Tog ddm "Nghien cim img dung vd phdt triin cong nghe" ISBN: 978-604-913-017-5 NGHIEN CUtJ THIET KE, CHE TAO HE THIET BI CUNG CAP NU^OfC TINH KHIET CAO CAP CHO LOC MAU CHAY THAN NHAN TAO Trjnh Dinh Trung, Trinh Ngoc Dieu, Ha Hoang Kiem, Nguyen H6ng Thuy Vien Vat Ly 10 - Dao Tin, Ba Dinh, Ha Ngi Email: trinhngocdieuvI@yahoo.com Tom tat: He thiet bi cung cdp nu&c tinh khiit cao cdp cho lge mdu chgy than nhdn tgo dd dugc nghien cim, che tgo theo quyit dinh sd 823/QD- KHCN ciia Viin Khoa hgc vd Cdng nghi Viet nam He dd dugc Trung tdm Ky thugt ( Tdng cue Tieu chudn luong chdt lugng) gidm dinh chdt lugng sd 09/NV/GD/051, ngdy 4/9/2009 Kit qud gidm dinh ve chi tieu chdt lugng nu&c hodn todn dgt v&i tieu chudn mr&c cdp cho lge mdu chgy than nhdn tgo ciia AAMI - Hoa Ky (Association for the Advancement of Medical Instrumentation), Bd Y te dd quy dinh dp dung cho lge mdu chgy than tgi Viet nam He dd dugc irng dung cho tren chuc benh viin vd ngodi nu&c, hien vdn dang hogt ddng tdt, ddm bdo cho hdng ngdn ca Igc mdu an todn Abstract: The equipment system to supply high-grade pure water for artificial kidney blood filter was researched and manufactured under Decision No 823/QDKHCN by Vietnam Academy of Science and Technology This system passed the Quality Survey No 09/NV/GD/051 conducted by Technical Centre (Directorate for Standards and Quality) on September 4, 2009 Results of the survey showed that the water quality accords completely with the criteria of water supply for artificial kidney blood filter established by AAMI (Association for the Advancement of Medical Instrumentation) of the USA, and It has been permitted by Ministry of Health to be applied to artificial kidney blood filter in Vietnam The system has been applied to a dozen of hospitals at home and abroad, and is being in good operation, ensuring thousands of cases of safe blood filter Mo dau Nam 1913 John Abelrowtree Turer ( My) thuc nghiem Igc mau diu tien tren ddng vat song vdi mang Igc Collodin, chdng ddng mau bing hirudin Sau 12 nam, din nam 1925 Gerg Hass (Dire) tien hanh Igc mau lin diu tien tren ngudi nhung kit qua cdn rit ban cbl Cho den ky thuat lge mau cho benh nhan suy than man dugc sir dung cang nhilu va da la mdt nhung phuong phap chii dao dl dilu tri cho benh nhan suy than man tren the gidi ciing nhu d Viet Nam Lge mau ngoai co the hay than nhan tao la phuong phap dieu trj thay the than giup dao thai cac chat tdn du mau, dieu chinh can bing nude, chit dien giai, can bang kilm- toan Trao ddi giira mau \'a djch lge (cd phin gidng djch ngoai te bao) thuc hien qua mang 52 Hoi nghi Khoa hoc ky- niem 35 ndm Vien Khoa hoc vd Cong nghe Viet Nam - Hd Noi 10 2010 ban tham thau Sir trao ddi cac chat hda tan va nude giiia hai ben mang dugc thuc hien theo CO che CO ban khuyech tan va sieu lge Neu cd sir chenh lech ndng phan mau (cac chat tdn du mau) va djch lge, thi qua trinh Igc dugc