Introduction to Molecular Biology and Genomics

Introduction to Molecular Biology and Genomics Introduction to Molecular Biology and Genomics Part One of a Short Course Series Functional Genomics and Computational Biology Greg Gonye Research Assist[.]

Introduction to Molecular Biology and Genomics Part One of a Short Course Series: Functional Genomics and Computational Biology Greg Gonye Research Assistant Professor of Pathology Anatomy and Cell Biology Daniel Baugh Institute for Functional Genomics and Computational Biology Context  Past decade and 100’s of millions of tax dollars to determine the “sequence” of the human “genome” What does this mean, why we care, what can we with it 1.6E+9 2.50E+06 1.4E+9 2.00E+06 1.2E+9 1.0E+9 800.0E+6 Records Residues 1.50E+06  Parallel increase in access to computational power  Opportunity and need to train new breed of scientist blending biology and engineering strengths to exploit the technologies available on a new scale 1.00E+06 600.0E+6 400.0E+6 5.00E+05 200.0E+6 Oct-97 Oct-96 Apr-97 Oct-95 Apr-96 Oct-94 Apr-95 Oct-93 Apr-94 Apr-93 Sep-92 Mar-91 Dec-91 Jun-90 Sep-89 Jun-88 Dec-88 Feb-87 Sep-87 May-86 Sep-84 May-85 0.00E+00 Dec-82 000.0E+0 Short Course Series  First steps towards a joint degree program with UD School of Engineering  Refinement of content and pace  Evaluation of interest/need  Tele-teaching technology - Introduction to Molecular Biology and Genomics (Oct-Nov) - Computational Biology (Jan-Feb) - Bioinformatics (Mar-Apr) Intro to Mol Biol And Genomics  High level objective to build foundation required to participate in the second and third classes of the series as well as outside the classes  Team taught by faculty involved in application of technologies  Introduction of molecular biology of cells and the technology it has spawned At Finer Grain  History of molecular biology’s origins  Introduction of technologies resulting from these biological discoveries  Create glossary of terms and jargon  Focus on large-scale high throughput technologies supporting genome scale science  Use experimental examples when possible Advertisement • Computational Biology (Jan-Feb) – Focus will be modeling approaches and utility of modeling and simulation of biological systems Frank Doyle Professor of Chemical Engineering, UDel fdoyle@udel.edu • Bioinformatics (Mar-Apr) – Focus will be use of computation in the analysis of different classes of data being generated by structural and functional genomics James Schwaber Professor of Pathology Anatomy and Cell Biology, TJU james.schwaber@mail.tju.edu Session I: From peas to helixes • Outline: – – – – – Inherited “trait” Role of chromosomes gene equals protein genes are DNA structure of DNA Inheritance: something is getting passed along: “factors” (Mendel, 1865) Mendel’s Experiments Mendelian Genetics • Alleles – dominant and recessive • Traits (phenotype) result of passage of “factors” (genotype) from parents to offspring • Predictable therefore discrete entities ... steps towards a joint degree program with UD School of Engineering  Refinement of content and pace  Evaluation of interest/need  Tele-teaching technology - Introduction to Molecular Biology and. .. Molecular Biology and Genomics (Oct-Nov) - Computational Biology (Jan-Feb) - Bioinformatics (Mar-Apr) Intro to Mol Biol And Genomics  High level objective to build foundation required to participate... 1.50E+06  Parallel increase in access to computational power  Opportunity and need to train new breed of scientist blending biology and engineering strengths to exploit the technologies available