(Yang et al., 2018) Pharmacist Intervention in Type Diabetes Mellitus Management: Need for the Identification of the Aspects of Care that Drives Optimal Patient Outcomes ACCP # 56314 Jessica M Wayne, PharmD Candidate , Allegra M Browne, PharmD Candidate , Ronald C Reed, BS Pharm, PharmD, FCCP, West Virginia University School of Pharmacy, Morgantown, FAES WV CONCLUSIONS: The components of care driving the literature-reported statistically significant improvement in T2DM patient outcomes provided by pharmacists remains unclear Although 14 sentinel published studies, examined here, provide some hint, they not provide definitive reasons for pharmacist success in T2DM clinic patient management Studies are needed to identify & quantify the aspects of care responsible for pharmacists’ success RESULTS INTRODUCTION / AIM • Diabetes is growing in prevalence as in 2014 a total of 387 million individuals worldwide were living with type-2 diabetic mellitus (T2DM) (Forouhi & Wareham, 2014) • Lowering HbA1c is critical in T2DM Every 1% decrease in HbA1c results in, as it relates to T2DM: • • • • • 21% reduction in risk for any diabetes endpoint 21% (95% CI: 15%-27%) decrease in deaths; 14% (95% CI: 8% -21%) decrease in MI 37% (95% CI: 15%-27%) decrease in microvascular complications (p < 0.0001 for all changes listed; (Stratton et al, BMJ 2000) • In recent years pharmacists have begun playing a larger and crucial role in the management of (T2DM) (Sisson & Kuhn, 2009) • Medications play a vital role in T2DM management; yet, other components of pharmacists’ interventions (e.g., education, adherence monitoring, more visits, more time allotted per visit, follow -up telephone/video visits), may play an important role, too • In this retrospective research review, we identified pharmacist intervention factors or components associated with successful patient outcomes, centered on measures to decrease % HbA1c • Our aim was to determine which and what # of factors (#1 to #6) were detailed in each article that meet our search criteria Table List of 14 select salient studies (of 25 identified), examining Pharmacist involvement impact in T2DM patient care, plus a list of potential factors of interventions hypothesized to contribute to patient care success Study Primary Outcome # • • • • span, English, human only, free full-text articles Inclusion criteria consisted of original research experiments, pharmacists in primary care environments, plus studies that documented pharmacist intervention type Preference was given to studies reporting HbA1c measurements as tangible, reliable evidence for pharmacists’ interventions, and to key terms appearing in the Title/Abstract Exclusion criteria consisted of meta-analysis/systemic reviews, studies without tangible results, and non-United States studies 433 articles were identified, via these search terms: [diabetes care] AND [pharmacist impact] [diabetes] AND [pharmacist care] AND [efficacy], [diabetes care] AND [pharmacists] AND [worse], [diabetes care] AND [pharmacist led] AND [efficacy], [a1c lowered] AND [pharmacist-led] AND [diabetes management], and [pharmacist led] AND [diabetes care] AND [patient satisfaction] Δ HbA1C at 6months compared to baseline Adherence to oral antidiabetic medication (OAD)& Δ HbA1C IG: -0.5 Δ vs CG: no Δ (p=0.04) IG: 84.3% adherence, − 1.5% Δ A1C vs CG: 82.4%, -1.4% Δ A1C (p < 0.0001 ) Δ HbA1C P