Edited with the trial version of Foxit Advanced PDF Editor To remove this notice, visit: www.foxitsoftware.com/shopping Thu5c &24#&(8 /:""0$" !! $$ %#$"$&'#" )($$ >48$E6"*42D15".42m.(42/.(K*h5 )D"$?$15?42B.)$)58i.)E"Kd$#*k4,>(*|$)/KOt.()58g4q.Kl.)} 4)*g5)w4*.35,*.4ON.(Ko*)/d$458k4Ko*42/.(K?*4)?/KOt.(,>$E4)i %`.4s*4B.)42[.(4I.(KOt.()58g4.()*A-42m.(h,@5%>*#k.).)@. +)F.(KOv$K*h542l4o4$?$#*g.$)y.(42A.6G.(-[$4)^.+*.)4)a.6> 4*--[$)3f75]4)*k.J*h542l#c.($?$$)g0)_-*.35,*.)/d$$?$4)5o$ K*h542lK?*4)?/KOt.(+)?$\.(3f,>-(*\-4,k#*g.$)y.(6>4{ 6/.(,*A.15".Kg.K?*4)?/KOt.( II B3NH %! !%'7 INSULIN Insulin aspart NOVOLOG Insulin detemir LEVEMIR Insulin glargine LANTUS Insulin glulisine APIDRA Insulin lispro HUMALOG NPH insulin suspension HUMULIN N, NOVOLIN N Regular insulin HUMULIN R, NOVOLIN R AMYLIN ANALOG Pramlintide SYMLIN ORAL AGENTS Acarbose PRECOSE Alogliptin NESINA Bromocriptine CYCLOSET Canagliflozin INVOKANA Colesevelam WELCHOL Dapagliflozin FARXIGA Glimepiride AMARYL Glipizide GLUCOTROL Glyburide DIAΒETA, GLYNASE PRESTAB Linagliptin TRADJENTA Metformin FORTAMET, GLUCOPHAGE Miglitol GLYSET Nateglinide STARLIX Pioglitazone ACTOS Repaglinide PRANDIN Rosiglitazone AVANDIA Saxagliptin ONGLYZA Sitagliptin JANUVIA Tolbutamide TOLBUTAMIDE ,k-b$K?*4)?/KOt.(K".((*"4I.($)E.(-d44[*€$M.(.)O 42A. 4/>. 4)g (*s* (Ot* 4" Os$ 4C.) $E 42*k5 (Ot* € 6> 42*k5 (Ot* 42A. 4/>. 4)g (*s* K".( 0)\* ,>- #[. 6s* $I. #k.) >8 J?*4)?/KOt.(+)F.(0)\*,>-r4#k.)KN.4)5^.->,>-r4.)E- $?$)r*$)y.(KOv$Kd$42O.($)5.(#u*4B.)42[.(4I.(KOt.()58g4 %/4)*g5)w44ON.(Ko*)/d$458k4Ko**.35,*.*k0)r*K?*4)?/KOt.( €0)@.K?*4)?/KOt.(JJ4)>.) .)E-JJ480& JJ480&JJ4)"*+~6>$?$4)iKd$#*k4(@82"#u*.(58A..)@. +)?$.)O%*4258h.4)5o$\.(4E-4b4.)|.(K*i-Kd$42O.($x" K?* 4)?/ KOt.( 480& 6> 480& J?* 4)?/ KOt.( 4)"* +~ KOv$ Kl.) ()L",>3}2p*,/[.%5.(.[0(,5$/3&+)u*0)?4)/d$KOv$$)_.K/?. ,^.K^542/.(,H$-".(4)"*J?*4)?/KOt.(4)"*+~+)F.(KOv$+*i- 3/?44o4$E4)i%`.4s*3*.)$/.4/+)E3*.)$M.(.)O)[KOt.()58g4 u42eKOv$3*.)2"#u*4)"*0)w-b$#k.))gKrI.,>.)-[.) 4a0 4)i%w$6>)/d$3{%w.(*.35,*.$E)*k515\4o4$)/.)|.