1726 P Propacetamol Trade Name$: D: Atosil Bayer Vital Eusedon Krewel Meuselbach Promethawern Pharma Wernigerode Promethazin-neuraxpharm neuraxpharm Prothazin Rodleben F: Algotropyl pro
Trang 1Proligestone P 1721
Trade Name(s):
Use: progestogen RN: 23873-85-0 MF: C24H3404 MW: 386.53 EINECS: 245-922-6
CN: 14,17-[propylidenebis(oxy)]pregn-4-ene-3,20-dione
Reference(s):
Sijde, D van der et al.: J Med Chem (JMCMAR) 15,909 (1972)
ZA 681 592 (Koninkl Nederl Gist & Spiritusfabriek; appl 22.2.1968; NL-prior 13.3.1967)
14.17-dihydroxy- propionaldehyde
starting material:
Cooley, G et al.: Tetrahedron Suppl (TETSAE) 7,325 (1966)
Proligestone
Forrnulation(s): vial 100 mg/ml
progesterane
(from Reichstein S)
Trade Name(s):
GB: Delvosteron (Mycpfarm);
wfm
Use: analeptic, central stimulant, depressant
RN: 493-92-5 MF: C,,H,,N MW: 217.36 EINECS: 207-784-5
LDS,,: 157 mglkg (R, p.0.)
CN: 1-[I-(phenylmethyl)butyI]pyrrolidine
hydrochloride
RN: 121 1-28-5 MF: C,5H,,N HCI MW: 253.82 EINECS: 214-917-0
LDS,: 25 mgkg (M, i.v.); 230 mglkg (M, p.0.);
40 mgkg (R, i.v.); 278 mg/kg (R, p.0.)
Trang 21722 P Prolonium iodide
Rqference(s):
DE 1 088 962 (Thomae; appl 1956)
DE 1 093 799 (Thomae; appl 1957; addition to DE 1 088 962)
H HZ, PtOZ or Roney-Ni
Formulatinn(s): drg 10 mg
2-0x0-1 -phenylpentane pyrrolidine
Trade Name(s):
1ng.)-comb.; wfrn -
Prolintone
Use: thyroid therapeutic
RN: 123-47-7 MF: C9H2,12N20 MW: 430.1 1 EINECS: 204-630-9
H
N
H,C/ ' C H ~
H3C CH3 iodide tr~methyl- 1.3-diiodo-2-
dirnethyl epichlorohydrin 1.3-bis(dimethylamin0)-
Prolonium iodide
Reference(s):
US 1 526 627 (Baycr; 1925; prior 1924)
Formulation(s): amp 400 mgl2 ml; drg 25 rng, 50 mg, 100 mg; drops 20 mglml; susp 50 mg15 ml; vial 50
mglml
Trade Name(s):
Trang 3Promazine P 1723
Use: neuroleptic, anti-emetic, antipsychotic
RN: 58-40-2 MF: C,7H2,N2S MW: 284.43 EINECS: 200-382-0
LD,,: 45 mgkg (M, i.v.); 40 1 mglkg (M, p.0.);
14.5 mg/kg (R, i.v.); 350 mglkg (R, p.0.)
CN: N,N-dimethyl-l OH-phenothiazine- 10-propanamine
monohydrochIoride
RN: 53-60-1 MF: C,7H2,N,S HC1 MW: 320.89 EINECS: 200-179-7
LD,,: 38 mgkg (M, i.v.);
29 m a g (R, i.v.); 400 mglkg (R, p.0.)
maleate (2:l)
RN: 4701-69-3 MF: CL7H2,N2S 1/2C4H404 MW: 684.93
phosphate
RN: 1508-27-6 MF: C,,H2,N2S xH,04P MW: unspecified
LD,: 60 mgkg (M , i.v.);
350 m a g (R, p.0.)
