Int. J. Med. Sci. 2005 2 79International Journal of Medical Sciences ISSN 1449-1907 www.medsci.org 2005 2(2):79-86 ©2005 Ivyspring International Publisher. All rights reserved Comparison of Classical and Clozapine Treatment on Schizophrenia Using Positive and Negative Syndrome Scale of Schizophrenia (PANSS) and SPECT Imaging Research paper Received: 2004.06.01 Accepted: 2005.05.01 Published: 2005.05.10 Mohammad Sharafi 1 2 1. fMRI Research Center, Columbia University, New York, NY, USA 2. Department of Psychiatry and Nuclear Medicine, Tehran Psychiatric Institute, Iran University of Medical Sciences, Tehran, Iran AAbbssttrraacctt Many neuroimaging studies of schizophrenia have shown abnormalities in the frontal cortex, limbic system, basal ganglia, temporal and parietal lobes. These findings are not specific or consistent enough to build up a coherent theory of the origin of the brain abnormality in schizophrenia. This paper describes a state-of-the-art approach of SPECT to correlate neuropsychological evaluation. PANSS scores and different brain focal abnormalities of two groups of patients receiving Clozapine and classical antipsychotic treatments were observed. A total of 20 drug-free patients, actively psychotic schizophrenic, were selected according to the DSM-IV criteria. Pre-Post-treatment was designed using PANSS and 99mTc- ECD-SPECT to assess regional Cerebral Blood Flow (rCBF). The results showed that after treatment, differences in PANSS scores were significant in both groups, with superior scores resulting from the Clozapine therapy. Results were supported by SPECT, which showed a greater improvement in the Clozapine group. Both positive and negative symptoms were improved with Clozapine as well. Before treatment, hypofrontality was the most common (85%) finding, whereas after treatment hypofrontality was mostly cleared. However, in some areas like temporal and caudate, hyperfrontality was induced. Negative symptoms showed linkage to hypofrontality in both groups before and after treatment, and both positive and negative symptoms were improved more with Clozapine therapy than with classical treatment. KKeeyy wwoorrddss Schizophrenia, SPECT imaging, PANSS scores AAuutthhoorr bbiiooggrraapphhyy Mohammad Sharafi obtained MD from Kerman Medical University, and a specialty in psychiatry from Iran University of Medical Sciences, where he worked in the research areas of schizophrenia, mood disorders and OCD by SPECT. He is currently working on research of brain fMRI and binge eating at fMRI Research Center, Columbia University. His main clinical interests include schizophrenia, mood disorders and brain mapping. CCoorrrreessppoonnddiinngg aaddddrreessss Mohammad Sharafi, 71-01, 35th Ave # 6, Jackson Heights, NY 11372. Email: msharafi2000@yahoo.com, Tel: 01-917-309-7938 Int. J. Med. Sci. 2005 2 801. Introduction Schizophrenia is a chronic and disabling brain disease affecting around 24 million people worldwide and more than 2 million Americans in a given year. Approximately 1 percent of the population develops schizophrenia during their lifetime [8-11]. Risk factors include birth in cities, birth in winter and early spring, and viral infections in the mother during the second and third trimesters of gestation. A strong association between hypofrontality and negative symptoms of schizophrenia, as well as with antipsychotic treatment, has been reported. Some studies have reported that about half Transform negative self-talk into positive affirmation Transform negative self-talk into positive affirmation Bởi: Joe Tye “Speaking wisely is essential when you speak to yourself Words matter We cannot risk speaking untruths to ourselves because of the strong likelihood that we will believe them” Jennifer Rothschild: Self Talk, Soul Talk: What to say When You Talk to Yourself Some 2,500 years ago, Confucius was asked what would be the first thing he would if he ruled China He answered that he would fix the language Your choice of words – both in speaking with others and in speaking with yourself – has a powerful impact on your self-identity and self-esteem Despite what the children’s song says, the words you use to describe yourself and your circumstances can be more harmful than any sticks and stones In his book Awaken the Giant Within, Anthony Robbins describes how to use Transformational Vocabulary to create a self-empowering mindset, to modulate negative emotions and intensify positive ones, to enrich the range of your experiences, and to break old self-defeating behavior patterns In one exercise, he recommends making a list of words with which you disempower yourself and converting them into more empowering words (Shortly