(#k.).)@. INCRETIN MIMETIC K?*4)?/KOt.(4)"*+~&4'/2-*.6>,8#52*%&$E4)i3{%w.(4)"8 Exenatide BYETTA, BYDUREON Liraglutide VICTOZA 4)g*.35,*.42/.(K*h542lK?*4)?/KOt.(4)"*+~ A %##&(8 JJ480&4)Ot.((d0u42e.)n4)".)4)*g5.*A.)/d$.(Ot* 42e 45q* u -r4 3o 4)i %*j. 4*g. $)a- #k.) $E 4)i 75]4 )*k. u ,y"45q*-5r.)N.JJ480&KOv$Kd$42O.(#u*3}4)*g5)w4 458k4 Ko* *.35,*. %/ 4g #>/ Q #l 0)? )x8 g #>/ Q #l 0)? )x8 $E 4)i ,> +g4 15\ $x" 15? 42B.) 4} -*j. KOv$ +)N* ->/ #u* 4?$ )@.*253)/d$$?$$)]4Kr$4z-F*42Ot.( 0002116803.INDD 335 B1ng 1 $;$/$%?#A@ $" 3=%$">22 6/23/2014 8:28:59 AM Edited with the trial version of Foxit Advanced PDF Editor To remove this notice, visit: www.foxitsoftware.com/shopping Type Type Tuổi khởi phát 5JB! 5J#% $%I Thể trạng 'B!0 !1 K$"C 5J$"C$%I A' Tỷ suất mắc 5% - 10% 90% - 95% Liên quan di truyền M!? @$> Thiếu hụt, khiếm khuyết insulin D- 6 G !.L'@$ ?2$D$ #% H >$D$ #%. #%."H >. g%?0T.`5,*_/N/)*0^5Pr/)569g/5x9,*I/)P+h6*G$PSw&PSt/) *69g57?%k/*/*A/O O591( &H/*|/)53+k6&*z/)P+i/*E/*&y$ 5*+g6*x5+/46-+/M//*+h66o/)/*+h65+i6/*+h6)a9/*+h6k/* /*A/O O591( %d5%6r&1*_+4{'x/)+/46-+/Pi53@/*/*|/)&R/ 5N/)PSt/)*69g5/)*+D.53n/)7?/)69*+i.5F/*.^/)'0/*+j. 50$/&(50/( "!u/)St+%E/*5*St/)4$6,*+N/1045$%40315+7(5g %?0T-6I/5+g53$.r5-Sw/)+/46-+/*e/)Pm/*Pi'6953E.z&+/46-+/ /h/ O+h6 /?9 P_. %_0 26@ 53E/* 'm *H$ -+1+' 1305+' 7? )-9&0)(/ ,*I/)8_93$$6,*+N/,*0_/)1*K55g%?0T5+g53$.r5-Sw/) +/46-+/PiP@1z/)7s+4}5N/))-6&04(7?$&+'$.+/530/).@66@ 53E/*/?9,C0'?+,*0_/) 1*K55+g14$6PH-?26@53E/*5+g5+/46-+/ 4$6N/ 69/*+D/v%k/*/*A/O O591( 5g%?0T%m1*@*y97? ,*I/)5*iP_.%_0Py+/46-+//h/&Q/)/*S-Sw/) +/46-+/ &a/ Pi P@1z/)7s+5*$9Pq+/p/)Pr)-6&04(530/).@6_/) #& ' Bk/*/*A/O O591( %6r&1*_+'J/)+/46-+/Pi53@/* 5N/)PSt/)*69g5/*+j.50$/&(50/(7?'6953E% v.z&&*`1 /*c/PSw&x&5+D6P+h653m7s++/46-+/-?'6953EPSt/)*69g5)a/ z&4+/*-L/*`5&H5*i7?53@/*/*|/)5*$9Pq+-s/&y$PSt/)*69g5 *+P+h653m7s++/46-+/5},+i.53$PSt/)*69g55*St/)869D/%e/) @9P0PSt/)5^+/*? Bng #.33$'!&-$'! ## O O591(&*+g.Pg/*R/ &@&53St/)*w1O Ok/*%m_/* *Sv/)%v+&@&9g65o/*S'+5369h/56q+%C01*E,*@/)+/46-+/v/)0^+ %+D/*R/-?26@53E/*5}.