INTRODUCTION TO IMMUNOLOGY AND MICROBIOLOGY

INTRODUCTION TO IMMUNOLOGY AND MICROBIOLOGY INTRODUCTION TO INFECTIOUS DISEASES PAUL A GULIG, PH D April 2, 8 30, 9 30 AM Office R1 250, 392 0050 Lab R1 144, 392 0682 email gulig@ufl edu 1 Randall, a[.]

INTRODUCTION TO INFECTIOUS DISEASES PAUL A GULIG, PH.D April 2, 8:30, 9:30 AM Office - R1-250, 392-0050 Lab R1-144, 392-0682 email: gulig@ufl.edu Randall, a first year IDP student, went on a picnic at Crescent Beach Before leaving for the beach he made chicken salad sandwiches, which sat in the hot car for five hours before being eaten The next afternoon he had nausea, diarrhea, and mild fever, which persisted for three days, just long enough to ruin the condo rental! Symptoms resolved by the time he returned to school • Diagnosis • Treatment • Keys Randall, a first year IDP student, went on a picnic at Crescent Beach Before leaving for the beach he made chicken salad sandwiches, which sat in the hot car for five hours before being eaten The next afternoon he had nausea, diarrhea, and mild fever, which persisted for three days, just long enough to ruin the condo rental! Symptoms resolved by the time he returned to school • Diagnosis – Salmonella gastroenteritis • Treatment - Symptomatic • Keys – Poor food preparation, bacterial invasion, intercellular communication Marsha, another IDP student, went on a picnic at Manatee Springs She ate some potato salad that had sat in on the picnic table while she was snorkeling Five hours later, she had severe, profuse vomiting, followed by some diarrhea It resolved in a day • Diagnosis • Treatment • Keys Marsha, another IDP student, went on a picnic at Manatee Springs She ate some potato salad that had sat in on the picnic table while she was snorkeling Five hours later, she had severe, profuse vomiting, followed by some diarrhea It resolved in a day • Diagnosis – Staphylococcal food poisoning (intoxication) • Treatment - Symptomatic • Keys – Poor food preparation, toxin-mediated damage Ann, a single 35 year old woman from Miami met a guy at a bar in South Beach After having a few drinks, they engaged in wild sex She experienced mild, flu-like symptoms a couple of weeks afterward One year later on giving blood, she was informed she was HIV-positive Despite treatment with newest combination HAART therapy, she developed protracted, watery diarrhea that could not be treated The diagnosis was made by observing oocysts in her stool She ultimately succumbed to her intestinal ailments None of here friends had ever experienced, nor ever would, her intestinal disease, although they encountered the agent frequently • Diagnosis • Treatment • Keys Ann, a single 35 year old woman from Miami met a guy at a bar in South Beach After having a few drinks, they engaged in wild sex One year later on giving blood, she was informed she was HIV-positive Despite treatment with newest combination HAART therapy, she developed protracted, watery diarrhea that could not be treated The diagnosis was made by observing oocysts in her stool She ultimately succumbed to her intestinal ailments None of here friends had ever experienced, nor ever would, her intestinal disease, although they encountered the agent frequently • Diagnosis – AIDS + Cryptosporidium parvum diarrhea • Treatment – HAART, no cure for Crypto • Keys – Viral mediated immunodeficiency, opportunistic infection Alice another graduate student from the IDP traveled up North to visit her family in Rochester, NY for spring break It was still very cold The first day home, she went to a movie The person sitting next to her had a “cold” and was sneezing, coughing, and blowing her nose Two days later, Alice had high fever, sore throat, respiratory congestion, aches, pains, and chills It lasted for the rest of break When Alice returned to class, with some residual sneezing and coughing, she gave the disease to all of her friends in class • Diagnosis • Treatment • Keys Alice another graduate student from the IDP traveled up North to visit her family in Rochester, NY for spring break It was still very cold The first day home, she went to a movie The person sitting next to her had a “cold” and was sneezing, coughing, and blowing her nose Two days later, Alice had high fever, sore throat, respiratory congestion, aches, pains, and chills It lasted for the rest of break When Alice returned to class, with some residual sneezing and coughing, she gave the disease to all of her friends in class • Diagnosis - Influenza • Treatment – Amantidine (early), Symptomatic • Keys – Viral respiratory infection, Host-host spreading Brad, a 35 year old investment banker went hiking in the Rocky Mountains of Colorado During his hiking trip he experienced severe watery diarrhea with gas and pain He just drank extra fluid to make up for the fluid loss from diarrhea The diarrhea did not resolve for more than two weeks after returning to New York City • Diagnosis • Treatment • Keys