omide
propyl chloride
Reference(s):
U S 2 519 886 (RhGne-Poulenc; 1950; F-prior 1945)
DE 824 944 (RhBne-Poulenc; appl 1950; F-prior 1945)
Wirth, W.: Arzneim.-Forsch (ARZNAD) 8, 507 (1958)
Promozine
50 mg/ml (as hydrochloride)
Trade Name(s):
Sinophenin (Rodleben) I: Talofen (Fournier Pierrel) USA: Sparine (Wyeth); wfm
Use: progestogen
RN: 34184-77-5 MF: C2,H3,02 MW: 326.48
CN: (17(3)-17-methyl-17-(1-oxopropyl)estra-4,9-dien-3-one
Trang 41724 P Promestriene
methyl ether triphenyl-
phosphorone
LiNH2
& H3 + r-cH3 + lithium
H C , I H I-
" 0 ornide
norpregno-1.3.5(1 O), 16- iodide
tetraene (I)
Li NH, C2H50H
CrO, HZS04
chromium
trioxide
Prornegestone
DOS 2 107 835 (Roussel-Uclaf; appl !8.2.l97 1; F-prior 20.2.1970)
US 3 679 7 14 (Roussel-1 Jclaf; 25.7.1972; F-prior 20.2.1970)
US 3 761 591 (Roussel-Uclaf; 25.9.1973; F-prior 20.2.1970)
synrhcsis of 3-methoxy-20-0x0- 19-norpregna- 1,3,5(10), 16-tetraene:
Krubiner, A.M.; Oliveto, E.P.: J Org Chem (JOCEAH) 31, 24 (1966)
Krubiner, A.M et al.: J Org Chcm (JOCEAH) 34, 3502 (1969)
Formulation(s): tabl 0.125 mg, 0.25 mg 0.5 mg
Trade Name(s):
F: Surgestone (Cassenne)
Use: estrogen RN: 39219-28-8 MF: C22H3202 MW: 328.50 EINECS: 254-361-6
CN: (17~)-17-methoxy-3-propoxyestra-1,3,5(10)-triene
Trang 5Promethazine P 1725
NaOC2H5 + H3C-Br
sodium
H3C*0
(4 v.)
Reference(s):
DE 2 215 499 (Sogeras; appl 29.3.1972; GB-prior 21.4.1971)
dimethyl sulfonyl
Fomulation(s): cream 1 %; vaginal cps 10 mg
Pramestriene
Trade Name(s):
sodium
Use: antihistaminic, sedative RN: 60-87-7 MF: CI7HmN2S MW: 284.43 EINECS: 200-489-2
LD,,: 40 mglkg (M, i.v.); 326 mglkg (M, p.0.);
45 mgkg (R, i.v.)
CN: N,N,a-trimethyl- 1 OH-phenothiazine- 10-ethanamine
monohydrochloride
RN: 58-33-3 MF: C,7-H20N,S HC1 MW: 320.89 EINECS: 200-375-2
LD,,: 50 mgkg (M, i.v.); 255 mg/kg (M, p.0.);
15 m g k g (R, i v.)