+j//*S530/)O O591( @&3o+-0^/&*69i/ *H$530/)O O591(,*I/)3a.3r/*S530/)O O591( !%k/* /*A/O O591(5*St/),*I/)%m/*+j.50$/&(50/(/*S/)&@&%+g/ &*z/).^/5F/*v5*i-?5SR/)5}/*$6 µ µ Người khỏe mạnh 80 ĐTĐ type 40 ĐTĐ type 0 Phút 10 Truyền glucose TM D$ #% K5J1$5J&-F /33$"%'E% #$4> 0002116803.INDD 336 "! O O591(Pf&53S/)%v+5E/*53^/),*@/)+/46-+/ &R26$/PF&*5*+g6/*^9&_.7s++/46-+/_/) 30/)O O591( f&'J5g%?0T7b/&G/,*_/N/)*0^5Pr/)/*S/)-Sw/)+/46-+/ 5+g53$,*I/)PyPiP+h6*G$PSt/)*69g5_/),*+)f11*_+5E/* 53$/),*@/)+/46-+//)?9&?/)5N/)v/)0^+%+D/*o+-Sw/)5g%?0 T )+_. 'a/ 5*(0 5*t+ )+$/ d& %k/* 3@+ 7s+ O O 591( %k/* /*A/O O591(5*St/)%C01*EC01*E-?.r5530/)/*|/)9g65o )H11*a/5^03$5E/*53^/),*@/)+/46-+/9g65oPSw&&0+-?/)69D/ /*A/&*F/*)A9O O591( #&' x&5+D6P+h653mO O591(-?'6953EPSt/)*69g5530/) )+s+*^/%E/*5*St/)7?/)N/&*f/53E*0B/5+g/53+i/&y$&@&%+g/ &*z/).^/5F/*+_.&A/5c15*i'x&P+h6&*l/*&*gPrN/-?. )+_.,*@/)+/46-+/7?)+K1.r54o%k/*/*A/P^5.z&PSt/)*69g5 x&5+D6569/*+D/*a6*g5&@&%k/*/*A/Ph61*_+4{&@&5*6o&6o/) P+h653mO O *(0'+j/5+g/%k/*5g%?0'a/T469,+k5,*+PH+/46-+/ 5*St/)PSw&4{'x/)PiPS$PSt/)*69g57h.z&.x&5+D6_/) 6/23/2014 8:29:00 AM Edited with the trial version of Foxit Advanced PDF Editor To remove this notice, visit: www.foxitsoftware.com/shopping III INSULIN VÀ INSULIN ANALOG +02)'+ ); &,/*,+# !B U+ !&V1 -#-1'" !V2 1T, 1q &' !&2g' -#-1'" GKm!+d' 3i'+&2 [+%*h1!W2+d'"'02)$'"#q1'_+!&V1-/,'+02)'+(&' b1&o5-&=+1T, 1&;+& '+02)'+ 3; -#-1'"# !U &' G_2 GKm! 1'^1 /1q125^+1n5K2D +02)'+ b1&U'1/q.2%+3;1&Y+",GB+e+%Gh '+02)'+ 1/,+% *+1n!'+02)'+"Ki'"!A+%c'); J*'+02)'+&KJ+%-&*,T+"Kl+%*l!B1&`GKm!&T+!&^ [+% !* a+& +&=+ 025 1&Y+ !B 1&` !W+ %'U* )'_2 0002116803.INDD 337 B"ng (86 7 0& & # 9'23 5'/ 6/23/2014 8:29:02 AM Edited with the trial version of Foxit Advanced PDF Editor To remove this notice, visit: www.foxitsoftware.com/shopping namud.vn - Cng Triệu chứng hạ đường huyết Đau đầu Hồi hộp IV CÁC CH INSULIN TRONG ! 