Tìm hiểu phụ gia tạo ngọt aspartame

Chất tạo ngọt Aspartame (E951) do một chuyên gia hoá học của tập đoàn GD Searle phát hiện vào năm 1965, sau đó được FDA (Cục quản lý an toàn dược phẩm và thực phẩm, Mỹ) cấp phép vào năm 1981. Ngày nay, mặc dù còn nhiều tranh cãi về tính an toàn đối với sức khoẻ người tiêu dùng, aspartame được sử dụng trong gần 6000 sản phẩm thực phẩm và dược phẩm, đặc biệt là trong các dòng sản phẩm “light” – ít năng lượng, cung cấp cho khoảng 250 triệu người trên khắp thế giới

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Nguồn gốc phát hiện phụ gia tạo ngọt Aspartame >?@ABCC6DEFG=4HI@6J*/KC@AJJLC,M@N-DC+D @O64GP=QBC*M5MRSJTNEUJV*8+WC@IRSJX6YJX6Q 'ZHJ>[@O64G\4]/C/Q6^JI_J9`*CJa`bC@Mc 3BdJe@fRgK*I_QCBCC6DMRSJBhIU@i  P))) B8X6 YJX6IRSJX6QM^Jj+@JJI9B8X6k+lmbO+RSQ J*J>J@e@8<=)*RgKen13o Phụ gia tạo ngọt Aspartame và ứng dụng trong kẹo bJ>JLCBCC6D • BCC6DJ5JdJ@AJ+ 4:  4\  <  = ] • NCV*cJ1+N-l-α-Aspartyl-L-phenylalanine l- methyl esterC/3-amino- N-(α-carboxyphenethyl) succinamic acid N-methyl ester] • RgI_pI?2] • 8Oe1+P);+] Cấu trúc phân tử Aspartame BCC6DMRSJRq6?@IR36BcKRCIDD+QFV*C+Q*C-rDDQ -CDJCQ(-rDDQ6@BrDDQ-@@s*+Q-@BrDDo BCC6DJ5e1Qj6*nQe6_]AJLCCBCC6DJC@><)) m7))+iB@3MRg6bC]N@,/QJtJi6+RS>uCBCC6DJvJ@M ARqMRqRBhIUjwRg]*/KQxAJLCJLCCBCC6Dwq eJ3xAJLCMRgBCJJC@BDQJ,6q+yJMi*QR+?e[@I+z*qQM +?  x  A  +z*  @  6]  1*  c    CBCC6D  3acesulfame potassium (acesulfame K)wJ@xAcRMRgAqMRgQKCBCC6D RgMRSJI_e1S3CJDB*+sC6D] {MJC@CBCC6Djxj1M|diketopiperazine :  =  < E3,6-dioxo- 5-benzyl-2-piperazineacetic acidHQeJ9xA] II. Sản xuất Aspartame BCC6DMRSJ?@}jCJ>5CAJ.CJICBCJQD/+C+CD6DC@+] 5e1S3D/+C+CDwe*XCJIC6B~MRSJB8BC]J5 `*    e*X  MRSJ  B  C  w  Ji  `*  D/+C+CD] 2K6D.•*w+K6DB8€*>CJJC€C62mCBCJ2mD/+C+C gJJJLe*XRCJ++*Bs+C*6@/DjCJD*6+*C6J*6] Tóm tắt quy trình sản xuất Aspartame: • i*KQL – Phenylalanin*MRSJ}V*w+K6DMRSJJ@8d3 6DC@+?