phenothiozine 2-chloro-N.N-
dimethyl-1 -
propanamine
Prornethazine
u
Formulation(s): amp 56 mg12 ml; f c tabl 25 mg; drg 25 mg; drops 20 mglml; suppos 12.5 mg, 25 mg,
50 mg; syrup 1 mglml, 5.65 mg; tabl 12.5 mg, 25 mg, 50 mg (as hydrochloride)
Trang 61726 P Propacetamol
Trade Name($):
D: Atosil (Bayer Vital)
Eusedon (Krewel
Meuselbach)
Promethawern (Pharma
Wernigerode)
Promethazin-neuraxpharm
(neuraxpharm)
Prothazin (Rodleben)
F: Algotropyl prornkthazine
(Thera France)-comb
FluisCdal (Elert6)-comb
PaxCladine noctCe
(Beaufour)-comb
Phknergan (Evans Medical)
Rhinathiol promCthazine
(SynthC1abo)-comb
Tussisedal (E1erte)-comb
GB: Avomine (RhGne-Poulenc Rorer)
Parmergan P 100 (Martindale)-comb
Phenergan (Rh6ne-Poulenc Rorer)
Sominex (Seton) I: Allerfen (Sella) Duplamin (Bruschettini)- comb
Fargan (Carlo Erba) Farganesse (Pharmacia &
Upjohn) Fenazil (Sella) Prometazina (Dynacren)
Prometazina Cloridrato (Ecobi)
generics and combination preparations
I: Hiberna (Yoshitorni) Pipolphen (Nakataki) Prothia (Kanto) Pyrethia (Shionogi) USA: Mepergan (Wyeth-Ayerst) Phenergan (Wyeth-Ayerst) gencrics and combination preparations
Use: analgesic (paracetamol prodrug) RN: 66532-85-2 MF: C14H20N203 MW: 264.33 EINECS: 266-390-1
CN: N,N-diethylglycine 4-(acetylamino)phenyI ester
munuhydrochloride
RN: 66532-86-3 MF: C,,H,,N,O, HCI MW: 300.79 EINECS: 266-391-7
Reference(s j:
BE 854 376 (Hexachimie, appl 9.5.1977)
DE 2 721 987 (Hexachimie; appl 14.5.1977)
US 4 127 671 (Hexachimie; 28.1 1.1978; prior 26.5.1977)
dieihyl-
synthesis of p-acetamidophenyl chloroacetate:
Dittert, L.W et al.: J Pharm Sci (JPMSAE) 57, 774 (1968)
Propoceiarnol
Furmulurion(s): amp 1 g (as hydrochloride)
Trude Name(s):
F: Pro-Dafalgan (UPSA)
Trang 7Propafenone P 1727
Use: antiarrhythmic RN: 54063-53-5 MF: C2iH27N0, MW: 341.45 EINECS: 258-955-6
LD,,: 440 mglkg (M, p.0.)
CN: 1-[2-[2-hydroxy-3-(propylamino)propoxy]phenyl]-3-phenyl-l-propanone
hydrochloride
RN: 34183-22-7 MF: CzlHZ7NO, HC1 MW: 377.91 EINECS: 251-867-9
LD,,: 25 mgkg (M, i.v.); 341 mglkg (M, p.0.);
18.8 mglkg (R, i.v.); 700 mglkg (R, p.0.);
10 mgkg (dog, i.v.)
1-(2-hydroxyphenyl)-3- epichlorohydrin
phenyl-1 -proponone
Reference(s):
DE 2 001 43 1 (Helopharm; appl 6.1.1970)
GB 1 307 455 (Helopharm; appl 7.7.1971)
US 4 474 986 (BASF; 2.10.1984; appl 18.3.1983; D-prior 19.3.1982)
Formulation(s): amp 70 mg120 ml; drg 10 mg; f c tabl 150 mg, 300 mg; USA: tabl 150 mg, 225 mg,
300 mg (as hydrochloride)
Trade Name(s):
Use: hypnotic RN: 545-93-7 MF: Ci,H,,BrN20, MW: 289.13 EINECS: 208-896-7
LD,,: 90 mgkg (R, s.c.)
CN: 5-(2-bromo-2-propeny1)-5-(1-methylethyl)-2,4,6(1H.3H,5H)-pyrimidinetrione
Trang 81728 P Propanidid
C 2
CH30
Rqference(s):
U S 1 622 129 (Riedel AG; 1927; D-prior 1923)
DRP 481 733 (Riedel-deHaen; appl 1923)
DRP 482 841 (Riedel-deHaen; appl 1923)
DRP 485 832 (Riedel-deHaen; appl 1923)
Formulation(s)c tabl 200 mg
Trade Name(s):
Use: anesthetic RN: 1421-14-3 MF: C,,H2,N05 MW: 337.42 EINECS: 215-822;7
LD,,,: 1 13 mglkg (M, i.v.);
81 m g k g (R, i.v.); > I 0 glkg (R, p.0.);
8 0 m g k g (dog, i.v.)