168/-1QUy((,-&7,A1,168/-11,&1,&3-)&(7-1+168/-17,w-+-&1 )8;75G7B()z1+1+d1 ,257&(7-1+7581+'G1,17*50*)-&7*&(7-1+9A )A-21+&(7-1+_1+ 7J07d77,w-+-&1.,x-3,B77B()z1+Q^7Qn1, 7521+0B89A)8;75G7B()z1+({&(B(/2^--168/-1Pr-9v-(B('B(6R ,-6~)z1+-168/-1(a17,c175p1+Qg('-m7(,MNQi1/-j1)L1+9A/2^- -168/-1QC;/AQ-j85`748&175p1+ A Insulin nhanh insulin th" Đánh trống ngực Lú lẫn Chóng mặt Toát mồ hôi Run Đói cồn cào Nhìn mờ A A A Mệt mỏi rã rời Loạn dưỡng mỡ Quá mẫn ! . ./ + '-- #+ ,#%+$-&" 0002116803.INDD 338 J(,i3,b0-168/-17,8u(1,J01A; '5 !% %2 2.!% &/"&3'6&410-168/-1 7,Uw1+/A/2^--168/-1(J7,w-+-&1)8;75G7B()z1+1+d17&1QUy((J 7,k7^208r-9v-.h0&-168/-1(I1/^-7,8u(1,J0 5&3-) &(7-1+ +Uw- 7& 7,&; Qs- 0u7 6r &(-) &0-1 7521+ -168/-1 7,Uw1+Qk7^25&(B(168/-1&/&/2+QJ(,H1,/A(B( # .,B( '5+x(,t+r(/;6-1*9A352/-1*x 9o75H 9A (,8r-,2B1Qs-9o75H(,21,&8 7,&;Qs-1A;/A0 (,27,8r(,`37,81,&1,,T17B()z1+:8`7,-m11,&1,,T19A7,w- +-&1)8;75G7B()z1+1+d1,T16&8.,-7-F0)Uv-)&!,w-+-&1Q^7 Qn1,7521+,8;i77UT1+({& .,2_1+ 3,M7629v- 3,M7({& '5!% (J)Uy( Qu1+)Uy(/(7UT1+71,U-6352-168/-1,J0-168/-11A;QUy( 6~)z1+0K3,q1+-168/-1+-_-3,J1+5&7521+.,-O148&QJ.-k0 62B7 QUw1+ ,8;i7 6&8 O1 1+2A- 5& (S1+ QUy( 6~ )z1+ Qk ,^ QUw1+ ,8;i71,&1,.,-(a1,J01A;7,Uw1+QUy()L1+3,r-,y39v-(B( /2^--168/-11j17B()z1+.E2)A-/2^-1A;)L1+Qk.-k062B7QUw1+ ,8;i7QJ- '53,_-)L1+ 3,M775Uv(.,-O17521+.,- (J7,k)L1+3,M775Uv(O1,2g( 3,M76&8.,- 'd7Qa8O1168/-11,&1,7,Uw1+QUy(6~)z1+1+2A-'T0-168/-1 5`77,H(,,y37-F0#0g()L-168/-17,Uw1+QUy()L1+'e1+QUw1+ 1A;1,`7.,-(a1 B Insulin tác d#ng trung bình - NPH insulin /A/2^-(J7,w-+-&17B()z1+7581+'G1,QUy(7s1+,y3 'e1+ (B(, 7,F0 h0 9A 3527&0-1* 9A2 -168/-1 7,Uw1+ 2 i7 ,y3 9v-3527&0-1*)Uv-)^1+3,|(1F1/2^--168/-11A;H77&1.i748_/A 7,8r(,`37,8(,c07,w-+-&1)8;75G7B()z1+)A-,T1-168/-1 QUy(6~)z1+1,U-168/-11j17521+P!P7;3*9A 7,Uw1+)L1+ D09v--168/-11,&1,,2g(-168/-17,Uw1+Qk.-k062B7)Uw1+,8;i7 6&8 O1 -168/-1 (,n )L1+ 7-F0 )Uv- )& (S1+ 6~)z1+Qk,^QUw1+,8;i77|(7,G1,U7521+ 1,-l072&1(*721 C Insulin tác d#ng kéo dài P-k0Qf1+Q-m1({&s llare7,`3,T1629v--168/-11+Uw-(,21F1 ,-7-F06h7^2.i77{&7^-9o75H7-F06&8QJ7,8r(QUy(+-_-3,J1+7}7} !,w-+-&1:8`7,-m17B()z1+({&1,J01A;(,c0,T1".,B'e1+ 3,f1+9A.,K1+(JQn1,_1+ 6/23/2014 8:29:04 AM Edited with the trial version of Foxit Advanced PDF Editor To remove this notice, visit: www.foxitsoftware.com/shopping Insulin aspart, insulin lispro, Insulin glulisine Regular insulin Nồng độ insulin huyết tương NPH insulin Insulin detemir Insulin glargine 12 Giờ 18 24 Bng % # $ & ' % " : !