electron microscopy 42 Nano research in HCMUT Research group Nano materials Nguyen Ngoc Hanh Nano catalyst, nano cellulose Phan Thanh Son Nam Nano catalyst, nano metals Phan Dinh Tuan Nano TiO2 Le Thi Hong Nhan Nano drugs, nano emulsions, solid lipid nano particles,… Le Thi Kim Phung 43 Nano drugs Preparation of nano materials from natural products Research content:  Effects of methods, conditions & ingredients on preparation of nano dispersions  Building optimal conditions for preparation  Product characterisations (physical, chemical properties & biological activities)  Stability evaluation of the nano dispersions in other storage conditions and with uses of additives Curcumin Bixin Nano emulsions Vitamin E Fragrange Nano particles Solid lipid nano particles Rutin Curcumin Preparation of nano materials from natural products 45 Preparation of nano materials from natural products Effect of presure of high presure homogenization to particle size and XRD diffraction of rutin suspensions with support of PEG400 10000 9000 8000 Lin (Counts) 7000 PEG 1200 bar 6000 PEG 1000 bar 5000 PEG 800 bar 4000 PEG 600 bar 3000 PEG 400 bar 2000 TEM of rutin materials PEG 200 bar 1000 rutin 46 1200 bar 10 15 20 2-Theta-Scale25 30 35 40 Application approach of natural products Gelatin jelly Agar jelly Nano dispersion of curcuminoids Gelatin candy Cosmetic cream Conclusion  Personal-care products: Functional products -> new trend  Nano systems: increase of biocompatibility of drugs  Contribution of nano researches:  Increasing use value of biological substances  Developing new research group at HCMUT (on nano materials)  Background for opening new academic major at HCMUT (Pharmaceutical engineering) 48 Thank you for your attention! 49