thuc hien de dam bao sir can bang ndng d trang thai binh thudng ciia chimg [5] Djch lge la yeu td rat quan trgng ky thuat Igc mau, vi nd true tiep tilp sue \'a trao ddi vdi mau benh nhan qua mang ban tham Thanli phan djch lge bao gdm nude tinh kliilt cao cip, cac chat dien giai cd ndng tuong duong vdi ndng ciia chiing mau ngudi binh thudng Vi the nude cung cap cho may than nhan tao phai la nude tinh khilt eao cip, bit huge phai dap img cae yeu ciu sau: - Khdng lam thay ddi phan va tinh chit hda ly ciia djch sau pha loang - Khdng cd cac ddc td vd co ( nhdm, ddng, chi, thiiy ngan ) va cac chit hiiu co ( nitrit, nitrat, ammoniac.) - Chat lugng nude phai dam bao tot vl mat vi khuin va nhiet td Tinh hinh nghien ciru che tao he thilt bj cung cSp nuoc tinh khilt cao cap cho loc mau chay than nhan tao a, Tren thi gi&i: Cac he thiet bj cung cip nude tinh khilt cao cip eho lge mau chay than nhan tao dugc nhilu hang cua My, Nhat Ban, Dire, Thuy Diln, Phap ( nhu Toray, B.Braun, Gambro, Cobe) dugc thilt kl cho quy trinh cdng nghe xir Iy dilu kien mdi trudng ngudn nude dau vao ma cae tap chat nude da dugc loai bd co ban, dat quy chuin ciia qudc gia chay Au va qudc tl Do dd quy trinh cdng nghe, he chi cin sir dung cdng nghe lge thim thau nguge (RO), khir cimg va khir triing la nude san phim dat tieu chuin cip cho Igc mau chay than nhan tao Trong dieu kien he thilt bj boat ddng dn djnh cao b, Trong nu&c: Tai cac benh vien, cac he thilt bj ngoai nhap dang gap bit lgi mdi trudng thue te ciia ciia Viet Nam bdi ngudn nude cung cip true tilp diu vao eho he cdn nhilu du lugng tap chit, khdng dat tieu chuin 1329/2002/BYT-QD eiia Bd Y tl quy djnh nude cip cho an udng Dieu lam cho thiet bj ngoai nhap nhanh gia hda, gay tdn kem cung nhu bit Igi cho qua trinh sir dung dieu trj ciia co sd y te Hien chua cd don vj nao tien hanh nghien ciiu chi tao mdt each chinh thdng, cung nhu cdng bd ket qua kiem djnh chi tieu chat Iugng nude diing cho Igc mau chay than nhan tao tir nghien cim 3.Tien hanh nghien ciiu thiet ke, che tao he thiet bi cung cap nuoc tinh khiet cao cap cho loc mau chay than nhan tao He thilt bj cung cip nude tinh khilt cao cip cho Ige mau chay than nhan tao la san phim ciia dk tai nghien eim phat triln khoa hgc va cdng nghe cip Vien Khoa hgc va Cdng nghe Viet Nam sd 823/QD-VKHCNyN, nim dl an " Nghien cim chi tgo vd sdn xudt trang thiit biyti din 2010" theo quylt djnh sd 18/2005/QD - TTg ciia Thii Tudng Chinh Phii D I tai tiln hanh vdi sir hgp tac nghien cim khoa hgc - y hgc img dung giira Vien Vat ly (Vien Khoa hgc va Cdng nghe Viet nam), Trung tam U'ng dung Vat Iy Y Sinh va Ky thuat mdi trudmg (Lien hiep cac Hdi Khoa hgc va Ky thuat Viet nam), benh vien Quan ddi 103 (Bd Qudc phdng), dai dien hang Gabro ( Thuy Diln tai Viet nam), nhim dap irng yeu ciu dilu trj lge mau chay than nhan tao, md ky thuat cao ciia nganh Y tl nude nha Nhu tren da de cap, ngudn