-[" " 7' 8& K&! "=( ,?& B^& $"8& #S, ]" $-%"& ,6 `& #7' 5" ,BA& ,e @0 $5 #S, )-L a +e "L" (!:& ,c ,c #!X" (!b !_( ]" $-%"& BA& ,e "&+-$"&.5 $* "& @B_+d`& $5%"&+-$"&&T&6$'K""&+-$"&#!;& :,6`& #7'5",!B^& @B_,*\&.]"6$'K""&+-$"&&50,*'& B^& !-0S,,*-& &!)& B^"&!,!B^& $5%!'Q,!M(!A&b& .]"B]" N&+-M,6A&!K@B^& !-0S,!;&%8' "%,'!K@B^& Q(&!"T-!A&)(!6@(@"T-,*W "&+-$"&,9!e L& -0&!"8&U&!&!&+d`& (!6@( @"T-,*W,9!e "L%@6& #'6"S& !b& %K!%6-&!X&!B"S&!b& .& %K,!%&,!N&#"&!+'.]"(!6@(AL& L& !6 @(@"T-,*W,9!e#!;& #!-0S&6'!'6U&!&!&%&U&!$-&?%@ /-M,!"U&"S&!b& %K! %6-&!X& B^"',-Z".5&!*& & B^"W!K@B^& !-0S,#!;& *& -08&&!&"T-,*W,9!e#!;& $5% "L%"S&!b& %K!%6-$]&)U&!&!&@6",!6'@B^& 0002116803.INDD 339 6/23/2014 8:29:05 AM Edited with the trial version of Foxit Advanced PDF Editor To remove this notice, visit: www.foxitsoftware.com/shopping Sáng Chiều Tối Insulin effect Thường Thường Thường B L S Morning Afternoon Đêm NPH Trước ngủ Evening Night Night S Insulin effect Morning Afternoon Lispro Lispro Night Glargine or detemir Insulin effect Lispro Evening B L S +6*(,*)3(>.FHe-'2!434b)5=3(e) ')!-,W#$Hd)-D,(U4(Y3FZ4F>/j-'3`35d)#>#3(4`#4`-'E`)5d) "]-(-(?-+?4-D,#U-/(`)(g/-()Z4+.R)3(4`#4`-'#B3([#B(.X# *(C-'2l$h-')-24+)-F[*)[,2.>3FHe-'(47Y3S-' 3(e)')!-3># $h-'#i!,c32`3(4`#4`-'"=-' ,c32`3>#$h-'/(h3(He-''X/ A Nhóm sulfonylurea (B,3(4`#-=7*A#(3(A#(3Y"=.I3)Y3)-24+)-$.FB-BFHg#6Y/ 5=.-(B,*A#(3)Y3)-24+)-)]-3R)#>#3(4`#31.-'-(B,FHg#2l $h-'-()Z4+=#>#4+&.-7+41%!3(Y(] "!.'a, +7 "%-#+!,)$% 5= Glyburide 18 h Glipizide 20 h Glimepiride 24 h Nateglinide h Repaglinide h Metformin 6h C # + : G#(Y3>#$h-'#(A-(#i!3(4`#+= % $%&!%>#4+&.-7+41%!/(.-'"Y*@-(/(h 3(4c#'?7*(l#n#,=-'3Y"=.+=,,f*@-(! +=,3D-'! -c)"=.5=')S)/(B-'-24+)-3k#>#"_#31.-'-c)"=.(@,5=.FB 3(4`##B3([#B3>#$h-'')S,2S-64T3'+4#.2%3R)'!