CN: 4-[2-(diethylamino)-2-oxoethoxy]-3-methoxybenzeneacetic acid propyl ester
CH3
N.N-diethylchloro- propyl hornovanillate
H C N
3 - y-0
0 0 ,
CH3
Propanidid
Rcference(s):
DE 1 134 981 (Bayer; appl 6.5.1960)
Formulation(s): amp 1.5 gl30 ml, 500 mg/10 ml
Trade Name(s):
Use: antispasmodic, anticholinergic RN: 50-34-0 MF: C,,H,,BrNO, MW: 448.40 EINECS: 200-030-6
LD,,,: 6400 p g k g (M, i.v.); 445 m g k g (M, p.0.);
4 m g k g (R, i.v.); 370 m g k g (R, p.0.)
CN: N-methyl-N-(l-methylethyl)-N-[2-[(9H-xanthen-9-ylcarbonyl)oxyJethyl]-2-popanaminium bromide
Trang 9Propatyl nitrate P 1729
& z chloride
xonthene-9-
corboxylic ocid
xonthene-9- carbonyl chloride
bromide
US 2 659 732 (Searle; 1953; appl 1952; prior 1950)
Formularion(s): tabl 7.5 rng, 15 mg
Trade Name(s):
Tensilan (Desitin); wfm I: Lexil (Roche)-comb
Propatyl nitrate
(Ettriol trinitrate)
Use: coronary vasodilator (angina pectoris) RN: 2921-92-8 MF: C,H,,N@!, MW: 269.17 EINECS: 220-866-5
CN: 2-ethyl-2-[(nitrooxy)methyl]-1,3-propanediol dinitrate (ester)
HNO,, H,SO,
HO
trirnethylol-
propane
I P r o p o t l nitrate
Reference(s):
MMard: Meml Poudres (MPOUAT) 35, 1 13 (1 953)
Bou jol: Meml Poudres (MPOUAT) 36.79 (1954)
Fomulation(s): tabl 10 mg
Trade Narne(s1:
F: Atrilon 5 (Winthrop); wfm GB: Gina (Winthrop); wfm J: Etrynit (Yoshitomi); wfm
Trang 101730 P Propentofylline
Propentofylline
(HWA-285)
Use: vasodilator, cognition enhancer RN: 55242-55-2 MF: C15H22N,0, MW: 306.37
LD,,,: 168 mglkg (M, i.v.); 780 mglkg (M, p.0.);
180 mglkg (R, i.v.); 940 m g k g (R, p.0.)
CN: 3,7-dihydro-3-methyl- 1-(5-oxohexy1)-7-propyl- 1 H-purine-2,6-dione
1,3-dimethyl-7-
1 -brorno-5-
hexonone
CH3 Propentofylline
Referertce(s):
DE 2 330 742 (Albert; appl 16.6.1973)
DE 2 366 501 (Albert; appl 16.6.1973)
US 4 289 776 (Hoechst; 15.9.1981; D-prior 16.6.1973)
synthesis of 3-methyl-7-propylxanthine:
Ohsaki, T et al.: Chem Pharm Bull (CPBTAL) 36, 877 (1988)
Forrnulafion(s): tabl 100 mg
Trade Narne(s):
J : Hextol (Hoechst; 1988)
Use: antibiotic RN: 551-27-9 MF: C,,HzzN20SS MW: 378.45 EINECS: 208-995-5
CN: [2S-(2c~,5c~,6~)]-3,3-dimethyl-7-oxo-6-[(1-oxo-2-phenoxybutyl)amlno]-4-thia-1- azabicyclo[3.2.0]heptane-2-carboxylic acid
monopotassium salt
KN: 1245-44-9 MF: ClRH2,KN2O,S MW: 416.54 EINECS: 214-993-5
LD,,,: 292 mglkg (M, i.v.);
5 glkg (R, p.0.)