nude cip diu vao cho he Igc RO cdn du luong nhilu tap chit, vi the van de nghien cim dugc dat cin phai giai quylt cua dk tai la: 53 Tog ddm "Nghien cim img dung vd phdt trien cong nghe" ISBN: 978-604-913-017-5 a, Tien hanh nghien ciiu, lua chon bo sung giai phap cong nghe khoi tiln vi loc cho he thiet bj: - Da tiln hanli khao sat thue trang mdt sd he thiet bj ciia nude ngoai dang sir dung tai benh vien Viet Nam Sau thdi gian ngan boat ddng, hien tugng thilt bj nhanh gia hda, dan tdi nude san pham eiing nhanh bj suy giam chat Iugng Do dd phai thudng xuyen thay thi vat lieu ehii dao he thdng mdi dam bao duge chat lugng dau - Da tiln hanh khao nghiem, phan tich, danh gia chi tieu chat Iugng nude may phd tai mdt sd dilm tren dja ban phd Ha Ndi va ngoai tinh (se la ngudn cung cap nude dau vao cho he thilt bj) Kit qua thu dugc eho thay cac du lugng tap chat nhu: sit, eae kim loai nang, amoni vugt qua ngudng eho phep rat cao, chua dat tieu chuan 1329/2002/BYT - QD ciia Bd Y te, dugc the hien tren bang Bdng 1^*^: Mdt sd du lugng tgp chdt nu&c mdy thdnh phd: Hang muc tap chat So TT Sat tdng (Fe) Amoni tinh theo NH4^ Tdng cimg Canxi (Ca) Magie (Mg) Clorua (CF) Don vj Diem lay mau mg/l Khu cdng nghiep Phiing, Ha Tay Khu Giap Bat, HN BV Hiru Nghj BV Quan ddi 103 BV Hun Nghj BV Hiru Nghj BV Quan ddi 103 BV Hai Duong mg/I mgCaC03/I mg/I mg/l mg/l Ham luong TC 1329/2002 Ket qua va nude cap dau thuc te vao he RO,Toray 0,5 2,96 15,6 194 178 48,8 17,3 34 21 1,5 lll(TC-Toray) 32 (TC-Toray) (TC-Toray) b, Xac lap quy trinh cong nghe de thiet ke khoi tien vi loc - Da nghien ciru - thi nghiem lira chgn dugc loai vat lieu ed tinh Ige da nang, dap img yeu cau khir dugc phan ldn cac tap chat nude ngudn dau vao Ket qua klia nang khir tap chat ciia vat lieu dugc lira chgn the hien tren bang Bang SoTT Khd ndng khu tgp chdt ciia vdt lieu dugc lira chgn Hang muc tap chat pH Do dan dien Tdng Cling Canxi (Ca) Magie (Mg) Sat tdng (Fe) Clorua (CF) Don vj - fjS/cm mgCaC03/I mg/I mg/I mg/l mg/l Ham luong M, M2 7.35 501 7,3 225 178 43.2 16,8 0,22 34 98 25 7,7 0,01 15 Ghi chii: Mj - Mdu nu&c mdy binh vien Qudn ddi 103, chua qua xir ly tien Igc M2 - Mdu nu&c mdy benh viin Qudn ddi 103, dugc xir ly tien lge 54 Hoi nghi Khoa hoc ky niem 35 ndm Vien Khoa hoc vd Cong nghe Viet Nam - Hd Noi 10 2010 - Da nghien ciiu - thi nghiem lira chgn dugc loai vat lieu cd tinh Ige dae biet giai quyet khii' amoni Kit qua sir dung loai vat lieu nay, sau nude dugc xir Iy chi tieu amoni giam xudng < 0,01 Dilu cd y nghTa quan trgng vl kha nang dap img mdt nhiimg tieu chuan nude sir dung cho nganh Y - Dugc Ket qua kha nang khir amoni eiia loai vat lieu da dugc lira chgn dugc the hien tren bang Bang '*': Khd ndng khu tgp amoni ciia vdt lieu dugc lira chgn S6TT Hang muc tap chat Don vj Ham luong mg/I Truoc duoc xu ly Amoni (nude ngudn dau vao) Sau duoc xir ly bang vat lieu duoc lua chon Amoni mg/I