after my own job loss experience, I transformed the words “scared” into “exhilarated,” “intimidated” into “challenged,” and “cocooned” into “recharging.”) Try the exercise yourself Divide a piece of paper in half Down one side make a list of disempowering adjectives that you apply to yourself Down the other make a list of empowering language that could be applied to the same adjectives Every day, select one old adjective that you are going to consciously transform into one of the new ones Make a list of all the negative labels you pin on yourself, and then each day convert one from a label to a description For example, “I’m lazy” may become “I don’t like to waste my time doing things for which there doesn’t seem to be much benefit.” 1/1 Even though globalization affects the world’s economies in a positive way, its negative side should not be forgotten. Discuss. In the present age, globalization is playing an increasingly important role in our lives. But in the meantime whether it is a blessing or a curse has sparked a heated debate. Some people argue that globalization has a fundamentally beneficial influence on our lives, while many others contend that it has a detrimental effect as well. A convincing argument can be made about globalization not only playing a pivotal role in the development of technology and economy, but also promoting the cultural exchange between different countries. To start with, it is the globalization that impelled many corporate to become international groups, thereby making a contribution to the local technology and employment. Specifically, when a multinational group establish a factory in a developing country, the new equipment, the new management skills and the job vacancies are all in the best interest of the local society. Moreover, people worldwide can get to know each other better through globalization. It is easy to see that more and more Hollywood blockbusters show cultures different from American, some recent examples are ‘Kungfu Panda’ and ‘The Mummy’. Admittedly, the profit driven side of globalization has severely affected young people. Today, in the metropolises in different countries, it is very common to see teenagers wearing NIKE T-shirts and Adidas footwear, playing Hip-Hop music on Apple iPods and eating at KFC. The culture that took a thousand years to form just seems similar in these cities; it seems as though you can only distinguish them by their language. Meanwhile, in some developing countries, sweat workshops are always a concerning issue. For instance, reports show that some teenagers employed by NIKE’s contractors work in smelly factories over 14 hours a day, but are only paid fifty cents per hour. To sum up, I would concede that globalization does come with some adverse effects. Despite that fact, benefits created by it far outweigh the disadvantages. Overall, I am convinced that we should further promote globalization and meanwhile the local government should take measures to combat culture assimilation and sweat workshops. This essay is extremely long (338 words instead of the advised 250-265). It has a sound structure, your position is clearly expressed, the information is well-organized, and structure-wise the sentences are fine. The vocabulary is impressive and there were only a few grammatical errors (see comments underlined in blue). Overall, this seems to be a band 7.5 + essay. This Provisional PDF corresponds to the article as it appeared upon acceptance. Fully formatted PDF and full text (HTML) versions will be made available soon. Raman enhancement of rhodamine adsorbed on Ag nanoparticles self-assembled into nanowire-like arrays Nanoscale Research Letters 2011, 6:629 doi:10.1186/1556-276X-6-629 Marianthi Panagopoulou (mr.panagopoulou@gmail.com) Nikolaos Pantiskos (nickpantiskos@yahoo.gr) Panos Photopoulos (pmphotopoulos@gmail.com) Jun Tang (tangjun@nuc.edu.cn) Dimitris Tsoukalas (dtsouk@imel.demokritos.gr) Yannis S Raptis (yraptis@central.ntua.gr) ISSN 1556-276X Article type Nano Express Submission date 24 June 2011 Acceptance date 14 December 2011 Publication date 14 December 2011 Article URL http://www.nanoscalereslett.com/content/6/1/629 This peer-reviewed article was published immediately upon acceptance. It can be downloaded, printed and distributed freely for any purposes (see copyright notice below). Articles in Nanoscale Research Letters are listed in PubMed and archived at PubMed Central. For information about publishing your research in Nanoscale Research Letters go to http://www.nanoscalereslett.com/authors/instructions/ For information about other SpringerOpen publications go to http://www.springeropen.com Nanoscale Research Letters © 2011 Panagopoulou et al. ; licensee Springer. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 1 Raman enhancement of rhodamine adsorbed on Ag nanoparticles self-assembled into nanowire-like arrays Marianthi Panagopoulou 1 , Nikolaos Pantiskos 1 , Panos Photopoulos 2 , Jun Tang 3 , Dimitris Tsoukalas 1,4 and Yannis S Raptis* 1 1 Physics Department, School of Applied Mathematical and Physical Sciences, National Technical University of Athens, Zografou Campus, Zografou, Athens 157 80, Greece 2 Department of Electronics, Technological Educational Institute of Athens, 12210 Aegaleo, Greece 3 North University of China, Taiyuan, Shanxi, People's Republic of China 4 Institute of Microelectronics, NCSR “Demokritos”, GR 15310 Ag. Paraskevi Greece *Corresponding author: yraptis@central.ntua.gr Email addresses: MP: mr.panagopoulou@gmail.com NP: nickpantiskos@yahoo.gr PP: pmphotopoulos@gmail.com JT: tangjun@nuc.edu.cn DT: dtsouk@imel.demokritos.gr YSR: yraptis@central.ntua.gr Abstract This work reports on Raman scattering of rhodamine (R6G) molecules absorbed on either randomly distributed or grating-like arrays of approximately 8-nm Ag nanoparticles developed by inert gas aggregation. Optimal growth and surface-enhanced Raman scattering (SERS) parameters have been obtained for the randomly distributed nanoparticles, while effects related to the aging of the silver nanoparticles were studied. Grating-like arrays of nanoparticles have been fabricated using line arrays templates formed either by fracture-induced structuring or by standard lithographic techniques. Grating structures fabricated by both methods exhibit an enhancement of the SERS signal, in comparison to the corresponding signal from randomly distributed Ag nanoparticles, as well as a preferential enhancement in the areas of the sharp features, and a dependence on the polarization direction of the incident exciting laser beam, with respect to the orientation of the gratings structuring. The observed spectroscopic features are consistent with a line-arrangement of hot-spots due to This Provisional PDF corresponds to the article as it appeared upon acceptance. Fully formatted PDF and full text (HTML) versions will be made available soon. Raman enhancement of rhodamine adsorbed on Ag nanoparticles self-assembled into nanowire-like arrays Nanoscale Research Letters 2011, 6:629 doi:10.1186/1556-276X-6-629 Marianthi Panagopoulou (mr.panagopoulou@gmail.com) Nikolaos Pantiskos (nickpantiskos@yahoo.gr) Panos Photopoulos (pmphotopoulos@gmail.com) Jun Tang (tangjun@nuc.edu.cn) Dimitris Tsoukalas (dtsouk@imel.demokritos.gr) Yannis S Raptis (yraptis@central.ntua.gr) ISSN 1556-276X Article type Nano Express Submission date 24 June 2011 Acceptance date 14 December 2011 Publication date 14 December 2011 Article URL http://www.nanoscalereslett.com/content/6/1/629 This peer-reviewed article was published immediately upon acceptance. It can be downloaded, printed and distributed freely for any purposes (see copyright notice below). Articles in Nanoscale Research Letters are listed in PubMed and archived at PubMed Central. For information about publishing your research in Nanoscale Research Letters go to http://www.nanoscalereslett.com/authors/instructions/ For information about other SpringerOpen publications go to http://www.springeropen.com Nanoscale Research Letters © 2011 Panagopoulou et al. ; licensee Springer. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 1 Raman enhancement of rhodamine adsorbed on Ag nanoparticles self-assembled into nanowire-like arrays Marianthi Panagopoulou 1 , Nikolaos Pantiskos 1 , Panos Photopoulos 2 , Jun Tang 3 , Dimitris Tsoukalas 1,4 and Yannis S Raptis* 1 1 Physics Department, School of Applied Mathematical and Physical Sciences, National Technical University of Athens, Zografou Campus, Zografou, Athens 157 80, Greece 2 Department of Electronics, Technological Educational Institute of Athens, 12210 Aegaleo, Greece 3 North University of China, Taiyuan, Shanxi, People's Republic of China 4 Institute of Microelectronics, NCSR “Demokritos”, GR 15310 Ag. Paraskevi Greece *Corresponding author: yraptis@central.ntua.gr Email addresses: MP: mr.panagopoulou@gmail.com NP: nickpantiskos@yahoo.gr PP: pmphotopoulos@gmail.com JT: tangjun@nuc.edu.cn DT: dtsouk@imel.demokritos.gr YSR: yraptis@central.ntua.gr Abstract This work reports on Raman scattering of rhodamine (R6G) molecules absorbed on either randomly distributed or grating-like arrays of approximately 8-nm Ag nanoparticles developed by inert gas aggregation. Optimal growth and surface-enhanced Raman scattering (SERS) parameters have been obtained for the randomly distributed nanoparticles, while effects