@SJ>A+L – phenylalanin metyl ester]9C€CBCJ8 V*C6V*w8dMJDJJxb@zhJ58RpM18 d?@CBCC6QM86j8@8dJt€8/CpJJxbJi1] • JB8X6BC*V*w€h+WMRSJjq6@jw8d+•@ <:gpM9]1M5MMRSJO+KP= @ E4:G @ THI*/w@ <:g‚CƒMRSJ+6*M1M9]„SBC*8dMRSJC +@a3I*6bJSe1p(4\ @ E) @ TH]*MRSJB~MRSJ+AJ MJKCƒ+6e] • ‚/Jt+B8X6*CI_J@8de1]y MRSJJ*/5CCBCC6Dj…8d3C€C€DJ]%8d/MRSJ YJ@4<gQ?6jƒ+3JdCI*IxJCJIQJ>€yJJ%I < ] -C*M5QJ>€yJJ%IMRSJ+@?juj…JJ+AJJRJ>M*I*6] %iJ>nJ9+?MRSJJ1j…JJ9CC@I*IxJDC@+MRSJ e1+?]‚/B~MRSJ+AJ+6eJ@CB8X6J*cJ_M5 +jCBCC6D] III. Công dụng của Aspartame BCC6D+6@J>?@xAC/J@MRgRgMRSJA+kMRg@ AJl]BCC6DJdCbJC+@qMRg`*E:e+@JC+@;C6H] M+?IRx@J>@^Jxe6+@?e5Jx*R6BcJ>+6A eJQI0j8@V*8BhIUQ+?RqMcfB@3JBhIUMRgK CBCC6DMRSJBhIUR6J>UC@>`*+@?YJX6Q}j e†@Qe†@JC@B*QMƒ*cQB‚CJ*CQJJB8X6keMRgloeJ86Bc+@? *cJQC6j|B*oC/QCBCC6DMaMRSJ[BhIUa?q4<= V*cJCK13I@e@8P])))B8X6] CKJd*63>`CBCC6MaJ@>/‚6c*/Mc3BdJeuD RgK*I_. • Nghiên cứu thứ nhấtmI@JJKJd*C'?JYJK=G])))U‚ mJ@>/‡+KV*CM1JK*URg€*/K+z*IR3JB@ICJ5Cˆ?@ Aj…CBCC6+*/JqB@.<‰Š36+@B@IC;/Q7=Š3<(7+@ ‰\Š3q:+@;/] • Nghiên cứu thứ haimI@‚e@CAJ*J ‹RV*cJCŒYJ K4\))J@J*b6QJ@>/BhIUCBCC6+z*IJ5+6O */Jq*RCQ,Mi*Iz/ie@?EpJ8J*MYJ+•J*JH• JvR+KV*CM1*/Jq6nJjj?JJi*1j@+/6@p‚J@J* J]`*M5pKJd*/+6e13J*/K6+@+n.63 J@M,ORg€*/K6+RSCBCC6>E3k‚+`*+RS>i 3+`*+RS>UJ5J>,MRSJMc3RglHwMa>/BY€*> B36JLCec*pJqJ@@C/@geŽJ9+j@Co R,/QjKJ?JIU+C/1MRg?@RqxAq >qMRgYKwJvMaJ5‚KJd*J@>/JIUU 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6DJLC6aYJX6)P]\]PQ)P]\]‰Q4<]G]4Q4G]G]<]4Q4<]G]<]7 <=)) 7< C*QJLEjC@ƒ6>6Q0QYJ,zJLz0QM,*QM„Q+HQ8@ jMa>*Jb@^JJK 4))) 77 „SJCJC@EjHjJCJC@ 7))) 7: „SJCJC@EjHjJCJC@ 7))) 7= „SJCJC@EI?B@H 4))) 7P CJC@I?Lj`6^eJ8zjK@ 7))) 7‰ -8X6JCJC@QBJ+C 7))) 7\ -8X6JCJC@QBJ+C <))) 7G JB8X6RqYBJ+CQB8X6C/1BJ+C 7))) :) †@Jd 7))) :4 †@6`6 7))) :< *Cj?z 7))) :7 †@JC@B* 7))) :: -8X6I_MCbYJX6E NB8X6CbjHQ+3 Lj`6^Ee8V*8HQR3JBcA 4))) := vJcJOBQjC@ƒ6J8/16?J€C/ 4))) :P ƒO6+6}vJcJjE N.j*M?@Qj *M}jBnoH 4))) :‰ 6ŽJJB8X6jR3Rg„S 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