-5=3D-'-(R7#S, )-24+)-f,C-'.R)")@- D* ( & !4*()4`-'3(4`#+)@-*Y35d)/1.3%)-(47Y3 3HG-'(U4(Y3#>#3(4`#3(4c#-(B,-=7+)@-*Y31T3,R-(5d) /1.3%3)-(47Y33HG-'$\3HG-'3>#^#(')S3(4`#FHg##(47[- (B!3R)'!-3(S)31k04!-Hd#3)[4(.X#/(?-(e)')!-3>#$h-' #i!#>#23k ( 0002116803.INDD 341 Pioglitazone >24 h Acarbose 6h Miglitol 6h B"ng 10 (e)')!-3>#$h-'#i! ,c32`3(4`#4`-' 6/23/2014 8:29:08 AM Edited with the trial version of Foxit Advanced PDF Editor To remove this notice, visit: www.foxitsoftware.com/shopping Thu5c u5ng '34'&&'(7 Glinide, Sulfonylureas Metformin, ức chế αGlucosidase Sulfonylurea, Glinides, TZD Metformin Ức chế DPP - GLUCOSE Hạ đường huyết Rối loạn tiêu hóa Tăng cân Buồn nôn Viêm tụy Bng 11 M6t s5&88(709 &5'&&'(7 Tác dng ph ; !m*$*$+T&D %?*% n0%1d +$e)0E*$ 5087A5>;/+(2TUJ-=2>v-€--2n6/7A=8-;86 72\42J71 An=-+ 5373./J-=2>v-28e=2Q+6/7A=8-;86 72\Barbiturate, Carbamazepine, Rifampin -Q=2p5I613f6=J-.~71-+=2>v-*J-=2>v-2e5393.6J>72\/60,;3B35€--2n6/7-2>Ap7 2Q+=e31+7-Q=2p5I6=V7171>A-[2eX\{712>An=-+Glinide.8XQ-2v71-2sXt7292v32}9 =2>v-=;M72Q6=2>v-Glinide-h7v-.>A72g==;87172Q6-P7X\}-2I72.871>A-[723q6=8+75+-=3-:>J-+8$>A 723M7|&3r=+6?i7-Q28e=-2g=7IA=;M7=2t=;\{71.\z3.e71…=2>v--l9†@>g=@€$;>71 >v- t-213f$2>v-5I6=V71-8v-42R711KA=V71=3n=37537:>J6€-?I71>A-[2e X\{712>An==2g92[7#%;g=723o> [-2n=J-.~71-2O72-+Metformin5I13f6g=15>-8g= 15>-8J6€-=e31+75I6y=71>AM772K7:>+7=;u715I6=V71X\{712>An==;871W$W=A9/ f722\|71 -2An>5M7X\{712>An=XQ3*Metformin-Z715I6-2j6:>J=;N722g9=2>X\{71=e3;>y=5I6=V71,k=13ƒ ?I-8g=23r7?NMetformin5I66g=-f613J-7187 63r7142>An7-J8Metformin5I-2sXt72Xh>=+A=;871X3o>=;tW$W=A9/ Metformin-Q=2pv->v7142J-eX\{712>An=-Q=2p@fA;+423v-4O-2=3n=7537?N?jA-Q=2p92f3-K772k-X3o>-2s7253o> C : Metformin2g9=2>=v=:>+X\{71>v712h>72\42R7153M74n=?z39;8=/372>An==\[71 42R71,t-2>Ap72Q+=2f3=;•|.e7171>AM7?m7:>+7\z-=3p> D : +A1V972g=5I;v358e7=3M>2Q+/=08;637-2v71-2sXt72-28,r7272K7A=2j7/! \z3 .85I6=V7171>A-[723q6=8+75+-=3-2f3.