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Tổng hợp và đặc trưng màng hydroxyapatit pha tạp một số nguyên tố vi lượng trên nền thép không rỉ 316L định hướng ứng dụng làm nẹp vít xươngTổng hợp và đặc trưng màng hydroxyapatit pha tạp một số nguyên tố vi lượng trên nền thép không rỉ 316L định hướng ứng dụng làm nẹp vít xươngTổng hợp và đặc trưng màng hydroxyapatit pha tạp một số nguyên tố vi lượng trên nền thép không rỉ 316L định hướng ứng dụng làm nẹp vít xươngTổng hợp và đặc trưng màng hydroxyapatit pha tạp một số nguyên tố vi lượng trên nền thép không rỉ 316L định hướng ứng dụng làm nẹp vít xươngTổng hợp và đặc trưng màng hydroxyapatit pha tạp một số nguyên tố vi lượng trên nền thép không rỉ 316L định hướng ứng dụng làm nẹp vít xươngTổng hợp và đặc trưng màng hydroxyapatit pha tạp một số nguyên tố vi lượng trên nền thép không rỉ 316L định hướng ứng dụng làm nẹp vít xươngTổng hợp và đặc trưng màng hydroxyapatit pha tạp một số nguyên tố vi lượng trên nền thép không rỉ 316L định hướng ứng dụng làm nẹp vít xương
B O VI C VI T NAM H C VI N KHOA H - H NH T NG H T PM TS G NG LU NG D NS I C 2018 i B O VI C VI T NAM H C VI N KHOA H - H NH T NG H M TS P NG LU NG D NS C : 62440119 N ng d n khoa h c: Mai Thanh ii i 2018 L iii uc li u, k t qu b tk m li u tham kh L IC Lu i Vi n K thu t nhi h i Vi Vi u, n u sinh n c nhi u s ng nghi p, b l ng bi Mai Thanh m i th c nt ng nh t t i ng d n khoa h u ki n thu n l i nh t th ng c c a Vi o o Vi n K thu t nhi c bi P om p th o v kim lo u ki n thu n l ct u t i Vi n il ic u c a TS C c vi u ki u v th nghi m t nghi n invivo ng c u BBP c ih , chia s ki n th thi t b ng d u hi d ct ng nghi p c iB c Khoa Khoa h ih cM a ch n, t i ch ng h u ki n thu n l i t th Cu m c nh t t i Gia i ngo c bi u sinh H nh iv M CL C DANH M VI T T T ix DANH M C B NG xiii DANH M M TH xv U NG QUAN t c a HAp tv c t sinh h c t ng h p HAp 1.2.1 D ng b t 1.2.2 D ng x mx p 1.2.3 D ng compozit 1.2.4 D ng ng h p HAp pha t p 1.3.1 Pha t p natri 1.3.2 Pha t 1.3.3 Pha t p stronti 10 1.3.4 Pha t p flo 11 1.3.5 Pha t 12 ng 1.3.6 Pha t p b c 12 1.3.7 Pha t p k m 12 1.4 Th nghi m ho c c a HAp 13 1.4.1 Th nghi m in vitro 1.4.1.1 Trong dung d 13 ng d 1.4.1.2 Trong dung d i ch mu 1.4.1.3 Th nghi m t 14 14 15 v 1.4.2 Th nghi m in vivo 1.5 15 ng d ng c a p 1.5 16 c b sung canxi ph 17 c 1.5.2.1 17 a ch a nh ng khuy t t t c 17 t gi 18 t li u thay th 1.6 a ch a nh ng khuy t t t c u HAp 18 c 19 C NGHI M U u ki n th c nghi m 22 t 22 2.1.2 V t li u n n 22 2.1.3 T ng h pb 22 2.1.3.1 H 22 2.1.3.2 T ng h p natri 2.1.3.3 T ng h NaHAp pha t p 2.1.3.4 T ng h 22 ho c flo 23 flo 23 2.1.4 Pha t p m t s i ion 24 2.1.4.1 T ng h ng, b c ho c k m 24 2.1.4.2 T ng h ng, b 2.1.5 T ng h b 22 m 24 ng, m 24 u 25 25 ng n th m ch h theo th i gian 2.2.1.2 T ng tr 25 25 25 vi i ion 26 26 2.2.3.1 Ph h ng ngo i 26 2.2.3.2 Nhi u x tia X 26 2.2.3.3 Hi 27 nt 2.2.3.4 Hi n vi l 27 ng tia X 27 2.2.3.6 Quang ph h p th 28 2.2.3.7 Ph kh 28 ng plasma c m