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ABSORPTION OF FUCOIDAN6- Fucoidan digestive enzymes including amylase, protease and lipase are attached to the plasma membrane.https://brainbarriers4you.eu/paracellular_v_transcell_en.ht

Group 1 | Presentation

NONG LAM UNIVERSITY HO CHI MINH CITY

FACULTY OF BIOLOGICAL SCIENCES

DIGESTION

AND ABSORPTION

OF FUCOIDAN

1

Ho Chi Minh City, April 6, 2023

MEMBER LIST

Nguyen Lan Anh

21126009

Nguyen Thi Lan

Anh

21126014

Do Ngoc Bao Chan

21126287

Huynh Ngoc Thuy Duong

21126037

Pham Thi My Hanh

21126054

Le Hoang Phuc

21126162

2

TOPIC OUTLINE

3

What is Fucoidan?

Practical application research

By Holly Monery, examiner.com.au

By Holly Monery, examiner.com.au

The components of Fucoidan Absorption of Fucoidan

1

Conclusion

2 3 4 5

1 WHAT IS FUCOIDAN?

Fucoidan

Cell wall polysaccharides found

in various species of brown seaweeds

Fucose-containing

sulfated polysaccharides

(FCSPs)

The algal dry weight

comprise 5–20%

4

By Robert Seeman, a blog about natural medicine

meicreatesherworld.blogspot.com

2 THE COMPONENTS OF FUCOIDAN

5

- Is a bioactive compound with high molecular weight

- Fucoidan extracts contain fucose, galactose, xylose, mannose, and

glucose

Fucose

An unusual

sugar

Produced by mammalian

cell

Present in a variety of

glycolipids and glycoproteins

3 ABSORPTION OF FUCOIDAN

6

- Fucoidan digestive enzymes including

amylase, protease and lipase are

attached to the plasma membrane.

https://brainbarriers4you.eu/paracellular_v_transcell_en.html

https://www.inspiritvr.com/ap-bio/unit-2/mechanisms-of-transport-study-guide

- Fucoidan can pass the intestinal barrier

through two parallel routes;

trasnscellular and paracellular.

- These compounds infiltrate enterocytes

by active transport via Na + - dependent

glucose transporters.

3 ABSORPTION OF FUCOIDAN

7

- The transported nutrients from fucoidan

as energy sources could enhance

intestinal barrier integrity and maintain intestinal homeostasis by interacting with various intestinal cells.

- But the permeation of high molecular weight polysaccharides, such as fucoidan, through the paracellular pathway was previously shown to be restricted by tight junctions.

4 PRACTICAL APPLICATION RESEARCH

8

(1) A study on newly weaned pigs that fucoidan-supplemented diets

significantly increased intestinal villous height

https://www.thethings.com/photos-pictures-prove-teacup-pig-cutest-pet-adorable-piglet/#care-for-a-cuppa

 Fucoidan can improve the intestinal health of animals by modulating

intestinal morphology

4 PRACTICAL APPLICATION RESEARCH

9

(2) In another study using pigs diets

containing laminarin and fucoidan.

https://www.pigadvocates.com/pig-nutrition.html

Decreased counts of Escherichia coli in the feces.



Increased the coefficient of total tract apparent digestibility.

4 PRACTICAL APPLICATION RESEARCH

1 0

(3) In a study using a dextran sulfate sodium salt mouse model of acute colitis

https://www.nature.com/articles/d41586-018-05694-w

 Mice fed with fucoidan extracts showed

+ Significant reduction in diarrhea and fecal blood

+ Decreased the infiltration of inflammatory cell

5 CONCLUSION

Dietary fucoidan enhance gut

immune functions through

immunomodulatory and

anti-inflammatory

1 1

WORK ASSIGNMENT

Anh

Do Ngoc Bao Chan

Huynh Ngoc Thuy Duong

1 2 Making powerpoint Do the compilation Making content

Making content Making content Report section

1 3

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