•71=2>v-423-Q72w36J>-[=36-g9X}=-g9-+ A=36723q6=;S712>An=28l--J-;v358e7-Q=2p.i7Xn7A=2j7h7x3A=367123r7;\}>h771•71=2>v-=;M7-J-,r7272K792f3v--f7:>+71X\{71 =Y726e-223q6=8+75+-=3-23n61l972\71=„5r=‚?871;g=-+8S71=2>v-4L8.I3-Q=2p5I613f62g9 =2>?3=+637 Tác dng ph: 18I3W$W=A9/ Metformin-P7X\}-=;t2y3-2€71,>w71=;€71X+7+71 Q5I613f642J7137537=;8712y3-2€717IA.i7Xn7;~71=;€71?I,r7272K7-Q=2p=2~=2+3 Ch : 0002116803.INDD 343 6/23/2014 8:29:10 AM Edited with the trial version of Foxit Advanced PDF Editor namud.vn - Cng To remove this notice, visit: www.foxitsoftware.com/shopping D Nhóm thiazolidinedione (TZD) A%%Q/)-@.5N/)5F/*/*^9%_.%y#+/46-+/#+5*6o%530/)/*H.$#0)p Pioglitazone 7@Rosiglitazone.d%&K+/46-+/%a/%*0*0^5Pr/)%y#5*6o%/*S/)/*H.5*6o%/@9,*I/) ,F%*5*F%*5f$@0T5+f5+/46-+/&0PH,*I/)%H/)69%R*^PSt/)*69f5&05N/)5+f526A.z% +/46-+/ A%-@.)+_.,*A/)+/46-+/$c/)%A%**0^5Pr/)/*S.r5%*`5Pp/)7b/ 5*x5*hU.r55*x5*h/c.530/)/*B/5f$@0*x5*hUPSw%*0^5*H#4e-@.5*#9Pq+ 4#0.C%y#.r54o)'/'269Pl/**0^5Pr/)%y#+/46-+/*j26_-@-@.5N/)Pr/*^9%_.%y#+/46-+/7s+ %A%.I.v)#/%R8SR/))St+5#%G/26#/5B.Pf/5A%&x/)%y#5*6o%-E//p/)Pr%*0-'45'30- Rosigli-tazone-@.5N/)53+)-9%'3+&'530/),*+Pioglitazone-@.)+_.53+)-9%'3+&'_*#+5*6o%Pg6 -@.5N/)%*0-'45'30-%H5*h&K/)PR/53l-+j6*0d%1*o+*w17s+%A%5*6o%6o/),*A% *0d% +/46-+/ +g6+/46-+/%a/)+_.,*+4|&x/)1*o+*w17s+/*H.5*6o%/@9,*69f/%A0 Pioglitazone-@-~#%*m/*@/)*0d%530/)P+g653lOO591'RosiglitazoneF5PSw%4|&x/)&0 %A%$+f/%o/d/)53E/5+..^%* C ch tác dng: Pioglitazone7@RosiglitazonePg6*`15*65o526#PSt/)6o/)7@-+E/,f5.^/* 7s+#-$6.+/*69f55SR/)_*#+5*6o%Pg6%*69h/*H#.^/*26#%A%+40:9. ,*A%/*#6 r57@+%*`5%*69h/*H#%y#Pioglitazone%G/*0^55F/*PioglitazoneF55*_+53{26#5*b/1*a/-s/ 5*6o%7@%A%%*`5 %*69h/ *H# PSw% 5*_+ 53{ 26# &l%* b5 530/) 1*B/ A% %*`5 %*69h/ *H# %y# RosiglitazonePSw%5*_+53{%*y9f626#/Ss%5+h6*I/)%a/%*k/*-+g653E/4695*b/569/*+E/53A/* 4|&x/)/*H.5*6o%/@9%*01*x/}P#/)%*0%0/$L D : Tác dng ph:r57@+53St/)*w1/*+i.Pr%)#/PCPSw%$A0%A0,*+&K/)5*6o%7@5*'0&J+Pl/* ,%*z%/N/))#/,*+&K/)5*6o%PSw%,*69f/%A0N/)%B/%H5*h86`5*+j/u/*H./@9&0-@. 5N/).v&Ss+7@z&l%* *LM +}/Ss%%H5*h-@.4695+.&+i/5+f/8`6*R/&0PH%a/53A/*4| &x/)/*H.5*6o%/@9%*0$j/*/*B/4695+./d/)"-+E/26#/Pf//)69%R.