related to the aging of the silver nanoparticles were studied. Grating-like arrays of nanoparticles have been fabricated using line arrays templates formed either by fracture-induced structuring or by standard lithographic techniques. Grating structures fabricated by both methods exhibit an enhancement of the SERS signal, in comparison to the corresponding signal from randomly distributed Ag nanoparticles, as well as a preferential enhancement in the areas of the sharp features, and a dependence on the polarization direction of the incident exciting laser beam, with respect to the orientation of the gratings structuring. The observed spectroscopic features are consistent with a line-arrangement of hot-spots due to Before&After BAmagazine.com ® i U X How to look real Set the stage with authentic visual cues Continued Continued How to look real 0617 Before&After BAmagazine.com ® i U X How to look real Before designing, check out the party! Here’s how to transform a dull layout into an energetic expression of the real event Before The Kentucky Mine Summer Concert Series in the Sierra Nevada mountains is low-budget entertainment under the stars From a small stage beneath 150-foot pines, the rousing sounds of bluegrass, balladeers and folk singers mingle with the sweet fragrance of summer in the forest It’s a great time Problem is, the Web banner promoting all this conveys none of it It’s well-crafted and tidy (right), but that’s what’s wrong Its neat lines and smooth surfaces project no energy, no musicality and no sense of place That’s because the designer was thinking layout and missed the event Here’s how to get all of that good stuff in KENTUCKY MINE AMPHITHEATER SUMMER CONCERT SERIES Foot stompin’ fun! Every Friday, p.m July thru August Where’s the party? The black hat hints at the country-western theme of the summer concerts, but nothing’s happening; the lines are too straight, the type is too static and the space is too empty to convey the rollicking, banjo-twanging, foot-stomping energy of the real thing of 11 How to look real 0617 Before&After ® How to look real of 11 BAmagazine.com i U X It was designed “by the book” The designer of this ad was unfamiliar with the event and so made a common mistake— he designed from his imagination Such results will almost always look artificial Reversed type is inauthentic Old printing was always dark on light Before KENTUCKY MINE AMPHITHEATER SUMMER CONCERT SERIES Foot stompin’ fun! Every Friday, p.m July thru August Inauthentic elements • Positive-negative color fields KENTUCKY MINE AMPHI• Straight edges and sharp corners • Contemporary color palette SUM- Sleek and smooth country? The “before” is crafted well enough It has a focal point, harmonious colors, consistent use of type, and things are neatly aligned But the result is lifeless That’s because it doesn’t express the subject Smooth surfaces and straight lines, for example, are elements of urban boardrooms (left), not the mountain outdoors (above) The banner mixes other visual signals: • Color fields are flat and smooth • Top bar is mechanical, and its type is reversed • Color palette is made up, not based on the real scene • The real outdoors has rocks, trees, wooden buildings, wagon wheels and dirt, all gritty, weathered and rough • Old-West printing had no fancy reverses • Old paper has color and texture of 11 How to look real 0617 Before&After ® How to look real BAmagazine.com of 11 i U X The type is static, and the space is too passive Usherwood Black has designed-in quirks, but the effect looks polished and synthetic The black hat has no owner, and music is nowhere in sight Before KENTUCKY MINE AMPHITHEATER SUMMER CONCERT SERIES Foot stompin’ fun! Every Friday, p.m July thru August Where’s the music? The hat is the focal point, and the “read breeze”—our natural left-to-right drift across a page— reinforces its position (the eye moves towards it), but it’s a passive image that conveys neither forest nor music nor party The result is a disconnect between image and message Dips SUMMER Half serifs Cupped feet Smooth edges Full serifs (Above) Quirky ITC Usherwood Black is an appealing type choice for several reasons, one of which are the unique half serifs on its M’s and N’s Although its characters are full of the irregularities one might see in old, wooden type, the edges are sharp and its overall line strong and uniform The result: Usherwood looks designed and not authentically old of 11 How to look real 0617 Before&After ® How to look real BAmagazine.com of 11 i U X It’s time to start over To convey the real event, we need authentic visual cues —real objects, real colors, real textures And because it’s a party, we need