ng -VIS 28 28 nh kh 28 29 nh chi nh n 29 Ca2+ nh t ng n 29 s 29 nghi 29 2.2.5.1 Th nghi m dung d ng d 2.2.5.2 Th nghi m t n 2.2.5.4 Th nghi m in vivo 34 O LU N p 3.1.1 T ng h 31 32 3.1 T ng h 3.1.1.2 M 29 30 2.2.5.3 Th nghi m kh T QU i 34 pb 34 p natri 34 NaHAp pha t , stronti ho c flo 44 53 vii 3.1.2 Pha t p m t s i ion 63 ng, b c ho c k m 63 ng, b 69 m ng, b h n m 71 71 3.1.3.2 Ph h ng ngo i 73 3.1.3.3 Gi 73 nhi u x tia X nh SEM 74 74 3.2 Th nghi m in vitro 76 3.2.1 Th nghi m in vitro 76 3.2.1.1 Trong dung d ng d ch th 3.2.1.2 Th nghi m t 76 82 3.2.1.3 Th nghi m kh n 3.2.2 Th nghi m in 84 85 3.2.2.1 K t qu c y v t li 3.2.2.2 K t qu v ch t li 85 90 99 K T LU N CHUNG NH i I C A LU 101 DANH M 102 U THAM KH O 104 viii DANH M VI T T T a, b, c ] AgNaHAp AZ31 B BK CuAgZnNaHAp natri, C Co CuFHAp CuNaHAp D K c tinh th d ] dE/dt DF HAp Natri h DMg DMgSrFNa DNa DSr Ecorr EDHA Eocp, Eo (Ca10-xMgx(PO4)6F2 FA10Mg FA0Mg/TKG316L, FA10Mg/TKG316L 10xMgx(PO4)6F2 ix FNaHAp HAp Hydroxyapatit HAp/AZ31 HAp HAp /TKG316L h icorr icorr,vln LK M m MC3T3-E1 MgFHAp MgNaHAp MgSrFNaHAp natri MgSrFNaHAp/TKG316L MNaHAp n NaHAp NaHAp/TKG316L 316L PLA/HAp PSHA Plasma q x ] DANH M Pham Thi Nam, Nguyen Thi Thom, Nguyen Thu Phuong, Vo Thi Hanh, Nguyen Thi Thu Trang, Vu Thi Hai Van, Trinh Hoang Trung, Tran Dai Lam, Dinh Thi Mai Thanh Electrodeposition of substainable fluoridated Hydroxylapatite coatings on 316L stainless steel for application in bone implaint Green Processing and Synthesis, 5, 499-510, 2016 (ISI) H nh, Ph m Th n Th Th H Mai Thanh T ng h g 316L T c 55(3), 348-354, 2017 Vo Thi Hanh, Pham Thi Nam, Dinh Thi Mai Thanh Electrodeposition and characterization of strontium hydroxyapatite coatings on 316L stailess steel Vietnam Journal of Chemistry, 55(3e12), 346-350, 2017 Mai Thanh T ng h H nh, Ph m Th 316L T ng Khoa h c i 62(3), 51-59, 2017 Vo Thi Hanh, Le Thi Duyen, Do Thi Hai, Pham Thi Nam, Nguyen Thi Thom, Nguyen Thu Phuong, Dinh Thi Mai Thanh Electrodeposition and characterization of Mg2+, Sr2+, F-, Na+ co-doped hydroxyapatite coatings on 316L stailess steel Processdings of 6th Asian Symposium on Advanced Materials, 740-746, 2017 , Ph m Th H nh, c u di n bi d Mai Thanh a v t li ng d 316L dung i T c 55(5E1,2), 114-119, 2017 Vo Thi Hanh, Pham Thi Nam, Nguyen Thu Phuong, Nguyen Thi Thom, Le Thi Phuong Thao, Dinh Thi Mai Thanh Electrodeposition and characterization of magnesium hydroxyapatite coatings on 316L stailess steel Vietnam Journal of Chemistry, 55(5), 657-662, 2017 Vo Thi Hanh, Pham Thi Nam, Nguyen Thu Phuong, Dinh Thi Mai Thanh Electrodeposition of co-doped hydroxyapatite coatings on 316L stailess steel Vietnam Journal of Science and Technology, 56 (01), 94-101, 2018 Mai Thanh nh H nh, Ph m Th ng c a NaNO3 2O2 t ng h 102 tr b T Khoa h ng -1059.2017-0011, d ki 63, 3/2018) 103 U THAM KH O A Sharifnabi, M Fathi, B Eftekhari, M Hossainalipour The structural and bio - 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