`58SR/)7@)C9 8SR/)+0)-+5#:0/'%H5*h-@.5N/)/)69%R6/)5*S$@/)26#/)r57@+1*B/5F%*)r18A%Pl/* 04+)-+5#:0/'%H5*h-@.5N/)5€-j/*p+.A6%R5+.7@5|70/)5+..^%*f526_-@7+j%4|&x/) 04+)-+5#:0/'%*kA1&x/)%*0%A%Po+5Sw/)Pd%$+j5#6,*+8'.8D55*E.%A%&}-+j6#/50@/7+j% *^/%*f/@9PCPSw%&v$n SR/)5~/*S'5(03.+/-@.)+_.,*A/)+/46-+/%H5*h-@.53z/)3x/)53u-^+u %A%1*x/}$l*r+53z/)P#/#/)$6p/)53z/)530/)5*t+,5+g/.C/,+/* Ch : E Thuc α-glucosidase Acarbose Miglitol * , +"()! ! 0002116803.INDD 344 6/23/2014 8:29:10 AM Edited with the trial version of Foxit Advanced PDF Editor To remove this notice, visit: www.foxitsoftware.com/shopping /F4 )s 4/0m; x )w )D4 */a0 :854. 8;u: W.2;*590+(9, :/{> 6/F4 *(8)54/>+8(:, :/D4/ 2;*59, +8(:, +5SM2D3.0a3SVw4./;>l:9(;R451/N4.1K*/:0l:049;204/(>2D3:R4.4/`>*a3049;2044I4 4/M3:/;s*4D>1/N4..F>/`SVw4./;>l:1/09~+z4.SU4:8q20o; ;>4/0I41/06/s0/y6*U/`SVw4./;>l:*M:/n:R4.2I4%/PQ3u:S0m;7;(4:8r4.2D1/0)q/`SVw4. /;>l:*M9~+z4.4/M3:/;s*4D>4I4S0m;:8q)h4..2;*59,/U42D+O4.9(**(859,SVw4.;s4.'!+?+7'!-8h'!)"h/7!#8-"7'" ':'"#-".a-+:' 9.0% T ri ệu ng Đ ơn t rị liệ u * Ph ố i hợ p thuố c * Metformin GLP-1 RA SGLT-2i DPP-4i AGi TZD SU/GLN Không GLP-1 RA MET GLP-1 RA DPP-4i SGLT-2i Basal Insulin + Ph ố i h ợp t h uố c * SGLT-2i TZD thuốc hàng Colesevelam Bromocriptine QR AGi SU/GLN MET thuốc hàng + thuốc hàng + Nếu không đạt mục tiêu tháng chuyển sang phối hợp Nếu không đạt mục thuốc tiêu tháng chuyển qua phối hợp thuốc INSULIN Hoặc Thuốc khác ± Phối hợp thuốc Basal insulin DPP-4i Colesevelam Bromocriptine QR AGi Thêm insulin chuyển qua dùng Insulin SU/GLN Refer to Insulin Algorithm Nếu không đạt mục tiêu tháng LEGEND sulin phối hợp DIỄN Phối hợp thuốc TZD chuyển qua dùng In- * Thứ tự thuốc hàng xếp theo ưu tiên sử dụng Có Sử dụng thận trọng thêm Insulin TIẾN Ít tác dụng phụ, có thêm lợi ích BỆNH COPYRIGHT © 2015 AACE MAY NOT BE REPRODUCED IN ANY FORM WITHOUT EXPRESS WRITTEN PERMISSION FROM AACE Guideline hướng dẫn điều trị ĐTĐ type AACE 2015 e6 AACE/ACE Comprehensive Diabetes Management Algorithm, Endocr Pract 2015;21(No 4) To remove this notice, visit: www.foxitsoftware.com/shopping