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Downstream Processing Novasep Solutions for the Industrial Biotech Industry: Process development and engineering capabilities combined with an unparalleled technological portfolio to maximize your return on investment Manuel Fernandez Process Design Industrial Biotech At Novasep, we can develop and supply your optimized purification process. www.novasep.com A Solution Provider Adapted to Your Project Strategies At Novasep, we strive to understand your manufacturing needs in order to propose the most cost-effective process solutions. We will partner with you to make your project a joint success. Based on our large palette of separation technologies, Novasep can: Design and develop optimized processes. Supply systems and equipment for the purification of food and functional ingredients as well as bio-industrial chemicals and ingredients. Produce development and validation lots for your functional ingredients in our facilities through our contract manufacturing services. Our facilities and experience in a broad range of applications enable us to adopt appropriate manufacturing standards including food GMP or pharmaceutical cGMP. Starting at early stage development, we design optimized solutions suited to your needs. We engineer and supply turnkey purification processes and systems with guaranteed performance. We can provide contract manufacturing services of functional ingredients should you consider interim or long-term outsourcing. A Unique and Flexible Business Model for Numerous Applications Your Process and/or Manufacturing Needs Technical Package Outsourcing Solution Insourcing Solution Novasep Process Development R&D Pilot Scale Industrial Scale Novasep Equipment & Turnkey Systems Novasep Customer Service Novasep CMO Services Food Ingredients Bio-Industries Functional Ingredients Sugars Starch Derivatives Milk & Whey Derivatives Vitamins Antibiotics Organic Acids Amino Acids Polyphenols Anthocyanes FOS Sweeteners A Unique Palette of Technologies and an Unparalleled Breadth of Key Unit Operations High, Medium and Low Pressure Batch Chromatography - Normal/reverse phase HPLC - Selective elution - Complex mixture fractionation and separations Membrane Processes - Microfiltration - Ultrafiltration - Nanofiltration - Reverse osmosis - Pre-treatment - Concentration - Desalting - Applexion ® NAP process - Polymeric and mineral membranes Adsorption & Ion Exchange - Salt conversion - Demineralization - Decolorization - Adsorption/desorption - Applexion ® XA resins Evaporation/Crystallization - Plate/tubular evaporators - Multiple effect mechanical vapor recompression - Falling films - Forced circulation - Draft tube baffle continuous crystallizer Reactions - Enzymatic: > Isomerization, hydrolysis - Catalytic: > Heterogeneous, chemical, homogenous Continuous Low Pressure Chromatography - Applexion ® SSMB (Sequential Simulated Moving Bed) - NS2P/FAST (Danisco Alliance) - Proprietary chromatography simulation software A Proven Track Record in Process Solutions Including: Flexible whey demineralization processes Cost-effective solutions for refined and industrial liquid sugars Environmentally friendly solutions for beet sugar factories Original process for the production of glucose and high fructose syrups High-purity antioxidant and protein extraction & purification Production of Fructo-Oligo-Saccharides (FOS) Efficient purification process for amino acids (glutamic acid, threonine, lysine, tryptophan, etc.) Production of bulk antibiotics (erythromycine, cephalosporin C, vancomycin, clavulanic acid, etc.) Purification of enzymes and yeast extracts Purification of organic acids and green biochemicals Production of bioethanol and biodiesel valuable co-products Electrodialysis - Mega ED RALEX ® technologies - Demineralization - Desalting From Process Development to Industrial Systems - Guaranteed By the diversity and complexity of the projects handled, Novasep has acquired great expertise and knowledge enabling us to offer a high level of service and assistance to our customers. We are flexible and adapt to your requirements in terms of quality, design and construction. Our engineers design customized units, equipment or systems ideally suited to your facilities and specific process needs. We can supply the purification system to your required scale and transfer the process with an unrivalled reliability and speed. Our expertise lies in bringing together different extraction and purification technologies. R&D scale: a strong focus on your process Novasep’s R&D team designs a single unit operation or a complete process combining different techno- logies adapted to your requirements. We have developed an advanced methodology using our proprietary computer simulation software. Novasep provides process development services including: Analytical method transfer/development Resin and membrane screening Extensive process modeling capabilities Piloting: a key step towards industrialization Novasep offers multiple services at the pilot scale including: Process optimization Process scale-up In-house piloting Customer site piloting Industrial design of your unit Process validation These activities enable us to provide you with: Process performance guarantees Complete process and guaranteed performances at industrial scale Novasep supplies complete industrial processes : Design of cost-effective solutions Basic process engineering Supply of process equipment with cost-effective local sourcing and engineering where applicable On-site assistance for commissioning Customer service Continuous improvement Enhanced process solutions Membrane CMO Services Ion Exchange Decolorization Chromatography Electrodialysis Process Optimization SSMB Demineralization Evaporation/Crystallization Piloting CMO Services: Our Unique Expertise at Your Service With Novasep, you benefit from a unique expertise acquired by our teams in both designing and using our patented chromatography solutions, ion exchange and cross-flow filtration technologies at Novasep’s own production facilities. As part of our global outsourcing solution for functional ingredients, we ensure a smooth transfer of the process package from lab to production. Our broad range of applications enable us to adopt the appropriate quality standards including food GMP or pharmaceutical cGMP. Novasep provides a global and cost-effective solution integrating your specification and your timelines. Our responsive customer service teams in Europe, the USA and China provide optimum process and equipment performance to our local & regional customers, ASAP! Extensive Technical Support Service to Answer your Questions Our customer service teams provide on-going technical assistance and are dedicated to addressing your challenges, when and where you need it. Training to Keep Optimum Performance Optimum performance is achieved with well-trained operators for all the different purification processes. Our experienced technical staff provides on-site training tailored to your needs. Spare Parts Services to Maintain Productivity with Minimum Downtime We maintain an inventory of standard parts for quick deliveries. Based on your process, we select spare parts which have been subject to in-depth evaluation and establish your basic on-site inventory. They are perfectly adapted to the process steps and meet applicable international and local standards. Upgrade to Extend the System’s Operating Life Our engineering and service teams can extend your equipment operating life without the capital expense of purchasing new equipment. Upgrades may also be a cost-effective alternative to new equipment and our team can provide custom solutions to meet your new requirements. Technical Expertise with On-Site Auditing Our customer service team strives to offer you customized solutions by auditing, improving and optimizing the throughput of new or existing equipment, reducing operating costs and guaranteeing optimum performance. billiotte.fr • 8114 - 02/2011 Printed on recycled paper www.novasep.com REST OF THE WORLD - Novasep Process Phone: +33 (0)4 72 01 27 27 industrialbiotech@novasep.com EUROPE - Novasep Process Phone: +33 (0)4 72 01 27 27 industrialbiotech@novasep.com NORTH AMERICA - Novasep Inc. Phone: +1 610 494 0447 industrialbiotech.north-am@novasep.com ASIAN COUNTRIES - Novasep Asia Phone: +86 (0)21 3895 0252 industrialbiotech.asia@novasep.com INDIA - Novasep Partner, Nishotech Phone: +91 22 41515151 industrialbiotech.india@novasep.com Copyright and Trademark Information: Groupe Novasep SAS and/or its affiliates (hereafter Groupe Novasep) own or licence the copyrights, trademarks, names, logos, and other rights to the information on this brochure. No right or licence is granted to any other party. Any unauthorized use without the express prior written consent of Groupe Novasep is prohibited. Disclaimers: The information contained on this brochure are provided «as is», for informational purposes only, without any representation or warranty of accuracy or completeness. In no event will Groupe Novasep be liable to any party for any damages or any other losses fro access or reliance upon any information contained on t JAPAN - Novasep Japan K.K Phone: +81 03 3221 1960 japan@novasep.com A.S.A.P. by Novasep: After Sales, Ask and we Provide, ASAP! . of functional ingredients should you consider interim or long-term outsourcing. A Unique and Flexible Business Model for Numerous Applications Your Process and/or Manufacturing Needs Technical Package Outsourcing Solution Insourcing Solution Novasep. Bio-Industries Functional Ingredients Sugars Starch Derivatives Milk & Whey Derivatives Vitamins Antibiotics Organic Acids Amino Acids Polyphenols Anthocyanes FOS Sweeteners A Unique Palette. chromatography simulation software A Proven Track Record in Process Solutions Including: Flexible whey demineralization processes Cost-effective solutions for refined and industrial liquid